109
Views
4
CrossRef citations to date
0
Altmetric
Research Article

Study of the genotoxic and cytotoxic effects of the α-, β-, and γ- Hexachlorocyclohexane isomers in human lymphocyte cells using the cytokinesis-block micronucleus assay

Pages 85-89 | Received 19 Dec 2015, Accepted 03 Apr 2016, Published online: 06 May 2016

References

  • Agency for Toxic Substances and Disease Registry (ATDR), Division of Toxicology/Toxicology Information Branch, U.S. Department of Health and Human Services, Public Health Service (20050: Toxicological profile for alpha-, beta-gamma-anddelta-Hexachlorocyclohexane.
  • Ahmed FE, Hart RW, Lewis NJ. (1977). Pesticide induced DNA damage and its repair in cultured human cells. Mutat Res 42:161–174.
  • Alvarado-Hernandez DL, Montero-Montoya R, Serrano-García L, et al. (2013). Assessment of exposure to organochlorine pesticides and levels of DNA damage in mother-infant pairs of an agrarian community. Environ Mol Mutagen 54:99–111.
  • Aresta A, Marzano CN, Lopane C, et al. (2015). Analytical investigations on the lindane bioremediation capability of the demosponge Hymeniacidon perlevis. Marine Poll Bull 90:143–149.
  • Baumann K, Angerer J, Heinrich R, et al. (1980). Occupational exposure to hexachlorocyclohexane: I. Body burden of HCH-isomers. Int Arch Occup Health 47:119–127.
  • Blair A, Cantor KP, Hoar Zahm S. (1998). Non-Hodgkin’s lymphoma and agricultural use of the insecticide lindane. Am J Ind Med 33:82–87.
  • Cifone MA. 1990. LLindane (technical): in the in vitro rat primary hepatocyte unscheduled DNA synthesis assay. Kensington, MD: Hazelton Laboratories America, Inc. HLA study no. 12024-0-447.
  • Edward L, Croom Timothy J, Shafer Marina V, et al. (2015). Improving in vitro to in vivo extrapolation by incorporating toxicokinetic measurements: a case study of lindane-induced neurotoxicity. Toxicol App Pharmacom 283:9–19.
  • Ennaceur S, Driss R, Marcos R. (2008a). Genotoxicity of the organochlorine pesticides 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) and hexachlorobenzene (HCB) in cultured human lymphocytes. Chemosphere 71:1335–1339.
  • Ennaceur S, Gandoura N, Driss MR. (2008b). Distribution of polychlorinated biphenyls and organochlorine pesticides in human breast milk from various locations in Tunisia: levels of contamination, influencing factors, and infant risk assessment. Environ Res 108:86–93.
  • Ennaceur S, Driss MR. (2010). Serum organochlorine pesticide and polychlorinated biphenyl levels measured in delivering women from different locations in Tunisia. Intern J Environ Anal Chem 90:821–828.
  • Fenech M. (1993). The cytokinesis-block micronucleus technique: a detailed description of the method and its application to genotoxicity studies in human populations. Mutat Res 285:35–44.
  • Iverson F, Ryan JJ, Lizotte R, et al. (1984). In vivo and in vitro binding of α- and γ-hexachlorocyclohexane to mouse liver macromolecules. Toxicol Lett 20:331–335.
  • Kalantzi OI, Hewitt R, Ford KJ, et al. (2004). Low dose induction of micronuclei by lindane. Carcinogenesis 25:613–622.
  • Kashyap SK. (1986). Health surveillance and biological monitoring of pesticide formulators in India. Toxicol Lett 33:107–114.
  • Kiraly J, Szentesi I, Ruzicska M, et al. (1979). Chromosome studies in workers producing organophosphate insecticides. Arch Environ Contam Toxicol 8:309–319.
  • Maldonado INP, Diaz-Barriga F, dela Fuente H, et al. (2004). DDT induces apoptosis in human mononuclear cells in vitro and is associated with increased apoptosis in exposed children. Environ Res 94:38–46.
  • Mattioli F, Robbiano L, Adamo D, et al. (1996). Genotoxic effects of a-hexachlorocyclohexane in primary cultures of rodent and human hepatocytes. Mutagenesis 11:79–83.
  • Morgan DP, Lin LI. (1978). Blood organochlorine pesticide concentrations, clinical hematology, and biochemistry in workers occupationally exposed to pesticides. Arch Environ Contam Toxicol 7:423–447.
  • Murli H. (1990). Lindane(technical): in an in vitro cytogenetic assay measuring chromosomalaberration frequencies in Chinese Hamster Ovary (CHO) cells with multiple harvests under conditions of metabolic activation. Kensington, MD: Hazelton Laboratories America, Inc. LA study no. 12024-0437C.
  • Nigam SK, Karnik AB, Majumder SK, et al. (1986). Serum hexachlorocyclohexane residues in workers engaged at a HCH manufacturing plant. Int Arch Occup Environ Health 57:315–320.
  • NTP (1984). National Toxicology Program Fiscal Year 1984 Annual Plan. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service, National Institute of Environmental Health Sciences, National Toxicology Program
  • Pastor S, Gutierrez S, Creus A, et al. (2001). Cytogenetic analysis of Greek farmers using the micronucleus assay in peripheral lymphocytes and buccal cells. Mutagenesis 16:539–545.
  • Pool-Zobel BL, Lotzman N, Knoll M, et al. (1994). Detection of genotoxic effects in human gastric and nasal mucosa cells isolated from biopsy samples. Environ Mol Mutagen 24:23–45.
  • Pool-Zobel BL, Guigas C, Klein R, et al. (1993). Assessment of genotoxic effects by lindane. Fd Chem Toxic 31:271–283.
  • Rambo IM. (2013). Aerobic degradation of α−, β−, γ − hexachlorocyclohexane by Narragansett Bay bacterioplankton. Senior Honors projects, Honors Program at the University of Rhode Island, USA, Paper 334:1–10.
  • Ribas G, Surrallés J, Xamena N, et al. (1998). Genotoxic evaluation of the herbicide paraquat in cultured human lymphocytes. Teratog Carcinog Mutagen 17:339–347.
  • Rocchi P, Perocco P, Alberghini W, et al. (1980). Effect of pesticides on scheduled and unscheduled DNA synthesis of rat thymocytes and human lymphocytes. Arch Toxicol 45:101–108.
  • Rupa DS, Reddy PP, Reddi OS. (1989). Genotoxic effect of BHC in cultured human lymphocytes. Hum Genet 83:271–273.
  • Surrallés J, Antoccia A, Creus A, et al. (1994). The effects of cytochalasin-B concentration on the frequency of micronucleus induced by four standard mutagens. Results from two laboratories. Mutagenesis 9:347–353.
  • Surrallés J, Carbonell I, Marcos R, et al. (1993). A collaborative study on the improvement of the micronucleus test in cultured human lymphocytes. Mutagenesis 7:407–410.
  • Tomczak S, Baumann K, Lehnert G. (1981). Occupational exposure to hexachlorocyclohexane: IV. Sex hormone alterations in HCH-exposed workers. Int Arch Occup Environ Health 48:283–287.
  • Zeljezic D, Vrhovac VG. (2004). Chromosomal aberrations, micronuclei and nuclear buds induced in human lymphocytes by 2,4,dichlorophenoxyacetic acid pesticide formulation. Toxicology 200:39–47.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.