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Xenobiotica
the fate of foreign compounds in biological systems
Volume 27, 1997 - Issue 2
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Research Article

Novel metabolites of warfarin produced by Beauveria bassiana and Streptomyces rimosus : a novel application of hplc- nmr

R. J. P. CANNELL* Glaxo Wellcome, Stevenage, SG1 2NY, UK Glaxo Wellcome, Greenford, UB6 0HE, UK
,
T. RASHID Glaxo Wellcome, Stevenage, SG1 2NY, UK Glaxo Wellcome, Greenford, UB6 0HE, UK
,
I. M. ISMAIL Glaxo Wellcome, Stevenage, SG1 2NY, UK Glaxo Wellcome, Greenford, UB6 0HE, UK
,
P. J. SIDEBOTTOM Glaxo Wellcome, Stevenage, SG1 2NY, UK Glaxo Wellcome, Greenford, UB6 0HE, UK
,
A. R. KNAGGS Glaxo Wellcome, Stevenage, SG1 2NY, UK Glaxo Wellcome, Greenford, UB6 0HE, UK
&
P. S. MARSHALL Glaxo Wellcome, Stevenage, SG1 2NY, UK Glaxo Wellcome, Greenford, UB6 0HE, UK
Pages 147-157 | Published online: 22 Sep 2008

References

  • BAX, A. and S UBRAMANIAN, S., 1986, Sensitivity- enhanced two-dimensional heteronuclear shift correlation NMR spectrosopy. Journal of Magnetic Resonance, 67, 565–569.
  • CANNELL R. J. P., KNAGGS, A. R., DAWSON, M. J., MANCHEE, G. R., EDDERSHAW, P. J., W ATERHOUSE I., SUTHERLAND, D. R., BOWERS, G. D. and S IDEBOTTOM, P. J., 1995, Microbial biotransformation of the angiotensin antagonist GR117289 by Streptomyces rimosus to identify a mammalian metabolite. Drug Metabolism and Disposition, 23, 724–729.
  • DAVIS, A. L., L AUE, E. D., KEELER, J., M OSKAU, D. and L OHMAN, J., 1991, Absorption-mode two-dimensional NMR spectra recorded using pulse field gradients. Journal of Magnetic Resonance, 94, 637–644.
  • GRIFFITHS, D. A., BEST, D. J. and JEZEQUEL, 5, G., 1991, The screening of selected microorganisms for use as models of mammalian drug metabolism. Applied Microbiology and Biotechnology, 35, 373–381.
  • GRIFFITHS, D. A., BROWN, D. E. and JEZEQUEL S, G., 1992, Biotransformation of warfarin by the fungus Beauveria bassiana. Applied Microbiology and Biotechnology, 27, 169–175.
  • GRIFFITHS, D. A., BROWN, D. E. and JEZEQUEL S G., 1993, Metabolism of xenobiotics by Beauveria bassiana. Xenobiotica, 23, 1085–1100.
  • HAMADA H., FUCHIKAMI, Y., JANSING, R. L. and KAMINSKY, L. S., 1993, Regioselective hydroxylation of warfarin by cell suspension cultures of Catharanthus roseus. Phytochemistry, 33, 599–600.
  • KAMINSKY, L. S., 1989, Warfarin as a probe of cytochrome P-450 function. Drug Metabolism Reviews, 20, 479–489.
  • KAMINSKY, K. S., DUNBAR, D. A., WANG, P. P., BEAUNE, P., L ARREY, D., GUENGERICH, F. P., S CHNELLMANN R. G. and S IPES, R. G., 1984, Human hepatic cytochrome P-450 composition as probed by in vitro microsomal metabolism of warfarin. Drug Metabolism and Disposition, 12, 470–477.
  • KAMINSKY, L. S., GUENGERICH, F. P., D ANNAN, G. A. and AUST, S. D., 1983, Comparisons of warfarin metabolism by liver microsomes of rats treated with a series of polybrominated biphenyl congeners and by the component-purified cytochrome P-450 isozymes. Archives of Biochemistry and Biophysics, 225, 398–404.
  • OBASEKI, A. O. and PORTER, W. R., 1987, Structure of analogs of warfarin in solution. Archiv for Pharmaci og Chemi: Scientific Edition, 15, 110–121.
  • PULLEN, F. S., S WANSON, AG., NEWMAN, M. J. and RICHARDS, D. S., 1995, On-line liquid chromatography/nuclear magnetic resonance /mass spectrometry—a powerful spectrometric tool for the analysis of mixtures of pharmaceutical interest. Rapid Communications in Mass Spectrometry, 9, 1003–1006.
  • RIZZO, J. D. and DAVIS, P. J., 1988, Microbial models of mammalian metabolism: production of a novel a-diketone metabolites of warfarin and phenprocoumon using Aspergillus niger. Xenobiotica, 18, 1425–1437.
  • RIZZO, J. D. and DAVIS, P. J., 1989, Microbial models of mammalian metabolism : conversion of warfarin to e-hydroxywarfarin using Cunninghamella baini. Journal of Pharmaceutical Sciences, 78, 183–189.
  • SMITH, R. V. and ROSAZZA, J. P., 1974, Microbial models of mammalian metabolism : aromatic hydroxylation. Archives of Biochemistry and Biophysics, 161, 551–558.
  • SPRAUL, M., HOFFMAN, M., WILSON, I. D., LENZ, E., NicooLsoN, J. K. and LINDON, J. C., 1993, Coupling of HPLC with 19F and 1H NMR spectroscopy to investigate the human urinary excretion of flurbiprofen metabolites. Journal of Pharmaceutical and Biomedical Analysis, 11, 1009–1015.
  • VALENTE, E. J., LINGAFELTER, E. C., PORTER, W. R. and T RAGER, W F., 1977, Structure of warfarin in Solution. Journal of Medicinal Chemistry, 20, 1489–1493.
  • WILSON, I. D., IsTicHoLsoN, J. K., HOFFMAN, M., SPRAUL, M. and LINDON, J. C., 1993, Investigation of the human metabolism of antipytine using coupled liquid chromatography and nuclear magnetic resonance spectroscopy of urine. Journal of Chromatography, 617, 324–328.
  • WONG, Y. W. J. and DAVIS, P. J., 1989, Microbial models of mammalian metabolism: stereoselective metabolism of warfarin in the fungus Cunninghamella elegans. Pharmaceutical Research, 6, 982–987.
  • WONG, Y. W. J. and DAVIS, P. J., 1991, Microbial models of mammalian metabolism: production of 3'-hydroxywarfarin, a new metabolite of warfarin using Cunninghamella elegans. Journal of Pharmaceutical Sciences, 80, 305–308.

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