Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 27, 1997 - Issue 6
67
Views
8
CrossRef citations to date
0
Altmetric
Research Article

Absorption, metabolism and excretion after oral administration of a new Ca antagonist, 14C-benidipine hydrochloride to man

, &
Pages 597-608 | Published online: 22 Sep 2008

References

  • BOcKEK, R. H., and GUENGERICH, F. P., 1986, Oxidation of 4-aryl substituted 2,6-dimety1-3,5-bis(alkoxycarbony1)-1,4-dihydropyridines by human liver microsomes and immunochemical evidence for the involvement of a form of cytochrome P450. Journal of Medicinal Chemistry, 29, 1596–1603.
  • FLINOIS, J.-P., CHABIN M., EGROS, F., DUFOUR, A., DE WAZ1ERS, I., MAS-CHAMBERLIN C., and BEAUNE, P. H., 1992, Metabolism rate of oxodipine in rats and humans: comparison of in vivo and in vitro data. Journal of Pharmacology and Experimental Therapeutics, 261, 381–386.
  • GUENGERICH, F. P., PETERSON, L. A., and BOEKEK, R. H., 1988, Cytochrome P-450 catalyzed hy-droxylation and carboxylic acid ester cleavage of Hantsch pyridine esters. Journal of Biological Chemistry, 263, 8176–8183.
  • KANN, J., KROL, G. J., R.AEmsED, K. D., BURKHOLDER, D. E., and LEvrrT, M. J., 1984, Bioequivalence and metabolism of nitrendipine administered orally to healthy volunteers. Journal of Car-diovascular Pharmacology, 6, S968–973.
  • KARASAW A., Kum), K., SHUTO, K., OKA, T., and NAKAMIZO, N., 1988a, Antihypertensive effects of the new calcium antagonist benidipine hydrochloride in rats. Arzneimittel -Forschung/Drug Research, 38, 1684–1690.
  • KARASAWA, A., IKEDA, J., YAMADA, K., Kum., K., OKA, T., and NAKAMIZO, N., 1988b, Antihypertensive effects of the new calcium antagonist benidipine hydrochloride in conscious, renal-hypertensive dogs. Arzneimittel-Forschung/Drug Research, 38, 1695–1697.
  • KARASAW A., Kum), K., SHUTO, K., OKA, T., and NAKAMIZO, N., 1988c, Antianginal effects of the new calcium antagonist benidipine hydrochloride in anesthetized rats and spontaneously hypertensive rats/electrocardiographic study. Arzneimittel-Forschung/Drug Research, 38, 1702–1706.
  • KOBAYASHI, H., OKUMURA, S., KOSAKA, Y., KOBAYASHI, S., INOUE, A., OKA, T., and NAKAMIZO, N., 1988a, Identification of benidipine hydrochloride metabolites in rats and dogs. Arzneimittel-ForschunglDrug Research, 38, 1753–1757.
  • KOBAYASHI, H., KOBAYASHI, S., INOUE, A., OKA, T., and NAKAMIZO, N., 1988b, Gas chromatographic method for the quantification of the new calcium antagonist benidipine hydrochloride in plasma using electron capture detection. Arzneimittel -Forschung /Drug Research, 38, 1730–1733.
  • KOBAYASHI, H., OHISHI, T., NISHBE, H., KOBAYASHI, S., INouE, A., and HIRATA, T., 1990a, Absorption, distribution and excretion of 14C-Benidipine • HC1 in rats. Xenobiotic Metabolism and Disposition, 5, 71–86.
  • KOBAYASHI, H., KOBAYASHI, S., INOUE, A., and HIRATA, T., 1990b, Absorption and excretion of 14 C-Benidipine • HC1 in dogs. Xenobiotic Metabolism and Disposition, 5, 87–93.
  • KOBAYASHI, H., KOBAYASHI, S., INOUE, A., HIRATA, T., TANAKA, H., and DEGUCHI, T., 1990c, Pharmacokinetics of Benidipine • HC1 in rats, dogs and monkeys. Xenobiotic Metabolism and Disposition, 5, 111–119.
  • KOBAYASHI, H., KOBAYASHI, S., INOUE, A., HIRATA, T., TANAKA, H., and DEGUCHI, T., 1990d, Absorption, distribution and excretion of 14 C-benidipine • HC1 in monkeys. Xenobiotic Metabolism and Disposition, 5, 95–101.
  • KOLARS, J. C., Awm, W. N., MERION, R. M., and WATICLNS, P. B., 1991, First pass metabolism of cyclosporine by the gut. Lancet, 338, 1488–1490.
  • KUROIWA, S., INOTSUME, N., and NAKANO, M., 1986, Reduction of a calcium antagonist nicardipine by gastrointestinal bacteria. Y akugaku Zasshi, 106, 698–702.
  • MAIER-LENZ, H., RODE, H., THIEME, G., WOLKE, E., KOBAYASHI, H., KOBAYASHI, S., and OKA, T., 1988, Benidipine—a new calcium-channel blocker of the dihydropyridine type/pharmacokinetics, pharmacodynamics, tolerance and dose finding in mild to moderate hypertension. Arzneimittel-Forschung/Drug Research, 38, 1757–1763.
  • MURRAY, G. I., BARNES, T. S., SEWELL, H. S., EWEN, S. W. B., MELVIN, W. T., and BURKE, M. D., 1988, The immunocytochemical localization and distribution of cytochrome P-450 in normal human hepatic and extrahepatic tissue with a monoclonal antibody to human cytochrome P-450. British Journal of Clinical Pharmacology, 25, 465–475.
  • MuTo, K., KURODA, T., KAWATO, H., NISHIKAWA, H., and NAICAMIZO, N., 1988, Synthesis of expected metabolites of benidipine hydrochloride. Arzneimittel-Forschung/Drug Research, 38, 1666-1670. RUSH, W. R., and GRAHAM, D. J. G., 1986, The metabolism of nicardipine hydrochloride in healthy male volunteers. Xenobiotka, 16, 341–349.
  • STONIER, D. A., BERESFORD, A. P., MACRAE, P. V., and HUMPHREY, M. J., 1988, The metabolism and pharmacokinetics of amlodipine in humans and animals. Journal of Cardiovascular Pharmacology, 12 (suppl. 7), S55–59.
  • TOKUMA Y TERASHITA, S., FUJIWARA, T., NAKAGAWA, K., NOGUCHI, H., TERAKAWA, M., SHISHIDO, A., and YASUDA, K., 1988, Urinary metabolites of a novel calcium antagonist nilvadipine. Xenobiotic Metabolism and Disposition, 2, 65–71.
  • Uri, S., SUGIMOTO, T., KOBAYASHI, S., and KOBAYASHI, H., 1990, Phase I clinical study of benidipine hydrochloride. Japanese Pharmacology and Therapeutics, 18 (suppl. 14), 7–20.
  • WEIDOLF, L., 1985, Metabolism of felodipine. Acta University of Uppsala, 102, 1–40.
  • WATKINS, P. B., WRIGHTON, S. A., SCHUETZ, E. G., MOLOWA, D. T., and GUZELIAN, P. S., 1987, Identification of glucocorticoid-inducible cytochrome P-450 in the intestinal mucosa of rats and man. Journal of Clinical Investigation, 80, 1029–1036.
  • Wu, C. Y., BENET, L. Z., HEBERT, M. F., GUPTA, S. K., ROWLAND, M., GOMEZ, D. Y., and WACHER, V. J., 1995, Differentiation of absorption and first-pass gut and hepatic metabolism in humans: studies with cyclosporine. Clinical Pharmacology and Therapeutics, 58, 492–497.
  • YAMADA, K., YASUI, S., HAYAKAWA, K., HIEZIMA, K., MURAKAMI, E., TAKEKOSHI, Y., YAMAZAKI, N., HIRAKAWA, S., I-rox, Y., TOYAMA, J., TOBATA, I., OGAWA, K., MIZUNO, Y., WATANABE, T., TAKEZAWA, H., NAKANO, T., TOYAMA, S., and NAKAJIMA, M., 1990, Clinical evaluation of benidipine hydrochloride (KW-3049) in angina pectoris—dose finding study by double blind method. Japanese Pharmacology and Therapeutics, 18 (suppl. 14), 191–210.
  • YOSHINAGA, K., IimuRA, K., ABE, K., Ism', T., SARUTA, T., KANEKO, Y., ProH, K., MASUYAMA, Y., KoKuHu, T., ARAKAWA, K., and SHIMIDZU, N., 1990, A study of benidipine hydrochloride (KW-3049) on the antihypertensive effects and safety in essential hypertensive patients in long-term treatment. Japanese Pharmacology and Therapeutics, 18 (suppl. 14), 81–102.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.