Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 27, 1997 - Issue 6
59
Views
35
CrossRef citations to date
0
Altmetric
Research Article

The isoflavones equol and genistein do not induce xenobiotic-metabolizing enzymes in mouse and in human cells

, , , &
Pages 587-596 | Published online: 22 Sep 2008

References

  • ADLERcREuTz, C. H. T., GOLDIN, B. R., GORBACH, S. L., HOCKERSTEDT, K. A. V., WATANABE, S., HAMA LAINEN, E. K., MARKKANEN, M. H., MAKELA, T. H., WÄHÄLÄ, K. T., HASE, TA. and FOTSIS, T., 1995, Soybean phytoestrogen intake and cancer risk. Journal of Nutrition, 125, 757S–770S.
  • BRADFORD, M. M., 1976, A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein dye binding. Analytical Biochemistry, 72, 248–250.
  • BROUARD, C., SIESS, M. H., VERNEVAUT, M. F. and SUSCHETET, M., 1988, Comparison of the effects of feeding quercetin or flavone on hepatic and intestinal drug metabolising enzymes of the rat. Food and Chemical Toxicology, 26, 99–103.
  • BUENING, M. K., CHANG, R. L, HUANG, M.-T., FORTNER, J. G., WOOD, A. W. and CONNEY, A. H., 1981, Activation and inhibition of benzo(a)pyrene and aflatoxin Bi metabolism in human liver microsomes by naturally occurring flavonoids. Cancer Research, 41, 67–72.
  • CAI, Q. and WEI, H., 1996, Effect of dietary genistein on antioxidant enzyme activities in SENCAR mice. Nutrition and Cancer, 25, 1–7.
  • HELSBY, N. A., CHIPMAN, J. K., GESCHER, A. and KERR, D., 1996, Inhibition of carcinogen-activating cytochrome P450 isoenzymes by potential chemopreventative isoflavonoids, genistein and equol. (submitted).
  • HENDERSON, C. J. and WOLF, C. R., 1992, Immunodetection of proteins by western blotting. Methods in
  • Molecular Biology, vol. 10. Immunochemkal protocols, edited by M. Manson (Totowa, Humana). IOANNIDES, C. and PARKE, D. V., 1993, Induction of cytochrome P4501 as an indicator of potential chemical carcinogenesis. Drug Metabolism Reviews, 25, 485–501.
  • KOOP, D. R., LAETHEM, C. L. and TIERNEY, D. J., 1989, The utility of p-nitrophenol hydroxylation in P450IIE1 analysis. Drug Metabolism Reviews, 20, 541–551.
  • LAUGHTON, M. J., HALLIWELL, B., EVANS, P. and HOULT, J. R. S., 1989, Antioxidant and pro-oxidant action of plant phenolics quercetin, gossypol and myricetin. Biochemical Pharmacology, 38, 2859–2865.
  • LAMARTIN1ERE, C. A., MOORE, J. B., BROWN, N. M., THOMPSON, R., HARDIN, M. J. and BARNE S., 1995, Genistein suppresses mammary cancer in rats. Carcinogen esis, 16, 2833–2840.
  • MESSINA, M. J., PERSKY, V., SETCHELL, K. D. R. and BARNES, S., 1994, Soy intake and cancer risk: a review of in vitro and in vivo data. Nutrition and Cancer, 21, 113–131.
  • MOSMANN, T., 1983, Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. Journal of Immunological Methods, 65, 55–63.
  • POHL, R. J. and FOUTS, J. R., 1980, A rapid method for assaying and metabolism of 7-ethoxyresorufin by microsomal subcellular fractions. Analytical Biochemistry, 107, 150–155.
  • PROCHASKA, H. J. and TALALAY, P., 1988, Regulatory mechanisms of monofunctional and bifunctional anticarcinogenic enzyme inducers in murine liver. Cancer Research, 48, 4776–4782.
  • RATTY, A. K. and DAS, N. P., 1988, Effects of flavonoids on non-enzymatic lipid peroxidation: structure—activity relationship. Biochemical Medicine and Metabolic Biology, 39, 69–79.
  • ROBACK, J. and GRYGLEWSKI, R. J., 1988, Flavonoids as a scavengers of superoxide anions. Biochemistry and Pharmacology, 37, 837–841.
  • SARIASLANI, F. S. and KuNz, D. A., 1986, Induction of cytochrome P450 in Streptomyces griseus by soybean flour. Biochemical and Biophysical Research Communications, 141, 405–410.
  • SIESS, M. H., LE BON, A. M. and SUSCHETET, M., 1992, Dietary modification of drug metabolising enzyme activities: dose response effect of flavonoids. Journal of Toxicology and Environmental Health, 35, 141–152.
  • TASSANEEYAKU W., VERONESE M. E., BIRKETT, D. J., GoNzALEz, F. J. and MINERS, J. O., 1993, Validation of 4-nitrophenol as an in vitro substrate probe for human liver CYP2E1 using cDNA expression and microsomal kinetic techniques. Biochemistry and Pharmacology, 46, 1975–1981.
  • THOMAS, P. E., REIK, L. M., RYAN, D. E. and LEVIN, W., 1983, Induction of 2 immunochemically related rat liver cytochrome P450 isozymes, cytochrome P450C and cytochrome P450D by structurally diverse xenobiotics. Journal of Biological Chemistry, 258, 4590–4598.
  • TODD, M. D., LEE, M. J., WILLIAMS, J. L., NALEZNEY J. M., GEE, P., BENJAMIN, M. B. and FARR, S. B., 1995, The CAT-Tox assay: a sensitive and specific measure of stress-induced transcription in transformed human liver cells. Fundamentals of Applied Toxicology, 28, 118–128.
  • TRELA, B. A. and CARLSON, G. P., 1987, Effect of flavanone on mixed-function oxidase and conjugation reactions in rats. Xenobiotica, 17, 11–16.
  • WATKINS, P. B., WRIGHTON, S. A., MAUREL, P., SCHUETZ, E. G., MENENDEZ -PICON, G., PARKER, G. A. and GUZELIAN, P. S., 1985, Identification of an inducible form of cytochrome P450 in human liver. Proceedings of the National Academy of Sciences, USA, 82, 6310–6314.
  • WATTENBERG, L. W., PAGE, M. A. and LEONG, J. L., 1968, Induction of increased benzopyrene hydroxylase activity by flavones and related compounds. Cancer Research, 28, 934–937.
  • Wu, H., BOWEN, R., CAI, Q., BARNES, S. and WANG, Y., 1995, Antioxidant and antipromotional effects of the soybean isoflavone genistein. Proceedings Society Experimental Biology eff Medicine, 208, 124–130.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.