Advanced search
Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 28, 1998 - Issue 1
Submit an article Journal homepage
186
Views
30
CrossRef citations to date
0
Altmetric
Research Article

Pharmacokinetics and metabolism of darifenacin in the mouse, rat, dog and man

K. C. BEAUMONT Departm ent of Drug Metabolism and Early ClinicalResearch Group, Pfizer Central Research, Sandwich CT13 9NJ, UK
,
N. J. CUSSANS Departm ent of Drug Metabolism and Early ClinicalResearch Group, Pfizer Central Research, Sandwich CT13 9NJ, UK
,
D. J. NICHOLS Departm ent of Drug Metabolism and Early ClinicalResearch Group, Pfizer Central Research, Sandwich CT13 9NJ, UK
&
D. A. SMITH Departm ent of Drug Metabolism and Early ClinicalResearch Group, Pfizer Central Research, Sandwich CT13 9NJ, UK
Pages 63-75 | Published online: 22 Sep 2008

References

  • FRANZ, P.M., MATTIUZ, E. L., HATCHER, B. L., DESANTE, K. A., BREAU, A. P., OCCOLOWITZ, J. L., DORMAN, D. E., SCHMID, C. R., GOLDBERG, M . J. and RusiN, A.,1993,Dispositionof Zatosetron, a serotonin receptor antagonist, in hum ans. Drug Metabolism and Disposition, 21, 249–254.
  • JOHN, BA., CHASSEAUD, L. F., WOOD S. G. and FORLOT, P., 1992, Metabolism of the anti-psoratic agent 5 -methoxypsoralen in humans: comparison with rat and dog. Xenobiotka 22, 1339–1351.
  • KAYE, B., HERRON, W. J., MACRAE, P. V., ROBINSON, S., STOPHER, D. A., VENN, R. F. and WILD, W 1996, Rapid, solid phase extraction technique for the high-throughput assay of darifenacin in human plasma. Analytical Chemistry, 68, 1658–1660.
  • MAYS, D. C., ROGERS, S. L., GUILER, R. C., SHARP, D. E., HECHT, S. G., STAUBUS, A. E. and GERBER, N., 1986, Disposition of 8-methoxypsoralen in the rat: methodology for measurement, dose-dependent pharmacokinetics, tissue distribution and identification of metabolites. Journal of Pharmacology and Experimental Therapeutics, 236, 364–373.
  • NEWGREEN, D. T. and NAYLOR, A. M., 1996, Characterisation of functional muscarinic receptors in human bladder. British Journal of Pharmacology, 119, 45P.
  • NORDHOLM, L., WASSMANN, 0., NEILSEN, P., THOEGERSEN, H. and GROENVALD, F., 1992, Identification of the major metabolites of [31-1]-(+ )-8-chloro -5 -(2,3-dihydrobenzfuran-7-y1)-7-m ethoxy-methyloxy-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine in rats. Xenobiotka, 23, 345.
  • QUINN, P., MCINTYRE, P., MINER, W. D. and WALLIS, R. M., 1996, In vivo profile of darifenacin, a selective muscarinic M3 receptor antagonist. British Journal of Pharmacology, 119, 198P.
  • SMITH, D. A.,1991,Aromatichydroxylationof arylalkylaminesin rodents. Drug Metabolism Reviews, 23, 355–373.
  • SOUDIJN, W., VAN WINJNGAARDEN, I. and ALLEWUN, F., 1967, D istribution, excretion and metabolism of neroleptics of the butyrophenone type. European Journal of Pharmacology, 1,47-57. WALLIS, R. M., BURGES, R. A., CROSS, P. E., MACKENZIE, A. R., NEWGREEN, D. T. and QuINN, P.,1995, D arifenacin, a selective muscarinic M3 antagonist. Pharmacological Research, 31S, 54.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.