PILOT-SCALE ULTRAFILTRATION OF CONCENTRATED PROTEIN PRECIPITATE SUSPENSIONS: THE EFFECT OF CONCENTRATION AND FLUID DYNAMICS

References

• Aimar , P. and Field , R.W. , Limiting flux in membrane separations, a model based on the viscositydependency of the mass transfer coefficient , Ckem. Eng, Sci ., 47 ( 3 ), 579 – 586 ( 1992 ).
   Web of Science ®Google Scholar
• Altena , F.W. , Belfort , G. , Otis , J. , Fiessinger , F. , Rovel , J. and Nicoletti , J. , Particle motion in a laminar slitflow, A fundamental fouling study . Desal 47 , 221 – 232 ( 1983 ).
   Web of Science ®Google Scholar
• Bashir , I. , [a-z]euss,M., Dynamic model for cross-flow microfiltration of microbial suspensions in porouslubes . Chem. Eng. Sci . 47 ( 1 ), 189 – 203 ( 1992 ).
   Web of Science ®Google Scholar
• Bell , D.J. , The physical characteristics of protein precipitates and their centrifugal recovery . Ph.D. Thesis , University College London , 1982 .
   Google Scholar
• Bixler , H.J. , [a-z]appe, G.C. US Patent 3541006, November 17, 1970 .
   Google Scholar
• Blatt , W.F. , Dravid , A. , Michaels , A.S. and Nelson , L. , “|ctSolute polarization and cake formation in membraneultrafiltration, causes, consequences and control techniques|c”", in Membrane science and technology,ed. Flinn JE , Plenum Press , New York ( 1970 ).
   Google Scholar
• Davis , R.H. , Modelling offouling of crossflowmicronllration membranes . Sep. Pur. Methods , 21 ( 2 ), 75 – 126 ( 1992 ).
   Web of Science ®Google Scholar
• Davis , R.H. and Birdsell , S.A. , Hydrodynamtc model and experiments for crossflow microfiltration . Chem.Eng. Commun ., 49 , 217 – 234 ( 1987 ).
   Google Scholar
• Davis , R.H. and Leighton , J.D. , Shear-induced transport of a particle layer along a porous wall . Chem. Eng.Sci . 42 , 275 – 281 ( 1987 ).
   Web of Science ®Google Scholar
• Davis , R.H. , [a-z]herwood J.D., A similarity solution for steady state crossflow microfiltration . Chem. Eng.Sci ., 45 ( 11 ), 3203 – 3209 ( 1990 ).
   Web of Science ®Google Scholar
• Devereux , N. and Hoare , M. , Membrane separation of protein presipitates, Studies with cross flow in hollowfibres . Biotechnol. Bioeng ., 28 , 422 – 431 ( 1986 ).
   PubMed Web of Science ®Google Scholar
• Devereux , N. , Hoare , M. and Dunnil , P. , The effect of protein precipitation on the concentration of proteinsby ultrafiltration . Chem Eng Commun . 45 , 255 – 276 ( 1986a ).
   Web of Science ®Google Scholar
• Devereux , N. , Hoare , M. and Dunnill , P. , Membrane separation of protein precipitates, unstirred batchstudies . Biotechnol. Bioeng . 28 , 88 – 96 ( 1986b ).
   PubMed Web of Science ®Google Scholar
• Devereiux , N. , Hoare , M. , Dunnill , P. and Bell , D.J. , “ The development of improved methods for theindustrial recovery of protein precipitates ”, in Solid-Liquid Separation, ed. Gregory, J ., EllisHorwood Ltd |., Chichester , UK . pp. 143 – 160 ( 1984 ).
   Google Scholar
• Doshi , M.R. and Trettin , D.R. , Filtration of Colloidal suspensions and macromolecular solutions inunstirred batch cell . Ind. Eng. Chem. Fundam ., 20 , 221 – 229 ( 1981 ).
   Web of Science ®Google Scholar
• Drew , D. A. , Schonberg , J. A. and Belfort , G. , Lateral inertia migration of a small sphere in fast laminar flowthrough a membrane duct . Chem. Eng. Sci ., 46 , 3219 – 3224 ( 1991 ).
   Web of Science ®Google Scholar
• Eckstein , E.C. , Bailey , D.G. and Shapiro , A.H. , Self-diffusion of particles in shear flow of a suspension . J. Fluid Mech ., 79 , 191 – 208 ( 1977 ).
   Web of Science ®Google Scholar
• Fane , A.G. , Ultrafiltration of suspensions . J. Memb. Sci ., 20 , 249 – 259 ( 1984 ).
   Web of Science ®Google Scholar
• Fane , A.G. , Fell , C.J.D. and Nor , M.T. , Ultrafiltration in the presence of suspended matter . I. Chem. E.Jubilee Symposium ., 73 , C1-C12 ( 1982 ).
   Google Scholar
• Fane , A.G. , “ Ultrafiltration, factors influencing flux and rejection ”, In Progress in filtration and separation,ed. Wakeman, R.J., Vol 4, Elsevier Science Pubs . Amsterdam , 1986 .
   Google Scholar
• Forstrom , R.J. , Voss , G.O. and Blackshear , P.L. , Fluid dynamics of particle (Platelet) deposition for filteringwalls, relationship to atherosclerosis . J. Fluids Eng. Trans. ASME ., Jun , 168 – 172 ( 1974 ).
   Google Scholar
• Gornall , A.G. , Bardawill , C.J. and David , M.M. , Determination of serum proteins by means of the biuretreaction . J. Biol. Chem ., 177 , 751 – 766 ( 1949 ).
   Web of Science ®Google Scholar
• Green , G , and Belfort , G. , Fouling of ultrafiltration membranes, Lateral migration and the particle trajectorymodel . Desal , 35 , 129 – 147 ( 1980 ).
   Web of Science ®Google Scholar
• Leighton , D.T. and Acrivos , A. , Measurement of shear-induced self-diffusion in concentrated suspensions ofspheres . J. Fluid Mech ., 177 , 109 – 131 ( 1987a ).
   Web of Science ®Google Scholar
• Leighton , D.T. and Acrivos , A. , The shear induced migration of particles in concentrated suspensions .J. Fluid Mech , 181 , 415 – 439 ( 1987b ).
   Web of Science ®Google Scholar
• Lojkine , M.H. , Field , R.W. and Howell , J.A. , Crossflow microfiltration of cell suspensions, a review of modelswith emphasis on particle size effects . Trans. I. Chem . E. 70 (C), 149 – 164 ( 1992 ).
   Google Scholar
• McDonogh , R.M. , Bauser , H. , Stroh , N. and Chmiel , H. , Separation efficiency of membranes in biotechnology, an experimental and mathematical study of flux control . Chem. Eng. Sci , 47 ( 1 ), 271 – 279 ( 1992 ).
   Web of Science ®Google Scholar
• Michaels , A.S. , New separation techniques for the CPI . Chem. Eng. Prog ., 64 ( 12 ), 31 – 43 ( 1968 ).
   Web of Science ®Google Scholar
• Nagata , N. Herouvis , K.J. , Dziewulski , D.M. and Belfort , G. , Cross-flow membrane microfiltration ofa bacterial fermentation broth . Biotechnol. Bioeng . 34 , 447 – 466 ( 1989 ).
   PubMed Web of Science ®Google Scholar
• Narandranathan , T.J. , Effect ofshear on protein with respect to their ultrafiltration . Ph.D. Thesis , UniversityCollege London ( 1981 ).
   Google Scholar
• Porter , M.C. , Concentration polarisation with membrane ultrafiltration . Ind. Eng. Chem. Prod. Res. Dev ., II, 234 – 248 ( 1972 ).
   Google Scholar
• Pritchard , M. , Howell , J.A. and Field , R.W. , The concentration of viscous fluids by ultrafiltration.Engineering of membrane processes. Conference May 1992 , Bavaria , Germany .
   Google Scholar
• Romero , C.A. and Davis , R.H. , Experimental verification of the shear-induced hydrodynamic diffusionmodel of crossflow microfiltration . J. Memb. Sci ., 62 , 249 – 273 ( 1991 ).
   Web of Science ®Google Scholar
• Romero , C.A. and Davis , R.H. , Transient model of crossflow microfiltration . Chem. Eng. Sci ., 45 ( 1 ), 13 – 25 ( 1990 ).
   Web of Science ®Google Scholar
• Saffman , P.G. , The lift on a small sphere in slow shear flow . J. Fluid Mech ., 22 ( 2 ), 385 – 400 ( 1965 ).
   Web of Science ®Google Scholar
• Saffman , P.G. , On the motion of small spheroidal particles in a viscous liquid . J. Fluid Mech . 1 , 540 – 553 ( 1956 ).
   Google Scholar
• Schonberg , J. A. and Hinch , E. J. , Inertial migration of a sphere in Poiseuilleflow . J. Fluid Mech ., 203 , 517 – 524 ( 1989 ).
   Web of Science ®Google Scholar
• Segré , G. and Silberberg , A. , Radial displacements in Poiseuille flow of suspensions . Nature ., 189 , 209 – 210 ( 1961 ).
   Web of Science ®Google Scholar
• Segré , G. , [a-z]ilberberg, A, Behaviour of macroscopic rigid spheres in Poiseuille flow. Part 2. Experimentalresults and interpretation . J. Fluid Mech ., 14 , 136 – 157 ( 1962 ).
   Web of Science ®Google Scholar
• Taylor , G. , The membrane filtration and the vacuum drying of proteins and enzymes . PhD. Thesis , Department of Chemical and Biochemical Engineering University College London , London , U.K . 1989 .
   Google Scholar
• Vasseur , P. and Cox , R.G. , The lateral migration of a spherical particle in two-dimensional shear flows .J. Fluid Mech ., 78 ( 2 ), 385 – 413 ( 1976 ).
   Google Scholar
• Vilker , V.L. , Colton , C.K. , Smith , K.A. and Green , D.L. , The osmotic pressure of concentrated protein andlipoprotein solutions and its significance to ultrafiltration . J. Memb. Sci , 20 , 63 – 77 ( 1984 ).
   Web of Science ®Google Scholar
• Wijmans , J.G. , Nakao , S. , Van den Berg , J.W.A. , Troetstra, F.R, and Smolders , C.A. , Hydrodynamicresistance of concentration polarization boundary layers in ultrafiltration . J. Memb. Sci , 22 , 117 – 135
   Web of Science ®Google Scholar