Stability and Structure of Binary and Ternary Metal Ion Complexes of Orotidinate 5′-Monophosphate (OMP^3-) in Aqueous Solution

References

• Abbreviations used: AMP2-, adenosine 5′-monophosphate; Arm, heteroaromatic N, base, (=Bpy or Phen); Bpy, 2,2′-bipyridyl; CMP2-, cytidine 5′-monophosphate; H3(OMP), orotidine 5′-monophos-phoric acid; H(Or), orotidine (= 3-β-D,-ribofuranosyl orotic acid); L, general ligand; M2 +, divalent metal ion; NMP2-, nucleoside 5′-monophosphate; OMP3-, orotidinate 5′-monophosphate; Or−, orotidinate; Phen, 1,10-phenanthroline; R-MP2-, phosphate monoester (R = noncoordinating organic residue); Tu, tubercidin; TuMP2-, tubercidin 5′-monophosphate (= 7-deaza-AMP2-); UMP2-, uridine 5′-monophosphate
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• It is interesting to note in this context that a divalent metal ion is indeed somewhat more affected by coulombic or charge effects than the (monovalent) proton. A decrease of the dielectric constant of the solvent as results from the addition of various amounts of 1,4-dioxane to an aqueous solution of the Cu2 + /D,)-ribose 5′-monophosphate (RibMP2-) system leads for the log cn Cu(RibMP) versus, pKH H(RibMP) plot to a slope m = 1.242 + 0.047 (c.f., ref. 33b). In addition, it is amazing to note that the carboxylate charge effect on the proton (0.25 log units; Section 4.1) times the mentioned slope results in an “expected” effect for Cu2+ of 0.31 log units; a value quite close to those given above in the text (Section 4.3). Clearly, for the (higher charged) OMP3- system the corresponding slope might even be somewhat steeper (e.g., close to 1.5, but in any case below 2); (b) Liang, G., Corfu, N., A., Sigel, H., Z. Naturforsch., B: Chemical Sciences, 44B, 538 (1989)
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