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Xenobiotica
the fate of foreign compounds in biological systems
Volume 28, 1998 - Issue 3
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Research Article

Identification of cytochrome P4503A4 as the major enzyme responsible for the metabolism of ivermectin by human liver microsomes

Z. ZENG Merck Research Laboratories, Merck & Co., Inc., Ry57-200, PO Box 2000, Rahway, NJ 07065, USA
,
N. W. ANDREW Merck Research Laboratories, Merck & Co., Inc., Ry57-200, PO Box 2000, Rahway, NJ 07065, USA
,
B. H. ARISON Merck Research Laboratories, Merck & Co., Inc., Ry57-200, PO Box 2000, Rahway, NJ 07065, USA
,
D. LUFFER-ATLAS Merck Research Laboratories, Merck & Co., Inc., Ry57-200, PO Box 2000, Rahway, NJ 07065, USA
&
R. W. WANG Merck Research Laboratories, Merck & Co., Inc., Ry57-200, PO Box 2000, Rahway, NJ 07065, USA
Pages 313-321 | Published online: 22 Sep 2008

References

  • BURG, R. W. and STAPLEY, E. O., 1989, Isolation and characterization of the producing organism. In Ivermectin and Avermectin, edited by W. C. Campbell (New York: Springer), pp. 24–32.
  • CMU, L. S. and Lu, A. Y. H., 1989, Metabolism and tissue residues. In Ivermectin and Avermectin, edited by W. C. Campbell (New York: Springer), pp. 131–143.
  • FISHER, M. H. and MROZ1K, H., 1989, Chemistry. In Ivermectin and Avermectin, edited by W. C. Campbell (New York: Springer), pp. 1–23.
  • HALLEY, B. A., NARASIMHAN, N. I., VENKATARAMAN, K., TAUB, R., GREEN -ERWIN, M. L., ANDREW, N. W. and WisLociu, P. G., 1992, Ivermectin and abamectin metabolism: differences and similarities. In Xenobiotics and Food-producing Animals: Metabolism and Residues, edited by D. H. Hutson, D. R. Hawkins, F. D. Paulson and C. B. Struble. ACS Symposium Series 503 (Washington: American Chemical Society), pp. 203–216.
  • NEWTON, D. J., WANG, R. W. and Lu, A. Y., 1995, Cytochrome P450 inhibitors, evaluation of specificities in the in vitro metabolism of therapeutic agents by human liver microsomes. Drug Metabolism and Disposition, 23, 154–158.
  • OMURA, T. and SATO, R., 1964, The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. Journal of Biological Chemistry, 239, 2370–2378.
  • SHOOP, W. L., MROZIK, H. and FISHER, M. H., 1995, Structure and activity of avermectins and milbemycin in animal health. Veterinary Parasitology, 59, 139–156.
  • SMITH, P. K., KROHN, R. I., HERMANSON, G. T., MALLIA, A. K., GARTNER, F. H., PROVENZANO, M. D., FUJIMOTO, E. K., GOEKE, N. M., OLSON, B. J. and KLENK, D. C., 1985, Measurement of protein using bicinchoninic acid. Anal itical Biochemistry, 150, 76–85.
  • WANG, R. W. and Lu, A. Y. H., 1997, Inhibitory anti-peptide antibody against human CYP3A4. Drug Metabolism and Disposition, 25, 762–767.
  • WATKINS, P. B., WRIGHTON, S. A., MAUREL, P., SCHUETZ, E. G., MENDEZ -PICON, G., PARKER, G. A. and GUZELIAN, P. S., 1985, Identification of an inducible form of cytochrome P450 in human liver. Proceedings of National Academy of Sciences, USA, 82, 6310–6314.
  • WAXMAN, D. J., ATTISANO, C., GUENGERICH, F. P. and LAPENSON, D. P., 1988, Human liver microsomal steroid metabolism: identification of the major microsomal steroid hormone 6/3-hydroxylase cytochrome P-450 enzyme. Archives of Biochemistry and Biophysics, 263, 424–436.
  • ZENG, Z., ANDREW, N. W., WODA, J. M., HALLEY, B. A., CROUCH, L. S. and WANG, R. W., 1996, Role of cytochrome P450 isoforms in the metabolism of abamectin and iverrnectin in rats. Journal of Agricultural and Food Chemistry, 44, 3374–3378.

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