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Xenobiotica
the fate of foreign compounds in biological systems
Volume 28, 1998 - Issue 11
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Research Article

Ex vivo gastrointestinal biotransformation of chlorothalonil in the germ-free and conventional rat

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Pages 1017-1028 | Published online: 22 Sep 2008

References

  • BAKKE, J. E., BERGMAN, A. L. and LARSEN, G. L., 1982, Metabolism of 2,4',5-trichlorobiphenyl by the mercapturic acid pathway. Science, 217, 645–647.
  • BAKKE, J. E., RAFTER, J., LARSEN, G. L., GUSTAFSSON, J. A. and GUSTAFSSON, B. E., 1981, Enterohepatic circulation of the mercapturic acid and cysteine conjugates of propachlor. Drug Metabolism and Disposition, 9, 525–528.
  • BESSI, H., RAST, C., NGUYEN -BA, G. and VASSEUR, P., 1992, Chlorothalonil promotes morphological transformation in hamster embryo cells but does not inhibit GAP junctional intercellular communication either in SHE cells or in the V79 cell line. Cancer Journal, 7, 248–253.
  • BOCK, K. W. and WINNE, D., 1975, Glucuronidation of 1-naphtol in the rat intestinal loop. Biochemical Pharmacology, 24, 859–862.
  • CHHABRA, R. S., 1979, Intestinal absorption and metabolism of xenobiotics. Environmental Health Perspectives, 33, 61–69.
  • DAVIS, M. E., 1988, Effect of AT-125 on the nephrotoxicity of hexachlorobutadiene in rats. Toxicology and Applied Pharmacology, 95, 44–52.
  • GIETL, Y., VAMVAKA S. and ANDERS M. W., 1991, Intestinal absorption of S-(pentachloro-butadieny1)-glutathione and S-(pentachlorobutadieny1)-L-cysteine, the glutathione and cysteine S-conjugates of hexachlorobuta-1,3-diene. Drug Metabolism and Disposition, 19, 703–707.
  • GOBAS, F. A., MACCORQUODALE, J. R. and HAFFNER, G. D., 1993, Intestinal absorption and bio-magnification of organochlorines. Environmental Toxicology and Chemistry, 12, 567-576. GORBACH, S. L., 1993, Perturbation of intestinal microflora. Veterinary and Human Toxicology, 35, 15–23.
  • HILLENWECK, A., CRAVEDI J.-P., DEBRAUWER L., KILLEEN, J. C., BLISS, M. and CORPET D. E., 1997, Chlorothalonil biotransforrnation by gastrointestinal microflora: in vitro comparative approach in rat, dog and human. Pesticide Biochemistry and Physiology, 58, 34–48.
  • ILETT, K. F., TEE, L. B. G., REEVES, P. T. and MINCHIN, R. F., 1990, Metabolism of drugs and other xenobiotics in the gut lumen and wall. Pharmacology and Therapeutics, 46, 67–93.
  • LARSEN, G. L., 1985, Distribution of cysteine conjugate /3-lyase in gastrointestinal bacteria and in the environment. Xenobiotka, 15, 199–209.
  • LEVIN, K. H. M. and STANLEY, M. M., 1967, Isolated perfused rat small bowel—technic, studies of viability, glucose absorption. Journal of Applied Physiology, 22, 604–610.
  • PEKAS J. C., LARSEN, G. L. and FEW, V. J., 1979, Propachlor detoxication in the small intestine: cysteine conjugation. Journal of Toxicology and Environmental Health, 5, 653–659.
  • ROSNER, E., KLos, C. and DEKANT, W., 1996, Biotransformation of the fungicide chlorothalonil by glutathione conjugation. Fundamental and Applied Toxicology, 33, 229–234.
  • SIEGERS, C. P., RlEMANN, D., THIES, E. and YOUNES, M., 1988, Glutathione and GSH-dependent enzymes in the gastrointestinal mucosa of the rat. Cancer Letters, 40, 71–76.
  • SPRAKT1ES, G., KARIM, A. and LAUTERBACH, F., 1984, Metabolism and transport ofp-aminobenzoic acid in the isolated mucosa of guinea pig jejunum and colon. Gastroenterology and Clinical Biology, 8, 872.
  • UHING, M. R. and KIMURA, R. E., 1995, Active transport of 3-0-methyl-glucose by the small intestine in chronically catheterized rats. Journal of Clinical Investigation, 95, 2799–2805.
  • YINCENZINI, M. T., FAVILLI, F., STIO, M. and IANTOMASI, T., 1991, Intestinal glutathione transport system: a possible detoxication role. Biochimka et Biophyska Acta, 1073, 571–579.
  • WEISIGER, R. A., PINKUS, L. M. and JAKOBY, W. B., 1980, Thiol S-methyltransferase: suggested role in detoxication of intestinal hydrogen sulfide. Biochemical Pharmacology, 29, 2885–2887.
  • WILKINSON, C. F. and KILLEEN, J. C. JR, 1996, A mechanistic interpretation of the oncogenicity of chlorothalonil in rodents and an assessment of human relevance. Regulatory Toxicology and Pharmacology, 24, 69–84.
  • WILSON, N. H., KILLEEN, J. C. JR, FORD, W. H., Siou, G., BUSEY W. M. and EILRICH, G. L., 1990, A 90-day study in rats with the monoglutathione conjugate of chlorothalonil. Toxicology Letters, 53, 155–156.
  • WILSON, T. H. and WISEMAN, G., 1954, The use of everted small intestine for the study of the transference of substances from the mucosal to the serosal surface. Journal of Physiology, 123, 116–125.

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