46
Views
37
CrossRef citations to date
0
Altmetric
Original Contributions

INDUCTION OF c-myc AND c-jun PROTO-ONCOGENE EXPRESSION IN RAT L6 MYOBLASTS BY CADMIUM IS INHIBITED BY ZINC PREINDUCTION OF THE METALLOTHIONEIN GENE

, , &
Pages 359-377 | Received 07 Aug 1995, Accepted 17 Oct 1995, Published online: 01 Jun 2011

REFERENCES

  • Almendral , J. M. , Sommer , D. , Macdonald-Bravo , H. , Burckhardt , J. , Perera , J. and Bravo , R. 1988 . Complexity of the early genetic response to growth factors in mouse fibroblasts . Mol. Cell. Biol. , 8 : 2140 – 2148 .
  • Anderson , R. D. , Birren , B. W. , Ganz , T. , Piletz , J. E. and Herschman , H. R. 1986 . Rat metallothionein I structural gene and three pseudogenes, one of which contains 5′-regulatory sequences . Mol. Cell Biol. , 6 : 302 – 314 .
  • Angel , P. , Allegretto , E. A. , Okino , S. T. , Hattori , K. , Boyle , W. J. , Hunter , T. and Karin , M. 1988 . Oncogene jun encodes a sequence-specific trans-activator similar to AP-1 . Nature , 332 : 166 – 171 .
  • Berg , J. M. 1986 . Potential metal-binding domains in nucleic acid binding proteins . Science , 232 : 485 – 487 .
  • Beyersman , D. , Block , C. and Malviya , A. N. 1994 . Effects of cadmium on nuclear protein kinase C . Environ. Health Perspect. , 102 : 177 – 180 .
  • Bradford , M. M. 1976 . A rapid and sensitive method for quantitation of micrograms quantities of protein utilizing the principle of protein-dye binding . Anal. Biochem. , 72 : 248 – 254 .
  • Cherian , M. G. and Chan , H. M. 1993 . “ Biological functions of metallothionein—An overview. ” . In Metallothionein III Edited by: Suzuki , K. T. , Imura , N. and Kimura , M. 87 – 110 . Basel : Birkhauser Verlag. .
  • Coogan , T. P. , Bare , R. M. and Waalkes , M. P. 1992 . Cadmium-induced DNA strand damage in cultured liver cells: Reduction in cadmium genotoxicity following zinc pretreatment . Tixicol. Appl. Pharmacol. , 113 : 227 – 233 .
  • Coogan , T. P. , Bare , R. M. , Bjornson , E. J. and Waalkes , M. P. 1994a . Enhanced metallothionein gene expression protects against cadmium genotoxicity in cultured rat liver cells . J. Toxicol. Environ. Health , 41 : 233 – 245 .
  • Coogan , T. P. , Shiraishi , N. and Waalkes , M. P. 1994b . Apparent quiescence of the metallothionein gene in the rat ventral prostate: Association with cadmium-induced prostate tumors in rats . Environ. Health Perspect. , 102 : 137 – 140 .
  • Coogan , T. P. , Shiraishi , N. and Waalkes , M. P. 1995 . Minimal basal activity and lack of metal-induced activation of the metallothionein gene correlates with lobe-specific sensitivity to the carcinogenic effects of cadmium in the rat prostate . Toxicol. Appl. Pharmacol. , 132 : 164 – 173 .
  • Cosma , G. N. , Currie , D. , Squibb , K. S. , Snyder , C. A. and Garte , S. J. 1991 . Detection of cadmium exposure in rats by induction of lymphocyte metallothionein gene expression . J. Toxicol. Environ. Health , 34 : 39 – 49 .
  • Courgeon , A. M. , Maisonhaut , C. and Best-Belpomme , M. 1984 . Heat shock proteins are induced by cadmium in Drosophila cells . Exp. Cell Res. , 153 : 515 – 521 .
  • Eaton , D. L. and Toal , B. F. 1982 . Evaluation of the Cd/hemoglobin affinity assay for the rapid determination of metallothionein in biological tissues . Toxicol. Appl. Pharmacol. , 66 : 134 – 142 .
  • Goering , P. L. and Klaassen , C. D. 1984 . Tolerance to cadmium-induced toxicity depends on presynthesized metallothionein in liver . J. Toxicol. Environ. Health , 14 : 803 – 812 .
  • Greenberg , M. E. , Hermanowski , A. L. and Ziff , E. B. 1986 . Effect of protein synthesis inhibitors on growth factor activation of c-fos, c-myc, and actin gene transcription . Mol. Cell. Biol. , 6 : 1050 – 1057 .
  • Gunn , S. A. , Gould , T. C. and Anderson , W. A. D. 1963 . Cadmium-induced interstitial cell tumors in rats and mice and their prevention by zinc . J. Natl. Cancer Inst. , 31 : 745 – 759 .
  • Gunn , S. A. , Gould , T. C. and Anderson , W. A. D. 1964 . Effect of zinc on cancerogenesis by cadmium . Proc. Soc. Exp. Biol. Med. , 115 : 653 – 657 .
  • Hayashi , K. , Makino , R. , Kawamura , H. , Arisawa , A. and Yoneda , K. 1987 . Characterization of rat c-myc and adjacent regions . Nucleic Acids Res. , 15 : 6419 – 6436 .
  • IARC . 1993 . Beryllium, cadmium, mercury, and exposures in the glass manufacturing industry . IARC Monogr. Eval. Carcinogen. Risks Hum. , 58 : 119 – 238 . IARC Scientific Publications, Lyon
  • Jin , P. and Ringertz , N. R. 1990 . Cadmium induces transcription of proto-oncogenes c-jun and c-myc in rat L6 myoblasts . J. Biol. Chem. , 265 : 14061 – 14064 .
  • Keyse , S. M. and Tyrrell , R. M. 1989 . Heme oxygenase is a major 32-kDa stress protein induced in human skin fibroblasts by UV radiation, hydrogen peroxide and sodium arsenite . Proc. Natl. Acad. Sci. USA , 86 : 99 – 103 .
  • Lau , L. F. and Nathans , D. 1987 . Expression of a set of growth-related immediate early genes in BALB/c 3T3 cells: Coordinate regulation with c-fos or c-myc. . Proc. Natl. Acad. Sci. USA , 84 : 1182 – 1186 .
  • Lewin , B. 1994 . “ Oncogenes: Gene expression and cancer. ” . In Cenes V Edited by: Lewin , B. 1181 – 1229 . Oxford : Oxford University Press and Cell Press. .
  • Luethy , J. D. and Holbrook , N. J. 1992 . Activation of the gacWl53 promoter by genotoxic agents: A rapid and specific response to DNA damage . Cancer Res. , 52 : 5 – 10 .
  • Marshall , C. J. 1989 . “ Oncogenes and cell proliferation. ” . In Oncogenes Edited by: Glover , D. M. and Hames , B. D. 1 – 21 . Oxford : IRL Press. .
  • Miller , R. J. 1987 . Multiple calcium channels and neuronal function . Science , 235 : 46 – 52 .
  • Mosmann , T. 1983 . Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays . J. Immunol. Methods , 65 : 55 – 63 .
  • Nelson , M. T. 1986 . Interactions of divalent cations with single calcium channels from rat brain synaptosomes . J. Gen. Physiol. , 87 : 201 – 222 .
  • Oberdörster , G. , Cherian , M. G. and Baggs , R. B. 1994 . Correlation between cadmium-induced pulmonary carcinogenicity, metallothionein expression, and inflammatory processes: A species comparison . Environ. Health Perspect. , 102 : 257 – 264 .
  • Onosaka , S. , Tanaka , K. , Doi , M. and Okahara , K. 1978 . A simplified procedure for the determination of metallothionein in animal tissues . Eisei Kagaku , 24 : 128 – 131 .
  • Predki , P. F. and Sarkar , B. 1994 . Metal replacement in “zinc-fingers” and its effect on DNA binding . Environ. Health Perspect. , 102 : 195 – 198 .
  • Rozengurt , E. 1986 . Early signals in mitogenic response . Science , 234 : 161 – 166 .
  • Shiraishi , N. , Hochadel , J. F. , Coogan , T. P. , Koropatnick , J. D. and Waalkes , M. P. 1995 . Cadmium-induced genotoxicity in the absence of cytotoxicity in rat testicular cells is associated with minimal activity of the metallothionein gene . Toxicol. Appl. Pharmacol. , 130 : 229 – 236 .
  • Smith , J. B. , Dwyer , S. D. and Smith , L. 1989 . Cadmium evokes inositol polyphosphate formation and calcium mobilization: Evidence for a cell surface receptor that cadmium stimulates and zinc antagonizes . J. Biol. Chem. , 264 : 7115 – 7118 .
  • Smith , J. B. , Smith , L. , Pijuan , V. , Zhuang , Y. and Chen , Y.-C. 1994 . Transmembrane signals and proto-oncogene induction evoked by carcinogenic metals and prevented by zinc . Environ. Health Perspect. , 102 : 41 – 44 .
  • Snow , E. T. 1992 . Metal carcinogenesis: Mechanistic implications . Pharmacol. Ther. , 53 : 31 – 65 .
  • Stanton , L. W. , Watt , R. and Marcu , K. B. 1983 . Translocation, breakage and truncated transcripts of c-myc oncogene in murine plasmacytomas . Nature , 303 : 401 – 406 .
  • Sunderman , F. W. Jr. 1990 . Cadmium substitution for zinc in finger-loop domains of gene-regulating proteins as a possible mechanism for the genotoxicity and carcinogenicity of cadmium compounds . Toxicol. Environ. Chem. , 27 : 131 – 141 .
  • Sunderman , F. W. Jr. and Barber , A. M. 1988 . Finger-loop, oncogenes, and metals . Ann. Clin. Lab. Science , 18 : 267 – 288 .
  • Suszkiw , J. , Toth , G. , Murawsky , M. and Cooper , G. P. 1984 . Effects of Pb2+ and Cd2+ on acetylcholine release and Ca2+ movements in synaptosomes and subcellular fractions from rat brain and Torpedo electric organ . Brain Res. , 323 : 31 – 46 .
  • Takenaka , S. , Oldiges , H. , Konig , H. , Hochrainer , D. and Oberdorster , G. 1993 . Carcinogenicity of cadmium chloride aerosols in Wistar rats . JNCI , 70 : 367 – 373 .
  • Templeton , D. M. and Cherian , M. G. 1991 . “ Toxicological significance of metallothionein. ” . In Methods in enzymology, Vol. 205, Metallobiochemistry, Part B, Metallothionein and related molecules Edited by: Riodan , J. F. and Vallee , B. L. 613 – 615 . New York : Academic Press. .
  • Tsien , R. W. 1983 . Calcium channels in excitable cell membranes . Annu. Rev. Physiol. , 45 : 341 – 358 .
  • VanBogelen , R. A. , Kelley , P. M. and Neidhardt , F. C. 1987 . Differential induction of heat shock, SOS and oxidation stress regulons and accumulation of nucleotides in Escherichia coli . J. Bacteriol. , 169 : 26 – 32 .
  • Vogt , P. K. and Bos , T. J. 1989 . The oncogene jun and nuclear signaling . Trends Biochem. Sci. , 14 : 172 – 175 .
  • Vogt , P. K. and Bos , T. J. 1990 . Jun: Oncogene and transcription factor . Adv. Cancer Res. , 55 : 1 – 35 .
  • Vogt , P. K. and Tjian , R. 1988 . jun: A transcriptional regulator turned oncogenic . Oncogene , 3 : 3 – 7 .
  • Waalkes , M. P. 1986 . Effect of dietary zinc deficiency on the accumulation of cadmium and metallothionein in selected tissues of the rat . J. Toxicol. Environ. Health , 18 : 301 – 313 .
  • Waalkes , M. P. and Goering , P. L. 1990 . Metallothionein and other cadmium-binding proteins: Recent developments . Chem. Res. Toxicol. , 3 : 281 – 288 .
  • Waalkes , M. P. and Rehm , S. 1994 . Cadmium and prostatic cancer . J. Toxicol. Environ. Health , 43 : 251 – 269 .
  • Waalkes , M. P. , Rehm , S. , Riggs , C. W. , Bare , R. M. , Devor , D. E. , Poirier , L. A. , Wenk , M. L. and Henneman , J. R. 1989 . Cadmium carcinogenesis in male Wistar [Crl:(WI)BR] rats: Dose-response analysis of effects of zinc on tumor induction in the prostate, in the testes and at the injection site . Cancer Res. , 49 : 4282 – 4288 .
  • Waalkes , M. P. , Kovatch , R. and Rehm , S. 1991 . Effect of chronic dietary zinc deficiency on cadmium toxicity and carcinogenesis in male Wistar [Hsd:(WI)BR] rat . Toxicol. Appl. Pharmacol. , 108 : 448 – 456 .
  • Waalkes , M. P. , Coogan , T. P. and Barter , R. A. 1992 . Toxicological principles in metal carcinogenesis with special emphasis on cadmium . Crit. Rev. Toxicol. , 22 : 175 – 201 .
  • Yiangou , M. , Ge , X. , Carter , K. C. and Papaconstantinou , J. 1991 . Induction of several acute-phase-protein genes by heavy metals: A new class of metal-responsive genes . Biochemistry , 30 : 3798 – 3806 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.