The impact of vaginal pH on induction of labour outcomes: a meta-analysis of observational studies

References

• 107 APBN. 2009. ACOG practice bulletin No. 107: Induction of labor. Obstetrics and Gynaecology 114:386–397.
   Google Scholar
• Abd-El-Maeboud KH, Ghazy AA, Nadeem AA, Al-Sharaky A, Khalil AE. 2007. Effect of vaginal pH on the efficacy of vaginal misoprostol for induction of midtrimester abortion. Journal of Obstetrics and Gynaecology Research 071101174848003–071101174848084.
   Web of Science ®Google Scholar
• Abd-El-Maeboud KH, Ghazy A, Ibrahim A, Hassan N, El-Bohoty A, Gamal-El-Din I. 2012. Vaginal acidity enhancement with a 3% acetic acid gel prior to misoprostol treatment for pregnancy termination in the midtrimester. International Journal of Gynecology & Obstetrics 119:248–252.
   PubMed Web of Science ®Google Scholar
• Basirat Z, Barat SH, Ghanbarpour A, Golsorkhtabar-Amiri M. 2012. Does vaginal pH affect the efficacy of dinoprostone in cervical ripening/labor duration? Clinical and Experimental Obstetrics & Gynecology 39:522–525.
   PubMed Web of Science ®Google Scholar
• Borenstein M, Hedges LV, Higgins JPT, Rothstein HR. 2010. A basic introduction to fixed-effect and random-effects models for meta-analysis. Research Synthesis Methods 1:97–111.
   PubMed Web of Science ®Google Scholar
• Chandra S, Allen V, Lee W, Fanning C, Young D. 2005. The effect of vaginal pH on labor induction with vaginal misoprostol. The Journal of Maternal-Fetal & Neonatal Medicine 17:387–391.
   PubMed Web of Science ®Google Scholar
• Crane JM, Butler B, Young DC, Hannah ME. 2006. Misoprostol compared with prostaglandin E2 for labour induction in women at term with intact membranes and unfavourable cervix: a systematic review. BJOG : An International Journal of Obstetrics and Gynaecology 113:1366–1376.
   PubMed Web of Science ®Google Scholar
• Creinin MD, Carbonell JLL, Schwartz JL, Varela L, Tanda R. 1999. A randomized trial of the effect of moistening misoprostol before vaginal administration when used with methotrexate for abortion. Contraception 59:11–16.
   PubMed Web of Science ®Google Scholar
• Goswami J, Choudhury SS, Deka G. 2015. Effect of vaginal pH in cervical ripening with dinoprostone gel. The New Indian Journal of OBGYN 2:32–36.
   Google Scholar
• Gunalp S, Bildirici I. 2000. The effect of vaginal pH on the efficacy of vaginal misoprostol for induction of labor. Acta Obstetricia et Gynecologica Scandinavica 79:283–285.
   PubMed Web of Science ®Google Scholar
• Hussain A, Ahsan F. 2005. The vagina as a route for systemic drug delivery. Journal of Controlled Release : Official Journal of the Controlled Release Society 103:301–313.
   PubMed Web of Science ®Google Scholar
• Hwang S, Owada E, Suhardja L, Ho NFH, Flynn GL, Higuchi WI. 1977. Systems approach to vaginal delivery of drugs IV: Methodology for determination of membrane surface pH. Journal of Pharmaceutical Sciences 66:778–781.
   PubMed Web of Science ®Google Scholar
• IntHout J, Ioannidis JPA, Borm GF. 2014. The Hartung-Knapp-Sidik-Jonkman method for random effects meta-analysis is straightforward and considerably outperforms the standard DerSimonian-Laird method. BMC Medical Research Methodology 14:25.
   PubMed Web of Science ®Google Scholar
• Lee VCY, Yung SSF, Li RHW, Watzer B, Schweer H, Ng EHY, et al. 2011. A randomized comparison of pharmacokinetics of a single vaginal dose of dry misoprostol or misoprostol moistened with normal saline or with acetic acid. Human Reproduction 26:2981–2987.
   PubMed Web of Science ®Google Scholar
• Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JPA, et al. 2009. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. Journal of Clinical Epidemiology 62:e1–34.
   PubMed Web of Science ®Google Scholar
• Martin JA, Hamilton BE, Osterman MJK, Driscoll AK. 2019. Births: Final Data for 2018. National Vital Statistics Reports : From the Centers for Disease Control and Prevention, National Center for Health Statistics, National Vital Statistics System 68:1–47.
   Google Scholar
• O'Hanlon DE, Come RA, Moench TR. 2019. Vaginal pH measured in vivo: lactobacilli determine pH and lactic acid concentration. BMC Microbiology 19:13.
   PubMed Web of Science ®Google Scholar
• Oğlak SC, Bademkıran MH, Obut M. 2020. Predictor variables in the success of slow-release dinoprostone used for cervical ripening in intrauterine growth restriction pregnancies. Journal of Gynecology Obstetrics and Human Reproduction 49:101739.
   PubMed Web of Science ®Google Scholar
• Önen S, Özaksit G, Yilmaz B. 2008. The role of vaginal pH on efficacy of controlled-release dinoprostone vaginal insert for cervical ripening/labor induction: a prospective double-blind study. J Turk Ger Gynecol Assoc 9:206–211.
   Google Scholar
• Poomalar GK, Fathima Shantini N, Ezhil R. 2022. Effect of vaginal pH on efficacy of dinoprostone gel for labour induction: a cross-sectional study. Journal of Obstetrics and Gynaecology : The Journal of the Institute of Obstetrics and Gynaecology 42:228–231.
   PubMedGoogle Scholar
• Ramsey PS, Ogburn PL, Jr., Harris DY, Heise RH, DiMarco CS, Ramin KD. 2003. Effect of vaginal pH on efficacy of the controlled-release dinoprostone vaginal insert for cervical ripening/labor induction. The Journal of Maternal-Fetal & Neonatal Medicine 13:250–253.
   PubMedGoogle Scholar
• Ramsey PS, Ogburn PL, Jr., Harris DY, Heise RH, Ramin KD. 2000. Effect of vaginal pH on efficacy of misoprostol for cervical ripening and labor induction. American Journal of Obstetrics and Gynecology 182:1616–1619.
   PubMed Web of Science ®Google Scholar
• Ramsey PS, Ogburn PL, Jr., Harris DY, Heise RH, Ramin KD. 2002. Effect of vaginal pH on efficacy of the dinoprostone gel for cervical ripening/labor induction. American Journal of Obstetrics and Gynecology 187:843–846.
   PubMed Web of Science ®Google Scholar
• Rashwan ASSA, Alalfy M, El-Sharkawy M, Eldesouky A, Ashour AS, Hassan A, et al. 2020. Comparative study regarding effect of pH on Misoprostol in induction of labor in full term primigravida pregnant women, a double blind randomized controlled trial. Journal of Perinatal Medicine 49:43–49.
   PubMed Web of Science ®Google Scholar
• Reproductive Health. 2010. WHO global survey on maternal and perinatal health. Induction of labour data. Geneva: World health Organization. http://www:who.int/reproductivehealth​/topics​/best_practices/global_survey
   Google Scholar
• Singh K, Fong YF, Prasad RN, Dong F. 1999. Does an acidic medium enhance the efficacy of vaginal misoprostol for pre-abortion cervical priming? Human Reproduction (Oxford, England) 14:1635–1637.
   PubMed Web of Science ®Google Scholar
• Singh U, Mehrotra S, Gupta HP, Dhakad A, Jain V. 2011. A prospective double blind trial investigating impact of vaginal pH on efficacy of prostaglandin gel for cervical ripening and course of labour. Journal of Obstetrics and Gynaecology : The Journal of the Institute of Obstetrics and Gynaecology 31:217–219.
   PubMedGoogle Scholar
• Souza JP, Pileggi C, Cecatti JG. 2007. Assessment of funnel plot asymmetry and publication bias in reproductive health meta-analyses: an analytic survey. Reproductive Health 4:3.
   PubMedGoogle Scholar
• Statistics. 2021. Publication, Part of NHS Maternity Statistics. NHS Maternity Statistics, England 2018-19 [PAS]. Publication date: 31/10/2019. NHS Digital.
   Google Scholar
• Wang L, Zheng J, Wang W, Fu J, Hou L. 2016. Efficacy and safety of misoprostol compared with the dinoprostone for labor induction at term: a meta-analysis. The Journal of Maternal-Fetal & Neonatal Medicine 29:1297–1307.
   PubMed Web of Science ®Google Scholar
• Yayla Abide Ç, Kurek Eken M, Ozkaya E, Yenidede I, Bostanci Ergen E, Kilicci C, et al. 2018. Effect of vaginal washing before intravaginal dinoprostone insertion for labor induction: A randomized clinical trial. The Journal of Obstetrics and Gynaecology Research 44:2149–2155.
   PubMed Web of Science ®Google Scholar
• WHO. 2011. WHO Recommendations for Induction of Labour. Geneva: World Health Organization.
   Google Scholar