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Original Articles

OPTIMAL CONTROL OF THE PENICILLIN G FED-BATCH FERMENTATION: AN ANALYSIS OF A MODIFIED UNSTRUCTURED MODEL

, , , , , & show all
Pages 337-353 | Received 06 Dec 1991, Accepted 13 Apr 1992, Published online: 06 Nov 2007

REFERENCES

  • Bajpai , R.K. , and ReuB , M. , ‘ A mechanistic Model for Penicillin Production ’, J. Chem. Tech. Biotechnol. , 30 , 332 – 344 ( 1980 ).
  • Bajpai , R.K. , and ReuB , M. , ‘ Evaluation of Feeding Strategies in Carbon-Regulated Secondary Metabolite Production through Mathematical Modelling ’, Biotechnol. Bioeng. , 23 , 717 – 738 ( 1981 ).
  • Bastin , G. , and Dochain , D. , On-line Estimation and Adaptive Control of Bioreactors , Elsevier Science Publishers B.V. ( 1990 ).
  • Heijnen , J.J. , Roels , J.A. , and Stouthamer , A.H. , ‘ Applications of Balancing Methods in Modeling the Penicillin Fermentation ’, Biotechnol. Bioeng. , 21 , 2175 – 2201 ( 1979 ).
  • Lim , H.C. , Tayeb , Y.J. , Modak , J.M. , and Bonte , P. , ‘ Computational algorithms for Optimal Feed Rates for a Class of Fed-Batch Fermentation Numerical Results for Penicillin and Cell Mass Production ’, Biotechnol. Bioeng. , 28 , 1408 – 1420 ( 1986 ).
  • Nicolai , B.M. , Van Impe , J.F. , Vanrolleghem , P.A. , and Vandewalle , J. , ‘ A Modified Unstructured Mathematical Model for the Penicillin G Fed-Batch Fermentation ’, Biotechnology Letters , 13 (7), 489 – 494 ( 1991 ).
  • Pontryagin , L.S. , Boltyanskii , V.G. , Gamkrelidze , R.V. , and Mishchenko , E.F. , The Mathematical Theory of Optimal Processes , Wiley-Interscience , New York ( 1962 ).
  • San , K.Y. , and Stephanopoulos , G. , ‘ Optimization of Fed-Batch Penicillin Fermentation A Case of Singular Optimal Control with State Constraints ’, Biotechnol. Bioeng. , 34 , 72 – 78 ( 1989 ).
  • Spriet , J.A. , ‘ The Control of Fermentation Processes ’, Proceedings of the Forum for Applied Biotechnology , Gent , Belgium , 1987 , 1371 – 1381 (1987) .
  • Van Impe , J.F. , Nicolai , B.M. , Spriet , J.A. , De Moor , B. , and Vandewalle , J. , ‘ Optimal Control of the Penicillin G Fed-Batch Fermentation An Analysis of the Model of Bajpai and ReuB ’, Proceedings of the European Simulation Multiconference , Copenhagen , Denmark , June 17-19 , 1991 , 867 – 872 (1991a) .
  • Van Impe , J.F. , Nicolai , B.M. , Vanrolleghem , P.A. , Spriet , J.A. , De Moor , B. , and Vandewalle , J. , ‘ Optimal Control of the Penicillin G Fed-Batch Fermentation An Analysis of a New Unstructured Model ’, Proceedings of the European Control Conference , Grenoble, France , July 2-5 , 1991 , 1624 – 1629 (1991b) .
  • Van Impe , J.F. , Nicolai , B.M. , De Moor , B. , and Vandewalle , J. , ‘ Evaluation of On-line Conventional and Adaptive Controllers for the Penicillin G Fed-Batch Fermentation based on Simulations using a New Mathematical Model ’, Proceedings of the European Simulation Multiconference , Copenhagen , Denmark , June 17-19 1991 , 873 – 878 (1991c) .
  • Van Impe , J.F. , ‘ Modeling and Optimal Adaptive Control of Biotechnological Processes ’, PhD thesis , Department of Electrical Engineering , K.U. Leuven ( 1992 ).

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