Advanced search
Publication Cover
Journal of Obstetrics and Gynaecology Volume 21, 2001 - Issue 2
Submit an article Journal homepage
14
Views
4
CrossRef citations to date
0
Altmetric
Research Article

Screening for trisomy 21: the significance of a positive second trimester serum screen in women screen negative after a nuchal translucency scan

A. Sau, K. Langford, B. Auld, D. Maxwell Department of Obstetrics & Gynaecology, Conquest Hospital, St Leonards-on-Sea, UK; Fetal Medicine Unit, Guys Hospital, London, UK
Pages 145-148 | Published online: 02 Jul 2009

  • Cuckle H. and Sehimi I. (1999) Calculating correct Down's syndrome risks. British Journal of Obstetrics and Gynaecology 106, 371-372.
  • Goodburn S.F., Yates J.R.W., Raggatt P.R., Carr C., Ferguson-Smith M.E., Kershaw A.J., Milton P.J.D. and Ferguson-Smith M.A. (1994) Second trimester maternal serum screening using alpha-fetoprotein, human chorionic gonadotrophin and unconjugated oestriol: experience of a regional programme. Prenatal Diagnosis 14, 391-402.
  • Haddow J.E. (1998) Antenatal screening for Down's syndrome: where are we and where next? Lancet 352, 336-337.
  • Haddow J.E., Palomaki G.E., Knight G.J., Williams J., Pulkkinen A., Canick J.A., Saller D.N. Jr and Bowes G.B. (1992) Prenatal screening for Down's syndrome with use of maternal serum markers. New England Journal of Medicine 327, 588-593.
  • Johnson M.P., Johnson A., Holzgreve W., Isada N.B., Wapner R.J., Treadwell M.C., Heeger S. and Evans M.I. (1993) First trimester simple hygroma: cause and outcome. American Journal of Obstetrics and Gynaecology 168, 156-161.
  • Kadir R.A. and Economides D.L. (1997) The effect of nuchal translucency measurement on second trimester biochemical screening for Down's syndrome. Ultrasound in Obstetrics and Gynecology 9, 244-247.
  • Mol B.W. (1999) Down's syndrome, cardiac anomalies and nuchal translucency. British Medical Journal 318, 81-85.
  • Neilson J.P. (1997) Assessment of fetal nuchal translucency test for Down's syndrome. Lancet 350, 754-755.
  • Nicolaides K.H., Azar G., Byrne D., Mansur C. and Marks K. (1992) Fetal nuchal translucency: ultrasound screening for chromosomal defects in first trimester of pregnancy. British Medical Journal 304, 867-869.
  • Nicolaides K.H., Brizot M.L. and Snijders R.J.M. (1994) Fetal nuchal translucency: ultrasound screening for fetal trisomy in the first trimester of pregnancy. British Journal of Obstetrics and Gynecology 101, 782-786.
  • Pandya P.P., Brizot M.L., Kuhn P., Snijders R.J.M. and Nicolaides K.H. (1994) First trimester fetal nuchal translucency thickness and risks for trisomies. Obstetrics and Gynecology 84, 420-423.
  • Pandya P.P., Kondylios A., Hilbert L., Snijders R.J.M. and Nicolaides K.H. (1995a) Chromosomal defects and outcome in 1015 fetuses with increased nuchal translucency. Ultrasound in Obstetrics and Gynecology 5, 15-19.
  • Pandya P.P., Snijders R.J., Johnson S. and Nicolaides K.H. (1995b) Natural history of trisomy 21 fetuses with increased nuchal translucency thickness. Ultrasound in Obstetrics and Gynecology 5, 381-383.
  • Pandya P.P., Snijders R.J.M., Johnson S.P., Brizot M.L. and Nicolaides K.H. (1995) Screening for fetal trisomies by maternal age and fetal nuchal translucency thickness at 10-14 weeks of gestation. British Journal of Obstetrics and Gynecology 102, 957-962.
  • Phillips O.P., Elias S., Shulman L.P., Anderson R.N., Morgan C.D., and Simpson J.L. (1992) Maternal serum screening for fetal Down's syndrome in women less than 35 years of age using alpha-fetoprotein hCG and unconjugated estriol: a prospective 2 year study. Obstetrics and Gynecology 80, 353-358.
  • Schulte-Vallentin M. and Schindler H. (1992) Non-echogenic nuchal oedema as a marker in trisomy 21 screening. Lancet 339, 1053.
  • Snijders R.J.M., Noble P., Sebire N., Souka A. and Nicolaides K.H. (1998) UK multicentre project on assessment of risk of trisomy 21 by maternal age and fetal nuchal-translucency thickness at 10-14 weeks of gestation. Lancet 351, 343-346.
  • Taipale P., Hiilesmaa V., Salonen R. and Ylostalo P. (1997) Increased nuchal translucency as a marker for fetal chromosomal defects. New England Journal of Medicine 337, 1654-1658.
  • Thilaganathan B., Slack A. and Wathen N.C. (1997) Effect of first trimester nuchal translucency on second trimester serum biochemical screening for Down's syndrome. Ultrasound in Obstetrics and Gynecology 10, 261-264.
  • Wald N.J., Kannard A., Densem J.W., Cuckle H.S., Chard T. and Butler L. (1992) Antenatal maternal serum screening for Down's syndrome: results of a demonstration project. British Medical Journal 305, 391-394.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.