Current Concepts of the Irritable Bowel Syndrome

References

• Thompson WG, Longstreth GF, Drossman DA, Heaton KW, Irvine EJ, Muller-Lissner SA. Functional bowel disorders and functional abdominal pain. Gut 1999;45 Suppl II:43–7.
   Google Scholar
• Thompson WG, Dotevall G, Drossman DA, Heaton KW, Kruis W. Irritable bowel syndrome: guidelines for the diagnosis. Gastroenterol Int 1989;2:92–5.
   Google Scholar
• American Gastroenterological Association., Medical position statement: irritable bowel syndrome. Gastroenterology 1997; 112:2118–9.
   PubMed Web of Science ®Google Scholar
• Drossman DA, Whitehead WE, Camilleri M. Irritable bowel syndrome: a technical review for practice guideline development. Gastroenterology 1997;112:2120–37.
   Google Scholar
• Manning AP, Thompson WG, Heaton KW, Morris AF. Towards positive diagnosis of the irritable bowel. Br Med J 1978;2:653–4.
   PubMed Web of Science ®Google Scholar
• Kruis W, Thieme CH, Weinzieri M, Schussler P, Hall J, Paulus W. A diagnostic score for the irritable bowel syndrome and its value in the exclusion of organic disease. Gastroenterology 1984;87:1–7.
   PubMed Web of Science ®Google Scholar
• Hungin APS, Tack J, Whorwell PJ, Mearin F. Symptoms and patterns in irritable bowel syndrome in the general population: the truth in IBS (T-IBS) survey. J Gastroenterol Hepatol 2002;17 Suppl 2:G13.
   Google Scholar
• Quigley EMM. The irritable bowel syndrome: motility, mind or message? Variations on an enigma. Dig Dis 1994;12:69–71.
   PubMed Web of Science ®Google Scholar
• Locke GR III, Zinsmeister AR, Talley NJ, Fett SL, Melton LJ III. Familial association in adults with functional gastrointestinal disorders. Mayo Clin Proc 2000;75:907–12.
   Google Scholar
• Morris-Yates A, Talley NJ, Boyce PM, Nandurkar S, Andrews G. Evidence for a genetic contribution to functional bowel disorder. Am J Gastroenterol 1998;93:1311–7.
   PubMed Web of Science ®Google Scholar
• Levy RL, Jones KR, Whitehead WE, Feld SI, Talley NJ, Corey LA. Irritable bowel syndrome in twins: heredity and social learning both contribute to etiology. Gastroenterology 2001;121: 799–804.
   PubMed Web of Science ®Google Scholar
• McKee DP, Quigley EMM. Intestinal motility in irritable bowel syndrome: Is IBS a motility disorder? Part 1: Definition of IBS and colonic motility. Dig Dis Sci 1993;38:1761–72.
   PubMed Web of Science ®Google Scholar
• McKee DP, Quigley EMM. Intestinal motility in irritable bowel syndrome: Is IBS a motility disorder? Part 2: Motility of the small bowel, esophagus, stomach and gall bladder. Dig Dis Sci 1993;38:1763–82.
   Web of Science ®Google Scholar
• Quigley EMM. Disturbances in small bowel motility. Bailliere’s Best Practice Res Clin Gastroenterol 1999;13:385–95.
   PubMed Web of Science ®Google Scholar
• Kellow JE, Phillips SF. Altered small bowel motility in irritable bowel syndrome is correlated with symptoms. Gastroenterology 1987:1885–93.
   PubMed Web of Science ®Google Scholar
• Kellow JE, Miller LJ, Phillips SF, Zinsmeister AR. Dysmotiltiy of the small intestine in irritable bowel syndrome. Gut 1988;29: 1236–43.
   PubMed Web of Science ®Google Scholar
• Kellow JE, Gill RC, Wingate DL. Prolonged ambulant recordings of small bowel motility demonstrate abnormalities in the irritable bowel syndrome. Gastroenterology 1990; 98: 1208–18.
   Google Scholar
• Gorard DA, Libby GW, Farthing MJ. Ambulatory small bowel motility in ‘diarrhoea’ predominant irritable syndrome. Gut 1994;35:203–10.
   Google Scholar
• Quigley EMM, Donovan JP, Lane MJ, Gallagher TF. Antroduodenal manometry: usefulness and limitations as an outpatient study. Dig Dis Sci 1992;37:20–8.
   PubMed Web of Science ®Google Scholar
• Schmidt T, Hackelsberger N, Widmer R, Meisel C, Pfeiffer A, Kaess H. Ambulatory 24-hour jejunal motility in diarrhea-predominant irritable bowel syndrome. Scand J Gastroenterol 1996;31:581–9.
   PubMed Web of Science ®Google Scholar
• Small PK, Loudon MA, Hau CM, Noor N, Campbell FC Large-scale ambulatory study of post-prandial jejunal motility in irritable bowel syndrome. Scand J Gastroenterol 1997;32:39–47.
   PubMed Web of Science ®Google Scholar
• Gorard DA, Vesselinova-Jenkins CK, Libby GW, Farthing MJ. Migrating motor complex in sleep in health and irritable bowel syndrome. Dig Dis Sci 1995;40:2383–9.
   PubMed Web of Science ®Google Scholar
• Lindberg G, Glia A, Nyberg B, Veress B. Lymphocytic epithelioganglionitis: a new entity causing severe motility disorders in the gut. Gastroenterology 1999;116:A1030.
   Web of Science ®Google Scholar
• Serra J, Azpiroz F, Malagelada J-R. Impaired transit and tolerance of intestinal gas in the irritable bowel syndrome. Gut 2001;48:14–9.
   Google Scholar
• Caldarella M-P, Serra J, Azpiroz F, Malagelada J-R. Stimulation of intestinal gas production is the key to treat gas retention in functional patients. Gastroenterology 2000;118:A138.
   Google Scholar
• Lasser RB, Bond JH, Levitt MD. Role of intestinal gas in functional abdominal pain. N Engl J Med 1975;293:524–6.
   Google Scholar
• Haderstorfer B, Psycholgin D, Whitehead WE, Schuster MM. Intestinal gas production from bacterial fermentation of undigested carbohydrate in irritable bowel syndrome. Am J Gastroenterol 1989;84:375–8.
   PubMed Web of Science ®Google Scholar
• King TS, Elia M, Hunter JO. Abnormal colonic fermentation in irritable bowel syndrome. Lancet 1998;352:1187–9.
   Google Scholar
• Serra J, Azpiroz F, Malagelada J-R. Mechanisms of intestinal gas retention in humans: impaired propulsion versus obstructed evacuation. Am J Physiol 2001;281:G138–50.
   Google Scholar
• Whorwell PJ. The problem of gas in the irritable bowel syndrome. Am J Gastroenterol 200;95: 1618–9.
   Google Scholar
• Koide A, Yamaguchi T, Odaka T, Koyama H, Tsuyuguchi T, Kitahara H, et al. Quantitative analysis of bowel gas using plain abdominal radiographs in patients with irritable bowel syndrome. Am J Gastroenterol 2000;95:1735–41.
   PubMed Web of Science ®Google Scholar
• Lewis MJV, Reilly B, Houghton LA, Whorwell PJ. Ambulatory abdominal wall plethysmography: towards objective assessment of abdominal distension in irritable bowel syndrome. Gut 2001; 48:216–20.
   PubMed Web of Science ®Google Scholar
• Jailwala J, Imperiale T, Kroenke K. Pharmacologic treatment of the irritable bowel syndrome: a systematic review of randomized, controlled trials. Ann Intern Med 2000; 133: 136–47.
   Google Scholar
• Akehurst R, Kalenthaler E. Treatment of irritable bowel syndrome: a review of randomized controlled trials. Gut 2001; 48:272–82.
   PubMed Web of Science ®Google Scholar
• Mayer EA, Gebhart GF. Basic and clinical aspects of visceral hyperalgesia. Gastroenterology 1994;107:291–3.
   Web of Science ®Google Scholar
• Mertz H, Naliboff B, Munakata J, Niazi N, Mayer EA. Altered rectal perception is a biological marker of patients with irritable bowel syndrome. Gastroenterology 1995;109:40–52.
   Google Scholar
• Swarbrick ET, Hegarty JE, Bat L, Wilhams CB, Dawson AM. Site of pain from the irritable bowel syndrome. Lancet 1980;2: 443–6.
   Google Scholar
• Schmulson M, Chang L, Naliboff B, Lee OY, Mayer EA. Correlation of symptom criteria with perception thresholds during rectosigmoid distension in irritable bowel syndrome patients. Am J Gastroenterol 2000;95:152–6.
   Google Scholar
• Accarino AM, Azpiroz F, Malagelada J-R. Selective dysfunction of mechanosensitive afferents in the irritable bowel syndrome. Gastroenterology 1995;108:636–43.
   Google Scholar
• Galati JS, McKee DP, Quigley EMM. The response to intraluminal gas in the irritable bowel syndrome: motility versus perception. Dig Dis Sci 1995;40:1381–7.
   Google Scholar
• Lembo T, Naliboff B, Munakata J, Fullerton S, Saba L, Tung S, et al. Symptoms and visceral perception in patients with pain-predominant irritable bowel syndrome. Am J Gastroenterol 1999;94:1320–6.
   PubMed Web of Science ®Google Scholar
• Van Ginkel R, Voskuijl WP, Benninga MA, Taminiau JAJM, Boeckxstaens GE. Alterations in rectal sensitivity and motility in childhood irritable bowel syndrome. Gastroenterology 2001; 120:31–8.
   Google Scholar
• Hobday D, Thompson DG. Role of functional brain imaging in gastroenterology in health and disease. Digest Liver Dis 2000; 32:101–3.
   Web of Science ®Google Scholar
• Aziz Q, Thompson DG. Clinical relevance of the gut brain axis. Gastroenterology 1997;114:559–78.
   Web of Science ®Google Scholar
• Mertz H, Morgan V, Tanner G, Pickens D, Price R, Shyr Y, et al. Regional cerebral activation in irritable bowel syndrome with painful and nonpainful stimuli. Gastroenterology 2000; 118: 842–8.
   PubMed Web of Science ®Google Scholar
• Kellow JE, Eckersley GM, Jones MR. Enhanced perception of physiological intestinal motility in the irritable bowel syndrome. Gastroenterology 1991;101:1621–7.
   Google Scholar
• Fukudo S, Nomura T, Hongo M. Impact of corticotrophin-releasing hormone on gastrointestinal motility and adrenocorticotrophic hormone in normal controls and patients with the irritable bowel syndrome. Gut 1998;42:845–9.
   Google Scholar
• Gaynes BN, Drossman DA. The role of psychosocial factors in irritable bowel syndrome. Bailliere’s Best Practice Res Clin Gastroenterol 1999;13:437–52.
   PubMed Web of Science ®Google Scholar
• Quigley EMM. Enteric neuropathology: recent advances and implications for clinical practice. Gastroenterologist 1997; 5: 233–41.
   PubMedGoogle Scholar
• Goin JC, Serin-Borda L, Bilder CR, Monastra Varrica L, Iantorno G, Rios MC, et al. Functional implications of circulating muscarinic cholinergic receptor autoantibodies in Chagasic patients with achalasia. Gastroenterology 1999; 117: 798–805.
   PubMed Web of Science ®Google Scholar
• Bellotti G, Bocchi EA, de Moraes AV, Higuchi ML, Barbero-Marcial M, SosaE, et al. In vivo detection of Trypanosoma cruzi antigens in hearts of patients with chronic Chagas’ heart disease. Am Heart J. 1996;131:301–7.
   Google Scholar
• Soykan I, Sivri B, Sarosiek I, Kiernan B, McCallum RW. Demography, clinical characteristics, psychological and abuse profiles, treatment and long-term follow-up of patients with gastroparesis. Dig Dis Sci 1998;43:2398–404.
   Google Scholar
• Simren M, Axelsson J, Gillberg R, Abrahamsson H, Svedlund J, Bjornsson ES. Quality of life in inflammatory bowel disease in remission: the impact of IBS-like symptoms and associated psychological factors. Am J Gastroenterol 2002;97:389–96.
   PubMed Web of Science ®Google Scholar
• Geboes K, Collins S. Structural abnormalities of the nervous system in Crohn’s disease and ulcerative colitis. Neurogastroenterol Mot 1998;10:189–202.
   PubMed Web of Science ®Google Scholar
• Shanahan F. Enteric neuropathology and inflammatory bowel disease. Neurogastroenterol Mot 1998;10:185–7.
   PubMed Web of Science ®Google Scholar
• Quigley EMM. Intestinal pseudo-obstruction. In: Champion MC, Orr WC, editors. Evolving concepts in gastrointestinal motility. Oxford: Blackwell Science; 1996. p. 171–99.
   Google Scholar
• Debinski HS, Kamm MA, Talbot IC, Khan G, Kangro HO, Jeffries DJ. DNA viruses in the pathogenesis of sporadic chronic idiopathic intestinal pseudo-obstruction. Gut 1997;41:100–6.
   PubMed Web of Science ®Google Scholar
• Lindberg G, Glia A, Nyberg B, Veress B. Lymphocytic epithelioganglionitis: a new entity causing severe motility disorders of the gut. Gastroenterology 1999;116:A1030.
   Web of Science ®Google Scholar
• Sanders DS, Carter MJ, Hurlstone DP, Pearce A, Ward AM, McAlindon ME, et al. Association of adult celiac disease with irritable bowel syndrome: a case-control study in patients fulfilling ROME II criteria referred to secondary care. Lancet 2001;358:1504–8.
   PubMed Web of Science ®Google Scholar
• Wahnschaffe U, Ullrich R, Riecken EO, Schulke JD. Celiac-like abnormalities in a subgroup of patients with irritable bowel syndrome. Gastroenterology 2001;121:1329–38.
   PubMed Web of Science ®Google Scholar
• O’Leary C, Wieneke P, Buckley S, O’Regan P, Cronin CC, Quigley EMM, et al. Celiac disease and irritable bowel-type symptoms. Am J Gastroenterol 2002;97:1463–7.
   Google Scholar
• Valori R. Coeliac disease in patients with irritable-bowel syndrome. Lancet 2001;358:1475.
   PubMed Web of Science ®Google Scholar
• McKendrick MW, Read MW. Irritable bowel syndrome: postsalmonella infection. J Infect 1994;29:1–3.
   PubMed Web of Science ®Google Scholar
• Neal KR, Hebdon J, Spiller R. Prevalence of gastrointestinal symptoms six months after bacterial gastroenteritis and risk factors for development of the irritable bowel syndrome. Br Med J 1997;314:779–82.
   Google Scholar
• Garcia Rodriguez LA, Ruigomez A. Increased risk of irritable bowel syndrome after bacterial gastroenteritis: cohort study. Br Med J 1999;318:565–6.
   PubMed Web of Science ®Google Scholar
• Gwee KA, Graham JC, McKendrick MW, Collins SM, Marshall JS, Walters SJ, et al. Psychometric scores and persistence of irritable bowel after infectious diarrhoea. Lancet 1996;347:150–3.
   PubMed Web of Science ®Google Scholar
• Gwee K-A, Leong Y-L, Graham C, McKendrick MW, Collins SM, Walters SJ, et al. The role of psychological and biological factors in post-infective gut dysfunction. Gut 1999;44:400–6.
   Google Scholar
• Spiller RC, Jenkins D, Thornley JP, Hebden JM, Wright T, Skinner M, et al. Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome. Gut 2000;47:804–11.
   PubMed Web of Science ®Google Scholar
• O’Sullivan M, Clayton N, Breslin NP, Hraman I, Bountra C, McLaren et al. Increased mast cells in the irritable bowel syndrome. Neurogastroenterol Motil 2000;12:449–5.
   PubMed Web of Science ®Google Scholar
• Ilnyckyj A, Choudhri SH, Duerksem D. Association of travel-related diarrhea (TD) with irritable bowel syndrome (IBS): is post-infectious IBS a true entity? Gastroenterology 1999; 16: A1011.
   Google Scholar
• Pimentel M, Chow EJ, Lin HC. Eradication of small bowel bacterial overgrowth reduces symptoms of irritable bowel syndrome. Am J Gastroenterol 2000;95:3503–6.
   Google Scholar
• Nobaek S, Johansson M-L, Molin G, Ahrne S, Jeppsson B. Alteration of intestinal microflora is associated with reduction in abdominal bloating and pain in patients with irritable bowel syndrome. Am J Gastroenterol 2000;95:1231–8.
   Google Scholar
• O’Sullivan MA, O’Morain CA. Bacterial supplementation in the irritable bowel syndrome. A randomized double-blind placebocontrolled crossover study. Dig Liver Dis 2000;32:294–301.
   PubMedGoogle Scholar
• Collins SM. The immunomodulation of enteric neuromuscular function: implications for motility and inflammatory disorders. Gastroenterology 1996;111:1683–99.
   PubMed Web of Science ®Google Scholar
• Drossman DA. Mind over matter in the post-infective irritable bowel. Gut 1999;44:306–8.
   PubMed Web of Science ®Google Scholar
• Shanahan F. Brain-gut axis and mucosal immunity: a perspective on mucosal psychoneuroimmunology. Sem Gastrointest Dis 1999;10:8–13.
   PubMedGoogle Scholar
• Munakata J, Naliboff B, Harraf F, Kodner A, Lembo T, Chang L, et al. Repetitive sigmoid stimulation induces rectal hyperalgesia in patients with irritable bowel syndrome. Gastroenterology 1997;112:55–63.
   PubMed Web of Science ®Google Scholar
• Adeyemi EO, Desai KD, Towsey M, Ghista D. Characterisation of autonomic dysfunction in patients with the irritable bowel syndrome by means of heart rate variablilty studies. Am J Gastroenterol 1999;94:816–23.
   PubMed Web of Science ®Google Scholar
• Heitkemper M, Burr RL, Jarrett M, Hertig V, Lustyk MK, Bond EF. Evidence for autonomic nervous system imbalance in women with the irritable bowel syndrome. Dig Dis Sci 1998;43: 2093–8.
   PubMed Web of Science ®Google Scholar