Advanced search
Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 27, 1997 - Issue 6
Submit an article Journal homepage
105
Views
9
CrossRef citations to date
0
Altmetric
Research Article

Intraperitoneal and intraportal administration of droloxifene to the Sprague-Dawley rat: assessing the first-pass effect

D. F. NICKERSON Drug Metabolism Department, Pfizer Inc, Central Research Division, Eastern Point Road, Groton, CT 06340, USA
&
S. M. TOLER* Drug Metabolism Department, Pfizer Inc, Central Research Division, Eastern Point Road, Groton, CT 06340, USA
Pages 627-632 | Received 16 Nov 1996, Published online: 22 Sep 2008

References

  • BREWSTER, D., HUMPHREY, M. J. and MCLEAVY, M. A., 1981, The systemic bioavailability of buprenorphine by various routes of administration. Journal of Pharmaceutics and Pharmacology, 33, 500–506.
  • CONWAY, W. D., SINGHVI, S. M., GIBALDI, M. and BOYES, R. N., 1973, The effect of route of administration on the metabolic fate of terbutaline in the rat. Xenobiotka, 3, 813–821.
  • IwAmoTo, K. and KLAASSEN, C. D., 1977, First-pass effect of morphine in rats. Journal of Pharmacology and Experimental Therapeutics, 200, 236–244.
  • LUKAS, G., BRINDLE, S. D. and GREENGARD, P., 1971, The route of absorption of intraperitoneally administered compounds. Journal of Pharmacology and Experimental Therapeutics, 178, 562–566. NICKERSON, D. F., TESS, D. A. and TOLER, S. M., 1997, First pass metabolism and biliary recirculation of droloxifene in female Sprague-Dawley rats. Xenobiotka (in press).
  • ROWLAND, M. and TOZER, T. N., 1980, Clinical Pharmacokinetics: Concepts and Applications (Philadelphia: Lea & Febiger).
  • TANAKA, Y., SEKIGUCHI, M., SAWAMOTO, T., HATA, T., Esumi, Y., SUGAI, S. and NINOMIYA, S., 1994, Pharmacokinetics of droloxifene in mice, rats, monkeys, premenopausal and postmenopausal patients. European Journal of Drug Metabolism and Pharmacology, 19, 47–58.
  • TESS, D. A., COLE, R. 0. and TOLER, S. M., 1995, Sensitive method for the quantitation of droloxifene in plasma and serum by high-performance liquid chromatography employing fluorimetric detection. Journal of Chromatography B, 674, 253–260.
  • ZHONG, W. Z., WILLIAMS, M. G., COOK, K. J., VANDEGlESSEN, T. L., Jos, B. W. and Rousco, K. E., 1994, First-pass effect of cis-3,4-dichloro-N-methyl-N-(2-(1-pyrrolidiny1)-cyclohexyl)-benza-mide (U-54494) in rats—a model with multiple cannulas for investigation of gastrointestinal and hepatic metabolism. Pharmaceutical Research, 11, 1524–1529.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.