Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 29, 1999 - Issue 10
281
Views
44
CrossRef citations to date
0
Altmetric
Research Article

Metabolism and excretion of citalopram in man: identification of O-acyl- and N-glucuronides

&
Pages 1033-1041 | Published online: 22 Sep 2008

References

  • DALGAARD, L., 1983, Preparation and hydrolysis of N-glucuronides of pyridine and piperidine. Acta Chimica Scandinavica, B37, 923–928.
  • FENSELAU C., 1994, Acyl glucuronides as chemically reactive intermediates. In F. C. Kauffman (ed.), Conjugation - Deconjugation Reactions in Drug Metabolism and Toxicity (Berlin: Springer), pp. 367–390.
  • GREEN, M. D. and TEPHLY, T. R., 1998, Glucuronidation of amine substrates by purified and expressed UDP-glucuronosyltransferase proteins. Drug Metabolism and Disposition, 26, 860–867.
  • HAWES, E. M., 1998, N'-glucuronidation, a common pathway in human metabolism of drugs with a tertiary amine group. Drug Metabolism and Disposition, 26, 830–837.
  • HANSEN -MOLLER J., CORNETT, C., DALGAARD, L. and HONORE HANSEN, S., 1988, Isolation and identification of the rearrangement products of diflunisal 1-o-acyl glucuronide. Journal of Pharmacology and Biomedical Analysis, 6,229–240.
  • HYTTEL, J., 1977, Neurochemical characterization of a new potent and selective uptake inhibitor (Lu 10-171). Psychopharmacology, 51,225–233.
  • JOFFE, P., LARSEN, F. S., PEDERSEN, V., RING -LARSEN, H., AAES - JORGENSEN, T. and SEDHU, J., 1998, Single-dose pharmacokinetics of citalopram in patients with moderate renal insuffiency or hepatic cirrhosis compared with healthy subjects. European Journal of Clinical Pharmacology, 54, 237–242.
  • Luo, H., HAWES, E. M., McKAY, G., KORCHINSKI, E. D. and MrooA, K. K., 1995, N'-Glucuronidation of aliphatic tertiary amines in human: antidepressant versus antipsychotic drugs. Xenobiotka, 25, 291–301.
  • MENDELS J., KIEV, A. and FABRE, L. F., 1999, Double-blind comparison of citalopram and placebo in depressed outpatients with melancholia. Depression and Anxiety, 9, 54–60.
  • MONTGOMERY, S. A., 1995, Selecting the optimum therapeutic dose of serotonin reuptake inhibitors: studies with citalopram. International Journal of Clinical Psychopharmacology, 10 (suppl. 1), 23–27.
  • OYEHAUG, E. OSTENSEN, E. T. and SALVESEN, B., 1984, High-performance liquid chromatographic determination of citalopram and four of its metabolites in plasma and urine samples from psychiatric patients. Journal of Chromatography, 308, 199–208.
  • STDHU, J., PRESKORN, M., POULSEN, M., SEGONZAC, A., GROLLIER, G. and LARSEN, F., 1997, Steady-state pharmacokinetics of the enantiomers of citalopram and its metabolites in humans. Chirality, 9, 686–692.
  • STYCZYNSKI, P. B., GREEN, M. D., COFFMAN, B. and TEPHLY, T. R., 1992, Studies on tertiary amine UDP-glucuronyltransferases from human and rabbit hepatic microsomes. Drug Metabolism and Disposition, 20,896–901.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.