Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 27, 1997 - Issue 9
90
Views
23
CrossRef citations to date
0
Altmetric
Research Article

Identification of human cytochrome P450 isoforms involved in the metabolism of brotizolam

, , , &
Pages 913-922 | Published online: 22 Sep 2008

References

  • BADCOCK, N. R., BARTHOLOMEUSZ, F. D., FREWIN, D. B., SANSOM, L. N. and REID, J. G., 1987, The pharmacokinetics of ketoconazole after chronic administration in adults. European Journal of Clinical Pharmacology, 33, 531–534.
  • BALDWIN, S. J., BLOOMER, J. C., SMITH, G. J., AYLTON, A. D., CLARICE, S. E. and CHENERY, R. J., 1995, Ketoconazole and sulphaphenazole as the respective selective inhibitors of P4503A and 2C9. Xenobiotica, 25, 261–270.
  • BECHTEL, W. D., MIERAU, J., BRANDT, K., FOSTER, H. J. and Pool(, K. H., 1986b, Metabolic fate of ['4 q-brotizolam in the rat, dog, monkey and man. Arzneimittelforschng, 36, 578–586.
  • BECHTEL, W. D., VAN WAYJEN, R. G. A. and VAN DEN EE, A., 1986a, Blood level, excretion, and metabolite pattern of P4 q-brotizolam in humans. Arzneimittelforschng, 36, 575–578.
  • GONZALEZ, F. J., 1992, Human cytochromes P450: problems and prospects. Trends in Pharmacological Science, 13, 346–352.
  • GUENGERICH, F. P., 1994, Catalytic selectivity of human cytochrome P450 enzymes: relevance to drug metabolism and toxicity. Toxicology Letters, 70, 133–138.
  • GUENGERICH, F. P., MULLER -ENOCH, D. and BLAIR, I. A., 1986, Oxidation of quinidine by human liver cytochrome P-450. Molecular Pharmacology, 30, 287–295.
  • HORAI, Y. and Ismzmu, T., 1988, Pharmacogenetics and its clinical implications part II. Oxidation polymorphism. Rational Drug Therapy, 22, 1–8.
  • KRONBACH, T., MATHYS, D., UMENO, M., GONZALEZ, F. J. and MEYER, U. A., 1989, oxidation of midazolam and triazolam by human liver cytochrome P450IIIA4. Molecular Pharmacology, 36, 89–96.
  • MAURICE, M., PICHARD, L., DAUJAT, M., FABRE, I., JOYEUX, H., DOMERGUE, J. and MAUREL, P., 1992, Effects of imidazole derivatives on cytochromes P450 from human hepatocytes in primary culture. F ASEB Journal, 6, 752–758.
  • NEWTON, D. J., WANG, R. W. and Lu, Y. H., 1995, Cytochrome P450 inhibitors: evaluation of specificities in the in vitro metabolism of therapeutic agents by human liver microsomes. Drug Metabolism and Disposition, 23, 154–158.
  • SANCHEZ-MARTINEZ, J. and LANDA-PALOS, D. M. J., 1982, A new thienodiazepine, brotizolam, for the treatment of insomnia. Journal of International Medical Research, 10, 118–121.
  • TALLARIDA, R. J. and MURRAY, R. B., 1986, Manual of Pharmacologic Calculations with Computer Programs (New York: Springer).
  • VARHE, A., OLIUCOLA, K. T. and NEUVONEN, P. J., 1994, Oral triazolam is potentially hazardous to patients receiving systemic antimycotics ketoconazole or itraconazole. Clinical Pharmacology and Therapeutics, 56, 601–607.
  • VON MOLTKE, L. L., GREENBLATT, D. J., COTREAU -BIBBO, M. M., HARMATZ, J. S. and SHADER, R. I., 1994, Inhibitors of alprazolam metabolism in vitro: effect of serotonin-reuptake-inhibitor antidepressants, ketoconazole and quinidine. British Journal of Clinical Pharmacology, 38, 23–31.
  • VON MOLTKE, L. L., GREENBLATT, D. J., HARMATZ, J. S., DUAN, S. X., HARREL, L. M., CONTREAU - BIBBO, M. M., PRICHARD, G. A., WRIGHT, C. E. and SHADER, R. I., 1996, Triazolam bio-transformation by human liver microsomes in vitro: effects of metabolic inhibitors and clinical confirmation of a predicted interaction with ketoconazole. Journal of Pharmacology and Experimental Therapeutics, 276, 370–379.
  • WIUGHTON, S. A. and RING, B. J., 1994, Inhibition of human CYP3A catalyzed 1'-hydroxy-midazolam formation by ketoconazole, nifedipine, erythromycin, cimitidine, and nizatidine. Pharmaceutical Research, 11, 921–924.
  • YASUI, N., OTANI, K., KANEKO, S., OHKUBO, T., 0 SANAI, T., SUGAWARA, K., CHIBA, K. and ISHIZAKI, T., 1996, A kinetic and dynamic study of oral alprazolam with and without erythromycin in humans: in vivo evidence for the involvement of CYP3A4 in alprazolam metabolism. Clinical Pharmacology and Therapeutics, 59, 514–519.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.