122
Views
17
CrossRef citations to date
0
Altmetric
Research Article

Fluted pumpkin seeds protect against busulfan-induced oxidative stress and testicular injuries in adult mice

, , &
Pages 22-32 | Received 05 May 2019, Accepted 04 Aug 2019, Published online: 30 Aug 2019

References

  • Abarikwu, S.O., 2014. Protective effect of quercetin on atrazine induced oxidative stress in the liver, kidney, brain, and heart of adult Wistar rats. Toxicology International, 21(2), 148–155.
  • Abarikwu, S.O., et al., 2012a. Rutin ameliorates cyclophosphamide-induced reproductive toxicity in male rats. Toxicology International, 19(2), 207–214.
  • Abarikwu, S.O., et al., 2017a. Oral administration of Moringa oleifera oil but not coconut oil prevents mercury-induced testicular toxicity in rats. Andrologia, 49(1), e12597.
  • Abarikwu, S.O., et al., 2017b. Rutin, an antioxidant flavonoid, induces glutathione and glutathione peroxidase activities to protect against ethanol effects in cadmium-induced oxidative stress in the testis of adult rats. Andrologia, 49(7), e12696.
  • Abarikwu, S.O., et al., 2019. Effect of Fe and Cd co-exposure on testicular steroid metabolism, morphometry, and spermatogenesis in mice. Biological Trace Element Research, 190(1), 109–123.
  • Abarikwu, S.O., Farombi, E.O., and Pant, A.B., 2012b. Kolaviron biflavanoids of Garcinia kola seeds protect atrazine-induced cytotoxicity in primary cultures of rat Leydig cells. International Journal of Toxicology, 31(4), 407–415.
  • Abu-soud, H., and Hazen, S.L., 2000. Nitric oxide modulates the catalytic activity of myeloperoxidase. Journal of Biological Chemistry, 275(8), 5425–5430.
  • Aghaei, S., et al., 2014. Protective effect of pumpkin seed extract on sperm characteristics, biochemical parameters and epididymal histology in adult male rats treated with cyclophosphamide. Andrologia, 46(8), 927–935.
  • Ahar, N.H., et al., 2014. The effect of busulfan on body weight, testis weight and MDA enzymes in male rats. International Journal of Women’s Health and Reproduction Sciences, 2 (5), 316–319.
  • Akang, E., et al., 2011. Telfairia occidentalis, a prophylactic medicine for alcohol’s damaging effect on the testis. Macedonian Journal of Medical Sciences, 4(4), 380–387.
  • Akang, E.N., et al., 2015. Histomorphometric studies of the effects of Telfairia occidentalis on alcohol-induced gonado-toxicity in male rats. Toxicology Reports, 2, 968–975.
  • Alada, A.R.A., 2000. The haematological effects of Telfairia occidentalis diet preparation. African Journal of Biomedical Research, 3, 185–186.
  • Anjum, S., Krishna, A., and Tsutsui, K., 2014. Inhibitory roles of the mammalian GnIH ortholog RFRP3 in testicular activities in adult mice. The Journal of Endocrinology, 223(1), 79–91.
  • Atanassova, N., et al., 1999. Permanent effects of neonatal estrogen exposure in rats on reproductive hormone levels, Sertoli cell number and the efficiency of spermatogenesis in adulthood. Endocrinology, 140(11), 5364–5373.
  • Azu, O.O., et al., 2014. Testicular histomorphologic and stereological alterations following short-term treatment with highly active antiretroviral drugs (HAART) in an experimental animal model. Andrology, 2(5), 772–779.
  • Baker, P.J., and O’Shaughnessy, P.J., 2001. Role of gonadotrophins in regulating numbers of Leydig and Sertoli cells during fetal and postnatal development in mice. Reproduction, 122, 227–234.
  • Berndtson, W.E., 1977. Methods for quantifying mammalian spermatogenesis: A review. Journal of Animal Science, 44(5), 818–883.
  • Chance, B., and Maehly, A.C., 1955. Assay of catalases and peroxidases. Methods in Enzymology, 2, 764–775.
  • Chi, H., et al., 2013. Effect of genistein administration on the recovery of spermatogenesis in the busulfan-treated rat testis. Clinical and Experimental Reproductive Medicine, 40(2), 60–66.
  • Clouthier, D.E., et al., 1996. Rat spermatogenesis in mouse testis. Nature, 381(6581), 418–421.
  • Cunha, L.C.S., et al., 2013. Chemical composition, cytotoxic and antimicrobial activity of essential oils from Cassia bakeriana Craib against aerobic and anaerobic oral pathogens. Molecules, 18(4), 4588–4598.
  • Dada, A.A., and Ejete-Iroh, V.C., 2015. Dietary fluted pumpkin (Telfairia occidentalis) improves reproductive índices in male African catfish (Clarias gariepinus) broodstock. Journal of Agricultural Science, 7(7), 228–234.
  • Eseyin, O.A., et al., 2018. Phytochemical analysis and antioxidant activity of the seed of Telfairia occidentalis Hook (Cucurbitaceae). Natural Product Research, 32(4), 444–447.
  • Gauthaman, K., Adaikan, P.G., and Prasad, R.N., 2002. Aphrodisiac properties of Tribulus Terrestris extract (Protodioscin) in normal and castrated rats. Life Sciences, 71(12), 1385–1396.
  • Gbile, Z. O., 1986. Ethnobotany, taxonomy and conservation of medicinal plants. In: E.A. Sofowora, ed. The State of Medicinal Plants Research in Nigeria. Ibadan, University of Ibadan Press, 13–29.
  • Ghobadi, E., et al., 2017. The mechanisms of cyclophosphamide-induced testicular toxicity and the protective agents. Expert Opinion on Drug Metabolism & Toxicology, 13(5), 525–536.
  • Habig, W.H., Pabst, M.J., and Jakoby, W.B., 1974. Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. Journal of Biological Chemistry, 249(22), 7130–7139.
  • Ji, M., et al., 2007. Effect of protopanaxatriol saponin on spermatogenic stem cell survival in busulfan-treated male mice. Reproductive Medicine and Biology, 6(2), 99–108.
  • Jiang, F.X., 1998. Behaviour of spermatogonia following recovery from busulfan treatment in the rat. Anatomy and Embryology, 198(1), 53–61.
  • Johnsen, S.G., 1970. Testicular biopsy score count – a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males. Hormone Research in Paediatrics, 1, 2–25.
  • Jung, S.W., et al., 2015. Effects of Korean Red Ginseng extract on busulfan-induced dysfunction of the male reproductive system. Journal of Ginseng Research, 39(3), 243–249.
  • Karashima, T., Zalatnai, A., and Schally, A.V., 1988. Protective effects of analogs of luteinizing hormone-releasing hormone against chemotherapy-induced testicular damage in rats. Proceedings of the National Academy of Sciences of Sciences, 85(7), 2329–2333.
  • Karstens, A., and Kramer, I., 2007. Chemical and physical stability of diluted busulfan infusion solutions. European Journal of Hospital Pharmacy, 13, 40–47.
  • Kayode, A.A.A., and Kayode, O.T., 2011. Some medicinal values of Telfairia occidentalis: A review. American Journal of Biochemistry and Molecular Biology, 1, 30–38.
  • Li, R., et al., 2016. The protective effects of melatonin against oxidative stress and inflammation induced by acute cadmium exposure in mice testis. Biological Trace Element Research, 170(1), 152–164.
  • Lowry, O.H., et al., 1951. Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry, 193(1), 265–275.
  • Mandarim-de-Lacerda, C.A., Fernandes-Santos, C., and Aguila, M.B., 2010. Image analysis and quantitative morphology. Methods in Molecular Biology, 611, 211–225.
  • Molineux, G., et al., 1986. An analysis of haemopoietic and micro environmental populations of mouse bone marrow after treatment with busulphan. Biomedicine and Pharmacotherapy, 40, 215–220.
  • Nelson, S.K., et al., 2006. The induction of human superoxide dismutase and catalase in vivo: a fundamentally new approach to antioxidant therapy. Free Radical Biology and Medicine, 40(2), 341–347.,
  • Nwangwa, E.K., et al., 2006. Testicular regenerative effects induced by the extract of Telfairia occidentalis in rats. Caderno de Pesquisa, Série Biology, 19, 27.
  • Ohkawa, H., Ohishi, N., and Yagi, K., 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analytical Biochemistry, 95(2), 351–358.
  • Oremosu, A.A., et al., 2013. Post-treatment with Telfairia occidentalis seed oil attenuates alcohol-induced testicular damage in Sprague Dawley rats. Iranian Journal of Reproductive Medicine, 11, 637–646.
  • Rebourcet, D., et al., 2014. Sertoli cells maintain Leydig cell number and peritubular myoid cell activity in the adult mouse testis. PLoS One, 9(8), e105687.
  • Reznikov, A., 1990. Feedback control of gonadotropin secretion in mammalian and human males: effects of gonadotropin receptor blockers. Endocrinology Experimental, 24, 267–273.
  • Ribeiro, C.T., et al., 2014. Effect of antioxidants on outcome of testicular torsion in rats of different ages. The Journal of Urology, 191(5 Suppl), 1578–1584.
  • Rotruck, J.T., et al., 1973. Selenium: biochemical role as a component of glutathione peroxidase. Science, 179(4073), 588–590.
  • Saalu, L.C., et al., 2010. The dose-dependent testiculoprotective and testiculotoxic potentials of Telfairia occidentalis hook f. leaves extract in rat. International Journal of Applied Research in Natural Products, 3, 27–38.
  • Salman, M.T., Olayaki, L.A., and Oyeyemi, W.A., 2008. Aqueous extract of Telfairia occidentalis leaves reduces blood sugar and increases haematological and reproductive indices in male rats. African Journal of Biotechnology, 7, 2299–2303.
  • Sedlak, J., and Lindsay, R.H., 1968. Estimation of total protein-bound and non-protein sulfhydryl groups in tissue with Ellman’s reagent. Analytical Biochemistry, 25, 192–205.
  • Shah, A.S., and Juvekar, A.R., 2010. In vitro and in vivo immunostimulatory activity of Woodfordia fruticos flowers on non-specific immunity. Pharmaceutical Biology, 48(9), 1066–1072.
  • Shuttlesworth, G.A., et al., 2000. Enhancement of A spermatogonial proliferation and differentiation in irradiated rats by GnRH antagonist administration. Endocrinology, 141(1), 37–49.
  • Simone, C.B., 2nd., et al., 2007. Antioxidants and other nutrients do not interfare with chemotherapy or radiation therapy and can increase kill and increase survival, Part 1. Alternative Therapies Health and Medicine, 13, 22–28.
  • Singh, M.P., Jakhar, R., and Kang, S.C., 2015. Morin hydrate attenuates the acrylamide-induced imbalance in antioxidant enzymes in a murine model. International Journal of Molecular Medicine, 36(4), 992–1000.
  • Skurikhin, E.G., et al., 2017. Regenerative potential of stem and progenitor cells from ischemic testes of C57Bl/6 mice in culture and in the model of spermatogenesis suppression caused by busulfan. Bulletin of Experimental Biology and Medicine, 162(3), 400–405.
  • Sravan Kumar, S., Manoj, P., and Giridhar, P., 2015. Fourier transform infrared spectroscopy (FTIR) analysis, chlorophyll content and antioxidant properties of native and defatted foliage of green leafy vegetables. Journal of Food Science and Technology, 52, 8131–8139.
  • Suzuki, K., et al., 1983. Assay method for myeloperoxidase in human polymorphonuclear leukocytes. Analytical Biochemistry, 132(2), 345–352.
  • Tempest, H.G., et al., 2008. Plants used in Chinese medicine for the treatment of male infertility possess antioxidant and anti-oestrogenic activity. Systems Biology in Reproductive Medicine, 54(4–5), 185–195.
  • Thomas, N., et al., 2013. Effects of methanolic seed extract of Telfairia occidentalis on blood coagulation in Albino rats. Nigerian Journal of Experimental and Clinical Biosciences, 1(1), 10–13.
  • Winterbourn, C.C., et al., 2006. Modeling the reactions of superoxide and myeloperoxidase in the neutrophil phagosome: implications for microbial killing. Journal of Biological Chemistry, 281(52), 39860–39869.
  • Zao, J.M., et al., 2015. Performance of busulfan dosing guidelines for pediatric hematopoietic stem cell transplant conditioning. Biology of Blood and Marrow Transplantation, 21(8), 1471–1478.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.