Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 28, 1998 - Issue 9
72
Views
43
CrossRef citations to date
0
Altmetric
Research Article

Development of a small-scale bioreactor for drug metabolism studies maintaining hepatospecific functions

, , , &
Pages 815-825 | Published online: 22 Sep 2008

References

  • BADER, A., KNOP, E., BoKER, K., FREHAUF, N., SCHETTLER, W., OLDHAFER, K., PICHLMAY R. and SEWING, K.-F., 1995a, A novel bioreactor design for in vitro reconstruction of in vivo liver characteristics. Artificial Organs, 19, 368–374.
  • BADER, A., KNOP, E., BöKER, K., FRIJHAUF, N., CROME, O., BoKER, K., CHRISTIANS, U., OLDHAFER, K., PICHLMAYR, R., RINGE, B. and SEWING, K.-F., 1995b, Reconstruction of liver tissue in vitro: geometry of characteristic flat bed, hollow fiber, and spouted bed bioreactors with reference to the in vivo liver. Artificial Organs, 19, 941–950.
  • BADER, A., KNOP, E., BoKER, K. H. W., CROME, 0., FRIIHAUF, N., GONSCHIOR, A., CHRISTIANS, U., ESSELMAN H., PICHLMAYR, R. and SEWING, K. F., 1996a, Tacrolims (FK 506) metabolism in primary rat hepatocytes depends on extracellular matrix geometry. NS Archives in Pharmacology, 353, 461–473.
  • BADER, A., KNOP, E., KERN, A., BOKER, K., FRUHAUF, N., CROME O., ESSELMANN, H., PAPE, C., KEMPKA, G. and SEWING, K.F., 1996b, 3-D coculture of hepatic sinusoidal cells with primary hepatocytes—design of an organotypical model. Experimental Cell Research, 226, 223–233.
  • BADER, A., REIMER, P., KNOP, E., CHRISTIANS, U., WEISSLEDE R. and SEWING, K.-F., 1995c, An organotypical in vitro model of the liver parenchyma for uptake studies of diagnostic MR receptor agents. Magnetic Research Imaging, 13, 991–996.
  • BADER, A., RINKES, I. H. B., CLOSS, I. E., RYAN, C. M., TONER, M., CUNNINGHAM, J. M., TOMPKINS, G. R. and YARMUSH, M. L., 1992, A stable long-term hepatocyte culture system for studies of physiologic processes: cytokine stimulation of the acute phase response in rat and human hepatocytes. Biotechnology Progress, 8, 219–225.
  • BADER, A., ZECH, K., CROME, 0., CHRISTIANS, U., PICHLMAYR, R. and SEWING, K.-F., 1994, Use of organotypical cultures of primary hepatocytes to analyze drug biotransformation in man and animals. Xenobiotica, 24, 623–633.
  • Du, J. C., TOMPKINS, R. G. and YARMUSH, M. L., 1992, Hepatocytes in collagen sandwich: evidence for transcriptional and translational regulation. Journal of Cell Biology, 116, 1043–1053.
  • ELSDALE, T. and BARD, J., 1972, Collagen substrata for studies on cell behavior. Journal of Cell Biology, 54, 626–637.
  • FELKER, T. E., GANTZ, D., TERCYAK, A. M., OLIVA, C., CLARK, S. B. and SMALL, D. M., 1991, A comparison of lipoprotein secretion, bile production and hepatic morphology in isolated rat livers perfused with a perfluorocarbon emulsion or rat erythrocytes. Hepatology, 14, 340–351.
  • JUNGERMANN, K., 1992, Role of intralobular compartmentation in hepatic metabolism. Diabetes Metabolism JUNGERMANN, K. and THURMAN, R. G., 1992, Hepatocyte heterogeneity in the metabolism of carbohydrates. Enzyme, 46, 33–58.
  • KERN, A., BADER, A., PICHLMAY R. and SEWING, K.-F., 1997, Drug metabolism in rat and human sandwich hepatocytes. Biochemical Pharmacology, 54, 761–772.
  • KNOP, E., BADER, A., BOKER, K., PICHLMAYR, R. and SEWING, K. F., 1995, Normal ultrastructure of primary hepatocytes depends on bipolar attachment to extracellular matrix. Anatomical Record, 242, 337–349.
  • KRAHENBUHL S., KRAHENBUHL, G. S., STUCKI, J., GEHR, P. and REICHEN, J., 1992, Stereological and functional analysis of liver mitochondria from rats with secondary biliary cirrhosis: impaired mitochondrial metabolism and increased mitochondrial content per hepatocyte. Hepatology, 15, 1167–1172.
  • LAZNICEK, M., LAZNICKOVA, A. and KVETINA, J., 1990, The role of the kidney and liver in the total metabolism of (1251) ortho-iodobenzoate in rats. Cesk Farm, 39, 353–356.
  • MASUDA, Y. and YAMAMORI, Y., 1991, Histological evidence for dissociation of lipid peroxidation and cell necrosis in bromotrichloromethane hepatotoxicity in the perfused rat liver. Japanese Journal of Pharmacology, 56, 143–150.
  • MORRISON, M. H., BARBER, H. E., FOSCHI, P. G. and HAWKSWORTH, G. M., 1986, The kinetics of 4-nitrophenol conjugation by perfused livers and hepatic microsomes from streptozocin-induced diabetic rats. Journal of Pharmaceutics and Pharmacology, 38, 188–194.
  • MULDER, G. J., TE, K. J., SCHIPPER, C. G., SNEL, W. H., PANG, K. S. and POLHUIJS, M., 1991, Stereoselectivity of glutathione conjugation in vivo, in the perfused liver and in isolated hepatocytes. Drug Metabolism Reviews, 23, 311–330.
  • PRZYBOCKI, J. M., REUHL, K. R., THURMAN, R. G. and KAUFFMAN, F. C., 1992, Involvement of nonparenchymal cells in oxygen-dependent hepatic injury by allyl alcohol. Toxicology and Applied Pharmacology, 115, 57–63.
  • ROTEM, A., TONER, M., BHATIA, S., Fox', B. D., TOMPKINS, R. G. and YARMLISH, M. L., 1994, Oxygen is a factor determining in vitro tissue assembly: effects on attachment and spreading of hepatocytes. Biotechnology and Bioengineering, 43, 654–660.
  • SEGLEN, P. O., 1976, Preparation of isolated rat liver cells. Methods in Cell Biology, 13, 29–83.
  • STARNES, H. J., TEWARI, A., FLOKAS, K., KOSEK, J. C., BROWN, D., VAN, K. A. and MONDON, C. E., 1991, Effectiveness of a purified human hemoglobin as a blood substitute in the perfused rat liver. Gastroenterology, 101, 1345–1353.
  • STURM, E. and ZECH, K., 1984, Biotransformation of Urapidil: isolation and identification of metabolites in mouse, rat, dog and man. Biomedicine and Mass Spectrometry, 11, 211–216.
  • VAUPEL E., 1995, Funktionen des Magen D arm Kanals. In Physiologie des Metuchen, 19, edited by R. F. Schmidt, and G. Thews (Berlin: Springer), pp. 806–846.
  • YAMANAKA, H., NLTKINA, S., HANDLER, J. A., CURRIN, R. T., LEMASTERS, J. J. and THURMAN, R. G., 1992, Transient activation of hepatic glycogenolysis by thrombin in perfused rat livers. European Journal of Biochemistry, 208, 753–759.
  • YARMUSH, M. L., DuNN, J. C. and TOMPKINS, R. G., 1992a, Assessment of artificial liver support technology. Cell Transplant, 1, 323–341.
  • YARMUSH, M. L., TONER, M., DUNN, J. C., ROTEM, A., HUBEL, A., AND TOMPKINS, R. G., 1992b, Hepatic tissue engineering. Development of critical technologies. Ann NY Acad Sci, 665, 238–252.
  • ZECH, K., ELTZE, M., KILIAN, U., SANDERS, K. H. and KOLASSA, N., 1984, Biotransformation of Urapidil: metabolites in serum and urine and their biological activity in vitro and in vivo. Archiv. Int. Pharm. Ther., 272, 180–196.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.