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Xenobiotica
the fate of foreign compounds in biological systems
Volume 27, 1997 - Issue 1
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Research Article

Tissue distribution and metabolism in rat of an ethynesulphonamide with filaricidal activity

N. Radembino Laboratoires de Me!thodologies Bioanalytiques, de Parasitologie et de Pharmacologie, Faculte! de Pharmacie, Cha#tenay-Malabry, France INSERM U71, Clermont Ferrand, France Laboratoire de Chimie analytique, Faculte! de Pharmacie, Clermont Ferrand, France
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M.- C. Dessalles Laboratoires de Me!thodologies Bioanalytiques, de Parasitologie et de Pharmacologie, Faculte! de Pharmacie, Cha#tenay-Malabry, France INSERM U71, Clermont Ferrand, France Laboratoire de Chimie analytique, Faculte! de Pharmacie, Clermont Ferrand, France
,
J.-H. Trouvin Laboratoires de Me!thodologies Bioanalytiques, de Parasitologie et de Pharmacologie, Faculte! de Pharmacie, Cha#tenay-Malabry, France INSERM U71, Clermont Ferrand, France Laboratoire de Chimie analytique, Faculte! de Pharmacie, Clermont Ferrand, France
,
P. M. Loiseau Laboratoires de Me!thodologies Bioanalytiques, de Parasitologie et de Pharmacologie, Faculte! de Pharmacie, Cha#tenay-Malabry, France INSERM U71, Clermont Ferrand, France Laboratoire de Chimie analytique, Faculte! de Pharmacie, Clermont Ferrand, France
,
P. Gayral Laboratoires de Me!thodologies Bioanalytiques, de Parasitologie et de Pharmacologie, Faculte! de Pharmacie, Cha#tenay-Malabry, France INSERM U71, Clermont Ferrand, France Laboratoire de Chimie analytique, Faculte! de Pharmacie, Clermont Ferrand, France
,
G. Mahuzier Laboratoires de Me!thodologies Bioanalytiques, de Parasitologie et de Pharmacologie, Faculte! de Pharmacie, Cha#tenay-Malabry, France INSERM U71, Clermont Ferrand, France Laboratoire de Chimie analytique, Faculte! de Pharmacie, Clermont Ferrand, France
,
M. Rapp Laboratoires de Me!thodologies Bioanalytiques, de Parasitologie et de Pharmacologie, Faculte! de Pharmacie, Cha#tenay-Malabry, France INSERM U71, Clermont Ferrand, France Laboratoire de Chimie analytique, Faculte! de Pharmacie, Clermont Ferrand, France
,
P. Labarre Laboratoires de Me!thodologies Bioanalytiques, de Parasitologie et de Pharmacologie, Faculte! de Pharmacie, Cha#tenay-Malabry, France INSERM U71, Clermont Ferrand, France Laboratoire de Chimie analytique, Faculte! de Pharmacie, Clermont Ferrand, France
,
D. Godeneche Laboratoires de Me!thodologies Bioanalytiques, de Parasitologie et de Pharmacologie, Faculte! de Pharmacie, Cha#tenay-Malabry, France INSERM U71, Clermont Ferrand, France Laboratoire de Chimie analytique, Faculte! de Pharmacie, Clermont Ferrand, France
,
J.-C. Madelmont Laboratoires de Me!thodologies Bioanalytiques, de Parasitologie et de Pharmacologie, Faculte! de Pharmacie, Cha#tenay-Malabry, France INSERM U71, Clermont Ferrand, France Laboratoire de Chimie analytique, Faculte! de Pharmacie, Clermont Ferrand, France
,
J.-C. Maurizis Laboratoires de Me!thodologies Bioanalytiques, de Parasitologie et de Pharmacologie, Faculte! de Pharmacie, Cha#tenay-Malabry, France INSERM U71, Clermont Ferrand, France Laboratoire de Chimie analytique, Faculte! de Pharmacie, Clermont Ferrand, France
,
A. Veyre Laboratoires de Me!thodologies Bioanalytiques, de Parasitologie et de Pharmacologie, Faculte! de Pharmacie, Cha#tenay-Malabry, France INSERM U71, Clermont Ferrand, France Laboratoire de Chimie analytique, Faculte! de Pharmacie, Clermont Ferrand, France
&
J.-L. Chabard Laboratoires de Me!thodologies Bioanalytiques, de Parasitologie et de Pharmacologie, Faculte! de Pharmacie, Cha#tenay-Malabry, France INSERM U71, Clermont Ferrand, France Laboratoire de Chimie analytique, Faculte! de Pharmacie, Clermont Ferrand, France
 show all
Pages 73-85 | Published online: 22 Sep 2008

References

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  • GAYRAL, P., 1990, La recherche de macrofilaricides dans le cadre de la lutte contre l'onchocercose Africaine. Bulletin de l' Acaderrnie Nationale de Merdecine, 174, 627–635.
  • GAYRAL, P., LOISEAU, P. M., BORIES, C., BRIENNE, M. J., LECLERCQ, M. and JACQUES, J., 1995, In vitro and in vivo antifilarial activity of ethynesulfonamides, epoxyethanesulfonamides and carboxamide analogues. Arzneimitte/-Forschung/Drug Research, 45, 1122–1127.
  • GODENECHE, D., MADELMONT, J. C., MOREAU, M. F., DUPRAT, J., CHABARD, J. L., PLAGNE, R. and MEYN1EL, G., 1985, Metabolic disposition of 2-chloroethyl nitrosocarbamoylcystamine in rats. Drug Metabolism and Disposition, 13,220–226.
  • GuyTON, A. C., 1989. In Traite' de Physiologie Medicale, Part 6 Liquids physiologiqueq edited by Doin (Paris), pp. 387.
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  • MAGGS, J. L., GRABOWSKI, P. S., ROSE, M. E. and PAR K., 1982, The biotransformation of 17 a-ethynyl [H] estradiol in the rat: irreversible binding and bilary metabolites. Xenobiotica, 12, 657–668.
  • MICHELOT, J., MADELMONT, J. C., JORDAN, D., MORNEX, R. and MEYN1FL, G., 1981, Metabolism of adiphenine. I. Absorption, distribution and excretion in rats and mice. Xenobiotica, 11, 123–130.
  • RAMACHANDRA, M. and SHARMA, S. C., 1974, Metabolism of Hetrazan in the rat. Indian Journal of Medical Research, 62, 581–582.
  • SCOTT, E. W. and MCKELLAR, Q. A., 1992, The distribution and some pharmacokinetic parameters of ivermectin in pigs. Veterinary Research Communication. 16, 139–146.
  • ULLBERG S., HAMMARSTRO M, L. and APPELGREN, L., 1977, The technics ofwhole body autoradiography. Cryosectioning of large specimens. Science Tools (special issue on whole-body autoradiography), 2–28.

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