References
- AGRAWAL, S., TEMSAMANI, J. and TANG, J. Y., 1991, Pharmacokinetics, biodistribution, and stability of oligodeoxynucleotide phosphorothioates in mice. Proceedings of the National Academy of Sciences, USA, 88, 7595–7599.
- AKHTAR S., KOLE, R. and JULIANO, R. L., 1992, Stability of antisense oligodeoxynucleotide analogues in cellular extracts and sera. Life Science, 49, 1793–1801.
- Aug O, S. F., BOBADILLA M., GARCIA-SANZ, M., LEJARRETA M., UNDA, F. and HILARIO, E., 1993a, In vivo delivery of human al-antitrypsin gene to mouse hepatocytes by liposomes. Biochemical and Biophysical Research Communications, 192, 174–181.
- Aug O, S. F., BOBADILLA M., UNDA, F. J., GARCIA-SANZ, M., HILARIO, E. and LEJARRETA, M., 1993b, Recombinant cDNA encapsulation in small liposomes with hapatocyte access ability. Journal of Microencapsulation, 10, 163–170.
- Aug O, S. F., BOBADILLA M., CRESPO, J. and LEJARRETA, M., 1996, Human al -antitrypsin gene transfer to in vivo mouse hepatocytes. Human Gene Therapy, 7, 531–536.
- Aug O, S. F., GARCIA-SANZ, M., IRIJARRIZAGA, A., ALFARO, J. and HERNANDEZ, J., 1990, High encapsulation efficiencies in sized liposomes produced by extrusion of dehydration-rehydration vesicles. Journal of Microencapsulaticn, 7, 479–503.
- Aug O, S. F., UNDA, F. J., IRIJARRIZAGA, A., ALFARO, J., HILARIO, E., PEREZ-YARZA, G., BOBADILLA, M. and LEJARRETA, M., 1992, Efficacy of liposome-encapsulated indomethacin in response against metastatic 3LL and B16F1 tumor cells. Laboratory Investigation, 66, 671–679.
- BENNETT, C. F., CHIANG, M. Y., Ca, H., SHOEMAKER, J. E. E. and MIRABELLI, C. K., 1992, Cationic lipids enhance cellular uptake and activity of phosphorothioate antisense oligonucleotides. Molecular Pharmacology, 41, 1023–1033.
- BMDP STATISTICAL SOFTWARE, INC., 1993 (Los Angeles).
- BOXENBALIM, H. G., RIEGELMAN, S. and ELASHOFF, R. M., 1974, Statistical estimations in pharmaco-kinetics. Journal of Pharmacokinetics and Biopharmaceutics, 2, 123–148.
- CRESPO, J., BLAYA, C., CRESPO, A. and ALnZT 0, S. F., 1996, Long-term expression of human alfa-1-antitrypsin gene in mice employing anionic and cationic liposome vectors. Biochemical Phar-macology, 51, 1309–1314.
- GIBALDI, M. and PERRIER, D., 1982, Pharmacokinetics, 2nd edn (New York: Marcel Dekker).
- GOODCHILD, J., Kim, B. and ZAMECNIK, P. C., 1991, The clearance degradation of oligonucleotides following intravenous injection of rabbits. Antisense Research Development, 1, 153–160.
- GREGORIADIS, G., 1984, Liposome Technology (Boca Raton: CRC Press).
- GREGORIADIS, G., 1995, Engineering liposomes for drug delivery: progress and problems. Tibtechnology, 13, 527–537.
- IVERSEN, P., MATA, J. and ZON, G., 1994, The single-injection pharmacokinetics of an antisense phosphorothioate oligodeoxynucleotide against rev (art/tRS) from human immunodeficiency virus (HIV) in the adult male rat. Antisen& Research Development, 4, 43–52.
- LESERMAN, L. D., MACHY, P., ARAGNOL, D. and Aug 0, S. F., 1987, Targeted therapy in vitro and in vivo: probing the limits. In New Advances in Developmental Cancer Chemotherapy (New York: Academic Press), pp. 299–331.
- STEWART, J. C. M., 1980, Colorimetric determination of phospholipids with ammonium ferrothio-cyanate. Analytical Biochemistry, 104, 10–14.
- TARRASON, G., BELLroo, D., ERrnA, R., VILAR6, S. and PHTLAIS, J., 1995, Digoxigenin-labeled phosphorothioate oligonucleotides: a new tool for the study of cellular uptake. Antigen& Research Development, 5, 193–201.
- THIERRY, A. R. and DRuscrinn, A., 1992, Intracellular activity of unmodified, phosphorothioate and liposomally encapsulated oligodeoxynucleotides for antisense activity. Nucleic Acid Research, 20, 5691–5698.