Advanced search
Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 29, 1999 - Issue 9
Submit an article Journal homepage
69
Views
6
CrossRef citations to date
0
Altmetric
Research Article

S-methylation of 2-mercaptopyrazine in rat liver microsomes and cytosol

D. H. Lee Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology, PO Box 131, Chungryang, Seoul, Korea
&
D. H. Kim Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology, PO Box 131, Chungryang, Seoul, Korea
Pages 909-916 | Published online: 22 Sep 2008

References

  • BORCHARDT, R. T., 1977, Synthesis and biological activity of analogs of adenosylhomocysteine as inhibitors of methyltransferases. In F. Salvatore, E. Borek, V. Zappia, Williams-Ashman and F. Schlenk (eds), Biochemistry of Adenosylmethionine (New York: Columbia University Press), pp. 151–171.
  • DRUMMER, 0. H., JARROTT, B. and Louis, W. H., 1982, Demonstration of a S-methyl metabolite of captopril in patients undergoing chronic captopril therapy. Clinical and Experimental Phar-macology and Physiology, 7 (suppl.), 81–96.
  • GLAUBER, T. A., KERREMANS, A. L. and WEINSH1LBOUM, R. M., 1992, Human hepatic microsomal thiol methyltransferase assay conditions, biochemical properties, and correlation studies. Drug Metabolism and Disposition, 20, 247–255.
  • GLAUSER, T. A., NELSON, A. N., ZEMBOWER, D. E., LIPSKY, J. J. and WEINSH1LBOUM, R. M., 1993, Diethyldithiocarbamate 5-methylation: Evidence for catalysis by human liver thiol methyl-transferase and thiopurine methyltransferase. Journal of Pharmacology and Experimental Therapeutics, 266, 23–32.
  • HAN, G. S. and LEE, M. G., 1999, Pharmacokinetics of a chemoprotective agent, 2-(allylthio)pyrazine, after intravenous and oral administration to rats: Liver, stomach first-pass effects. Drug Metabolism and Disposition, 27, 221–226.
  • KANO, K. W. and KIM, N. D., 1998, Effects of mercaptopyrazine, a metabolite of 2-(allylthio)pyrazine, on LPS-induced sepsis model. Presented at the 50th Annual Meeting of The Korean Society of Pharmacology, 5–6 November, Muju, Korea.
  • Kim, S. G., CH0, J. Y., KIM, S. H. and Kim, N. D., 1996, Protective effects of 2-(allylthio)pyrazine on retinoyl palmitate- and pyridine-potentiated carbon tetrachloride-induced hepatotoxicity: effect on Ox-174 DNA strand breakage. Yakhak Hoeji, 40, 723–733.
  • Kim, N. D., KWAK, M. K. and KIM, S. G., 1997, Inhibition of cytochrome P450 2E1 expression by 2-(allylthio)pyrazine, a potential chemoprotective agent: hepatoprotective effects. Biochemical Pharmacology, 53, 261–269.
  • Km, R. A., JARDINE, I., KERREMANS, A. and WEINSH1LBOUM, R. M., 1984, Human erythrocytes membrane thiol methyltransferase: 5-methylation of captopril, N-acetylcysteine, and 7-a-thio-spirolactone. Drug Metabolism and Disposition, 12, 717–724.
  • LILL, J. S., MAYS, D. C. and LIPSKY, J. J., 1996, 5-methylation of diethyldithiocarbamic acid in rat liver microsomes. Xenobiotka, 26, 1025–1033.
  • REMY, C. N. 1963, Metabolism of thiopyrimidines and thiopurines: 5-methylation with 5-adenosyl-methionine transmethylase and catabolism in mammalian tissue. Journal of Biological Chemistry, 238, 1078–1084.
  • SURH, Y. J., KIM, S. G., PARK, K. K., SHON, Y., LEE J. M., Krm, N. D. and MILLER, J. A., 1998, Chemopreventive effects of 2-(allylthio)pyrazine on hepatic lesion, mutagenesis, and tumori-genesis induced by vinyl carbamate or vinyl carbamate epoxide. Carcinogenesis, 19, 1263–1267.
  • WEINSHILBOUM, R. M., SLADEK, S. and KLUMPP S., 1979, Human erythrocyte thiol methyltransferase: Radiochemical microassay and biochemical properties. Clinica et Chimica Acta, 97, 59–71.
  • WOODSON, L. C., AmEs, M. M., SELASSIE, C. D., HANSCH, C. and WEINSHILBOUM, R. M., 1983, Thiopurine methyltransferase: Aromatic thiol substrates and inhibition by benzoic acid derivatives. Molecular Pharmacology, 24, 471–478.
  • WOODSON, L. C. and WErNsumBoum, R. M., 1983, Human kidney thiopurine methyltransferase: purification and biochemical properties. Biochemical Pharmacology, 32, 819–826.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.