216
Views
0
CrossRef citations to date
0
Altmetric
Research Aricles

Effect of rosuvastatin on spatial learning, memory, and anxiety-like behaviour in ovariectomized rats

, , , &

References

  • Barnes CA. 1979. Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat. Journal of Comparative and Physiological Psychology 93:74–104.
  • Barros JWF, Tonon KS, Borges CS, Silva PV, Lozano AFQ, Pacheco TL, et al. 2020. Short- and long-term effects on reproductive parameters of female Wistar rats after exposure to rosuvastatin starting in pre-puberty. Current Research in Toxicology 1:149–160.
  • Biglia N, Bounous VE, De Seta F, Lello S, Nappi RE, Paoletti AM. 2019. Non-hormonal strategies for managing menopausal symptoms in cancer survivors: an update. Ecancermedicalscience 13:909.
  • Caliman IF, Lamas AZ, Dalpiaz PL, Medeiros AR, Abreu GR, Figueiredo SG, et al. 2013. Endothelial relaxation mechanisms and oxidative stress are restored by atorvastatin therapy in ovariectomized rats. PloS One 8:e80892.
  • Campos GV, de Souza AMA, Ji H, West CA, Wu X, Lee DL, et al. 2020. The angiotensin type 1 receptor antagonist losartan prevents ovariectomy-induced cognitive dysfunction and anxiety-like behavior in Long Evans rats. Cellular and Molecular Neurobiology 40:407–420.
  • Conde DM, Verdade RC, Valadares ALR, Mella LFB, Pedro AO, Costa-Paiva L. 2021. Menopause and cognitive impairment: a narrative review of current knowledge. World Journal of Psychiatry 11:412–428.
  • Cora MC, Kooistra L, Travlos G. 2015. Vaginal cytology of the laboratory rat and mouse: review and criteria for the staging of the estrous cycle using stained vaginal smears. Toxicologic Pathology 43:776–793.
  • Davies JT, Delfino SF, Feinberg CE, Johnson MF, Nappi VL, Olinger JT, et al. 2016. Current and emerging uses of statins in clinical therapeutics: a review. Lipid Insights 9:13–29.
  • Degen GH, Janning P, Diel P, Bolt HM. 2002. Estrogenic isoflavones in rodent diets. Toxicology Letters 128:145–157.
  • Djiogue S, Djiyou Djeuda AB, Seke Etet PF, Ketcha Wanda GJM, Djikem Tadah RN, Njamen D. 2018. Memory and exploratory behavior impairment in ovariectomized Wistar rats. Behavioral and Brain Functions: BBF 14:14.
  • Eslami SM, Khorshidi L, Ghasemi M, Rashidian A, Mirghazanfari M, Nezhadi A, et al. 2021. Protective effects of atorvastatin and rosuvastatin on 3,4-methylenedioxymethamphetamine (MDMA)-induced spatial learning and memory impairment. Inflammopharmacology 29:1807–1818.
  • Fedotova JO. 2019. Vitamin D3 treatment differentially affects anxiety-like behavior in the old ovariectomized female rats and old ovariectomized female rats treated with low dose of 17β-estradiol. BMC Medical Genetics 20:49.
  • Gava G, Orsili I, Alvisi S, Mancini I, Seracchioli R, Meriggiola MC. 2019. Cognition, mood and sleep in menopausal transition: the role of menopause hormone therapy. Medicina (Kaunas) 55:668.
  • Geifman N, Brinton RD, Kennedy RE, Schneider LS, Butte AJ. 2017. Evidence for benefit of statins to modify cognitive decline and risk in Alzheimer's disease. Alzheimer's Research & Therapy 9:10.
  • Georgakis MK, Beskou-Kontou T, Theodoridis I, Skalkidou A, Petridou ET. 2019. Surgical menopause in association with cognitive function and risk of dementia: A systematic review and meta-analysis. Psychoneuroendocrinology 106:9–19.
  • Hickey M, Moss KM, Brand A, Wrede CD, Domchek SM, Meiser B, et al. 2021. What happens after menopause? (WHAM): a prospective controlled study of depression and anxiety up to 12 months after premenopausal risk-reducing bilateral salpingo-oophorectomy. Gynecologic Oncology 161:527–534.
  • Hill DA, Crider M, Hill SR. 2016. Hormone therapy and other treatments for symptoms of menopause. American Family Physician 94:884–889.
  • Husain I, Khan S, Khan S, Madaan T, Kumar S, Najmi AK. 2019. Unfolding the pleiotropic facades of rosuvastatin in therapeutic intervention of myriads of neurodegenerative disorders. Clinical and Experimental Pharmacology & Physiology 46:283–291.
  • Kathuria S, Mahadevan N, Balakumar P. 2013. Possible involvement of PPARγ-associated eNOS signaling activation in rosuvastatin-mediated prevention of nicotine-induced experimental vascular endothelial abnormalities. Molecular and Cellular Biochemistry 374:61–72.
  • Kingsberg SA, Larkin LC, Liu JH. 2020. Clinical effects of early or surgical menopause. Obstetrics and Gynecology 135:853–868.
  • Koebele SV, Nishimura KJ, Bimonte-Nelson HA, Kemmou S, Ortiz JB, Judd JM, et al. 2020. A long-term cyclic plus tonic regimen of 17β-estradiol improves the ability to handle a high spatial working memory load in ovariectomized middle-aged female rats. Hormones and Behavior 118:104656.
  • Lephart ED, West TW, Weber KS, Rhees RW, Setchell KD, Adlercreutz H, et al. 2002. Neurobehavioral effects of dietary soy phytoestrogens. Neurotoxicology and Teratology 24:5–16.
  • Luine V, Frankfurt M. 2020. Estrogenic regulation of memory: the first 50 years. Hormones and Behavior 121:104711.
  • Martinez-Coria H, Yeung ST, Ager RR, Rodriguez-Ortiz CJ, Baglietto-Vargas D, LaFerla FM. 2015. Repeated cognitive stimulation alleviates memory impairments in an Alzheimer's disease mouse model. Brain Research Bulletin 117:10–15.
  • Marzban Abbasabadi B, Tadjalli M. 2016. Effect of soy milk on circulating 17-β estradiol, number of neurons in cerebral cortex and hippocampus and determination of their ratio in neonatal ovariectomized rats. Veterinary Research Forum: An International Quarterly Journal 7:347–351.
  • Monteiro SC, Matté C, Bavaresco CS, Netto CA, Wyse AT. 2005. Vitamins E and C pretreatment prevents ovariectomy-induced memory deficits in water maze. Neurobiology of Learning and Memory 84:192–199.
  • Morris R. 1984. Developments of a water-maze procedure for studying spatial learning in the rat. Journal of Neuroscience Methods 11:47–60.
  • National Research Council. 2011. Guide for the care and use of laboratory animals. 8th ed. Washington (DC): The National Academies Press.
  • Nicholls SJ, Uno K, Kataoka Y. 2011. Clinical experience with rosuvastatin in the management of hyperlipidemia and the reduction of cardiovascular risk. Expert Review of Cardiovascular Therapy 9:1383–1390.
  • Orprayoon N, Santibenchakul S, Hemrungrojn S, Phutrakool P, Kengsakul M, Jaisamrarn U, et al. 2021. Effect of surgical menopause and frontal lobe cognitive function. Climacteric: The Journal of the International Menopause Society 24:389–393.
  • Pellow S, Chopin P, File SE, Briley M. 1985. Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. Journal of Neuroscience Methods 14:149–167.
  • Picazo O, Estrada-Camarena E, Hernandez-Aragon A. 2006. Influence of the post-ovariectomy time frame on the experimental anxiety and the behavioural actions of some anxiolytic agents. European Journal of Pharmacology 530:88–94.
  • Prashantha Kumar BR, Kumar AP, Jose JA, Prabitha P, Yuvaraj S, Chipurupalli S, et al. 2020. Minutes of PPAR-γ agonism and neuroprotection. Neurochemistry International 140:104814.
  • Puga-Olguín A, Rodríguez-Landa JF, Rovirosa-Hernández MJ, Germán-Ponciano LJ, Caba M, Meza E, et al. 2019. Long-term ovariectomy increases anxiety- and despair-like behaviors associated with lower Fos immunoreactivity in the lateral septal nucleus in rats. Behavioural Brain Research 360:185–195.
  • Rodriguez A, Zhang H, Klaminder J, Brodin T, Andersson PL, Andersson M. 2018. ToxTrac: a fast and robust software for tracking organisms. Methods in Ecology and Evolution 9:460–464.
  • Rodríguez-Landa JF. 2022. Considerations of timing post-ovariectomy in mice and rats in studying anxiety- and depression-like behaviors associated with surgical menopause in women. Frontiers in Behavioral Neuroscience 16:829274.
  • Rodríguez-Landa JF, Cueto-Escobedo J, Puga-Olguín A, Rivadeneyra-Domínguez E, Bernal-Morales B, Herrera-Huerta EV, et al. 2017. The phytoestrogen genistein produces similar effects as 17β-estradiol on anxiety-like behavior in rats at 12 weeks after ovariectomy. BioMed Research International 2017:9073816.
  • Saad MA, Al-Shorbagy MY, Arab HH. 2022. Targeting the TLR4/NF-κΒ axis and NLRP1/3 inflammasomes by rosuvastatin: a role in impeding ovariectomy-induced cognitive decline neuropathology in rats. Molecular Neurobiology 59:4562–4577.
  • Sayan-Ozacmak H, Ozacmak VH, Barut F, Jakubowska-Dogru E. 2011. Neuroprotective efficacy of the peroxisome proliferator-activated receptor-γ ligand in chronic cerebral hypoperfusion. Current Neurovascular Research 8:190–199.
  • Schrader AJ, Taylor RM, Lowery-Gionta EG, Moore NLT. 2018. Repeated elevated plus maze trials as a measure for tracking within-subjects behavioral performance in rats (Rattus norvegicus). PLoS One 13:e0207804.
  • Schultz BG, Patten DK, Berlau DJ. 2018. The role of statins in both cognitive impairment and protection against dementia: a tale of two mechanisms. Translational Neurodegeneration 7:5.
  • Thonusin C, Pantiya P, Jaiwongkam T, Kerdphoo S, Arunsak B, Amput P, et al. 2020. A proprotein convertase subtilisin/kexin type 9 inhibitor provides comparable efficacy with lower detriment than statins on mitochondria of oxidative muscle of obese estrogen-deprived rats. Menopause (New York, N.Y.) 27:1155–1166.
  • Wang BX, Li KP, Yu T, Feng HY. 2019. Rosuvastatin promotes osteogenic differentiation of mesenchymal stem cells in the rat model of osteoporosis by the Wnt/β-catenin signal. European Review for Medical and Pharmacological Sciences 23:10161–10168.
  • Xu X, Zhang Z. 2006. Effects of estradiol benzoate on learning-memory behavior and synaptic structure in ovariectomized mice. Life Sciences 79:1553–1560.
  • Yousefzadeh N, Kashfi K, Jeddi S, Ghasemi A. 2020. Ovariectomized rat model of osteoporosis: a practical guide. EXCLI Journal 19:89–107.
  • Zhang JY, Liu B, Wang YN, Zhang WN, Wang FJ. 2014. Effect of rosuvastatin on OX40L and PPAR-γ expression in human umbilical vein endothelial cells and atherosclerotic cerebral infarction patients. Journal of Molecular Neuroscience: MN 52:261–268.
  • Zheng L, Cai Y, Qiu B, Lan L, Lin J, Fan Y. 2020. Rosuvastatin improves cognitive function of chronic hypertensive rats by attenuating white matter lesions and beta-amyloid deposits. BioMed Research International 2020:4864017.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.