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Research Article

Evaluation of multikinase inhibitor LDN193189 induced hepatotoxicity in teleost fish Poecilia latipinna

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Pages 565-576 | Received 22 Dec 2017, Accepted 11 Feb 2018, Published online: 02 Mar 2018

References

  • Ali, J.L., et al., 2015. Differential cellular responses induced by dorsomorphin and LDN-193189 in chemotherapy-sensitive and chemotherapy-resistant human epithelial ovarian cancer cells. International Journal of Cancer, 136 (5), E455–E469.
  • Alt, Y., et al., 2016. The impact of liver cell injury on health-related quality of life in patients with chronic liver disease. PLoS One, 11 (3), e0151200.
  • Balboni, A.L., et al., 2013. ΔNp63α-mediated activation of bone morphogenetic protein signaling governs stem cell activity and plasticity in normal and malignant mammary epithelial cells. Cancer Research, 73 (2), 1020–1030.
  • Beutler, E. and Gelbart, T., 1986. Improved assay of the enzymes of glutathione synthesis: γ-glutamylcysteine synthetase and glutathione synthetase. Clinicachimica Acta, 158 (1), 115–123.
  • Bradford, M.M., 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry, 72 (1–2), 248–254.
  • Buijs, J.T., et al., 2012. The BMP2/7 heterodimer inhibits the human breast cancer stem cell subpopulation and bone metastases formation. Oncogene, 31 (17), 2164–2174.
  • Cowey, C.B. and Walton, M.J., 1989. Intermediary metabolism. Fish Nutrition, 2, 259–329.
  • Crofts, F.G., et al., 1997. Metabolism of 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP) by human cytochrome P4501B1. Carcinogenesis, 18 (9), 1793–1798.
  • Crofts, F.G., Sutter, T.R., and Strickland, P.T., 1998. Metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by human cytochrome P4501A1, P4501A2 and P4501B1. Carcinogenesis, 19 (11), 1969–1973.
  • Cuny, G.D., et al., 2008. Structure–activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors. Bioorganic & Medicinal Chemistry Letters, 18 (15), 4388–4392.
  • Dai, H., et al., 2013. Contribution of Bcl-2 phosphorylation to Bak binding and drug resistance. Cancer Research, 73 (23), 6998–7008.
  • Dakhoul, L. and Chalasani, N., 2017. Causality assessment for suspected drug-induced liver injury in patients with underlying chronic liver disease. Clinical Liver Disease, 9 (3), 63–65.
  • Dar, S.A., et al., 2017. Studies of anthelminthic benzimidazole derivatives on cytochrome P450 1A (CYP1A) dependent detoxification mechanism in Labeorohita. Aquaculture, 481, 79–84.
  • Ekstedt, M., et al., 2006. Long-term follow-up of patients with NAFLD and elevated liver enzymes. Hepatology, 44 (4), 865–873.
  • Evans, D.H. ed., 2008. Osmotic and ionic regulation: cells and animals. USA: CRC Press.
  • Finney, D. J. and Tattersfield, F., 1952. Probit analysis. Cambridge: Cambridge University Press.
  • Fotinos, A., et al., 2014. Bone morphogenetic protein-focused strategies to induce cytotoxicity in lung cancer cells. Anticancer Research, 34 (5), 2095–2104.
  • Ghafourifar, P., et al., 1999. Ceramide induces cytochrome C release from isolated mitochondria Importance. Journal of Biological Chemistry, 274 (10), 6080–6084.
  • Giannini, E., et al., 1999. Progressive liver functional impairment is associated with an increase in AST/ALT ratio. Digestive Diseases and Sciences, 44 (6), 1249–1253.
  • Goel, A., Dani, V., and Dhawan, D.K., 2005. Protective effects of zinc on lipid peroxidation, antioxidant enzymes and hepatic histoarchitecture in chlorpyrifos-induced toxicity. Chemico-Biological Interactions, 156 (2–3), 131–140.
  • Guengerich, F.P., 1999. Cytochrome P-450 3A4: regulation and role in drug metabolism. Annual Review of Pharmacology and Toxicology, 39 (1), 1–17.
  • Gunawan, B.K. and Kaplowitz, N., 2007. Mechanisms of drug-induced liver disease. Clinics in Liver Disease, 11 (3), 459–475.
  • Horie, Y., et al., 2017. Assessment of the lethal and sublethal effects of 20 environmental chemicals in zebrafish embryos and larvae by using OECD TG 212. Journal of Applied Toxicology, 37 (10), 1245–1253.
  • Hose, J.E., et al., 1996. Sublethal effects of the (Exxon Valdez) oil spill on herring embryos and larvae: morphological, cytogenetic, and histopathological assessments, 1989–1991. Canadian Journal of Fisheries and Aquatic Sciences, 53 (10), 2355–2365.
  • Huggett, D.B., et al., 2003. A theoretical model for utilizing mammalian pharmacology and safety data to prioritize potential impacts of human pharmaceuticals to fish. Human and Ecological Risk Assessment, 9 (7), 1789–1799.,
  • Hyder, M.A., Hasan, M., and Mohieldein, A.H., 2013. Comparative levels of ALT, AST, ALP and GGT in liver associated diseases. European Journal of Experimental Biology, 3 (2), 280–284.
  • Kanchana, N. and Sadiq, A.M., 2011. Hepatoprotective effect of Plumbago zeylanica on paracetamol induced liver toxicity in rats. International Journal of Pharmacy and Pharmaceutical Science, 3 (1), 151–154.
  • Kaplowitz, N., 2001. Drug-induced liver disorders: implications for drug development and regulation. Drug Safety, 24 (7), 483–490.
  • Kaplowitz, N., 2004. Drug-induced liver injury. Clinical Infectious Diseases, 38(Supplement2), S44–S48.
  • Konecny, G.E., et al., 2009. Activity of the multikinase inhibitor dasatinib against ovarian cancer cells. British Journal of Cancer, 101 (10), 1699–1708.
  • Lee, G.T., et al., 2013. Bone morphogenetic protein‐6 induces castration resistance in prostate cancer cells through tumor infiltrating macrophages. Cancer Science, 104 (8), 1027–1032.
  • Liu, C.W., et al., 2014. Snail regulates Nanog status during the epithelial–mesenchymal transition via the Smad1/Akt/GSK3β signaling pathway in non-small-cell lung cancer. Oncotarget, 5 (11), 3880.
  • Livak, K.J. and Schmittgen, T.D., 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2−ΔΔCT method. Methods, 25 (4), 402–408.
  • Loaeza-del-Castillo, A., et al., 2008. AST to platelet ratio index (APRI) for the noninvasive evaluation of liver fibrosis. Annals of Hepatology, 7 (4), 350–357.
  • Luch, A., et al., 1999. Metabolic activation of dibenzo [a,l] pyrene by human cytochrome P450 1A1 and P450 1B1 expressed in V79 Chinese hamster cells. Chemical Research in Toxicology, 12 (4), 353–364.
  • Marklund, S. and Marklund, G., 1974. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. European Journal of Biochemistry, 47 (3), 469–474.
  • McDermott, M.S., et al., 2017. Inhibition of CDK8 mediator kinase suppresses estrogen dependent transcription and the growth of estrogen receptor positive breast cancer. Oncotarget, 8 (8), 12558.
  • Mohedas, A.H., et al., 2013. Development of an ALK2-biased BMP type I receptor kinase inhibitor. ACS Chemical Biology, 8 (6), 1291–1302.
  • Paglia, D.E. and Valentine, W.N., 1967. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. The Journal of Laboratory and Clinical Medicine, 70 (1), 158–169.
  • Parkinson, A., 1996. Biotransformation of xenobiotics. In: C.D. Klaassen, ed. Casarett and Doull’s toxicology: the basic science of poisons. New York: McGraw-Hill, 113–186.
  • Paulo, D.V., Fontes, F.M., and Flores-Lopes, F., 2012. Histopathological alterations observed in the liver of Poecilia vivipara (Cyprinodontiformes: Poeciliidae) as a tool for the environmental quality assessment of the Cachoeira River, BA. Brazilian Journal of Biology, 72 (1), 131–140.
  • Poleksić, V. and Mitrović-Tutundžić, V., 1994. Fish gills as a monitor of sublethal and chronic effects of pollution. In: R. Muller and R. Lloyd, eds. Sublethal and chronic effects of pollutants on freshwater fish. Oxford: Fishing News Books, 339–352.
  • Qu, H., et al., 2016. Smad4 suppresses the tumorigenesis and aggressiveness of neuroblastoma through repressing the expression of heparanase. Scientific Reports, 6, 32628.
  • Rajaram, S., et al., 2017. BMP signaling regulates the skeletal and connective tissue differentiation during caudal fin regeneration in sailfin molly (Poecilia latipinna). Development, Growth & Differentiation, 59 (8), 629–638.,
  • Ramachandran, R. and Kakar, S., 2009. Histological patterns in drug-induced liver disease. Journal of Clinical Pathology, 62 (6), 481–492.
  • Robinson, K., et al., 2003. Case report: fatal cholestatic liver failure associated with gemcitabine therapy. Digestive Diseases and Sciences, 48 (9), 1804–1808.
  • Rodriguez-Frias, E.A. and Lee, W.M., 2007. Cancer chemotherapy I: hepatocellular injury. Clinics in Liver Disease, 11 (3), 641–662.
  • Schuetz, E.G., et al., 1993. Regulation of human liver cytochromes P‐450 in family 3A in primary and continuous culture of human hepatocytes. Hepatology, 18 (5), 1254–1262.,
  • Shapiro, M.A. and Lewis, J.H., 2007. Causality assessment of drug-induced hepatotoxicity: promises and pitfalls. Clinics in Liver Disease, 11 (3), 477–505.
  • Sharbidre, A.A., Metkari, V., and Patode, P., 2011. Effect of methyl parathion and chlorpyrifos on certain biomarkers in various tissues of guppy fish, Poecilia reticulata. Pesticide Biochemistry and Physiology, 101 (2), 132–141.
  • Shimada, T., et al., 1996. Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1. Cancer Research, 56 (13), 2979–2984.
  • Sinha, A.K., 1972. Colorimetric assay of catalase. Analytical Biochemistry, 47 (2), 389–394.
  • Vliegenthart, A.D., et al., 2014. Zebrafish as model organisms for studying drug-induced liver injury. British Journal of Clinical Pharmacology, 78 (6), 1217–1227.
  • Vogt, J., Traynor, R., and Sapkota, G.P., 2011. The specificities of small molecule inhibitors of the TGFss and BMP pathways. Cellular Signalling, 23 (11), 1831–1842.
  • Voorneveld, P.W., et al., 2013. Reduced expression of bone morphogenetic protein receptor IA in pancreatic cancer is associated with a poor prognosis. British Journal of Cancer, 109 (7), 1805–1812.
  • Vucicevic, L., et al., 2009. AMP-activated protein kinase-dependent and independent mechanisms underlying in vitro antiglioma action of compound C. Biochemical Pharmacology, 77 (11), 1684–1693.
  • Wang, C.J., et al., 2000. Protective effect of Hibiscus anthocyanins against tert-butyl hydroperoxide-induced hepatic toxicity in rats. Food and Chemical Toxicology, 38 (5), 411–416.,
  • Wang, K., et al., 2009. Circulating microRNAs, potential biomarkers for drug-induced liver injury. Proceedings of the National Academy of Sciences, 106 (11), 4402–4407.
  • Watanabe, T., et al., 2009. Dose-dependent alterations in gene expression in mouse liver induced by diethylnitrosamine and ethylnitrosourea and determined by quantitative real-time PCR. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 673 (1), 9–20.
  • Weber, G., Banerjee, G., and Bronstein, S.B., 1961. Role of enzymes in homeostasis III. Selective induction of increases of liver enzymes involved in carbohydrate metabolism. Journal of Biological Chemistry, 236 (12), 3106–3111.
  • Wolf, J.C. and Wolfe, M.J., 2005. A brief overview of nonneoplastic hepatic toxicity in fish. Toxicological Pathology, 33 (1), 75–85.
  • Yu, P.B., et al., 2008. Bone morphogenetic protein (BMP) type II receptor is required for BMP-mediated growth arrest and differentiation in pulmonary artery smooth muscle cells. Journal of Biological Chemistry, 283 (7), 3877.
  • Yuan, S.X., et al., 2016. BMP9/p38 MAPK is essential for the antiproliferative effect of resveratrol on human colon cancer. Oncology Reports, 35 (2), 939–947.
  • Zanger, U.M. and Schwab, M., 2013. Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. Pharmacology & Therapeutics, 138 (1), 103–141.
  • Zhang, J., Yang, P.L., and Gray, N.S., 2009. Targeting cancer with small molecule kinase inhibitors. Nature Reviews Cancer, 9 (1), 28–39.
  • Zimmerman, H. J., 1999. Hepatotoxicity: the adverse effects of drugs and other chemicals on the liver. USA: Lippincott Williams & Wilkins.

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