Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 27, 1997 - Issue 5
44
Views
10
CrossRef citations to date
0
Altmetric
Research Article

Intestinal UDP-glucuronosyltransferase activities in rat and rabbit

&
Pages 413-421 | Published online: 22 Sep 2008

References

  • AITIO, A., 1974, UDP-glucuronyltransferase activity in various rat tissues. International Journal of Biochemistry, 5, 325–330.
  • BANSAL, S. K. and GESSNER, T., 1980, A unified method for the assay of uridine diphospho - glucuronyltransferase activities toward various aglycones using uridine diphospho [U-'4C] glucuronic acid. Analytical Biochemistry, 109, 321–329.
  • BOCK, K. W., CLAUSBRUCH, U. C. V., KAUFMANN, R., LILIENBLUM W., DESCH, F., PFEIL, H. and PLATT, K. L., 1980, Functional heterogeneity of UDP-glucuronyltransferase in rat tissues. Biochemical Pharmacology, 29, 495–500.
  • BOUTIN, J. A., ANTOINE, B., BATT, A. and SmsT, G., 1984, Heterogeneity of hepatic microsomal UDP-glucuronosyltransferase(s) activities: comparison between human and mammalian species activities. Chemico-Biological Interactions, 52, 173–184.
  • BUENING, M. K. and FRANKLIN, M. R., 1976, The formation of cytochrome P-450 metabolic intermediate complexes in microsomal fractions from extrahepatic tissues of the rabbit. Drug Metabolism and Disposition, 4, 556–561.
  • BuRcHELL, B., NEBERT, D. W., NELSON, D. R., BOCK, K. W., TYANAGI, T., JANSEN, P. L. M., LANCET, D., MULDER, G. J., CHOWDHURY, J. R., SIEST, G., TEPHLY, T. R. and MACICENZIE, P. I., 1991, The UDP glucuronosyltransferase gene superfamily: suggested nomenclature based on evol-utionary divergence. DNA and Cell Biology, 10, 487–494.
  • CAPPIELLO, M., GIULIANI, L. and PAaFici, G. M., 1991, Distribution of UDP-glucuronosyltransferase and its endogenous substrate uridine 5'-diphosphoglucuronic acid in human tissues. European Journal of Clinical Pharmacology, 41, 345–350.
  • CHHABRA, R. S. and FOUTS, J. R., 1976, Biochemical properties of some microsomal xenobiotic-metabolizing enzymes in rabbit small intestine. Drug Metabolism and Disposition, 4, 208–214.
  • CHHABRA, R. S., POHL, R. J. and FOUTS, J. R., 1974, A comparative study of xenobiotic-metabolizing enzymes in liver and intestine of various animal species. Drug Metabolism and Disposition, 2, 443–447.
  • CHOWDHURY, J. R., NOVIKOFF, P. M., CHOWDHURY, N. R. and NOVIKOFF, A. B., 1985, Distribution of UDP-glucuronosyltransferase in rat tissue. Proceedings of the National Academy of Sciences, USA, 82, 2990–2994.
  • COOMES, M. W., NORSLING, A., PoHL, R. J., MULLER, D. and FOUTS, J. R., 1983, Foreign compound metabolism by isolated skin cells from the hairless mouse. Journal of Pharmacology and Experimental Therapeutics, 225, 770–777.
  • DAHM, K., BREUER, H. and LINDLAU, M., 1966, Charakterisierung und kinetik einer mikrosomalen UDP-glucuronat: testosteron-glucuronyltransferase beim menschen. Hoppe-Seyler's Zeitschrift fur Physiologische Chemie, 345, 139–149.
  • DUTTON, G. J., 1980, Glucuronidation of Drugs and Other Compounds. (Boca Raton: CRC Press). FRANKLIN, M. R. and ESTABROOK, R. W., 1971, On the inhibitory action of mersalyl on microsomal drug oxidation. A rigid organization of the electron transport chain. Archives of Biochemistry and Biophysics, 143, 318–329.
  • GOON, D. and KLAASSEN, C. D., 1992, Effects of microsomal enzyme inducers upon UDP-glucuronic acid concentration and UDP-glucuronosyltransferase activity in the rat intestine and liver. Toxicology and Applied Pharmacology, 115, 253–260.
  • GREEN, M. D., CLARICE, D. J., OTURA, E. M., STYCZYNSKI, P. B., JACKSON, M. R., BURCHELL, B. and TEPHLY, T. R., 1995, Cloning and expression of rat liver phenobarbital-inducible UDP-glucuronosyltransferase (2B12) with specificity for monoterpenoid alcohols. Archives of Bio-chemistry and Biophysics, 322, 460–468.
  • GREGUS, Z., WATKINS, J. B., THOMPSON, T. N., HARVEY, M. J., ROZMAN, K. and KLAASSEN, C. D., 1983, Hepatic Phase land Phase II biotransformations in quail and trout: comparisons to other species commonly used in toxicity testing. Toxicology and Applied Pharmacology, 67, 430–431.
  • HÄ NNINEN, O., AITIO, A. and HARTIALA, K., 1968, Gastrointestinal distribution of glucuronide synthesis and the relevant enzymes in the rat. Scandinavian Journal of Gastroenterology, 3, 461–464.
  • HÄNNINEN, O. and AITIO, A., 1968, Enhanced glucuronide formation in different tissues following drug administration. Biochemical Pharmacology, 17, 2307–2311.
  • HARMSWORTH, W. L. and FRANKLIN, M. R., 1990, Induction of hepatic and extrahepatic cytochrome P-450 and monooxygenase activities by N-substituted imidazoles. Xenobiotka, 20, 1053-1063. HARTIALA, K. J. W., PULKKINEN, M. O., and SAVOLA, P., 1964, /3-D-Glucosiduronic acid conjugation by the mucosa of various organs. Nature, 201, 1036.
  • HIETANEN, E. and VAINIO, H., 1973, Interspecies variations in small intestinal and hepatic drug hydroxylation and glucuronidation. Acta Pharmacologka et Toxicologica, 33, 57–64.
  • IwAmoTo, K. and KLAASSEN, C. D., 1977, First-pass effect of morphine in rats. Journal of Pharmacology and Experimental Therapeutics, 200, 236–244.
  • JACKSON, M. R., FOURNEL -GIGLEUX, S., HARDING, D. and BURCHELL, B., 1988, Examination of the substrate specificity of cloned rat kidney phenol UDP-glucuronyltransferase expressed in COS-7 cells. Molecular Pharmacology, 34, 638–642.
  • KASHFI, K., MCDOUGALL, M. D. and DANNENBERG, A. J., 1995, Comparative effects of omeprazole On xenobiotic metabolizing enzymes in the rat and human. Clinical Pharmacology and Therapeutics, 58, 625–630.
  • KASHFI, K., YANG, E. K., CHOWDHURY, J. R., CHOWDHURY, N. R. and DANNENBERG, A. J., 1994, Regulation of uridine diphosphate glucuronosyltransferase expression by phenolic antioxidants. Cancer Research, 54, 5856–5859.
  • KING, C. D., GREEN, M. D., Rios, G. R., CoFFmAN, B. L., OWENS, I. S., BISHOP, W. P. and TEPHLY T. R. 1996, The glucuronidation of exogenous compounds by stably expressed rat and human UDP-glucuronosyltransferase H. Archives of Biochemistry and Biophysics, 332, 92–100.
  • KOSTER, A. S. J. and NOORDHOEK, J., 1982, Similarity of rat intestinal and hepatic microsomal 7-hydroxycoumarin-UDP-glucuronyltransferase: in vitro activation by triton X-100, UDP-N-acetylglucosamine and MgC12. Biochemical Pharmacology, 31, 2701–2704.
  • KOSTER, A. S. J. and NOORDHOEK, J., 1983, Glucuronidation in the rat intestinal wall. Comparison of isolated mucosal cells, latent microsomes and activated microsomes. Biochemical Pharmacology, 32, 895–900.
  • KOSTER, A. S. J., SCHIRMER, G. and BOCK, K. W., 1986, Immunochemical and functional charac-terization of UDP-glucuronosyltransferase from rat liver, intestine and kidney. Biochemical Pharmacology, 35, 3971–3975.
  • LAMB, J. G., STRAUB, P. and TUKEY, R. H., 1994, Cloning and characterization of cDNAs encoding mouse Ugt1.6 and rabbit UGT1.6: differential induction by 2,3,7,8-tetrachlorodibenzodioxin. Biochemistry, 33, 10513–10520.
  • LOWRY, O. H., ROSEBROUGH, N. J., FARR, A. L. and RANDALL, R. J., 1951, Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry, 193, 265–275.
  • LuciER, G. W., SONAWANE, B. R. and MCDANIEL, O. S., 1977, Glucuronidation and deglucuronidation reactions in hepatic and extrahepatic tissues during perinatal development. Drug Metabolism and Disposition, 5, 279–287.
  • MACKENZIE, P. I., 1987, Rat liver UDP-glucuronosyltransferase. Identification of cDNAs encoding two enzymes which glucuronidate testosterone, dihydrotestosterone and /3-estradiol. Journal of Biological Chemistry, 262, 9744–9749.
  • MACKENZIE, P. I., 1990, The cDNA sequence and expression of a variant 17/3-hydroxysteroid UDP-glucuronosyltransferase. Journal of Biological Chemistry, 265, 8699–8703.
  • MISTRY, M. AND HOUSTON, J. B., 1987, Glucuronidation in vitro and in vivo. Comparison of intestinal and hepatic conjugation of morphine, naloxone, and buprenorphine. Drug Metabolism and Disposition, 15, 710–717.
  • PACIFICI, G. M., FRANCHI, M., BENCINI, C., REPETTI, F., DILAscio, N. and MURARO, G. B., 1988, Tissue distribution of drug-metabolizing enzymes in humans. Xenobiotka, 18, 849–856.
  • PETERS, W. H. M., NAGENGAST, F. M. and VAN TONGEREN, J. H. M., 1989, Glutathione S-transferase, cytochrome P450, and uridine 5'-diphosphate-glucuronosyltransferase in human small intestine and liver. Gastroenterology, 96, 783–789.
  • PRITCHARD, M., FOURNEL -GIGLEUX S., SIEST, G., MACICENZIE, P.1. and MAGDALOU, J., 1994, A recombinant phenobarbital inducible rat liver UDP-glucuronosyltransferase (UDP-glucuronosyltransferase 2B1) stably expressed in V79 cells catalyzes the glucuronidation of morphine, phenols and carboxylic acids. Molecular Pharmacology, 45, 42–50.
  • PRUEKSARITANONT, T., GORHAM, L. M., HOCHMAN, J. H., TRAN, L. O. and VYAS, K. P., 1996, Comparative studies of drug-metabolizing enzymes in dog, monkey, and human small intestines, and in Caco-2 cells. Drug Metabolism and Disposition, 24, 634–642.
  • RADOIVIINSKA, A., LITTLE, J. M., LESTER, R. and MACKENZIE, P. I., 1994, Bile acid glucuronidation by rat liver microsomes and cDNA expressed UDP-glucuronosyltransferase. Biochimica et Biophyska Acta, 1205, 75–82.
  • SANCHEZ Pozzi, E. J., CATANIA, V. A., LUQUITA, M. G., ROMA, M. G., RODRIGUEZ GARAY, E. A. and MOTTINO, A. D., 1994, Effect of oral administration of ursodeoxycholic acid on rat hepatic and intestinal UDP-glucuronosyltransferase. Canadian Journal of Physiology and Pharmacology, 72, 1265–1271.
  • SMITH, R. L. and WILLIAMS, R. T., 1966, Implication of the conjugation of drugs and other exogenous compounds. In Glucuronk Acid, edited by G. J. Dutton (New York: Academic), pp. 457–491.
  • TUKEY, R. H., PENDURTHI, U. R., NGUYEN, N. T., GREEN, M. D. and TEPHLY, T. R., 1993, Cloning and characterization of rabbit liver UDP-glucuronosyltransferase cDNAs. Journal of Biological Chemistry, 268, 15260–15266.
  • WATKINS, J. B., WIRTHWEIN, D. P. and SANDERS, R. A., 1991, Comparative study of phase II biotransformation in rabbit ocular tissues. Drug Metabolism and Disposition, 19, 708–713.
  • YOSHIMURA, T., TANAKA, S. and HOME, T., 1992, Species difference and tissue distribution of uridine diphosphate-glucuronyltransferase activities toward E6080,1-naphthol and 4-hydroxybiphenyl. Journal of Pharmacobio-Dynamics, 15, 387–393.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.