Assessment of the cytotoxicity and genotoxicity properties of Uvaria chamae P. Beauv (Annonaceae) and Morinda lucida Benth (Rubiaceae) in mice

References

• Addae-Kyereme, J., et al., 2001. Antiplasmodial activities of some Ghanaian plants traditionally used for fever/malaria treatment and of some alkaloids isolated from Pleiocarpa mutica; in vivo antimalarial activity of pleiocarpine. Journal of Ethnopharmacology, 76, 99–103.
   PubMed Web of Science ®Google Scholar
• Adejo, G.O. and Atawodi, S.E., 2014. Acute toxicity and genotoxic effects of all parts of Morinda lucida Benth on PUC 18 plasmid DNA. Natural Products Chemistry & Research, S1, 006.
   Google Scholar
• Adejumo, O.E., et al., 2010. In vitro antisickling activities and phytochemical evaluation of Plumbago zeylanica and Uvaria chamae. African Journal of Biotechnology, 9, 9032–9036.
   Google Scholar
• Adelodun, V.O., et al., 2013. Evaluation of antitrypanosomal and anti inflammatory activities of selected Nigerian medicinal plants in mice. African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM, 10, 469–476.
   PubMedGoogle Scholar
• Adepiti, A.O. and Iwalewa, E.O., 2016. Evaluation of the combination of Uvaria chamae (P. Beauv.) and amodiaquine in murine malaria. Journal of Ethnopharmacology, 193, 30–35.
   PubMed Web of Science ®Google Scholar
• Adewunmi, C.O. and Adesogan, E.K., 1984. Anthraquinones and oruwacin from Morinda lucida as possible agents in fascioliasis and schistosomasis. Fitoterapia, 55, 259–263.
   Google Scholar
• Ajaiyeoba, E.O., Abiodun, O.O., and Falade, M.O., 2006. In vitro cytotoxicity studies of 20 plants used in Nigerian antimalarial ethnomedicine. Phytomedicine: International Journal of Phytotherapy and Phytopharmacology, 13, 295–298.
   PubMed Web of Science ®Google Scholar
• Akintonwa, A., et al., 2009. Mutagenic screening of some commonly used medicinal plants in Nigeria. Journal of Ethnopharmacology, 125, 461–470.
   PubMed Web of Science ®Google Scholar
• Asuzu, I.U. and Chineme, C.N., 1990. Effects of Morinda lucida leaf extract on Trypanosoma brucei brucei infection in mice. Journal of Ethnopharmacology, 30, 307–313.
   PubMed Web of Science ®Google Scholar
• Castro, L.S., Perazzo, F.F., and Maistro, E.L., 2009. Genotoxicity testing of Ambelania occidentalis (Apocynaceae) leaf extract in vivo. Genetics and Molecular Research: GMR, 8, 440–447.
   PubMed Web of Science ®Google Scholar
• Cimanga, R.K., et al., 2006. Bioassay-guided isolation of antimalarial triterpenoid acids from the leaves of Morinda lucida. Pharmaceutical Biology, 44, 677–681.
   Web of Science ®Google Scholar
• EMEA, 2008. Guidelines on the assessment of genotoxicity of herbal substance/preparation. London, UK: European Medicines Agency, 4–6.
   Google Scholar
• Fall, D., et al., 2002. Cis-bullatencin, a linear acetogenin from roots of Uvaria chamae. Natural Product Letters, 16, 315–321.
   PubMed Web of Science ®Google Scholar
• Fall, D., et al., 2004. Chamuvarinin, an acetogenin bearing a tetrahydropyran ring from the roots of Uvaria chamae. Journal of Natural Products, 67, 1041–1043.
   PubMed Web of Science ®Google Scholar
• Farnsworth, N.R., et al., 1985. Medicinal plants in therapy. Bulletin of the World Health Organization, 63, 965–981.
   PubMed Web of Science ®Google Scholar
• Geriyol, P., Basavanneppa, H.B., and Dhananjaya, B.L.P., 2015. Protecting effect of caffeine against vinblastine (an anticancer drug) induced genotoxicity in mice. Drug and Chemical Toxicology, 38, 188–195.
   PubMed Web of Science ®Google Scholar
• Hufford, C.D. and Lasswell, W.L., 1976. Uvaretin and isouvaretin. Two novel cytotoxic c-benzylflavanones from Uvaria chamae L. The Journal of Organic Chemistry, 41, 1297–1298.
   PubMed Web of Science ®Google Scholar
• Koumaglo, K., et al., 1992. Effects of three compounds extracted from Morinda lucida on Plasmodium falciparum. Planta Medica, 58, 533–534.
   PubMed Web of Science ®Google Scholar
• Martinez, M.M., et al., 2002. Progression rate of Chinese herb nephropathy: impact of Aristolochia fangchi ingested dose. Nephrology, Dialysis, Transplantation, 17, 408–412.
   PubMed Web of Science ®Google Scholar
• NRC, National Research Council, 1996. Guide for the care and use of laboratory animals. 8th ed. Washington, DC: National Academy Press.
   Google Scholar
• Nweze, E.I., Okafor, J.I., and Njoku, O., 2004. Antimicrobial activities of methanolic extracts of Trema guineense (Schum and Thonn) and Morinda lucida Benth used in Nigeria. Bio-Research, 2, 39–44.
   Google Scholar
• Olajide, O.A., et al., 1999. Evaluation of the anti-diabetic property of Morinda lucida leaves in streptozotocin-diabetic rats. The Journal of Pharmacy and Pharmacology, 51, 1321–1324.
   PubMed Web of Science ®Google Scholar
• Oluremi, B.B., Osungunna, M.O., and Omafuma, O.O., 2010. Comparative assessment of antibacterial activity of Uvaria chamae parts. African Journal of Microbiology Research, 4, 1391–1394.
   Google Scholar
• Philipov, S., et al., 2000. Phytochemical study and cytotoxic activity of alkaloids from Uvaria chamae P. Beauv. Die Pharmazie, 55, 688–689.
   PubMed Web of Science ®Google Scholar
• Rath, G., Ndonzao, M., and Hostettman, K., 1995. Antifungal anthraquinones from Morinda lucida. Pharmaceutical Biology, 33, 104–111.
   Google Scholar
• Tazehkand, M.N., Topaktas, M., and Yilmaz, M.B., 2016. Assessment of chromosomal aberration in the bone marrow cells of Swiss Albino mice treated by 4-methylimidazole. Drug and Chemical Toxicology, 39, 307–311.
   PubMed Web of Science ®Google Scholar
• Uwaifo, A.O., Okorie, D.A., and Bababunmi, E.A., 1979. Mutagenicity of chamuvaritin: a benzyldihydrochalcone isolated from a medicinal plant. Cancer Letters, 8, 87–92.
   PubMed Web of Science ®Google Scholar
• Vilar, J.B., et al., 2008. Assessment of the mutagenic, antimutagenic and cytotoxic activities of ethanolic extract of araticum (Annona crassiflora Mart. 1841) by micronucleus test in mice. Brazilian Journal of Biology = Revista Brasleira De Biologia, 68, 141–147.
   PubMed Web of Science ®Google Scholar