Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 29, 1999 - Issue 1
83
Views
34
CrossRef citations to date
0
Altmetric
Research Article

Species differences in the hepatic and intestinal metabolism of cyclosporine

, , &
Pages 3-9 | Published online: 22 Sep 2008

References

  • BLECK, J. S S CHL ITT H. J., CHRISTIANS, U., TH1ESEMANN C., STROHMEYER S S CHOTTMANN, R., W ONIGEIT, K. and SEWING, K. F., 1989, Urinary excretion of cyclosporin and 17 of its metabolites in renal allograft recipients. Pharmacology, 39, 160–164.
  • GOMEZ, D. Y., WACHER, V. J., TOMLANOVICH, S. J., HEBERT, M. F. and BENET, L. Z., 1995, The effect of ketaconazole on the intestinal metabolism and bioavailability of cyclosporine. Clinical Pharmacology and Therapeutics, 58, 15–19.
  • GORNALL, A. G., BARDAWILL, C. S. and DAVID, M. M., 1949, Determination of serum proteins by means of biuret reaction. Journal of Biological Chemistry, 177, 751–766.
  • HEBERT, M. F., ROBERTS, J. P., PRUEKSARITANONT, T. and BENET, L. Z., 1992, Bioavailability of cyclosporine with concomitant rifampicin administration is markedly less than predicted by hepatic enzyme induction. Clinical Pharmacology and Therapeutics, 52, 453–457.
  • KOLARS, J. C., STETSON, P. L., RUSH, B. D., RUWART, M. J., SCHM1EDLEN -REN, P., DUELL, E. A., VOORHEES J. J. and WATKINS, P. B., 1992, Cyclosporine metabolism by P450IIIA in rat enterocytes—another determinant of oral bioavailability ? Transplantation, 53, 596–602.
  • OMURA, T. and SATO, R., 1964, The carbon monoxide binding pigment of liver microsomes. journal of Biological Chemistry, 239, 2370–2378.
  • SCHWINGHAMMER, T. L., PRZEPIORKA, D., VENKATARAMANAN, R., WANG, C. P., BURCKART, G. J., ROSENFELD, C. S. and SHADDUCK, R. K., 1991, The kinetics of cyclosporine and its metabolites in bone marrow transplant patients. British Journal of Clinical Pharmacology, 32, 2797–2799.
  • SMITH, D. A., 1991, Species differences in metabolism and pharmacokinetics: are we close to an understanding? Drug Metabolism Reviews, 23, 355–373.
  • STOHS, S. J., GRAFSTROM, R. C., BURKE, M. D., MOLDEUS, P. W. and ORRENIUS, S. G., 1976, The isolation of rat intestinal microsomes with stable cytochrome P450 and their metabolism of Benzo(a)pyrene. Archives of Biochemistry and Biophysics, 177, 105–116.
  • VENKATARAMANAN, R., WANG, C. P., HABUCKY, K., PTACHCINSKI, R. J., BURCKART, G. J., KONERU, B., BAKER, R., TODO, S. and STARZL, T. E., 1988, Species specific cyclosporine metabolism. Transplant Proceedings, 20, 680–683.
  • WATKINS, P. B., WRIGHTON, S. A. SCHEUTZ, E.G., MOLOWA, D. T. and GUZELIAN, P. S., 1987, Identification of glucocorticoid inducible cytochrome P450 in the intestinal mucosa of rats and man. Journal of Clinical Investigation, 80, 1029–1036.
  • WITKAmp, R. F., LOHUIS, J. A., NIJMEIJER, S. M., KOLICER, H. J., NOORDHOEK, J. and VAN MIERT, A. S., 1992, Species and sex related differences in the plasma clearance and metabolite formation of antipyrine: a comparative study in four animal species: cattle, goat, rat and rabbit. Xenobiotica, 21, 148–192.
  • Wu, C. Y., BENET, L. Z., HEBERT, M. F., GUPTA, S. K., ROWLAND, M., GOMEZ, D. Y. and WACHER, V. J., 1995, Differentiation of absorption and first pass gut and hepatic metabolism in humans: studies with cyclosporine. Clinical Pharmacology and Therapeutics, 58, 492–497.
  • Wu, Y. M., VENKATARAMANAN, R., SUZUKI, M., ZHU, Y., ABDALLAH, H., EMEIGH, J., BURCKART, G. J., WARTY, V. S., FUNG, J. J., Tom, S. and STARZL, T. E., 1991, Interaction between FK506 and cyclosporine in dogs. Transplant Proceedings, 23, 2797–2799.
  • YEE, G. C. and SALOMON, D. R., 1992, Cyclosporine. In W. E. Evans, J. J. Schentag and W. J. Jusko (eds), Applied Pharmacokinetics : Principles of Therapeutic Drug Monitoring (Vancouver: Applied Therapeutics), pp 28.9–13.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.