245
Views
132
CrossRef citations to date
0
Altmetric
Original Articles

OLFACTORY TRANSPORT: A DIRECT ROUTE OF DELIVERY OF INHALED MANGANESE PHOSPHATE TO THE RAT BRAIN

, , , , &
Pages 1493-1511 | Published online: 07 Jan 2011

References

  • Andersen , M. E. , Gearhart , J. M. and Clewell , H. J. III. 1999 . Pharmacokinetic data needs to support risk assessments for inhaled and ingested manganese . Neurotoxicology , 20 : 161 – 171 .
  • Gross , E. A. , Swenberg , J. A. , Fields , S. and Popp , J. A. 1982 . Comparative morphometry of the nasal cavity in rats and mice . J. Anat. , 135 : 83 – 88 .
  • Henriksson , J. and Tjälve , H. 2000 . Manganese taken up into the CNS via the olfactory pathway in rats affects astrocytes . Toxicol. Sci. , 55 : 392 – 398 .
  • Kimbell , J. S. , Godo , M. N. , Gross , E. A. , Joyner , D. R. , Richardson , R. B. and Morgan , K. T. 1997 . Computer simulation of inspiratory airflow in all regions of the F344 rat nasal passages . Toxicol. Appl. Pharmacol. , 145 : 388 – 398 .
  • Kontur , P. J. and Fechter , L. D. 1988 . Brain regional manganese levels and monoamine metabolism in manganese-treated neonatal rats . Neurotoxicol. Teratol. , 10 : 295 – 303 .
  • Kucharski , D. , Johanson , I. B. and Hall , W. G. 1986 . Unilateral olfactory conditioning in 6-day-old rat pups . Behav. Neural Biol. , 46 : 472 – 490 .
  • Lynam , D. R. , Roos , J. W. , Pfeifer , G. D. , Fort , B. F. and Pullin , T. G. 1999 . Environmental effects and exposures to manganese from use of methylcyclopentadienyl manganese tricarbonyl (MMT) in gasoline . Neurotoxicology , 20 : 145 – 150 .
  • Ressler , T. , Wong , J. and Roos , J. 1999 . Manganese speciation in exhaust particulates of automobiles using MMT containing gasoline . J. Synchrotron Radiat. , 6 : 656 – 658 .
  • Ressler , T. , Wong , J. , Roos , J. and Smith , I. L. 2000 . Quantitative speciation of Mn-bearing particulates emitted from autos burning (methylcyclopentadienyl)manganese tricarbonyl-added gasolines using XANES spectroscopy . Environ. Sci. Technol. , 34 : 950 – 958 .
  • Wieczorek , H. and Oberdörster , G. 1989 . Kinetics of inhaled 54MnCI2 aerosols: Influence of inhaled concentration . Pol. J. Occup. Med. , 2 : 248 – 260 .
  • Zayed , J. , Hong , B. and L'Espérance , G. 1999 . Characterization of manganese-containing particles collected from the exhaust emissions of automobiles running with MMT additive . Environ. Sci. Technol. , 33 : 3341 – 3346 .
  • Arvidson , B. 1994 . A review of axonal transport of metals . Toxicology , 88 : 1 – 14 .
  • Brenneman , K. A. , Cattley , R. C. , Ali , S. F. and Dorman , D. C. 1999 . Manganese-induced developmental neurotoxicity in the CD rat: Is oxidative damage a mechanism of action? . Neurotoxicology , 20 : 477 – 488 .
  • Brenneman , K. A. , Wong. , B. A. , Bucellato , M. A. , Costa , E. R. , Gross , E. A. and Dorman , D. C. 2000 . Direct olfactory transport of inhaled manganese (54MnCI2) to the rat brain: Toxicokinetic investigations in a unilateral nasal occlusion model . Toxicol. Appl. Pharmacol. , 169 : 238 – 248 .
  • Cannon , W. C. , Blanton , E. F. and McDonald , K. E. 1983 . The flow-past chamber: An improved nose-only exposure system for rodents . Am. Ind. Hyg. Assoc. J. , 44 : 923 – 928 .
  • Shargel , L. and Yu , A. B. C. 1985 . “ Multicompartment models ” . In Applied biopharmaceutics and pharmacokinetics , Edited by: Shargel , L. and Yu , A. B. C. 51 – 66 . Norwalk, CT : Appleton-Century-Crofts .
  • Colmenares , C. , Deutsch , S. , Evans , C. , Nelson , A. J. , Terminello , L. J. , Reynolds , J. G. , Roos , J. W. and Smith , I. L . 1999 . Analysis of manganese particulates from automotive decomposition of methylcyclopentadienyl manganese tricarbonyl . Appl. Surf. Sci. , 151 : 189 – 202 .
  • Davis , J. M. 1999 . Inhalation health risks of manganese: an EPA perspective . Neumtoxicology , 20 : 511 – 518 .
  • Dorman , D. C. , Struve , M. F. , Vitarella , D. , Byerly , F. I. , Goetz , J. and Miller , R. 2000 . Neurotoxicity of manganese chloride in neonatal and adult CD rat following subchronic (21-day) high-dose oral exposure . J. Appl. Toxicol. , 20 : 179 – 187 .
  • Dorman , D. C. , Struve , M. F. , James , R. A. , Marshall , M. W. , Parkinson , C. U. and Wong. , B. A. 2001 . Influence of particle solubility on the delivery of inhaled manganese to the rat brain: Manganese sulfate and manganese tetroxide pharmacokinetics following repeated (14-day) exposure . Toxicol. Appl. Pharmacol. , 170 : 79 – 87 .
  • Gianutsos , G. , Morrow , G. R. and Morris , J. B. 1997 . Accumulation of manganese in rat brain following intranasal administration . Fundam. Appl. Toxicol. , 37 : 102 – 105 .
  • Malecki , E. A. , Devenyi , A. G. , Beard , J. L. and Connor , J. R. 1999 . Existing and emerging mechanisms for transport of iron and manganese to the brain . J. Neurosci. Res. , 56 : 113 – 122 .
  • National Research Council . 1996 . Guide for the care and use of laboratory animals , Washington, DC : National Academic Press .
  • Nelson , K. , Golnick , J. , Korn , T. and Angle , C. 1993 . Manganese encephalopathy: Utility of early magnetic resonance imaging . Br. J. Ind. Med. , 50 : 510 – 513 .
  • Pal , P. K. , Samii , A. and Calne , D. B. 1999 . Manganese neurotoxicity: a review of clinical features, imaging and pathology . Neurotoxicology , 20 : 22 7 – 238 .
  • Proctor , D. F. and Chang , J. C. F. 1983 . “ Comparative anatomy and physiology of the nasal cavity ” . In Nasal tumors in animals and man, vol. I, Anatomy, physiology, and epidemiology , Edited by: Reznik , G. and Stinson , S. F. 1 – 33 . Boca Raton, FL : CRC Press .
  • Shipley , M. T. , McLean , J. H. and Ennis , M. 1995 . “ Olfactory system ” . In The rat nervous system , 2nd , Edited by: Paxinos , G. 899 – 926 . San Diego, CA : Academic Press .
  • Rhoads , K. and Sanders , C. L. 1985 . Lung clearance, translocation, and acute toxicity of arsenic, beryllium, cadmium, cobalt, lead, selenium, vanadium and ytterbium oxides following deposition in rat lung . Environ. Res. , 36 : 359 – 378 .
  • Roels , H. , Meiers , G. , Delos , M. , Ortega , I. , Lauwerys , R. , Buchet , J. P. and Lison , D. 1997 . Influence of the route of administration and the chemical form (MnCI2, MnO2) on the absorption and cerebral distribution of manganese in rats . Arch. Toxicol. , 71 : 223 – 230 .
  • Roos, J. W., Lenane, D. L., Dykes, K. L., Scull, H. M., and Openshaw, M. J. 2000. A systems approach to improved exhaust catalyst durability: The role of the MMT fuel additive. Society of Automotive Engineers paper 2000-01-1880.
  • Schreider , J. P. 1983 . “ Nasal airway anatomy and inhalation deposition in experimental animals and people ” . In Nasal tumors in animals and man, vol. III, Experimental nasal carcinogenesis , Edited by: Reznik , G. and Stinson , S. F. 1 – 25 . Boca Raton, FL : CRC Press .
  • Schlesinger , R. B. 1995 . “ Deposition and clearance of inhaled particles ” . In Concepts in inhalation toxicology , Edited by: McClellan , R. O. and Henderson , R. F. 191 – 224 . Washington, DC : Taylor & Francis .
  • Tjälve , H. and Henriksson , J. 1999 . Uptake of metals in the brain via olfactory pathways . Neurotoxicology , 20 : 181 – 195 .
  • Tjälve , H. , Mejare , C. and Borg-Neczak , K. 1995 . Uptake and transport of manganese in primary and secondary olfactory neurones in pike . Pharmacol. Toxicol. , 77 : 23 – 31 .
  • Tjälve , H. , Henriksson , J. , Talkvist , J. , Larsson , B. S. and Lindquist , N. G. 1996 . Uptake of manganese and cadmium from the nasal mucosa into the central nervous system via olfactory pathways in rats . Pharmacol. Toxicol. , 79 : 347 – 356 .
  • U.S. Environmental Protection Agency. 1996 . Air quality criteria for paniculate matter, EPA/600/P-95/001, vol. 2 , Washington DC : Office of Research and Development .
  • Vitarella , D. , Moss , O. R. and Dorman , D. C. 2000a . Pulmonary clearance of manganese phosphate, manganese sulfate, and manganese tetroxide by CD rats following intratracheal instillation, Inhal . Toxicol. , 12 : 941 – 957 .
  • Vitarella , D. , Wong , B. A. , Moss , O. R. and Dorman , D. C. 2000b . Pharmacokinetics of inhaled manganese phosphate in male Sprague-Dawley rats following subacute (14-day) exposure . Toxicol. Appl. Pharmacol. , 163 : 279 – 285 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.