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Research Articles

Evaluation of the cytotoxic and genotoxic effects of mycotoxin fusaric acid

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Pages 149-157 | Received 03 Apr 2018, Accepted 06 Jul 2018, Published online: 11 Sep 2018

References

  • Abdul, N.S., Nagiah, S., and Chuturgoon, A.A., 2016. Fusaric acid induces mitochondrial stress in human hepatocellular carcinoma (HepG2) cells. Toxicon, 119, 336–344.
  • Ahmad, J., Alhadlaq, H.A., and Alshamsan, A., 2016. Differential cytotoxicity of copper ferrite nanoparticles in different human cells. Journal of Applied Toxicology, 36 (10), 1284–1293.
  • Aksoy, H., et al., 2008. Moniliformin Mikotoksininin in Vitro Genotoksik Etkileri. SAÜ Fen Edebiyat Dergisi, 10 (2), 1–14.
  • Ataseven, N., et al., 2016. Genotoxicity of monosodium glutamate. Food and Chemical Toxicology, 91, 8–18.
  • Bacon, C.W., Porter, J.K., and Norred, W.P., 1995. Toxic interaction of fumonisin B1 and fusaric acid measured by injection into fertile chicken egg. Mycopathologia, 129 (1), 29–35.
  • Bacon, C.W., et al., 1996. Production of fusaric acid by Fusarium species. Applied and Environmental Microbiology, 62 (11), 4039–4043.
  • Behm, C., Degen, G.H., and Föllmann, W., 2009. The Fusarium toxin enniatin B exerts no genotoxic activity, but pronounced cytotoxicity in vitro. Molecular Nutrition & Food Research, 53 (4), 423–430.
  • Binder, E.M., 2007. Managing the risk of mycotoxins in modern feed production. Animal Feed Science and Technology, 133 (1–2), 149–166.
  • CAST 2003. Mycotoxins: Risks in plant, animal and human systems (Report No. 139). Ames, IA: Council for Agricultural Science and Technology.
  • Çelik, M., Aksoy, H., and Yılmaz, S., 2010. Evaluation of beauvericin genotoxicity with the chromosomal aberrations, sister-chromatid exchanges and micronucleus assays. Ecotoxicology and Environmental Safety, 73 (7), 1553–1557.
  • Cetin, Y., and Bullerman, L.B., 2005. Cytotoxicity of Fusarium mycotoxins to mammalian cell cultures as determined by the MTT bioassay. Food and Chemical Toxicology , 43 (5), 755–764.
  • Collins, A.R., 2015. The comet assay: a heavenly method! Mutagenesis, 30 (1), 1–4.
  • Dąbrowski, M., et al., 2016. Changes in the subpopulations of porcine peripheral blood lymphocytes induced by exposure to low doses of zearalenone (ZEN) and deoxynivalenol (DON). Molecules, 21 (5), 557.
  • Dhani, S., et al., 2017. Fusaric Acid immunotoxicity and MAPK activation in normal peripheral blood mononuclear cells and Thp-1 cells. Scientific Reports, 7 (1), 3051
  • De Nijs, M., Rombouts, F., and Notermans, S., 1996. Fusarium molds and their mycotoxins. Journal of Food Safety, 16 (1), 15–58.
  • Doak, S. H., Liu, Y., and Chen, C., 2012. Genotoxicity and cancer. In: B. Fadeel, A. Pietroiusti, and A.A. Shvedova, eds. Adverse effects of engineered nanomaterials. Boston USA: Academic Press, 243–261.
  • Eroğlu, Y., Eroğlu, H.E., and Ilbas, A.I., 2007. Gamma ray reduces mitotik index in embriyonic roots of Hordeum vulgare L. Advanced Biomedical Research, 1 (1–2), 26–28.
  • Evans, H. J., 1984. Human peripheral blood lymphocytes for the analysis of chromosome aberrations in mutagentests in mutagen tests. In: B.J. Kilbey, M. Legator, W. Nichols, C. Ramel, eds. Handbook of mutagenicity test procedures. Amsterdam: Elsevier Science Publishers, 405–427.
  • Fei, C., et al., 2015. Safety evaluation of a triazine compound nitromezuril by assessing bacterial reverse mutation, sperm abnormalities, micronucleus and chromosomal aberration. Regulatory Toxicology and Pharmacology, 71 (3), 585–589.
  • Fenech, M., 2000. The in vitro micronucleus technique. Mutation Research, 455 (1–2), 81–95.
  • Fernandez-Pol, J.A., Klos, D.J., and Hamilton, P.D., 1993. Cytotoxic activity of fusaric acid on human adenocarcinoma cells in tissue culture. Anticancer Research, 13 (1), 57–64.
  • Gaumann, E., 1957. Fusaric acid as a wilt toxin. Phytopathology, 47, 342–357.
  • Ghazi, T., et al., 2017. Fusaric acid induces DNA damage and post-translational modifications of p53 in human hepatocellular carcinoma (HepG2) cells. Journal of Cellular Biochemistry, 118 (11), 3866–3874.
  • Jaglowski, J.R., and Stack, B.C., 2006. Enhanced growth inhibition of squamous cell carcinoma of the head and neck by combination therapy of fusaric acid and paclitaxel or carboplatin. Cancer Letters, 243 (1), 58–63.
  • Jestoi, M., 2008. Emerging Fusarium-mycotoxins fusaproliferin, beauvericin, enniatins, and moniliformin-A. Critical Reviews in Food Science and Nutrition, 48 (1), 21–49.
  • Kirsch-Volders, M., et al., 2011. The in vitro MN assay in 2011: origin and fate, biological significance protocols, high throughput methodologies and toxicological relevance. Archives of Toxicology, 85 (8), 873–899.
  • Klaric, M.S., et al., 2010. Beauvericin and ochratoxin A genotoxicity evaluated using the alkaline comet assay: single and combined genotoxic action. Archives of Toxicology, 84 (8), 641–650.
  • Langie, S.A.S., Azqueta, A., and Collins, A.R., 2015. The comet assay: past, present, and future. Frontiers in Genetics, 6, 266
  • Lorenzi, D., L., et al., 2005. Genotoxic activity of the Fumonisin B1 mycotoxin in cultures of bovine lymphocytes. Italian Journal of Animal Science, 4 (4), 395–402.
  • Mamur, S., et al., 2010. Does potassium sorbate induce genotoxic or mutagenic effects in lymphocytes? Toxicology in Vitro, 24 (3), 790–794.
  • Mamur, S., et al., 2016. DNA damage in hemodialysis patients with chronic kidney disease; a test of the role of diabetes mellitus; a comet assay investigation. Mutation Research, 800-801, 22–27.
  • Mezes, M., 2008. Mycotoxins and other contaminants in rabbit feeds. Nutrition and digestive physiology. 9th World Rabbit Congress. 10–13 June, Verona, Italy.
  • Mosmann, T., 1983. Rapid colometric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. Journal of Immunological Methods, 65 (1–2), 55–63.
  • Mourelatos, D., 2016. Sister chromatid exchange assay as a predictor of tumor chemoresponse. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 803–804, 1–12.
  • Nguyen, P.-A., et al., 2017. Crop molds and mycotoxins: alternative management using biocontrol. Biological Control, 104, 10–27.
  • Ogata, S., et al., 2001. Apoptosis induced by picolinic acid-related compounds in HL-60 cells. Bioscience, Biotechnology, and Biochemistry, 65 (10), 2337–2233.
  • Palus, J., et al., 2003. Genotoxic effects of occupational exposure to lead and cadmium. Mutation Research, 540 (1), 19–28.
  • Perry, P. E., and Thompson, E. J., 1984. The methodology of sister chromatid exchanges. In: B.J. Kilbey, M. Legator, W. Nichols, C. Ramel, eds. Handbook of mutagenicity test procedures. Amsterdam: Elsevier Science Publishers, 495–529.
  • Porter, J.K., et al., 1995. Fusaric acid in Fusarium moniliforme cultures, corn, and feeds toxic to livestock and the neurochemical effects in the brain and pineal gland of rats. Natural Toxins, 3 (2), 91–100.
  • Porter, J.K., et al., 1996. Lactational passage of fusaric acid from the feed of nursing dams to the neonate rat and effects on pineal neurochemistry in the F1 and F2 generations at weaning. Journal of Toxicology and Environmental Health, 49 (2), 161–175.
  • Prosperini, A., et al., 2012. Study of the cytotoxic activity of beauvericin and fusaproliferin and bioavailability in vitro on Caco-2 cells. Food and Chemical Toxicology, 50 (7), 2356–2361.
  • Ruiz, M.J., et al., 2011. Toxicological interactions between the mycotoxins beauvericin, deoxynivalenol and T-2 toxin in CHO-K1 cells in vitro. Toxicon, 58 (4), 315–326.
  • Reddy, R.V., et al., 1996. Developmental toxic effects of fusaric acid in CD1 mice. Bulletin of Environmental Contamination and Toxicology, 57 (3), 354–360.
  • Riss, T.L., et al., 2016. Cell viability assays. Assay guidance manual. Bethesda, MD: Eli Lilly & Company and the National Center for Anvancing Translational Sciences, 1–31.
  • Rocha, M.E.B., et al., 2014. Mycotoxins and their effects on human and animal health. Food Control, 36 (1), 159–165.
  • Ruda, J.M., et al., 2006. The effect of single agent oral fusaric acid (FA) on the growth of subcutaneously xenografted SCC-1 cells in a nude mouse model. Investigational New Drugs, 24 (5), 377–381.
  • Ruyck, K.D., et al., 2015. Dietary mycotoxins, co-exposure, and carcinogenesis in humans: short review. Mutation Research, 766, 32–41.
  • Samadi, L., and Behboodi, B.S., 2006. Fusaric acid induces apoptosis in saffron root-tip cells: roles of caspase-like activity, cytochrome c, and H2O2. Planta, 225 (1), 223–234.
  • Schneider, E.L., et al., 1981. Simultaneous examination of sister-chromatid exchanges and cell replication kinetics in tumor and normal cells in vivo. Cancer Research, 41, 4973–4975.
  • Singh, N.P., et al., 1988. A simple technique forquantitation of low levels of DNA damage in individual cells. Experimental Cell Research, 175 (1), 184–191.
  • Speit, G., and Houpter, S., 1985. On the mechanism of differential Giemsa staining of Bromodeoxyuridine substitute chromosomes. II. Differences between the demonstration of sister chromatid differentiation and replication patterns. Human Genetics, 70 (2), 126–129.
  • Stack, B.C., Jr., et al., 2014. Determination of oral bioavailability of fusaric acid in male Sprague-Dawley rats. Drugs in R&D, 14 (2), 139–145.
  • Stanciu, O., et al., 2017. Occurrence and co-occurrence of Fusarium mycotoxins in wheat grains and wheat flour from Romania. Food Control, 73, 147–155.
  • Stankovic, S., et al., 2007. Pathogenicity and mycotoxin production by Fusarium proliferatum isolated from onion and garlic in Serbia. European Journal of Plant Pathology, 118 (2), 165–172.
  • Stoev, S., et al., 2009. Cytotoxic effect of some mycotoxins and their combinations on human peripheral blood mononuclear cells as measured by the MTT assay. The Open Toxinology Journal, 2 (1), 1–8.
  • Surrallés, J., et al., 1995. Induction of micronuclei by five pyrethroid insecticides in whole blood and isolated human lymphocytes cultures. Mutation Research, 341 (3), 169–184.
  • Turner, N.W., et al., 2015. Analytical methods for determination of mycotoxins: an update (2009–2014). Analytica Chimica Acta, 901, 12–33.
  • Vesonder, R.F., Gasdorf, H., and Peterson, R.E., 1993. Comparison of the cytotoxicities of Fusarium metabolites and Alternaria metabolite AAL-toxin to cultured mammalian cell lines. Archives of Environmental Contamination and Toxicology, 24 (4), 473–477.
  • Voss, K.A., et al., 1999. Fusaric acid and modification of the subchronic toxicity to rats of fumonisins in F. moniliforme culture material. Food and Chemical Toxicology, 37 (8), 853–861.
  • Ware, L.Y., et al., 2017. Occurrence of mycotoxins in commercial infant formulas locally produced in Ouagadougou (Burkina Faso). Food Control, 73, 518–523.
  • Wood, G.E., 1992. Mycotoxins in foods and feeds in the United States. Journal of Animal Science, 70 (12), 3941–3948.
  • Wu, F., Groopman, J.D., and Pestka, J.J., 2014. Public health impacts of foodborne mycotoxins. Annual Review of Food Science and Technology, 5, 351–372.
  • Wu, H.S., et al., 2008. Effect of fusaric acid on biomass and photosynthesis of watermelon seedlings leaves. Caryologia, 61 (3), 258–268.
  • Yabuta, T., Kambe, K., and Hayashi, T., 1937. Biochemistry of the bakanaefungus. I. Fusarinic acid, a new product of the bakanae fungus. Journal of the Chemical Society, 10, 1059–1068.
  • Ye, J., Montero, M., and Stack, B.C., Jr, 2013. Effects of fusaric acid treatment on HEp2 and docetaxel-resistant HEp2 laryngeal squamous cell carcinoma. Chemotherapy, 59 (2), 121–128.
  • Yılmaz, S., et al., 2014. Evaluation of the genotoxicity of clomiphene citrate. Mutation Research. Genetic Toxicology and Environmental Mutagenesis, 759, 21–27.
  • Yüzbaşıoğlu, D., et al., 2006. Clastogenicity of the fungicide afugan in cultured human lymphocytes. Mutation Research, 604 (1–2), 53–59.
  • Zain, M.E., 2011. Impact of mycotoxins on humans and animals. Journal of Saudi Chemical Society, 15 (2), 129–144.
  • Zouaoui, N., et al., 2016. Cytotoxic effects induced by patulin, sterigmatocystin and beauvericin on CHO-K1 cells. Food and Chemical Toxicology, 89, 92–103.

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