240
Views
3
CrossRef citations to date
0
Altmetric
Research Article

2-(Naphthalene-2-thio)-5,8-dimethoxy-1,4-naphthoquinone induces apoptosis via ROS-mediated MAPK, AKT, and STAT3 signaling pathways in HepG2 human hepatocellular carcinoma cells

, , , , , , , , , , , , , & ORCID Icon show all
Pages 33-43 | Received 02 Mar 2019, Accepted 09 Aug 2019, Published online: 06 Sep 2019

References

  • BIAN. 2012. Progress in research on correlation among STAT3, CyclinD1, P21 genes and tumors. Journal of Otology, 7(1), 19–24
  • Chuang, S.M., Wang, I., and Yang, J.L., 2000. Roles of JNK, p38 and ERK mitogen-activated protein kinases in the growth inhibition and apoptosis induced by cadmium. Carcinogenesis, 21(7), 1423–1432.
  • Chung, Y., et al., 2004. Synthesis and evaluation of antitumor activity of 2- and 6-[(1,3-benzothiazol-2-yl)aminomethyl]-5,8-dimethoxy-1,4-naphthoquinone derivatives. Archives of Pharmacal Research, 27(9), 893–900.
  • Darvin, P., et al., 2015. Tannic acid inhibits the Jak2/STAT3 pathway and induces G1/S arrest and mitochondrial apoptosis in YD-38 gingival cancer cells. International Journal of Oncology, 47(3), 1111–1120.
  • Elkholi, R., et al., 2014. Putting the pieces together: How is the mitochondrial pathway of apoptosis regulated in cancer and chemotherapy? Cancer and Metabolism, 2(1), 16.
  • Ferlay, J., et al., 2010. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. International Journal of Cancer, 127(12), 2893–2917.
  • Fesik, S.W., 2005. Promoting apoptosis as a strategy for cancer drug discovery. Nature Reviews. Cancer, 5(11), 876–885.
  • Ghobrial, I.M., Witzig, T.E., and Adjei, A.A., 2005. Targeting apoptosis pathways in cancer therapy. CA: A Cancer Journal for Clinicians, 55(3), 178–194.
  • Gong, K., and Li, W., 2011. Shikonin, a Chinese plant-derived naphthoquinone, induces apoptosis in hepatocellular carcinoma cells through reactive oxygen species: a potential new treatment for hepatocellular carcinoma. Free Radical Biology and Medicine, 51(12), 2259–2271.
  • Gross, A., 2016. BCL-2 family proteins as regulators of mitochondria metabolism. Biochimica et Biophysica Acta, 1857(8), 1243–1246.
  • Huang, W.W., et al., 2012. Cucurbitacin E Induces G2/M Phase Arrest through STAT3/p53/p21 Signaling and provokes apoptosis via Fas/CD95 and Mitochondria-Dependent pathways in human bladder cancer T24 cells. Evidence-Based Complementray and Alternative Medicine, 2012:952762.
  • Jemal, A., et al., 2009. Cancer statistics, 2009. CA: A Cancer Journal for Clinicians, 59(4), 225–249.,
  • Jin, J., Xiong, Y., and Cen, B., 2017. Bcl-2 and Bcl-xL mediate resistance to receptor tyrosine kinase-targeted therapy in lung and gastric cancer. Anti-Cancer Drugs, 28(10), 1141–1149.
  • Kardeh, S., Ashkani-Esfahani, S., and Alizadeh, A.M., 2014. Paradoxical action of reactive oxygen species in creation and therapy of cancer. European Journal of Pharmacology, 735(1), 150–168.
  • Lee, H.J., et al., 2007. 6-(1-Oxobutyl)-5,8-dimethoxy-1,4-naphthoquinone inhibits Lewis lung cancer by antiangiogenesis and apoptosis. International Journal of Cancer, 120(11), 2481–2490.
  • Lin, J., et al., 2002. p53 regulates Stat3 phosphorylation and DNA binding activity in human prostate cancer cells expressing constitutively active Stat3. Oncogene, 21(19), 3082–3088.
  • Liu, C., Zhang, C., and Feng, Z., 2014. Tumor suppressor p53 and its gain-of-function mutants in cancer. Acta Biochimica et Biophysica Sinica), 46 (3), 170–179.
  • Liu, B., et al., 2009. Molecular mechanisms of Polygonatum cyrtonema lectin-induced apoptosis and autophagy in cancer cells. Autophagy, 5 (2), 253–255.
  • Liu, C., et al., 2018. Novel 1,4-naphthoquinone derivatives induce apoptosis via ROS-mediated p38/MAPK, Akt and STAT3 signaling in human hepatoma Hep3B cells. The International Journal of Biochemistry and Cell Biology, 96, 9–19.
  • Luo, C.Q., et al., 2018. Reactive oxygen species-responsive nanoprodrug with quinone methides-mediated GSH depletion for improved chlorambucil breast cancers therapy. Journal of Controlled Release: Official Journal of the Controlled Release Society, 274, 56–68.
  • Luo, D., et al., 2016. URI prevents potassium dichromate-induced oxidative stress and cell death in gastric cancer cells. American Journal of Translational Research, 8(12), 5399–5409.
  • Mahapatra, A., et al., 2007. Activity of 7-methyljuglone derivatives against Mycobacterium tuberculosis and as subversive substrates for mycothiol disulfide reductase. Bioorganic and Medicinal Chemistry, 15(24), 7638–7646.
  • Milackova, I., et al., 2015. 2-Chloro-1,4-naphthoquinone derivative of quercetin as an inhibitor of aldose reductase and anti-inflammatory agent. Journal of Enzyme Inhibition and Medicinal Chemistry, 30(1), 107–113.
  • Ong, J., et al., 2015. 2-Methoxy-1,4-naphthoquinone (MNQ) induces apoptosis of A549 lung adenocarcinoma cells via oxidation-triggered JNK and p38 MAPK signaling pathways. Life Sciences, 135, 158–164.
  • Pan, B.S., et al., 2015a. Cordycepin induced MA-10 mouse Leydig tumor cell apoptosis by regulating p38 MAPKs and PI3K/AKT signaling pathways. Free Radical Biology and Medicine, 5, S32.
  • Pan, S.T., et al., 2015b. Plumbagin induces G2/M arrest, apoptosis, and autophagy via p38 MAPK- and PI3K/Akt/mTOR-mediated pathways in human tongue squamous cell carcinoma cells. Drug Design Development and Therapy, 9, 1601–1626.
  • Robertson, J.D., and Orrenius, S., 2000. Molecular mechanisms of apoptosis induced by cytotoxic chemicals. Critical Reviews in Toxicology, 30 (5), 609–627.
  • Sauer, H., Wartenberg, M., and Hescheler, J., 2001. Reactive oxygen species as intracellular messengers during cell growth and differentiation. Cellular Physiology and Biochemistry, 11(4), 173–186.
  • Schimmer, A.D., et al., 2001. BAD induces apoptosis in cells Over-expressing Bcl-2 or Bcl-xL without loss of mitochondrial membrane potential. Leukemia and Lymphoma, 42(3), 429–443.
  • Tandon, V.K., Singh, R.V., and Yadav, D.B., 2004. Synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antiviral, antifungal and anticancer agents. Bioorganic and Medicinal Chemistry Letters, 14(11), 2901–2904.
  • Thannickal, V.J., and Fanburg, B.L., 2000. Reactive oxygen species in cell signaling. American Journal of Physiology, 279(6), L1005–L1028.
  • Wang, S.H., et al., 2015. Synthesis and biological evaluation of Lipophilic 1,4-Naphthoquinone derivatives against human cancer cell lines. Molecules, 20(7), 11994–12015.
  • Wong, W.W., and Puthalakath, H., 2008. Bcl-2 family proteins: the sentinels of the mitochondrial apoptosis pathway. Iubmb Life, 60(6), 390–397.
  • Wu, T.H., et al., 2006. Inhibition of cell growth and induction of G1-phase cell cycle arrest in hepatoma cells by steroid extract from Meretrix meretrix. Cancer Letters, 232(2), 199–205.
  • Wu, X.J., Kassie, F., and Mersch-Sundermann, V., 2005. The role of reactive oxygen species (ROS) production on diallyl disulfide (DADS) induced apoptosis and cell cycle arrest in human A549 lung carcinoma cells. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 579(1–2), 115–124.
  • Yang, F., et al., 2010. Sunitinib induces apoptosis and growth arrest of medulloblastoma tumor cells by inhibiting STAT3 and AKT signaling pathways. Molecular Cancer Research, 8(1), 35–45.
  • Yee, S.B., et al., 2015. Growth inhibition of luteolin on HepG2 cells is induced via p53 and Fas/Fas-ligand besides the TGF-β pathway. International Journal of Oncology, 47(2), 747–754.
  • Yun, S.B., et al., 2011. Regulation of reactive oxygen species generation in cell signaling. Molecules and Cells, 32(6), 491–509.
  • Zhang, J., et al., 2016. ROS and ROS-mediated cellular signaling. Oxidative Medicine and Cellular Longevity, 2016, 4350965.
  • Zhang, M., et al., 2015. The roles of ROS and caspases in TRAIL-induced apoptosis and necroptosis in human pancreatic cancer cells. Plos One, 10(5), e0127386.
  • Zhao, D., et al., 2017. Molecularly targeted therapies for p53-mutant cancers. Cellular and Molecular Life Sciences: CMLS, 74(22), 4171–4187.
  • Zhao, H.F., et al., 2015. The phosphatidylinositol 3-kinase/Akt and c-Jun N-terminal kinase signaling in cancer: alliance or contradiction? (Review). International Journal of Oncology, 47(2), 429–436.
  • Zhou, C., et al., 2018. Down-regulation of STAT3 induces the apoptosis and G1 cell cycle arrest in esophageal carcinoma ECA109 cells. Cancer Cell International, 18, 53
  • Zhou, L., et al., 2011. Crosstalk between estrogen receptor and mitogen-activated protein kinase signaling in the development and progression of endometrial cancer. International Journal Gynecol Cancer, 21(8), 1357–1365.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.