Association between rs1049174 NKG2D gene polymorphism and idiopathic recurrent spontaneous abortion in Iranian women: a case-control study

References

• Asadi-Saghandi A, Shams A, Eslami G, Mirghanizadeh SA, Eskandari-Nasab E. 2016. Peginterferon alfa-2a/Ribavirin treatment efficacy in chronic hepatitis C patients is related to natural killer group 2D gene rs1049174 GC polymorphism. Virusdisease 27:369–374.
   PubMedGoogle Scholar
• Choi YK, Kwak-Kim J. 2008. Cytokine gene polymorphisms in recurrent spontaneous abortions: a comprehensive review. American Journal of Reproductive Immunology (New York, N.Y.: 1989) 60:91–110.
   PubMed Web of Science ®Google Scholar
• El Costa H, Tabiasco J, Berrebi A, Parant O, Aguerre-Girr M, Piccinni MP, Le Bouteiller P. 2009. Effector functions of human decidual NK cells in healthy early pregnancy are dependent on the specific engagement of natural cytotoxicity receptors. Journal of Reproductive Immunology 82:142–147.
   PubMed Web of Science ®Google Scholar
• Espinoza JL, Nguyen VH, Ichimura H, Pham TT, Nguyen CH, Pham TV, et al. 2016. A functional polymorphism in the NKG2D gene modulates NK-cell cytotoxicity and is associated with susceptibility to human papilloma virus-related cancers. Scientific Reports 6:39231.
   PubMed Web of Science ®Google Scholar
• Furue H, Kumimoto H, Matsuo K, Suzuki T, Hasegawa Y, Shinoda M, et al. 2008. Opposite impact of NKG2D genotype by lifestyle exposure to risk of aerodigestive tract cancer among Japanese. International Journal of Cancer 123:181–186.
   PubMed Web of Science ®Google Scholar
• Furue H, Matsuo K, Kumimoto H, Hiraki A, Suzuki T, Yatabe Y, et al. 2008. Decreased risk of colorectal cancer with the high natural killer cell activity NKG2D genotype in Japanese. Carcinogenesis 29:316–320.
   PubMed Web of Science ®Google Scholar
• Gimeno L, Martinez-Banaclocha H, Bernardo MV, Bolarin JM, Marin L, Lopez-Hernandez R, et al. 2019. NKG2D polymorphism in melanoma patients from Southeastern Spain. Cancers 11:438.
   Web of Science ®Google Scholar
• Glienke J, Sobanov Y, Brostjan C, Steffens C, Nguyen C, Lehrach H, et al. 1998. The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex. Immunogenetics 48:163–173.
   PubMed Web of Science ®Google Scholar
• Hanif MI, Khan A, Arif A, Shoeb E. 2019. Cytogenetic investigation of couples with recurrent spontaneous miscarriages. Pakistan Journal of Medical Sciences 35:1422–1427.
   PubMed Web of Science ®Google Scholar
• Hao F, Zhou X, Jin L. 2020. Natural killer cells: functional differences in recurrent spontaneous abortiondagger. Biology of Reproduction 102:524–531.
   PubMed Web of Science ®Google Scholar
• Hayashi T, Imai K, Morishita Y, Hayashi I, Kusunoki Y, Nakachi K. 2006. Identification of the NKG2D haplotypes associated with natural cytotoxic activity of peripheral blood lymphocytes and cancer immunosurveillance. Cancer Research 66:563–570.
   PubMed Web of Science ®Google Scholar
• Hedlund M, Stenqvist AC, Nagaeva O, Kjellberg L, Wulff M, Baranov V, Mincheva-Nilsson L. 2009. Human placenta expresses and secretes NKG2D ligands via exosomes that down-modulate the cognate receptor expression: evidence for immunosuppressive function. Journal of Immunology 183:340–351.
   PubMed Web of Science ®Google Scholar
• Hizem S, Mtiraoui N, Massaoudi S, Fortier C, Boukouaci W, Kahina A, et al. 2014. Polymorphisms in genes coding for the NK-cell receptor NKG2D and its ligand MICA in recurrent miscarriage. American Journal of Reproductive Immunology (New York, N.Y.: 1989) 72:577–585.
   PubMed Web of Science ®Google Scholar
• Le Bouteiller P. 2013. Human decidual NK cells: unique and tightly regulated effector functions in healthy and pathogen-infected pregnancies. Frontiers in Immunology 4:404.
   PubMed Web of Science ®Google Scholar
• Long EO, Rajagopalan S. 2002. Stress signals activate natural killer cells. The Journal of Experimental Medicine 196:1399–1402.
   PubMed Web of Science ®Google Scholar
• Lucas ES, Vrljicak P, Muter J, Diniz-Da-Costa MM, Brighton PJ, Kong CS, et al. 2020. Recurrent pregnancy loss is associated with a pro-senescent decidual response during the peri-implantation window. Communications Biology 3:37.
   PubMed Web of Science ®Google Scholar
• Malhotra A, Shanker A. 2011. NK cells: immune cross-talk and therapeutic implications. Immunotherapy 3:1143–1166.
   PubMed Web of Science ®Google Scholar
• Mariaselvam CM, Tamouza R, Krishnamoorthy R, Charron D, Misra DP, Jain VK, Negi VS. 2017. Association of NKG2D gene variants with susceptibility and severity of rheumatoid arthritis. Clinical and Experimental Immunology 187:369–375.
   PubMed Web of Science ®Google Scholar
• Marlin R, Duriez M, Berkane N, De Truchis C, Madec Y, Rey-Cuille MA, et al. 2012. Dynamic shift from CD85j/ILT-2 to NKG2D NK receptor expression pattern on human decidual NK during the first trimester of pregnancy. PLOS One 7:e30017.
   PubMed Web of Science ®Google Scholar
• Matthiesen L, Kalkunte S, Sharma S. 2012. Multiple pregnancy failures: an immunological paradigm. American Journal of Reproductive Immunology (New York, N.Y.: 1989) 67:334–340.
   PubMed Web of Science ®Google Scholar
• Mei B, Zhang SR, Chen YL, Wang CF. 2012. Defects in NKG2D ligand expression result in failed tolerance induction at the maternal-fetal interface: a possible cause for recurrent miscarriage. Medical Hypotheses 79:465–467.
   PubMed Web of Science ®Google Scholar
• Miller SA, Dykes DD, Polesky HF. 1988. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Research 16:1215.
   PubMed Web of Science ®Google Scholar
• Mincheva-Nilsson L, Nagaeva O, Chen T, Stendahl U, Antsiferova J, Mogren I, et al. 2006. Placenta-derived soluble MHC class I chain-related molecules down-regulate NKG2D receptor on peripheral blood mononuclear cells during human pregnancy: a possible novel immune escape mechanism for fetal survival. Journal of Immunology (Baltimore, MD: 1950) 176:3585–3592.
   PubMed Web of Science ®Google Scholar
• Murphy SP, Tayade C, Ashkar AA, Hatta K, Zhang J, Croy BA. 2009. Interferon gamma in successful pregnancies. Biology of Reproduction 80:848–859.
   PubMed Web of Science ®Google Scholar
• Park DW, Yang KM. 2011. Hormonal regulation of uterine chemokines and immune cells. Clinical and Experimental Reproductive Medicine 38:179–185.
   PubMedGoogle Scholar
• Pegram HJ, Andrews DM, Smyth MJ, Darcy PK, Kershaw MH. 2011. Activating and inhibitory receptors of natural killer cells. Immunology and Cell Biology 89:216–224.
   PubMed Web of Science ®Google Scholar
• Pei CZ, Kim YJ, Baek KH. 2019. Pathogenetic factors involved in recurrent pregnancy loss from multiple aspects. Obstetrics and Gynecology Science 62:212–223.
   PubMedGoogle Scholar
• Pereza N, Ostojic S, Kapovic M, Peterlin B. 2017. Systematic review and meta-analysis of genetic association studies in idiopathic recurrent spontaneous abortion. Fertility and Sterility 107:150–159 e2.
   PubMed Web of Science ®Google Scholar
• Raulet DH, Gasser S, Gowen BG, Deng W, Jung H. 2013. Regulation of ligands for the NKG2D activating receptor. Annual Review of Immunology 31:413–441.
   PubMed Web of Science ®Google Scholar
• Rpl E, Bender Atik R, Christiansen OB, Elson J, Kolte AM, Lewis S, et al. 2018. ESHRE guideline: recurrent pregnancy loss. Human Reproduction Open 2018:hoy004.
   PubMedGoogle Scholar
• Shankarkumar U, Pawar A, Gaonkar P, Parasannavar D, Salvi V, Ghosh K. 2008. HLA allele associations in idiopathic recurrent spontaneous abortion patients from India. Journal of Human Reproductive Science 1:19–24.
   PubMedGoogle Scholar
• Talebi AR, Fesahat F, Mangoli E, Ghasemzadeh J, Nayeri M, Sadeghian-Nodoshan F. 2016. Relationship between sperm protamine deficiency and apoptosis in couples with unexplained repeated spontaneous abortions. International Journal of Reproductive BioMedicine 14(3):199.
   Google Scholar
• Talebi AR, Ghasemzadeh J, Khalili MA, Halvaei I, Fesahat F. 2018. Sperm chromatin quality and DNA integrity in partial versus total globozoospermia. Andrologia 50(1):e12823.
   Google Scholar
• Vacca P, Cantoni C, Prato C, Fulcheri E, Moretta A, Moretta L, Mingari MC. 2008. Regulatory role of NKp44, NKp46, DNAM-1 and NKG2D receptors in the interaction between NK cells and trophoblast cells. Evidence for divergent functional profiles of decidual versus peripheral NK cells. International Immunology 20:1395–1405.
   PubMed Web of Science ®Google Scholar
• Van Den Heuvel MJ, Horrocks J, Bashar S, Taylor S, Burke S, Hatta K, et al. 2005. Menstrual cycle hormones induce changes in functional interactions between lymphocytes and decidual vascular endothelial cells. The Journal of Clinical Endocrinology and Metabolism 90:2835–2842.
   PubMed Web of Science ®Google Scholar
• Xu X, Du C, Li H, Du J, Yan X, Peng L, et al. 2015. Association of VEGF genetic polymorphisms with recurrent spontaneous abortion risk: a systematic review and meta-analysis. PLOS One 10:e0123696.
   PubMed Web of Science ®Google Scholar
• Yougbare I, Wei-She T, Zdravic D, Chen P, Zhu G, Leong-Poi H, et al. 2015. Natural killer cells contribute to pathophysiology of placenta leading to miscarriage in fetal and neonatal alloimmune thrombocytopenia. Blood 126:2254–2254.
   PubMed Web of Science ®Google Scholar
• Zarnani A-H. 2015. Recurrent pregnancy loss through the lens of immunology. Journal of Reproduction and Infertility 16:59–60.
   PubMedGoogle Scholar
• Zhang Y, Zhao A, Wang X, Shi G, Jin H, Lin Q. 2008. Expressions of natural cytotoxicity receptors and NKG2D on decidual natural killer cells in patients having spontaneous abortions. Fertility and Sterility 90:1931–1937.
   PubMed Web of Science ®Google Scholar
• Zhao X, Jiang Y, Wang L, Li Z, Li Q, Feng X. 2018. Advances in understanding the immune imbalance between T-lymphocyte subsets and NK cells in recurrent spontaneous abortion. Geburtshilfe Und Frauenheilkunde 78:677–683.
   PubMed Web of Science ®Google Scholar
• Zingoni A, Molfetta R, Fionda C, Soriani A, Paolini R, Cippitelli M, et al. 2018. NKG2D and its ligands: "one for all, all for one". Frontier Immunology 9:476.
   PubMed Web of Science ®Google Scholar