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Xenobiotica
the fate of foreign compounds in biological systems
Volume 27, 1997 - Issue 9
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Research Article

Changes in drug-metabolizing enzymes of rats in ciprofibrate-induced hepatic nodules

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Pages 951-960 | Published online: 22 Sep 2008

References

  • ELLMAN, G. L., 1959, Tissue sulphydryl group. Archives in Biochemistry and Biophysics, 82, 70-77. ERNSTER, L., 1967, DT-diaphorase. In Methods on Enzymology, edited by R. W. Estabrook and M. E. Pullman (New York: Academic), vol. 10, pp. 309–317.
  • FARBER, E., 1980, The sequential analysis of liver cancer induction. Biochimica et Biophysica Acta, 605, 149–176.
  • FARBER, E., 1982, The biology of carcinogen-induced hepatocyte nodules and related lesions in the rat. Toxicology Pathology, 10, 197–201.
  • FARBER, E., 1984, The biochemistry of preneoplastic liver; a common metabolic pattern in hepatocyte nodules. Canadian Journal of Biochemistry and Cell Biology, 62, 486–494.
  • FLATMARK, T., CHRISTIANSEN, E. N. and KRYVI, H., 1983, Evidence for a negative modulating effect of erucic acid on the peroxisomal )3-oxidation enzyme system and biogenesis in rat liver. Biochimica et Biophyska Acta, 753, 460–465.
  • GHOSHAL, A. K. and FARBER, E., 1984, The induction of liver cancer by dietary deficiency of choline and methionine without added carcinogens. Carcinogenesis (London), 5, 1367–1370.
  • Gissox, G. G., ORTON, T. C. and TAMBURINI, P. P., 1982, Cytochrome P450 induction by clofibrate: purification properties of a hepatic cytochrome P450 relatively specific for the 12- and 11-hydroxylation of dodeca acid (lauric acid). Biochemical Journal, 203, 161–168.
  • HABIG, W. H., PABST, M. J. and JACOBY, W. B., 1974, Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. Journal of Biological Chemistry, 249, 7130–7139.
  • HAWKINS, J. M., JoxEs, W. E., BONNER, F. W. and GIBSON, G. G., 1987, The effect of peroxisomal proliferators on microsomal, peroxisomal, and mitochondrial enzyme activities in the liver and kidney. Drug Metabolism Reviews, 18, 441–515.
  • KOJIMA J., KANATANI M., KATO, M., TOJOH, F. and NAKAMURA, N., 1979, Serum glycylproline dipeptidyl aminopeptidase activity in human hepatic cancer. Clinica et Chimica Acta, 93, 181–187. LAEMMLI U. K., 1970, Cleavage of structure proteins during the assembly of the head of Bacteriophage T4. Nature (London), 227, 680–685.
  • LAKE, B. G., GRAY, T. J. B., SMITH, A. G. and EVANS, J. G., 1990, Hepatic peroxisome proliferation and oxidative stress. Biochemical Society Transactions, 18, 94–97.
  • Liu, P. T., IOANNIDES C., SHAVILA, J., SYMONS, A. M. and PARKE, D. V., 1993, Effect of ether anaesthesia and fasting on various cytochromes P450 of rat liver and kidney. Biochemical Pharmacology, 45, 871–877.
  • LOWRY, 0. H., ROSEBROUGH, N. J., FARR, A. L. and RANDALL, R. J., 1951, Protein measurement with the folin phenol reagent. Journal of Biological Chemistry, 193, 265–275.
  • MAZEL, P., 1971, Experiments illustrating drug metabolism in vitro. In Fundamentals of Drug Metabolism and Drug Disposition, edited by N. M. LaDu, G. H. Mandel and E. L. Way (Baltimore: Williams and Wilkins), pp. 546–582.
  • MILLER, G. L., 1959, Protein determination for a large number of samples. Analytical C hemistry, 31, 964. NASH, T., 1953, The colorimetric estimation of formaldehyde by means of Hantzsch reaction. Biochemical Journal, 55, 416–421.
  • NEWBERNE, P. M., 1976, Experimental hepatocellular carcinogenesis. Cancer Research, 36, 2573-2578. OMURA, T. and SATO, R., 1964, The carbon monoxide binding pigment of liver microsomes. journal of Biological Chemistry, 239, 2370–2378.
  • PARKE, D. V., 1994, Mechanisms of chemical carcinogenesis. Environmental Health Perspectives, 102, 852–853.
  • PARKE, D. V. and GRAY, T. J. B., 1978, A comparative study of the enzymic and morphological changes of livers of rats fed butylated hydroxytoluene, safrole, Ponceau MX, or 2-acetamidofluorene. In Primary Liver Tumours. Falk Symposium No. 25, edited by H. Remmer, P. Bannasch, H. M. Bolt and H. Popper (Lancaster: MTP Press), pp. 335–346.
  • PARKE, D. V. and IOANNIDES, C., 1984, Reactive intermediates and oxygen toxicity in liver injury. In Mechanisms of Hepatocyte Injury and Death. Falk Symposium No. 38, edited by D. Keppler, H. Poppler, L. Bianchi and W. Reulter (Lancaster: MTP Press), pp. 37–48.
  • PARKE, D. V. and SAPOT A., 1996, Chemical toxicity and reactive oxygen species. International Journal of Occupational Medicine and Environmental Health 9, 331–340.
  • PAUL, K. G., THEORELL, H. and AKESON, A., 1953, The molar light absorption of pyridine ferroprotoporphyrin (pyridine haemochromogen). Acta Chimica Scandinavica, 7, 1284–1287.
  • RAO, M. S., KOKKINAKIS, D. M., SUBBARAO, V. and REDDY, J. K., 1987, Peroxisome proliferator-induced hepatocarcinogenesis : levels of activity and detoxifying enzymes in hepatocellular carcinomas induced by ciprofibrate. Carcinogenesis, 8, 19–23.
  • RAO, M. S., LALWANI, N. D. and REDDY, J. K., 1984, Sequential histologic study of rat liver during peroxisome proliferator [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]-acetic acid (Wy-14,643)-induced carcinogenesis. Journal of the National Cancer Institute, 73, 983–990.
  • REDDY, J. K. and LALWANI, N. D., 1983, Carcinogenesis by hepatic peroxisome proliferators: evaluation of the hypolipodaemic drugs and industrial plasticisers to humans. CRC Critical Reviews in Toxicology, 12, 1–58.
  • REDDY, J. K., LALWANI, N. D., REDDY, M. D. and QUERESHI, S. A., 1982, Excessive accumulation of autofluorescent lipofucsin in the liver during hepatocarcinogenesis by methyl clofenopate and other hypolipidemic peroxisome proliferators. Cancer Research, 42, 259–266.
  • Roomi, MW., COLUMBANO, A., LEDDA-COLUMBANO, G. M. and SARMA, D. S. R., 1986, Lead nitrate induces certain biochemical properties characteristics of hepatocyte nodules. Carcinogenesis, 7, 1643–1646.
  • Roomi, M. W., 1987, Molecular pathology of rat hepatic nodules. PhD thesis, University of Surrey, Guildford, pp. 83–112.
  • Roomi, M. W., Ho, R. K., SARMA, D. S. R. and FARBER, E., 1985, A common biochemical pattern in preneoplastic hepatocyte nodules generated in four different models in the rats. Cancer Research, 45, 564–571.
  • Roomi, M. W., RAO, M. S., REDDY, J. K., CAMERON, R. G. and FARBER, E., 1987, Modulation of the phenolic expression of rat hepatic nodule by hypolipidemic agent ciprofibrate. Proceedings of the American Association of Cancer Research, 28, 658.
  • SNEDECOR, G. W. and COCHRAN, W. S., 1967, Correlations. In Statistical Methods, 6th edn (Ames: IA, Iowa State University Press) pp. 172–198.
  • SZASZ, G., 1976, Reaction rate method for y-glutamyl transferase activity in serum. Clin. Chem., 22, 2051–2055.
  • VINCENT, S. H. and A/I-UTTER -EBERHARD, U., 1985, A protein in the Z class of liver cytosolic proteins in the rat that preferentially binds heme. Journal of Biological Chemistry, 260, 14521–14528.
  • ZAKIM, D. and VESSEY, D. A., 1973, Techniques for the characterization of UDP-glucuronyltransferase, glucose-6-phosphate and other tightly bound microsomal enzymes. Methods of Biochemical Analysis, 21, 1–37.

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