'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data

References

• AICHER, L., WAHL, D., ARCE, A., GRENET, O. and STEINER, S., 1998, New insights into cyclosporine A nephrotoxicity by proteome analysis. Electrophoresis, 19, 1998–2003.
   PubMed Web of Science ®Google Scholar
• ANDERSON, N. L., TAYLOR, J., HOFMANN, J. P., ESQUER -BLASCO, R., SWIFT, S. and ANDERSON, N. G., 1996, Simultaneous measurement of hundreds of liver proteins: application in assessment of liver function. Toxicologic Pathology, 24, 72–76.
   Google Scholar
• ANTHONY, M. L., SWEATMAN, B. C. BEDDELL, C. R., LINDON, J. C. and NICHOLSON, J. K., 1994, Pattern recognition classification of the site of nephrotoxicity based on metabolic data derived from high resolution proton nuclear magnetic resonance spectra of urine. Molecular Pharmacology, 46, 199–211.
   PubMed Web of Science ®Google Scholar
• BALES, J. R., HIGHAM, D. P., HOWE, I., NICHOLSON, J. K. and SADLER, P. J., 1984, Use of high resolution proton nuclear magnetic resonance spectroscopy for rapid multi-component analysis of urine. Clinical Chemistry, 30, 426–432.
   PubMed Web of Science ®Google Scholar
• BECKWITH -HALL, B. M., NICHOLSON, J. K., NicHoLLs, A., FOXALL, P. J. D., LINDON, J. C., CONNOR, S. C., ABDI, M., CONNELLY, J. and HOLMES, E., 1998, Nuclear magnetic resonance spectroscopic and principal components analysis investigations into biochemical effects of three model hepatotoxins. Chemical Research in Toxicology, 11, 260–272.
   Google Scholar
• ELFARRA, A. A., JAKossoN, I. and ANDERS, M. W., 1986, Mechanism of S-(1,2 -dichlorovinyl) glutathione-induced nephrotoxicity Biochemical Pharmacology, 35, 283–288.
   Google Scholar
• GARTLAND, K. P. R., BEDDELL, C., LINDON, J. C. and NICHOLSON, J. K., 1991, The application of pattern recognition methods to the analysis and classification of toxicological data derived from NMR spectroscopy of urine. Molecular Pharmacology, 39, 629–642.
   Google Scholar
• GARTLAND, K. P. R., BONNER, F. and NICHOLSON, J. K., 1989, Investigations into the biochemical effects of region-specific nephrotoxins. Molecular Pharmacology, 35, 242–251.
   Google Scholar
• GEISOW, M. J., 1998, Proteomics : one small step for a digital computer, one giant leap for humankind. Nature Biotechnology, 16, 206.
   PubMed Web of Science ®Google Scholar
• GOODACRE, R. RISCHERT, D. J., EVANS, P. M. and KELL, D. B., 1996, Rapid authentication of animal cell lines using pyrolysis mass spectrometry and autoassociative artificial neural networks. Cyto-technology, 21, 231–241.
   Google Scholar
• GRAY, J., NICHOLSON, J. K., CREASY, D. M. and TIMBRELL, J. A., 1990, Studies on the relationship between testicular toxicity and urinary and plasma creatine concentration. Archives of Toxicology, 64, 443–450.
   PubMed Web of Science ®Google Scholar
• HoLmEs, E., BONNER, F. W., SWEATMAN, B. C., LINDON, J. C., BEDDELL, C. R., RAHR, E. and NICHOLSON, J. K., 1992, NMR spectroscopy and pattern recognition analysis of the biochemical processes associated with the progression and recovery from nephrotoxic lesions in the rat induced by mercury (II) chloride and 2-bromoethanamine. Molecular Pharmacology, 42, 922–930.
   PubMed Web of Science ®Google Scholar
• HoLmEs, E., FOXALL, P. J. D., NICHOLSON, J. K., NEILD, G. H., BROWN, S. M. BEDDELL, C., SWEATMAN B. C., RAHR, E., LINDON, J. C., SPRAUL, M. and NErDIG, P., 1994, Automatic data reduction and pattern recognition methods for analysis of 1H nuclear magnetic resonance spectra of human urine form normal and pathological states. Analytical Biochemistry, 220, 284–296.
   Google Scholar
• HOLMES, E., NICHOLLS, A. W., LINDON, J. C., RAMO S., SPRAUL M., NEIDIG, P., CONNOR, S. C., CONNELLY, J., DAMMENT S. J. P., HASELDEN J. N. and NICHOLSON, J. K., 1998a, Development of a model for classification of toxin-induced lesions using 1H-NMR spectroscopy of urine combined with pattern recognition. NMR in Biomedicine, 11, 1–10.
   Google Scholar
• HOLMES, E., NICHOLSON, J. K., NICHOLLS, A. W., LINDON, J. C., CONNOR, S. C., POLLY, S. and CONNELLY, J., 1998b, Identification of novel biomarkers of renal toxicity using automatic data reduction techniques and PCA of proton NMR spectra of urine. Chemometrics and Intelligent Laboratory Systems, 44, 251–261.
   Web of Science ®Google Scholar
• KACSER, H., 1993, Recent developments beyond metabolic control analysis. Biochemical Society Transactions, 23, 387–391.
   Web of Science ®Google Scholar
• KACSER, H. and BURNS, J. A., 1973, The control of flux. In D. D. Davies (ed.), Rate Control of Biological Processes. Symposium of the Society for Experimental Biology, Vol. 27 (Cambridge: Cambridge University Press), pp. 65–104.
   Google Scholar
• KLENK, H. P. et al., 1997, The complete genome sequence of the hyperthermophilic, sulfate-reducing archaeon Archaeoglobus fulgidus. Nature, 390, 364–370.
   Google Scholar
• KOWALSKI, B., SHARAF, D. and ILLMAN, D., 1986, Chemometrics (New York: Wiley).
   Google Scholar
• Mock, D., VORREUTHER, R., SHICHA, H., HUMPFER, E., LIPINSKI, M., SPRAUL, M., FOXALL, P. J. D., NICHOLSON, J. K. and LINDON, J. C., 1998, Biochemical classification of kidney carcinoma biopsy samples using magic angle spinning 1H-NMR spectroscopy. Journal of Pharmaceutical and Biomedical Analysis, 17, 125–132.
   Google Scholar
• NICHOLSON, J. K., BUCKINGHAM, M. J. and SIR, P. J., 1983, High resolution proton NMR studies of vertebrate blood and plasma. Biochemical Journal, 211, 605–615.
   PubMed Web of Science ®Google Scholar
• NICHOLSON, J. K., HIGHAM, D., TIMBRELL, J. A. and SIR, P. J., 1989, Quantitative 1H-NMR urinalysis studies on the biochemical effects of acute cadmium exposure in the rat. Molecular Pharmacology, 36, 398–404.
   PubMed Web of Science ®Google Scholar
• NICHOLSON, J. K., TIMBRELL, J. A. and SADLER, P. J., 1985, Proton NMR spectra of urine as indicators of renal damage: Mercury nephrotoxicity in rats. Molecular Pharmacology, 27, 644–651.
   PubMed Web of Science ®Google Scholar
• NICHOLSON, J. K. and WILSON, I. D., 1989, High resolution proton NMR spectroscopy of biological fluids. Progress in NMR Spectroscopy, 21, 449–501.
   Web of Science ®Google Scholar
• SANINS S. M., TIMBRELL, J. A., ELCOMBE, C. R. and NICHOLSON, J. K., 1990, Hepatotoxin-induced hypertaurinuria: a proton NMR study. Archives of Toxicology, 64, 407–411.
   Google Scholar
• SINCLAIR, B., 1999, Everything s great when it sits on a chip: a bright future for DNA arrays. The Scientist, 13, 18–20.
   Web of Science ®Google Scholar
• SPRAUL M., HOFMANN, M., ACKERMANN, M., NICHOLLS, A. W., DAMMENT S. J. P., HASELDEN J. N., SHOCKCOR, J. P., NICHOLSON, J. K. and LINDON, J. C., 1997, Flow injection 1H-NMR spectroscopy combined with pattern recognition: implications for rapid structural studies and high throughput biochemical screening. Analytical Communications, 34, 339–341.
   Google Scholar
• THE C. elegarts SEQUENCING CONSORTIUM, 1998, Genome sequence of the nematode C. elegans. Science [special issue], 11 December, 2041–2046.
   Google Scholar