363
Views
5
CrossRef citations to date
0
Altmetric
Original Articles: Gynaecology

Small molecule inhibitor of nicotinamide N-methyltransferase shows anti-proliferative activity in HeLa cells

, , , , &

References

  • Akar S, Harmankaya İ, Uğraş S, Çelik Ç. 2019. Expression and clinical significance of nicotinamide N-methyltransferase in cervical squamous cell carcinoma. International Journal of Gynecological Pathology 39:289–295.
  • Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. 2018. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians 68:394–424.
  • Chen H, Lin R, Zhang Z, Wei Q, Zhong Z, Huang J, Xu Y. 2019. Sirtuin 1 knockdown inhibits glioma cell proliferation and potentiates temozolomide toxicity via facilitation of reactive oxygen species generation. Oncology Letters 17:5343–5350.
  • Croucher DR, Saunders DN, Lobov S, Ranson M. 2008. Revisiting the biological roles of PAI2 (SERPINB2) in cancer. Nature Reviews. Cancer 8:535–545.
  • Eckert MA, Coscia F, Chryplewicz A, Chang JW, Hernandez KM, Pan S, et al. 2019. Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts. Nature 569:723–728.
  • Ferlay J, Ervik M, Lam F, Colombet M, Mery L, Piñeros M, et al. 2018. Global cancer observatory: cancer today. Lyon (France): International Agency for Research on Cancer.
  • Geraets D, Alemany L, Guimera N, de Sanjose S, de Koning M, Molijn A, et al. 2012. Detection of rare and possibly carcinogenic human papillomavirus genotypes as single infections in invasive cervical cancer. The Journal of Pathology 228:534–543.
  • Hanahan D, Weinberg RA. 2011. Hallmarks of cancer: the next generation. Cell 144:646–674.
  • Hong S, Moreno-Navarrete JM, Wei X, Kikukawa Y, Tzameli I, Prasad D, et al. 2015. Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization. Nature Medicine 21:887–894.
  • Kanska J, Aspuria P-JP, Taylor-Harding B, Spurka L, Funari V, Orsulic S, et al. 2017. Glucose deprivation elicits phenotypic plasticity via ZEB1-mediated expression of NNMT. Oncotarget 8:26200–26220.
  • Lehmann W, Mossmann D, Kleemann J, Mock K, Meisinger C, Brummer T, et al. 2016. ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types. Nature Communications 7:10498.
  • Liang L, Zeng M, Pan H, Liu H, He Y. 2018. Nicotinamide N-methyltransferase promotes epithelial-mesenchymal transition in gastric cancer cells by activating transforming growth factor-β1 expression. Oncology Letters 15:4592–4598.
  • Mazzio EA, Soliman KF. 2017. HTP nutraceutical screening for histone deacetylase inhibitors and effects of HDACis on tumor-suppressing miRNAs by trichostatin A and grapeseed (Vitis vinifera) in HeLa cells. Cancer Genomics & Proteomics 14:17–33.
  • Neelakantan H, Brightwell CR, Graber TG, Maroto R, Wang HL, McHardy SF, et al. 2019. Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle. Biochemical Pharmacology 163:481–492.
  • Neelakantan H, Vance V, Wetzel MD, Wang HL, McHardy SF, Finnerty CC, et al. 2018. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. Biochemical Pharmacology 147:141–152.
  • Palanichamy K, Kanji S, Gordon N, Thirumoorthy K, Jacob JR, Litzenberg KT, et al. 2017. NNMT silencing activates tumor suppressor PP2A, inactivates oncogenic STKs, and inhibits tumor forming ability. Clinical Cancer Research 23:2325–2334.
  • Ulanovskaya OA, Zuhl AM, Cravatt BF. 2013. NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink. Nature Chemical Biology 9:300–306.
  • Wang Y, Zeng J, Wu W, Xie S, Yu H, Li G, et al. 2019. Nicotinamide N-methyltransferase enhances chemoresistance in breast cancer through SIRT1 protein stabilization. Breast Cancer Research 21:64.
  • Wellen KE, Thompson CB. 2012. A two-way street: reciprocal regulation of metabolism and signalling. Nature Reviews Molecular Cell Biology 13:270–276.
  • Xie X, Liu H, Wang Y, Zhou Y, Yu H, Li G, et al. 2016. Nicotinamide N-methyltransferase enhances resistance to 5-fluorouracil in colorectal cancer cells through inhibition of the ASK1-p38 MAPK pathway. Oncotarget 7:45837–45848.
  • Xu Y, Liu P, Zheng D-H, Wu N, Zhu L, Xing C, et al. 2016. Expression profile and prognostic value of NNMT in patients with pancreatic cancer. Oncotarget 7:19975–19981.
  • You Z, Liu Y, Liu X. 2018. Nicotinamide N-methyltransferase enhances the progression of prostate cancer by stabilizing sirtuin 1. Oncology Letters 6:9195–9201.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.