Advanced search
Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 29, 1999 - Issue 5
Submit an article Journal homepage
26
Views
9
CrossRef citations to date
0
Altmetric
Research Article

Biotransformation of the antipsychotic agent, mazapertine, in dog-mass spectral characterization and identification of metabolites

W. N. WU Division of Preclinical Development and OE Division of Drug Discovery, The R. W. Johnson Pharmaceutical Research Institute , Spring House, PA 19477, USA
,
L. A. McKOWN Division of Preclinical Development and OE Division of Drug Discovery, The R. W. Johnson Pharmaceutical Research Institute , Spring House, PA 19477, USA
,
A. R. TAKACS Division of Preclinical Development and OE Division of Drug Discovery, The R. W. Johnson Pharmaceutical Research Institute , Spring House, PA 19477, USA
,
W. J. JONES Division of Preclinical Development and OE Division of Drug Discovery, The R. W. Johnson Pharmaceutical Research Institute , Spring House, PA 19477, USA
&
A. B. REITZ Division of Preclinical Development and OE Division of Drug Discovery, The R. W. Johnson Pharmaceutical Research Institute , Spring House, PA 19477, USA
Pages 453-466 | Published online: 22 Sep 2008

References

  • BUCLIN, T., STUCKI, R., JAQUET -MUELLER, F., MUNAFO, A., BAULDAUF, C., BRUNNER -FERBER, F. and BIOLLAZ, J., 1993a, Tolerability and psychopharmacological profile of the novel antipsychotic mazapertine (RWJ-37796) in healthy volunteers. Clinical Pharmacology and Therapeutics, 53,179 (abstract, 94th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics).
  • BUCLIN, T., STUCKI, R., JAQUET -MUELLER, F., MUNAFO, A., BAULDAUF, C., BRUNNER -FERBER, F., PIQUET, V. and BIOLLAZ, J., 1993b, Tolerance, psychopharmacological profile and pharmaco-kinetics of a new neuroleptic, mazapertine (RWJ-37796), in healthy volunteers. Schweizerische Medizinische Wochenschrift, 123 (16, S50), 39.
  • GISCLON, L. G. and CURTIN, C. R., 1993, The effect of food on the bioavailability (BA) of a new antipsychotic drug (RWJ-37796). Pharmaceutical Research, 10, S-398 (abstract, AAPS 8th Annual Meeting).
  • REITZ, A. B., BENNET, D. J., BLUM, P. S., CODD, E. E., MARYANOFF, C. A., ORTEGON, M. E., RENZI, M. J., SCOTT, M. K., SHANK, R. P. and VAUGHT, J. L., 1994, A new arylpiperazine antipsychotic with high D2/D3/5-H TiA/aiA-adrenergic affinity and a low potential for extrapyramidal effects. Journal of Medicinal Chemistry, 37, 1060–1062.
  • REITZ, A. B., McDoNNELL, M. E., BAXTER, E. W., CODD, E. E. and Wu, W. N., 1997, The synthesis and evaluation of the major metabolites of mazapertine. Bioorgank and Medicinal Chemistry Letters, 7, 1927–1930.
  • WONG, D. F., YUNG, B. C. K., GIORGIANNI, J. A., CHEN, C., CHAN, B., GISCLON, L. G., DANNALS R. F., RAVERT, H. T., SHAYA, E., CURTIN, C. R. and OFFORD, S. J., 1993, D2 Dopamine receptor occupancy as a function of intravenous rising dose of mazapertine (RWJ-37796) in normal living human brain. journal of Nuclear Medicine, 34,109 (abstract, 40th Annual Meeting of the Society of Nuclear Medicine).
  • Wu, W. N., McKowN, L. A., GAUTHIER, A. D., JoNEs, W. J. and TAKACS, A. R., 1994a, Metabolism and excretion of the antipsychotic agent, RWJ-3776 in rats. Pharmaceutical Research, 11, S-336 (abstract, the 9th AAPS Annual Meeting).
  • Wu, W. N., McKowN, L. A., JoNEs, W. J., TAKACS, A. R., REITZ, A. Band MCDONNELL, M. E., 1994b, Mass spectral characterization and identification of the metabolites of the antipsychotic agent, RWJ-37796, in dogs. Proceedings of the 42nd ASMS Conference on Mass Spectrometry, 344.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.