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Xenobiotica
the fate of foreign compounds in biological systems
Volume 29, 1999 - Issue 4
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Research Article

Intracellular localization and metabolism of the phenanthridinium trypanocide, ethidium bromide, by isolated rat hepatocytes

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Pages 349-360 | Published online: 22 Sep 2008

References

  • BERG, S. S., 1963, The search for new trypanocides. Part VIII. Coupling of m-amidinobenzenediazonium chloride with 3,8-diamino-5-ethyl-6-phenylphenanthridinium chloride. Journal of the Chemical Society, 3635–3640.
  • BORST, P., 1972, Mitochondrial nucleic acids. Annual Review of Biochemistry, 41, 333–376.
  • BRATTON, C. A. and MARSHALL, E. K., 1939, A new coupling component for sulphanilamide determination. Journal of Biological Chemistry, 128, 537–550.
  • COOLBEAR, K. P. and MIDGLEY, M., 1986, Characteristics of ethidium uptake by the Trypanosomatid flagellates, Crithidia fasciculata and Leptomonas seymouri. Antimicrobial Agents and Chemotherapy, 29, 258–262.
  • ELSDALE, T. and BARD, J., 1972, Collagen substrata for studies on cell behaviour. Journal of Cell Biology, 54, 626–637.
  • FIRTH, W. J., WATKINS, C. L., GRAVES, D. E. and YIELDING, L. W., 1983, Synthesis and characterization of ethidium analogs: emphasis on amino and azido substituents (1). Heterocyclic Chemistry, 20, 759–765.
  • FRMRE, C., LECOINTE, P. and PAOLETTI C., 1981, Metabolism of ethidium bromide in rats. Drug Metabolism and Disposition, 9, 156–160.
  • GAUGAIN, B., FRAIRE, C., LECOINTE, P., PAOLETTI, C. and ROQUES, B. P., 1981, Chemical structure of ethidium bromide metabolites extracted from rat bile. FEBS Letters, 129, 70–76.
  • GILBERT, R. J. and NEWTON, B. A., 1982, Ethidium bromide: pharmacokinetics and efficacy against trypanosome infections in rabbits and calves. Parasitology, 85, 127–148.
  • KANDANSWAMY, T. S. and HENDERSON, J. F., 1963, The metabolism of ethidium in normal and neoplastic tissues. Cancer Research, 23, 250–253.
  • KINABO, L. D. B. and BOGAN, J. A., 1987, Binding of isometamdium to calf thymus DNA and lipids: pharmacological implications. Journal of Veterinary Pharmacology and Therapeutics, 10, 357–362. LAVOIE, E. J., ADAMS, E. A., SHIGEMATSU, A. and HOFFMANN, D., 1985, Metabolites of phenanthridine formed by rat liver homogenate. Drug Metabolism and Disposition, 13, 71–75.
  • LEACH, T. M. and ROBERTS, C. L., 1981, Present status of chemotherapy and chemoprophylaxis of animal trypanosomiasis in the eastern hemisphere. Pharmacology and Therapeutics, 13, 91–147.
  • LECOINTE, P., BICHET, N., FRAIRE, C. and PAOLETTI C., 1981, The hepatic metabolism of ethidium bromide to reactive mutagenic species: biochemical and structural requirements. Biochemical Pharmacology, 30, 601–609.
  • MACGREGOR, J. T. and CLARKSON, T. W., 1971, Metabolism and biliary excretion of phenanthridinium salts — 1. Nature of the biliary metabolites. Biochemical Pharmacology, 20, 2833-2846. MOLDEUS, P., HOGBERG, J. and ORRENIUS, S., 1978, Isolation and use of liver cells. Methods in Enzymology, 52, 60–71.
  • MURILLA, G. A., MDACHI, R. E., IsmAIL, A. A. and KARANJA, W. M., 1996, Bioavailability, pharmaco-kinetics, and tissue distribution of ' C homidium after parenteral administration to Boran cattle. Journal of Veterinary Pharmacology and Therapeutics, 19, 142–148.
  • SHuLL, L. R., KIRSCH, D. G., LOHSE, C. L. and WISN1EWSKI, J. A., 1987, Application of isolated hepatocytes to studies of drug metabolism in large food animals. Xenobiotka, 17, 345–363. TIMBRELL, J. A., 1991, Principles of Biochemical Toxicology (London: Taylor & Francis).
  • WALLS, L. P., 1945, Researches in the phenanthridinium series. Part VI. The relationship between structure and trypanocidal properties. Journal of the Chemical Society, 294–300.
  • WANG, C. C., 1995, Molecular mechanisms and therapeutic approaches to the treatment of African trypanosomiasis. Annual Review of Pharmacology and Toxicology, 35, 93–127.
  • WARING, M. J., 1966, Cross-linking and intercalation in nucleic acids. In B. A. Newton and P. E. Reynolds (eds), Biochemical Studies of Antimicrobial Drugs (London: Cambridge University Press), pp. 235–265.

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