References
- BROSEN, K., ZEUGIN, T. and MEYER, U. A., 1991, Role of P450IID6, the target of the sparteine-debrisoquin oxidation polymorphism, in the metabolism of imipramine. Clinical Pharmacology and Therapeutics, 49, 609–617.
- CHIBA, M., FUJITA, S. and Suzum, T., 1988, Parallel pathway interactions in imipramine metabolism in rats. Journal of Pharmaceutical Sciences, 77, 944–947.
- CHIBA, K., SAITOH, A., KOYAMA, E., TAM, M., HAYASHI, M. and ISHIZAKI, T., 1994, The role of 5-mephenytoin 4'-hydroxylase in imipramine metabolism by human liver microsomes : a two-enzyme kinetic analysis of N-demethylation and 2-hydroxylation. British Journal of Clinical Pharmacology, 37, 237–242.
- FUJITA S., KITAGAWA, H., CHIBA, M., SUZUKI, T., OHTA, M. and KITANI, K., 1985, Age and sex associated differences in the relative abundance of multiple species of cytochrome P-450 in rat liver microsomes. A separation by HPLC of hepatic microsomal cytochrome P-450 species. Biochemical Pharmacology, 34, 1861–4.
- FUJITA S., MORIMOTO, R., CHIBA, M., KITANI, K. and Suzum, T., 1989, Evaluation of the involvement of a male specific cytochrome P-450 isozyme in senescence-associated decline of hepatic drug metabolism in male rats. Biochemical Pharmacology, 38, 3925–3931.
- GONZALEZ, F. J., 1988, The molecular biology of cytochrome P450s. Pharmacological Reviews, 40, 243–88.
- GONZALEZ, F. J., 1996, The CYP2D subfamily. In Cytochronte P450: Metabolic and Toxicological Aspects, edited by Costas Ioannides (New York: CRC Press), pp. 183–210.
- HIGGINS, G. K. and ANDERSON R. M., 1931, Experimental pathology of the liver. 1. Restoration of the liver of the white rat following partial surgical removal. Archives of Pathology, 12, 186–212.
- IMAOKA S., TERANO, Y. and FUNAE, Y., 1987, Purification and characterization of two constitutive cytochromes P-450 (F-1 and F-2) from adult female rats: identification of P-450E-1 as the phenobarbital-inducible cytochrome P-450 in male rat liver. Biochimica et Biophyska Acta, 916, 358–367.
- ISHIDA, R., FUJITA, S. and Suzum, T., 1988, Bunitrolol metabolism and its inhibition by cimetidine. Journal of Pharmacy and Pharmacology, 40, 64–65.
- KITAGAWA, H., FUJITA S S UZUKI, T. and KITANI, K., 1985, Disappearance of sex difference in rat liver drug metabolism in old age. Biochemical Pharmacology, 34, 579–81.
- LAEMMLI U. K., 1970, Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature, 227, 680–685.
- LAX, E. R., KREUZFELDER, E. and SCHRIEFERES, H., 1979, Time-studies of the changes in the sex-dependent activities of enzymes of hepatic steroid metabolism in the rat following gonadectomy. Hoppe Seylers Zeitschrift fur Physiologische, 360, 1799–1805.
- LEMOINE, A., GAUTIER, J. C., AZOULAY, D., KIFFEL, L., BELLOC, C., GUENGERICH, F. P., MAUREL, P., BEAUNE, P. and LEROUX, J. P., 1993, Major pathway of imipramine metabolism is catalyzed by cytochromes P-450 1A2 and P-450 3A4 in human liver. Molecular Pharmacology, 43, 827-832. LENNARD, P. R., 1990, Image analysis for all. Nature, 347, 103–104.
- LIDDLE, C., MURRAY, M. and FARRELL, G. C., 1989, Effect of liver regeneration on hepatic cytochrome P450 isozymes and serum sex steroids in the male rat. Gastroenterology, 96, 864–72.
- LOWRY, 0. H., 1951, Protein measurement with the folin phenol regent. Journal of Biological Chemistry, 193, 265–275.
- MADSEN, H., NIELSEN, K. K. and BRosEN, K., 1995, Imipramine metabolism in relation to the sparteine and mephenytoin oxidation polymorphisms—a population study. British Journal of Clinical Pharmacology, 39, 433–439.
- MARIE, I. J., DALET, C., BLANCHARD, J. M., ASTRE, C., SZAWLOWSKI, A., SAINT AUBERT, B., JoYEux, H. and MAUREL, P., 1988, Inhibition of cytochrome P-450p (P450IIIAI) gene expression during liver regeneration from two-thirds hepatectomy in the rat. Biochemical Pharmacology, 37, 3515–3521.
- OMURA, T. and SATO, R., 1964, The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its femoprotein nature. Journal of Biological Chemistry, 239, 2370–2378.
- RAM, P. A. and WAXMAN, D. J., 1990, Pretranslational control by thyroid hormone of rat liver steroid 5 alpha-reductase and comparison to the thyroid dependence of two growth hormone-regulated CYP2C mRNAs. Journal of Biological Chemistry, 265, 19223–19229.
- RONIS, M. J., LUMPKIN, C. K., THOMAS, P. E., INGELMAN -SUNDBERG, M. and BADGER, T. M., 1992, The microsomal monooxygenase system of regenerating liver. An examination of the role of estradiol in the demasculinization of drug metabolism produced by 213 partial hepatectomy. Biochemical Pharmacology, 43, 567–573.
- SALLEE, F. R. and PoLLocK, B. G., 1990, Clinical pharmacokinetics of imipramine and desipramine. Clinical Pharmacokinetics, 18, 346–364.
- SUZUKI, T., NARIMATSU, S., FUJITA, S., MASUBUCHI, Y., UMEDA, S., IMAOKA, S. and FUNAE, Y., 1992, Purification and characterization of a cytochrome P-450 isozyme catalyzing bunitrolol 4-hydroxylation in liver microsomes of male rats. Drug Metabolism and Disposition, 20, 367–373.
- VERMEULEN, N. P. E., 1996, Role of metabolism in chemical toxicity. In Cytochrome P450: Metabolic and Toxicological Aspects, edited by Costas Ioannides (New York: CRC Press), pp. 29–52.
- YAMAMOTO, Y., MASUDA, M., KAZUSAKA, A., IMAOKA, S., FUNAE, Y. and FUJITA, S., 1995, Purification and characterization of a form of cytochrome P450 from bear liver microsomes. Biochemical Pharmacology, 49, 965–970.