The evaluation of anti-breast cancer activity and safety pharmacology of the ethanol extract of Aralia elata Seem. leaves

References

• Akram, M., et al., 2017. Awareness and current knowledge of breast cancer. Biological Research, 50 (1), 33.
   PubMed Web of Science ®Google Scholar
• Anampa, J., Makower, D., and Sparano, J.A., 2015. Progress in adjuvant chemotherapy for breast cancer: an overview. BMC Medicine, 13, 195.
   PubMed Web of Science ®Google Scholar
• Bae, J.-W., et al., 2015. Characterizing the human equivalent dose of herbal medicines in animal toxicity studies. Journal of Ethnopharmacology, 162, 1–6.
   PubMed Web of Science ®Google Scholar
• Boér, K., 2010. Adjuvant chemotherapy of early stage breast cancer. Orvosi Hetilap, 151 (9), 344–353.
   PubMedGoogle Scholar
• CFDA, 2014. Technical guidelines of safety pharmacological study for Chinese medicine and natural drugs. Beijing CFDA Guidelines For the Evaluation of Drug, 3–4. Available from: http://samr.cfda.gov.cn/WS01/CL1616/101015.html
   Google Scholar
• Chang, H., et al., 2017. Increased central dopaminergic activity might be involved in the behavioral abnormality of cuprizone exposure mice. Behavioural Brain Research, 331, 143–150.
   PubMed Web of Science ®Google Scholar
• Cho, Y.J., et al., 2016. Eclalbasaponin II induces autophagic and apoptotic cell death in human ovarian cancer cells. Journal of Pharmacological Sciences, 132 (1), 6–14.
   PubMed Web of Science ®Google Scholar
• Demirci, D., et al., 2014. Sildenafil enhances locomotor activity in young mice and exerts anxiogenic effects in both young and aged mice. Medical Science Monitor Basic Research, 20, 15–21.
   PubMedGoogle Scholar
• Gülçin, I., et al., 2006. The antioxidant activity of a triterpenoid glycoside isolated from the berries of Hedera colchica: 3-O-(beta-d-glucopyranosyl)-hederagenin. Phytotherapy Research: PTR, 20 (2), 130–134.
   PubMed Web of Science ®Google Scholar
• HogenEsch, H. and Nikitin, A.Y., 2012. Challenges in pre-clinical testing of anti-cancer drugs in cell culture and in animal models. Journal of Controlled Release, 164 (2), 183–186.
   PubMed Web of Science ®Google Scholar
• Jemal A., et al., 2011. Global cancer statistics. CA-A Cancer Journal for Clinicians, 61 (2), 69–90.
   PubMed Web of Science ®Google Scholar
• Kim, Y.S., et al., 2017. Aralia elata (Miq) seem extract decreases o-GlcNAc transferase expression and retinal cell death in diabetic mice. Journal of Medicinal Food, 20 (10), 989–1001.
   PubMed Web of Science ®Google Scholar
• Kinter, L.B. and Valentin, J., 2002. Safety pharmacology and risk assessment. Fundamental and Clinical Pharmacology, 16 (3), 175–182.
   PubMed Web of Science ®Google Scholar
• Kuang, H.X., et al., 2013. Triterpene glucosides from the leaves of Aralia elata and their cytotoxic activities. Chemistry & Biodiversity, 10 (4), 703–710.
   PubMed Web of Science ®Google Scholar
• Lee, S., Christakos, S., and Small, M.B., 1993. Apoptosis and signal transduction: clues to a molecular mechanism. Current Opinion in Cell Biology, 5 (2), 286–291.
   PubMed Web of Science ®Google Scholar
• Li, F-J., et al., 2013. Total saponins from leaves of Aralia elata seem exhibit antitumor effects on human breast cancer in vitro and vivo. Chinese Pharmacological Bulletin, 29 (12), 1663–1667.
   Google Scholar
• Li, F.J., et al., 2015. Acute and sub-chronic toxicity study of the ethanol extract from leaves of Aralia elata in rats. Journal of Ethnopharmacology, 175, 499–508.
   PubMed Web of Science ®Google Scholar
• Li, F.J., et al., 2016. Sub-chronic safety evaluation of the ethanol extract of Aralia elata leaves in beagle dogs. Regulatory Toxicology and Pharmacology, 79, 1–11.
   PubMed Web of Science ®Google Scholar
• Liu, G., et al., 2016. A polysaccharide from the leaves of Aralia elata induces apoptosis in U-2 OS cells via mitochondrial-dependent pathway. International Journal of Biological Macromolecules, 93 (Pt A), 418–425.
   PubMed Web of Science ®Google Scholar
• Liu, X.L., et al., 2019. Vitexin induces apoptosis through mitochondrial pathway and PI3K/Akt/mTOR signaling in human non-small cell lung cancer A549 cells. Biological Research, 52 (1), 7.
   PubMed Web of Science ®Google Scholar
• Luo, Y., et al., 2015. Total aralosides of Aralia elata (Miq) seem (TASAES) ameliorate nonalcoholic steatohepatitis by modulating IRE1α-mediated JNK and NF-κB pathways in ApoE–/– mice. Journal of Ethnopharmacology, 163, 241–250.
   PubMed Web of Science ®Google Scholar
• New Medical College of Jiangsu, ed., 1977. Dictionary of Chinese Materia Medica. Shanghai: Shanghai Scientific and Technological Publishing, 2583.
   Google Scholar
• Qi, F., et al., 2010. Cinobufacini, an aqueous extract from Bufo bufo gargarizans Cantor, induces apoptosis through a mitochondria-mediated pathway in human hepatocellular carcinoma cells. Journal of Ethnopharmacology, 128 (3), 654–661.
   PubMed Web of Science ®Google Scholar
• Qi, F., et al., 2012. Induction of apoptosis by cinobufacini preparation through mitochondria- and fas-mediated caspase-dependent pathways in human hepatocellular carcinoma cells. Food and Chemical Toxicology, 50 (2), 295–302.
   PubMed Web of Science ®Google Scholar
• Saito, S., et al., 1993. Comparison of cytoprotective effects of saponins isolated from leaves of Aralia elata Seem. (Araliaceae) with synthesized bisdesmosides of oleanoic acid and hederagenin on carbon tetrachloride-induced hepatic injury. Chemical & Pharmaceutical Bulletin, 41 (8), 1395–1401.
   PubMed Web of Science ®Google Scholar
• SFDA, 2014. Technical guidelines of safety pharmacology studies for traditional Chinese medicine, natural drugs and chemical drugs. Beijing. SFDA Guidelines for Evaluation of Drugs, 1–8.
   Google Scholar
• Shapiro, C.L. and Recht, A., 2001. Side effects of adjuvant treatment of breast cancer. The New England Journal of Medicine, 344 (26), 1997–2008.
   PubMed Web of Science ®Google Scholar
• Shikov, A.N., et al., 2014. Medicinal plants of the Russian pharmacopoeia; their history and applications. Journal of Ethnopharmacology, 154 (3), 481–536.
   PubMed Web of Science ®Google Scholar
• Shikov, A.N., et al., 2016. Aralia elata var. mandshurica (Rupr. & Maxim.) J.Wen: an overview of pharmacological studies. Phytomedicine, 23 (12), 1409–1421.
   PubMed Web of Science ®Google Scholar
• Tagousop, C.N., et al., 2018. Antimicrobial activities of saponins from Melanthera elliptica and their synergistic effects with antibiotics against pathogenic phenotypes. Chemistry Central Journal, 12 (1), 97–108.
   PubMedGoogle Scholar
• Varricchi, G., et al., 2018. Antineoplastic drug-induced cardiotoxicity: a redox perspective. Frontiers in Physiology, 9, 167.
   PubMed Web of Science ®Google Scholar
• Wang, M., et al., 2014. Effect of the total saponins of Aralia elata (Miq) Seem on cardiac contractile function and intracellular calcium cycling regulation. Journal of Ethnopharmacology, 155 (1), 240–247.
   PubMed Web of Science ®Google Scholar
• Wang, R.Y., et al., 2018. Total saponins of Aralia elata (Miq) seem alleviate calcium homeostasis imbalance and endoplasmic reticulum stress related apoptosis induced by myocardial ischemia/reperfusion injury. Cellular Physiology and Biochemistry, 50 (1), 28–40.
   PubMed Web of Science ®Google Scholar
• Wang, W., et al., 2018a. Eclalbasaponin I from Aralia elata (Miq.) Seem. reduces oxidative stress-induced neural cell death by autophagy activation. Biomedicine & Pharmacotherapy, 97, 152–161.
   PubMed Web of Science ®Google Scholar
• Ward, G., et al., 2012. Comparison of non-invasive and implanted telemetric measurement of blood pressure and electrocardiogram in conscious beagle dogs. Journal of Pharmacological and Toxicological Methods, 66 (2), 106–113.
   PubMed Web of Science ®Google Scholar
• Xi, S.G., et al., 2009. Protective effect of total aralosides of Aralia elata (Miq) Seem (TASAES) against diabetic cardiomyopathy in rats during the early stage, and possible mechanisms. Experimental and Molecular Medicine, 41 (8), 538–547.
   PubMed Web of Science ®Google Scholar
• Yang, H., et al., 2017. Anticancer activity in vitro and biological safety evaluation in vivo of Sika deer antler protein. Journal of Food Biochemistry, 41 (6), e12421.
   Web of Science ®Google Scholar
• Yimam, M., et al., 2016. Effect of a botanical composition, up446, on respiratory, cardiovascular and central nervous systems in beagle dogs and rats. Regulatory Toxicology and Pharmacology, 77, 184–191.
   PubMed Web of Science ®Google Scholar
• Yin, L.Y., et al., 2017. Effects of ETS on apoptosis of human colorectal cancer ht-29 cells. Chinese Journal of Information on TCM, 24, 49–52.
   Google Scholar
• Yin, L.Y., et al., 2018. Effect of total saponins in Aralia elata leaves on TLR-4/NF-κB signal pathway and inflammatory factors in xenografts from nude mice bearing human colon cancer cells. Chinese Journal of Experimental Traditional Medical Formulae, 24 (24), 152–157.
   Google Scholar
• Yongming, P., et al., 2015. Involvement of peroxisome proliferator-activated receptors in cardiac and vascular remodeling in a novel minipig model of insulin resistance and atherosclerosis induced by consumption of a high-fat/cholesterol diet. Cardiovascular Diabetology, 14 (1), 6.
   PubMed Web of Science ®Google Scholar
• Yook, C.S., 1981. Medicinal plants of Korea. Seoul: Jinmyung Publ. Co., Ltd., 272.
   Google Scholar
• Yu, S., et al., 2018. Gigantol inhibits wnt/β-catenin signaling and exhibits anticancer activity in breast cancer cells. BMC Complementary and Alternative Medicine, 18, 59.
   PubMed Web of Science ®Google Scholar
• Zang, Y., 2012. Studies on the constituents and cytotoxic activities of Aralia elata leaves. Doctorate dissertation. Shenyang Pharmaceutical University, China (in Chinese).
   Google Scholar
• Zhang, Y., et al., 2018. Triterpene saponins with a-glucosidase and PTP1B inhibitory activities from the leaves of Aralia elata. Phytochemistry Letters, 26, 197–183.
   Web of Science ®Google Scholar
• Zhou, X.Y., et al., 2017. Safety pharmacology and subchronic toxicity of jinqing granules in rats. BMC Veterinary Research, 13 (1), 179–191.
   PubMed Web of Science ®Google Scholar