Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 29, 1999 - Issue 6
34
Views
13
CrossRef citations to date
0
Altmetric
Research Article

In vivo and in vitro pharmacokinetics and metabolism studies of 26,26,26,27,27,27-6F-1,25(OH)2 vitamin D3 (Falecalcitriol) in rat: induction of vitamin D3-24-hydroxylase (CYP24) responsible for 23S-hydroxylation in target tissues and the drop in serum levels

, , , , &
Pages 603-613 | Published online: 22 Sep 2008

References

  • AKENo, N., SAIKATSU, S. and HORIUCHI, N., 1993, Increase of renal 25-hydroxyvitamin D3-24-hydroxylase activity and its messenger ribonucleic acid level in la-hydroxyvitamin D3-administered rats: possibility of the presence of two forms of 24-hydroxylase. Journal of Nutrition Science and V itaminology, 39, 89–100.
  • AKENO N., SAIKATSU, S., KIMURA, S. and HORIUCHI, N., 1994, Induction of vitamin D 24-hydroxylase messenger RNA and activity by 22-oxacalcitriol in mouse kidney and duodenum: possible role in decrease of plasma 1a,25-dihydroxyvitamin D. Biochemistry and Pharmacology, 48, 2081–2090.
  • AKIYOSHI -SHIBATA, M., SAKAKI, T., OHYAMA, Y., NOSHIRO, M., OKUDA, K. and YABUSAKI, Y., 1994, Further oxidation of hydroxycalcitriol by calcitriol 24-hydroxylase. A study with the mature enzyme expressed in Escherkhia coli. European Journal of Biochemistry, 224, 335–343.
  • BECKMAN, M. J., TADIKONDA, P., WERNRE, E., PRAHL, J., YAMADA, S. and DELucA, H. F., 1996, Human 25-hydroxyvitamin D.-24-hydroxylase, a multicatalytic enzyme. Biochemistry, 35, 8465-8472. BLIGH, E. G. and DYER, W. J., 1957, A rapid method of total lipid extraction and purification. Canadian Journal of Biochemistry, 37, 911–917.
  • CHEN, M. L., HEINRICH, G., OHYAMA, Y., OKUDA, K., OMDAHL, J. L., CHEN, T. C. and HOLIC, M. F., 1994, Expression of 25-hydroxyvitamin D.-24-hydroxylase mRNA in cultured human keratino-cytes. Proceedings of the Society for Experimental Biology and Medicine, 207, 57–61.
  • CHOMCZYNSKI, P. and SACCHI, N., 1987, Single-step method of RNA isolation by acid guanidinum thiocyanate-phenol-chloroform extraction. Analytical Biochemistry, 162, 156–159.
  • FURUICHI, T., KAWATA, S., Asox, Y., KUMAKI, K. and OHYAMA, Y., 1998, Differential time course of induction of 1a,25-dihydroxyvitamin D.-24-hydroxylase mRNA expression in rats by 1a,25-dihydroxyvitamin D. and its analogs. Life Sciences, 62, 453–459.
  • HARADA, M., MIYAHARA, T., KAGITA -KONDO, S., KOZAKAI, A., HIGUCHI, S., OTOMO, S. and KOZUKA, H., 1994, Differences in metabolism between 26,26,26,27, 27,27-hexafluoro-1a,25-dihydroxyvitamin D. and 1a,25-dihydroxyvitamin D. in cultured neonatal mouse calvaria. Research Communications in Molecular Pathology and Pharmacology, 86, 183–193.
  • HAYASHI, H., AKIYOSHI -SHIBATA, M., SAKAKI, T. and YABUSAKI, Y., 1998, Rat CYP24 catalyses 23S-hydroxylation of 26,26,26,27,27,27-hexafluorocalcitriol in vitro. Xenobiotka, 28, 457–463.
  • HONDA, A., NAKASHIMA, N., SHIDA, Y., Morn, Y., NAGATA, A. and IsmzuKA, S., 1993, Modification of 1a,25-dihydroxyvitamin D. metabolism by introduction of 26,26,26,27,27,27-hexafluoro atoms in human promyelocytic leukaemia (HL-60) cells: isolation and identification of a novel bioactive metabolite, 26,26,26,27, 27,27-hexafluoro-1a,23(S),25-trihydroxyvitamin D. Biochemical Jour-nal, 295, 509–516.
  • INABA, M., BURGOS-TRINIDAD M. and DELucA, H. F., 1991, Characteristics of the 25 -hydroxyvitamin D.- and 1,25-dihydroxyvitamin D.-24-hydroxylase(s) from HL-60 cells. Archives in Biochemistry and Biophysics, 284, 257–263.
  • INABA, M., OKITNO, S., NISHIZAWA, Y., IMANISHI, Y., KATSUMATA, T., SUGATA, I. and MORII, H., 1993, Effect of substituting fluorine for hydrogen at C-26 and C-27 on the side chain of 1,25-dihydroxyvitamin D. Biochemistry and Pharmacology, 45, 2331–2336.
  • KIRIYAMA, T., OKAMOTO, S., EJIMA, E., KURIHARA, N., HAICETA, Y., Pro, N., I zumi, M., KUMEGAWA, M. and NAGATAKI, S., 1991, Effect of a highly potent fluoro analog of 1,25-dihydroxyvitamin D. on human bone-derived cells. Endocrinology, 128, 81–86.
  • KOMURO, S., KANAMARU, H., NAKATSUKA I. and YOSHITAKE, A., 1996b, Disposition and metabolism of ST-630 (2) Metabolism after single administration of 'H-ST-630 in rats. Xenobiotic Metabolism and Disposition, 11, 518–529.
  • KOMURO, S., KANAMARU, H., NAKATSUKA I., YOSHITAICE, A., ISHIZAKI, M., NEMOTO, H., UEDA, K., EBINE, H., NINOMIYA, S. and Esumi, Y., 1996a, Disposition and metabolism of ST-630 (1) Absorption, distribution and excretion after single oral administration of 'H-ST-630 in rats. Xenobiotic Metabolism and Disposition, 11, 505–517.
  • LOHNES, D. and JoNEs, G., 1987, Side chain metabolism of vitamin D. in osteosarcoma cell line UMR. Journal of Biological Chemistry, 262, 14394–14401.
  • NAPOLI, J. L. and HORST, R. L., 1983, (235)-1,23,25-trihydroxycholecalciferol, an intestinal metabolite of 1,24-dihydroxycholecalciferol. Biochemical Journal, 214, 261–264.
  • OZONO, K., SONE, T. and PIKE, J. W., 1991, The genomic mechanism of action of 1,25-dihydroxyvitamin D. Journal of Bone and Mineral Research, 6, 1021–1027.
  • ROY, S. and TENENHOUSE, H. S., 1996, Transcriptional regulation and renal localization of 1,25-dihydroxyvitamin D.-24-hydroxylase gene expression: effect of the Hyp mutation and 1,25-dihydroxyvitamin D. Endocrinology, 137, 2938–2946.
  • SASAKI, H., HARADA, H., HANDA, Y., MORINO, H., SUZAWA, M., SHIMPO, E., KATSUMATA, T., MASUHIRO Y., MATSUDA, K., EBIHARA, K., ONO, T., MASUSIGE, S. and KATO, S., 1995, Transcriptional activity of a fluorinated vitamin D analog on VDR-RXR-mediated gene expression. Biochemistry, 34, 370–377.
  • TANAKA, Y., DELucA, H. F., KOBAYASHI, Y. and IKEKAwA, N., 1984, 26,26,26,27,27,27-Hexafluoro-1,25-dihydroxyvitamin D.: a highly potent, long-lasting analog of 1,25-dihydroxyvitamin D. Archives of Biochemistry and Biophysics, 229, 348–354.
  • VIETH, R., Komi, S. W., BALFE, J. W., RAWLINS, M. and TINMOUTH, W. W., 1990, Tracer kinetics and actions of oral and intraperitoneal 1,25 -dihydroxyvitamin D. administration in rats. Kidney International, 38, 857–861.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.