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Research Article

Inhibitory effect of chlormethiazole on the toxicokinetics of diethylnitrosamine in normal and hepatofibrotic rats

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Pages 600-607 | Received 15 Sep 2017, Accepted 24 Feb 2018, Published online: 12 Apr 2018

References

  • Abdelmegeed, M.A., et al., 2017. Cytochrome P450-2E1 promotes fast food-mediated hepatic fibrosis. Scientific Reports, 7, 39764.
  • Chang, W., et al., 2016. Protective effects of Celastrol on diethylnitrosamine-induced hepatocellular carcinoma in rats and its mechanisms. European Journal of Pharmacology, 784, 173–180.
  • Chen, Y.Y., et al., 2014. Inhibition of cytochrome P4502E1 by chlormethiazole attenuated acute ethanol-induced fatty liver. Chemico-Biological Interactions, 222, 18–26.
  • Ding, Y.F., et al., 2017. Hepatic inflammation-fibrosis-cancer axis in the rat hepatocellular carcinoma induced by diethylnitrosamine. Journal of Cancer Research and Clinical Oncology, 143 (5), 821–834.
  • Dinis-Oliveira, R.J., 2016. Oxidative and non-oxidative metabolomics of ethanol. Current Drug Metabolism, 17 (4), 327–335.
  • Eap, C.B., et al., 1998. Inhibition of CYP2E1 by chlormethiazole as measured by chlorzoxazone pharmacokinetics in patients with alcoholism and in healthy volunteers. Clinical Pharmacology & Therapeutics, 64 (1), 52–57.
  • Elsharkawy, A.M. and Mann, D.A., 2007. Nuclear factor-kappaB and the hepatic inflammation–fibrosis–cancer axis. Hepatology, 46 (2), 590–597.
  • Gao, J., et al., 2016. Changes in cytochrome P450s-mediated drug clearance in patients with hepatocellular carcinoma in vitro and in vivo: a bottom-up approach. Oncotarget, 7 (19), 28612–28623.
  • Gao, J., et al., 2017. High CYP2E1 activity correlates with hepatofibrogenesis induced by nitrosamines. Oncotarget, 8 (68), 112199–112210.
  • Gao, N., Zou, D., and Qiao, H.L., 2013. Concentration-dependent inhibitory effect of Baicalin on the plasma protein binding and metabolism of chlorzoxazone, a CYP2E1 probe substrate, in rats in vitro and in vivo. PLos One, 8 (1), e53038.
  • Gebhardt, A.C., et al., 1997. Chlormethiazole inhibition of cytochrome P450 2E1 as assessed by chlorzoxazone hydroxylation in humans. Hepatology, 26 (4), 957–961.
  • Gouillon, Z., et al., 2000. Inhibition of ethanol-induced liver disease in the intragastric feeding rat model by chlormethiazole. Proceedings of the Society for Experimental Biology and Medicine, 224 (4), 302–308.
  • Hacker, H.J., et al., 1991. Histochemical profile of mouse hepatocellular adenomas and carcinomas induced by a single dose of diethylnitrosamine. Cancer Research, 51 (7), 1952–1958.
  • Hu, Y., et al., 1994. Chlormethiazole as an efficient inhibitor of cytochrome P450 2E1 expression in rat liver. Journal of Pharmacology and Experimental Therapeutics, 269 (3), 1286–1291.
  • Il’nitskaya, S.I., et al., 2016. Stimulation of diethylnitrosamine metabolism reduces its general toxic and hepatocarcinogenic effects. Bulletin of Experimental Biology and Medicine, 162 (1), 98–101.
  • Imaida, K., et al., 1981. Dose responses of five hepatocarcinogens for the initiation of rat hepatocarcinogenesis. Cancer Letters, 14 (3), 279–283.
  • Jing, Y., et al., 2015. Aminotriazole alleviates acetaminophen poisoning via downregulating P450 2E1 and suppressing inflammation. PLos One, 10 (4), e0122781.
  • Kaledin, V.I., et al., 2015. Effect of hepatic P450 2e1 activity modulation on the toxicity and carcinogenicity of diethylnitrosamine in mice. Biofizika, 60 (6), 1166–1173.
  • Kang, J.S., et al., 2007. Role of CYP2E1 in diethylnitrosamine-induced hepatocarcinogenesis in vivo. Cancer Research, 67 (23), 11141–11146.
  • Lee, H.C., et al., 1999. Protective effect of chlormethiazole, a sedative, against acetaminophen-induced liver injury in mice. Korean Journal of Internal Medicine, 14 (2), 27–33.
  • Liu, J., et al., 2016. Inhibition of diethylnitrosamine-induced liver cancer in rats by Rhizoma paridis saponin. Environmental Toxicology and Pharmacology, 46, 103–109.
  • Lu, Y., et al., 2008. Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice. Hepatology (Baltimore, MD), 47 (5), 1483–1494.
  • Na, S., et al., 2017. The induction of cytochrome P450 2E1 by ethanol leads to the loss of synaptic proteins via PPARα down-regulation. Toxicology, 385, 18–27.
  • Santos, N.P., et al., 2012. Histology, bioenergetics and oxidative stress in mouse liver exposed to N-diethylnitrosamine. In Vivo (Athens, Greece), 26 (6), 921–929.
  • Seitz, H.K. and Wang, X.D., 2013. The role of cytochrome P450 2E1 in ethanol-mediated carcinogenesis. Sub-cellular Biochemistry, 67, 131–143.
  • Simi, A. and Ingelman-Sundberg, M., 1999. Post-translational inhibition of cytochrome P-450 2E1 expression by chlomethiazole in Fao hepatoma cells. Journal of Pharmacology and Experimental Therapeutics, 289 (2), 847–852.
  • Vandevrede, L., et al., 2014. Novel analogues of chlormethiazole are neuroprotective in four cellular models of neurodegeneration by a mechanism with variable dependence on GABA(A) receptor potentiation. British Journal of Pharmacology, 171 (2), 389–402.
  • Velasco-Loyden, G., et al., 2017. Cancer chemoprevention by an adenosine derivative in a model of cirrhosis-hepatocellular carcinoma induced by diethylnitrosamine in rats. Tumour Biology, 39 (2), 1010428317691190.
  • Wang, M., et al., 2016. An improved in vitro method for screening toxin and medicine targeting CYP2E1. Environmental Toxicology and Pharmacology, 47, 86–91.
  • Wang, Y., et al., 2009. Ethanol-induced cytochrome P4502E1 causes carcinogenic etheno-DNA lesions in alcoholic liver disease. Hepatology, 50 (2), 453–461.
  • Wilby, M.J. and Hutchinson, P.J., 2004. The pharmacology of chlormethiazole: a potential neuroprotective agent? CNS Drug Reviews, 10 (4), 281–294.
  • Ye, Q., et al., 2012. Cytochrome P450 2E1 inhibition prevents hepatic carcinogenesis induced by diethylnitrosamine in alcohol-fed rats. Hepatobiliary Surgery and Nutrition, 1 (1), 5–18.
  • Ye, Q., et al., 2013. Cytochrome P4502E1 inhibitor, chlormethiazole, decreases lipopolysaccharide-induced inflammation in rat Kupffer cells with ethanol treatment. Hepatology Research, 43 (10), 1115–1123.
  • Zhou, J., et al., 2016. Significant change of cytochrome P450s activities in patients with hepatocellular carcinoma. Oncotarget, 7 (31), 50612–50623.
  • Zimmers, T.A., et al., 2008. Effect of in vivo loss of GDF-15 on hepatocellular carcinogenesis. Journal of Cancer Research & Clinical Oncology, 134 (7), 753–759.

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