Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 29, 1999 - Issue 7
83
Views
10
CrossRef citations to date
0
Altmetric
Research Article

Biotransformation of protriptyline by filamentous fungi and yeasts

, , , &
Pages 733-746 | Published online: 22 Sep 2008

References

  • AYD, F. J., 1968, A clinical appraisal of protriptyline (vivactil): the latest FDA approved antidepressant. Lippincott's Medical Science, 54–59.
  • BELVEDERE, G., FRIGERIO, A., PANTAROTTO C., ROVEL V., ZANOL M., PARRAVICINI, F. and PIFFERI, G., 1975, Mass spectrometric identification of 10,11-dihydro-10,11-dihydroxyprotriptyline in rat urine after administration of protriptyline. Farmaco Edizione Scientifica, 30, 904–911.
  • CLARK, A. M. and HUFFORD, C. D., 1991, Use of microorganisms for the studies of drug metabolism: an update. Medicinal Research Reviews, 2, 473–501.
  • COUDONE, F., FIALIP J., ESCHALIER, A. and LAVARENNE, J., 1994. Plasma and brain pharmacokinetics of amitriptyline and its demethylated and hydroxylated metabolites after acute intraperitoneal injection in mice. European Journal of Drug Metabolism and Pharmacokinetics, 19, 5–11.
  • DAMS, P. J., 1988, Microbial models of mammalian drug metabolism. Developments in Industrial Microbiology, 29, 197–219.
  • HANSEN, E. B., JR, CERNIGLLk, C. E., KORFMACHER, W. A., MILLER, D. W. and HEFLICH, R. H., 1987, Microbial transformation of the antihistamine pyrilamine maleate : formation of potential mammalian metabolites. Drug Metabolism and Disposition, 15, 97–106.
  • HEZARI, M. and DAVIS, P. J., 1992, Microbial models of mammalian metabolism: N-dealkylation of furosemide to yield the mammalian metabolite CSA using Cunninghamella elegans. Drug Metabolism and Disposition, 20, 882–888.
  • HEZARI, M. and DAVIS, P. J., 1993, Microbial models of mammalian metabolism: furosemide glucoside formation using the fungus Cunninghamella elegans. Drug Metabolism and Disposition, 21, 259–267.
  • HUCKER, H. B., BALLETTO, A. J., DEMETRIADES J., ARISON, B. H. and ZACCHEI, A. G., 1974, Epoxide metabolites of protriptyline in rat urine. Drug Metabolism and Disposition, 3, 80–84.
  • HUCKER, H. B., BALLETTO, A. J., ZACCHEI, A. G. and ARISON, B. H., 1979, Metabolism of protriptyline by rabbit liver in vitro. Pharmacology, 19, 278–281.
  • HUFFORD, C. D., CAPITON, G. A., CLARK, A. M. and BAKER, J. K., 1981, Metabolism of imipramine by microorganisms. Journal of Pharmaceutical Sciences, 70, 151–155.
  • MELLSTROM, B. and VON BAHR, C., 1981, Demethylation and hydroxylation of amitriptyline, nortriptyline, and 10-hydroxyamitriptyline in human liver microsomes. Drug Metabolism and Disposition, 9, 565–568.
  • MERCK, SHARPE & DOHME, 1968, Protriptyline HC1. Clinical Pharmacology and Therapeutics, 9,409-412. ROSAZZA, J. P. and SMITH, R. V., 1979, Microbial models for drug metabolism. Advances in Applied Microbiology, 25, 169–207.
  • Rovo, V., BELVEDERE, G., PANTAROTTO, C. and FRIGERIO, A., 1976, Isolation of 10,11-epoxide of protriptyline in rat urine after protriptyline administration. Journal of Pharmaceutical Sciences, 65, 810–815.
  • SHOUN, H., S UDO, Y. and BEPPU, T., 1985, Subterminal hydroxylation of fatty acids by a cytochrome P-450 dependent enzyme system from a fungus, Fusarium oxysporum. Journal of Biochemistry, 97, 755–763.
  • SHOUN, H., SUDO, Y., SETO, Y. and BEPPU, T., 1983, Purification and properties of a cytochrome P-450 of a fungus, Fusarium oxysporum. Journal of Biochemistry, 94, 1219–1229.
  • SISENWINE S., no, C. 0., SHRADER, S. R. and RUELIUS, H. W., 1976, The biotransformation of protriptyline in man, pig, and dog. Journal of Pharmacology and Experimental Therapeutics, 175, 51–59.
  • YANG, W. and DAVIS, P. J., 1992, Microbial models of mammalian metabolism: biotransformations of N-methylcarbazole using the fungus Cunninghamella echinulata. Drug Metabolism and Disposition, 20, 38–46.
  • ZHANG, D., EVANS, F. E., FREEMAN, J. P., DUHART, B. T., JR and CERNIGLIA, C. E., 1995a, Bio-transformation of amitriptyline by Cunninghamella elegans. Drug Metabolism and Disposition, 23, 1417–1425.
  • ZHANG, D., EVANS, F. E., FREEMAN, J. P., YANG, Y., DECK, J. and CERNIGLIA, C. E., 1995b, Formation of mammalian metabolites of cyclobenzaprine by the fungus, Cunninghamella elegans. Chemico-Biological Interactions, 102, 79–92.
  • ZHANG, D., YANG, Y., LEAICEY, J. E. A. and CERNIGLIA, C. E., 1996, Phase I and Phase II enzymes produced by Cunninghamella elegans for the metabolism of xenobiotics. FEMS Microbiology Letters, 138, 221–226.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.