Advanced search
Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 27, 1997 - Issue 12
Submit an article Journal homepage
26
Views
2
CrossRef citations to date
0
Altmetric
Research Article

Biliary excretion and microfloral transformation of major conjugated metabolites of 2,4-dinitrotoluene and 2,6-dinitrotoluene in the male Wistar rat

M.-A. MORI School of Health Sciences, Kyushu University, 3-1-1 Maidashi,Higashi-ku, Fukuoka 812, Japan Faculty of Engineering,Toyama University, 3190 Gofuku, Toyama 930, Japan OE Faculty of Medicine,ToyamaMedical and PharmaceuticalUniversity, 2630 Sugitani, Toyama 930-01, Japan
,
M. SAYAMA School of Health Sciences, Kyushu University, 3-1-1 Maidashi,Higashi-ku, Fukuoka 812, Japan Faculty of Engineering,Toyama University, 3190 Gofuku, Toyama 930, Japan OE Faculty of Medicine,ToyamaMedical and PharmaceuticalUniversity, 2630 Sugitani, Toyama 930-01, Japan
,
M. SHOJI School of Health Sciences, Kyushu University, 3-1-1 Maidashi,Higashi-ku, Fukuoka 812, Japan Faculty of Engineering,Toyama University, 3190 Gofuku, Toyama 930, Japan OE Faculty of Medicine,ToyamaMedical and PharmaceuticalUniversity, 2630 Sugitani, Toyama 930-01, Japan
,
M. INOUE School of Health Sciences, Kyushu University, 3-1-1 Maidashi,Higashi-ku, Fukuoka 812, Japan Faculty of Engineering,Toyama University, 3190 Gofuku, Toyama 930, Japan OE Faculty of Medicine,ToyamaMedical and PharmaceuticalUniversity, 2630 Sugitani, Toyama 930-01, Japan
,
T. KAWAGOSHI School of Health Sciences, Kyushu University, 3-1-1 Maidashi,Higashi-ku, Fukuoka 812, Japan Faculty of Engineering,Toyama University, 3190 Gofuku, Toyama 930, Japan OE Faculty of Medicine,ToyamaMedical and PharmaceuticalUniversity, 2630 Sugitani, Toyama 930-01, Japan
,
M. MAEDA School of Health Sciences, Kyushu University, 3-1-1 Maidashi,Higashi-ku, Fukuoka 812, Japan Faculty of Engineering,Toyama University, 3190 Gofuku, Toyama 930, Japan OE Faculty of Medicine,ToyamaMedical and PharmaceuticalUniversity, 2630 Sugitani, Toyama 930-01, Japan
&
T. HONDA School of Health Sciences, Kyushu University, 3-1-1 Maidashi,Higashi-ku, Fukuoka 812, Japan Faculty of Engineering,Toyama University, 3190 Gofuku, Toyama 930, Japan OE Faculty of Medicine,ToyamaMedical and PharmaceuticalUniversity, 2630 Sugitani, Toyama 930-01, Japan
 show all
Pages 1225-1236 | Published online: 22 Sep 2008

References

  • ABOU -EL -MAKAREM, M. M., MILLBURN, P., SMITH, R. L. and WILLIAMS, R. T., 1967, Biliary excretion of foreign compounds: benzeneand its derivativesin the rat. Biochemical Journal, 105, 1269–1273.
  • BOND, J. A., MEDINSKY, M. A., DENT, J. G. and RICKERT, D. E., 1981, Sex-dependentmetabolism and biliary excretion of [2,4-14C]dinitrotoluem in isolated perfused rat liver. Journal of Pharmacology and Experimental Therapeutics, 219, 598–603.
  • INGEBRIGTSEN, K. and FRosuE, A., 1980, Intestinal metabolism of DNOC and DNBP in the rat. Acta Pharmacologica et Toxicologica, 46, 326–328.
  • KEDDERIS, G. L DYROFF, M. C. and RICICERT D. E., 1984, H epaticm acrom olecularcovalent binding of the hepatocarcinogen 2,6-dinotrotoluene and its 2,4-isomer in vivo: modulation by the sulfotransferase inhibitors pentachloropheml and 2,6-dichloro-4-nitrophenol.Carcinogenesis, 5, 1199–1204.
  • LONG, R. M. and RICICERT, D. E.,1982, Metabolism and excretion of 2,6-dinitro Citoluenein vivo and isolated perfused rat livers. Drug Metabolism and Disposition, 10, 455–458.
  • MORI, M., INOUE, M., NUNOZAWA, T., MIYAHARA, T. and KOZUKA, H., 1986, Preparation of some acetylated, reduced and oxidized derivatives of 2,4-diaminotoluene and 2,6-dinitrotoluene. Chemical and Pharmaceutical Bulletin, 34, 4859–4861.
  • MORI, M., KAWAJIRI, T., SAYAMA, M., MIYAHARA, T. and KOZUKA, H., 1989b, Metabolism of 2,4-dinitrotolueneand 2,6-dinitrotoluene,and their dinitrobenzylalcohols and dinitrobenzaldehydes by Wistar and Sprague-Dawley rat liver microsomal and cytosol fractions. Chemical and Pharmaceutical Bulletin, 37, 1904–1908.
  • MORI, M., KAWAJIRI, T., SAYAMA M., TANIUCHI, Y., MIYAHARA, T. and KOZUKA, H., 1989a, Metabolism of 2,6-dinitrotoluene in male Wistar rat. Xenobiotica, 19, 731–741.
  • MORI, M., KUDO, Y., NUNOZAWA, T., MIYAHARA, T. and KozuKA, H., 1985b, Intestinal metabolism of 2,4-dinitrotoluene in rats. Chemical and Pharmaceutical Bulletin, 33, 327–332.
  • MORI, M., MIYAHARA, T., MOTO -0, K., FUKUKAWA, M., KOZUKA, H., MIYAGOSHI, M. and NAGAYAMA T., 1985a, Mutagenicity of urinary metabolites of 2,4-dinitrotoluene to Salmonella typhimurium . Chemical and Pharmaceutical Bulletin, 33, 1687–1693.
  • MORI, M., NARUSE, Y. and KOZUKA, H.,1981, I dentification of urinary metabolites of 2,4-dinitrotoluene (2,4-DNT) in rat. Chemical and Pharmaceutical Bulletin, 29, 1147–1150.
  • MORI, M., SHOJI, M., DOHRIN M., KAWAGOSHI, T., HONDA, T. and KOZUKA, H., 1996, Further studies on the urinary metabolites of 2,4-dinitrotoluene and 2,6-dinitrotoluene in the male Wistar rat. Xenobiotka, 26, 79–88.
  • SAYAMA M., MORI, M., ISHIDA, K., OKUMURA, K. and KOZUKA, H., 1989a, Enterohepaticcirculationof 2,4-dinitrobenzaldehyde, a mutagenic metabolite of 2,4-dinitrotoluene, in male Wistar rat. Xenobiotka, 19, 83–92.
  • SAYAMA M., MORI, M., MARUYAMA, Y., INouE, M. and KOZUKA, H., 1993, Intestinalmetabolism of 2,6-dinitrotoluene in male Wistar rats. Xenobiotica, 23, 123–131.
  • SAYAMA M., MORI, M., SHIROKAWA, T., INouE, M., MIYAHARA, T. and KoZUKA, H., 1989b, Mutagenicityof 2, 6-dinotrotolueneand its metabolites,and their related compoundsin Salmonella typhimurium . Mutation Research, 226, 181–184.
  • SHOJI, M., MORI, M., KAWAJIRI, T., SAYAMA, M., MORI, Y MIYAHARA, T., HONDA, T. and KOZUKA, H., 1987, Metabolism of 2,4-dinitrotoluene, 2,4-dinitrobenzyl alcohol and 2,4-dinitrobenz-aldehyde by rat liver microsomaland cytosol fractions. Chemical and Pharmaceutical Bulletin, 35, 1579–1586.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.