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Xenobiotica
the fate of foreign compounds in biological systems
Volume 28, 1998 - Issue 11
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Research Article

Trimethadione metabolism by human liver cytochrome P450: evidence for the involvement of CYP2E1

Pages 1041-1047 | Published online: 22 Sep 2008

References

  • BUTLER, T. C. and POOLE, D. T., 1965, Determination of trimethadione and metharbital by rat liver microsomal enzymes: substrate concentration-yield relationships and competition between substrates. Biochemical Pharmacology, 14, 937–942.
  • JuBDTA -RomET, M., CRAWFORD, K., CYR, T. and INAB, T., 1994, Terfenadine metabolism in human liver: in vitro inhibition by macrolide antibiotics and azole antifungals. Drug Metabolism and Disposition, 22, 849–857.
  • KHARASCH, E. D., THUMMEL, K. E., MHYRE, J. and LILLIBRIDGE, J. H., 1993, Single dose disulfiram inhibition of chlorzoxazone metabolism: a clinical probe for P4502E1. Clinical Pharmacology and Therapeutics, 53, 643–650.
  • KOBAYASHI, S., TANAKA, E., OGUCHI, K., YOSHIDA, T., KUROIWA, Y. and YASUHARA, H., 1984, A method for estimation of hepatic drug-metabolizing capacity; determination of concentration of trimethadione and its metabolite in human serum. journal of Pharmaco-Bio Dynamics, 7,329–335.
  • NAKAMURA, M., TANAKA, E., MISAWA, S., SHIMADA, T., IMAOKA, S. and FUNAE, Y., 1994, Trimethadione metabolism, a useful indicator for assessing hepatic drug-oxidizing capacity. Biochemical Pharmacology, 47, 247–251.
  • NISHIMURA, Y., KOBAYASHI, S., KURATA, N., UoTIDA, E. and YASUHARA, H., 1992, The effects of inducers of different types of cytochrome P450 isozymes on serum dimethadione/trimethadione ratio in rats. Showa University Journal of Medical Sciences, 4, 7–14.
  • NISHIMURA, Y., KURATA, N., KOBAYASHI, S., UCHIDA, E. and YASUHARA, H., 1995, The effects of inhibitors and substrates of different types of cytochrome P450 isozymes on serum dimethadione/ trimethadione ratio in rats in vivo. Research Communications in Chemical Pathology and Pharmacology, 87, 145–154.
  • NISHIMURA, Y., KURATA, N., WATANABE, M., UCHIDA, E. and YASUHARA, H., 1996, Trimethadione N-demethylation by rat liver CYP2E1 in vitro. Research Communications in Molecular Pathology and Pharmacology, 93, 43–56.
  • PETER, R., BOCKER, R., BEAUNE, P. H., IWASAKI, M., GUENGERICH, F. P. and YANG, C. S., 1990, Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-450 11E1. Chemical Research in Toxicology, 3, 566–573.
  • SAKAI, H., KOBAYASHI, S., UCHIDA, E., KAI, K., TANAKA, E., KURATA, N. and YASUHARA, H., 1989, The mechanism of inhibition of hepatic drug metabolizing enzymes by quinidine in wistar rats. Asia Pacific Journal of Pharmacology, 4, 197–202.
  • TANAKA, E., KOBAYASHI, S., ARAMPHONGPHAN, A., KURATA, N., OGUCHI, K., KUROIWA, Y. and YASUHARA, H., 1985a, The effect of indomethacin on hepatic drug-oxidizing capacity in the rat: trimethadione and antipyrine metabolism as an indicator. Journal of Pharmaco-Bio Dynamics, 8, 773–779.
  • TANAKA, E., KOBAYASHI, S., NAKAMURA, K., UoTBDA, E. and YASUHARA, H., 1989, Simplified approach for determination of hepatic drug-oxidizing capacity using trimethadione metabolism as an indicator. Biopharmaceutics and Drug Disposition, 10, 617–620.
  • TANAKA, E., KOBAYASHI, S., OGUCHI, K., KUROIWA, Y. and YASUHARA, H., 1985b, The effects of short-term administration of ibuprofen on trimethadione metabolism and antipyrine metabolite formation in the rat. Research Communications in Chemical Pathology and Pharmacology, 48, 317–320.
  • TANAKA, E. and MISAWA, S., 1985, Effects of cimetidine and ranitidine on trimethadione metabolism in the rat. Research Communications in Chemical Pathology and Pharmacology, 47, 461–464.
  • TANAKA, E., MISAWA, S. and KUROIWA, Y., 1985c, Effects of cimetidine and diethylaminoethyl 2,2-diphenylvalerate HCL (SKF525 -A) on trimethadione metabolism in the rat. Journal of Pharmaco-Bio Dynamics, 8, 767–772.

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