Agomelatine protects heart and aorta against lipopolysaccharide-induced cardiovascular toxicity via inhibition of NF-kβ phosphorylation

References

• Abareshi, A., et al., 2017. Effect of angiotensin-converting enzyme inhibitor on cardiac fibrosis and oxidative stress status in lipopolysaccharide-induced inflammation model in rats. International Journal of Preventive Medicine, 8, 69.
   PubMed Web of Science ®Google Scholar
• Aguiar, C.C.T., et al., 2013. Effects of agomelatine on oxidative stress in the brain of mice after chemically induced seizures. Cellular and Molecular Neurobiology, 33 (6), 825–835.
   PubMed Web of Science ®Google Scholar
• Alghaithy, A.A., et al., 2011. Anti-inflammatory effects of the chloroform extract of Pulicaria guestii ameliorated the neutrophil infiltration and nitric oxide generation in rats. Toxicol Ind Health, 27 (10), 899–910.
   PubMed Web of Science ®Google Scholar
• Amir, O., et al., 2010. Circulating interleukin-10: association with higher mortality in systolic heart failure patients with elevated tumor necrosis factor-alpha. IMAJ-Israel Medical Association Journal, 12 (3), 158.
   PubMed Web of Science ®Google Scholar
• Annagür, A., et al., 2015. Total antioxidant and total oxidant states, and serum paraoxonase-1 in neonatal sepsis. Pediatrics International: Official Journal of the Japan Pediatric Society, 57 (4), 608–613.
   PubMed Web of Science ®Google Scholar
• Asgharzadeh, F., et al., 2018. Thymoquinone prevents myocardial and perivascular fibrosis induced by chronic lipopolysaccharide exposure in male rats:-thymoquinone and cardiac fibrosis. Journal of Pharmacopuncture, 21 (4), 284–293.
   PubMed Web of Science ®Google Scholar
• Aslan, R., et al., 2014. The correlation of the total antioxidant status (TAS), total oxidant status (TOS) and paraoxonase activity (PON1) with smoking. Clinical Biochemistry, 47 (6), 393–397.
   PubMed Web of Science ®Google Scholar
• Bradford, M.M., 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry, 72 (1–2), 248–254.
   PubMed Web of Science ®Google Scholar
• Canbolat, M.F., Savas, H.B., and Gultekin, F., 2017. Improved catalytic activity by catalase immobilization using γ‐cyclodextrin and electrospun PCL nanofibers. Journal of Applied Polymer Science, 134 (4), 44404.
   Web of Science ®Google Scholar
• Cao, J., et al., 2017. Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity. Nature Communications, 8 (1), 131.
   PubMed Web of Science ®Google Scholar
• Chrissobolis, S., et al., 2011. Oxidative stress and endothelial dysfunction in cerebrovascular disease. Frontiers in Bioscience, 16 (1), 1733–1745.
   PubMed Web of Science ®Google Scholar
• Chumboatong, W., et al., 2017. Neuroprotection of agomelatine against cerebral ischemia/reperfusion injury through an antiapoptotic pathway in rat. Neurochemistry International, 102, 114–122.
   PubMed Web of Science ®Google Scholar
• Corda, S., et al., 2001. Rapid reactive oxygen species production by mitochondria in endothelial cells exposed to tumor necrosis factor-α is mediated by ceramide. American Journal of Respiratory Cell and Molecular Biology, 24 (6), 762–768.
   PubMed Web of Science ®Google Scholar
• Dare, A.J., et al., 2009. A systematic review of experimental treatments for mitochondrial dysfunction in sepsis and multiple organ dysfunction syndrome. Free Radical Biology and Medicine, 47 (11), 1517–1525.
   PubMed Web of Science ®Google Scholar
• Durrant, J.R., et al., 2009. Voluntary wheel running restores endothelial function in conduit arteries of old mice: direct evidence for reduced oxidative stress, increased superoxide dismutase activity and down‐regulation of NADPH oxidase. The Journal of Physiology, 587 (13), 3271–3285.
   PubMed Web of Science ®Google Scholar
• Erel, O., 2004. A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clinical Biochemistry, 37 (4), 277–285.
   PubMed Web of Science ®Google Scholar
• Erel, O., 2005. A new automated colorimetric method for measuring total oxidant status. Clinical Biochemistry, 38 (12), 1103–1111.
   PubMed Web of Science ®Google Scholar
• Flierl, M.A., et al., 2008. Molecular events in the cardiomyopathy of sepsis. Molecular Medicine (Cambridge, Mass.), 14 (5-6), 327–336.
   PubMed Web of Science ®Google Scholar
• Flynn, A., Mani, B.C., and Mather, P.J., 2010. Sepsis-induced cardiomyopathy: a review of pathophysiologic mechanisms. Heart Failure Reviews, 15 (6), 605–611.
   PubMed Web of Science ®Google Scholar
• Ghosh, J., et al., 2009. Taurine prevents arsenic-induced cardiac oxidative stress and apoptotic damage: Role of NF-κB, p38 and JNK MAPK pathway. Toxicology and Applied Pharmacology, 240 (1), 73–87.
   PubMed Web of Science ®Google Scholar
• Gill, R., Tsung, A., and Billiar, T., 2010. Linking oxidative stress to inflammation: Toll-like receptors. Free Radical Biology and Medicine, 48 (9), 1121–1132.
   PubMed Web of Science ®Google Scholar
• Gupta, S., et al., 2015. Neuroprotective effects of agomelatine and vinpocetine against chronic cerebral hypoperfusion induced vascular dementia. Current Neurovascular Research, 12 (3), 240–252.
   PubMed Web of Science ®Google Scholar
• Hayden, M.S., and Ghosh, S., 2014. Regulation of NF-κB by TNF family cytokines. Seminars in Immunology, 26 (3), 253–266.
   PubMed Web of Science ®Google Scholar
• Hayden, M.S., and Ghosh, S., 2008. Shared principles in NF-kappaB signaling. Cell, 132 (3), 344–362.
   PubMed Web of Science ®Google Scholar
• He, C., et al., 2018. Edaravone improves septic cardiac function by inducing an HIF-1α/HO-1 pathway. Oxidative Medicine and Cellular Longevity, 2018, 1.
   Web of Science ®Google Scholar
• Hobbs, S., et al., 2018. LPS-stimulated NF-κB p65 dynamic response marks the initiation of TNF expression and transition to IL-10 expression in RAW 264.7 macrophages. Physiological Reports, 6 (21), e13914.
   PubMed Web of Science ®Google Scholar
• Hotchkiss, R.S., et al., 2016. Sepsis and septic shock. Nature Reviews Disease Primers, 2 (1), 16045.
   PubMed Web of Science ®Google Scholar
• Huang, L., et al., 2018. Berberine alleviates endothelial glycocalyx degradation and promotes glycocalyx restoration in LPS-induced ARDS. International Immunopharmacology, 65, 96–107.
   PubMed Web of Science ®Google Scholar
• Karakus, E., et al., 2013. Agomelatine: an antidepressant with new potent hepatoprotective effects on paracetamol-induced liver damage in rats. Human and Experimental Toxicology, 32 (8), 846–857.
   PubMed Web of Science ®Google Scholar
• Kauppinen, A., et al., 2013. Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders. Cellular Signalling, 25 (10), 1939–1948.
   PubMed Web of Science ®Google Scholar
• Khodir, A.E., et al., 2016. Montelukast attenuates lipopolysaccharide-induced cardiac injury in rats. Human and Experimental Toxicology, 35 (4), 388–397.
   PubMed Web of Science ®Google Scholar
• Kroemer, G., Galluzzi, L., and Brenner, C., 2007. Mitochondrial membrane permeabilization in cell death. Physiological Reviews, 87 (1), 99–163.
   PubMed Web of Science ®Google Scholar
• Lei, S., et al., 2018. Remifentanil attenuates lipopolysaccharide-induced oxidative injury by downregulating PKCβ2 activation and inhibiting autophagy in H9C2 cardiomyocytes. Life Sciences, 213, 109–115.
   PubMed Web of Science ®Google Scholar
• Levy, R.J., 2007. Mitochondrial dysfunction, bioenergetic impairment, and metabolic down-regulation in sepsis. Shock, 28 (1), 24–28.
   PubMed Web of Science ®Google Scholar
• Lin, W.J., and Yeh, W.C., 2005. Implication of Toll-like receptor and tumor necrosis factor α signaling in septic shock. Shock, 24 (3), 206–209.
   PubMed Web of Science ®Google Scholar
• Liu, B., et al., 2018. NF-κB p65 Knock-down inhibits TF, PAI-1 and promotes activated protein C production in lipopolysaccharide-stimulated alveolar epithelial cells type II. Experimental Lung Research, 44 (4-5), 241–251.
   PubMed Web of Science ®Google Scholar
• Lu, T.M., et al., 2014. Downregulation of Sirt1 as aging change in advanced heart failure. Journal of Biomedical Science, 21 (1), 57.
   PubMed Web of Science ®Google Scholar
• Lu, Y.F., et al., 2017. The protective effects of taurine on experimental autoimmune myocarditis. European Review for Medical and Pharmacological Sciences, 21 (8), 1868–1875.
   PubMed Web of Science ®Google Scholar
• Mantzarlis, K., Tsolaki, V., and Zakynthinos, E., 2017. Role of oxidative stress and mitochondrial dysfunction in sepsis and potential therapies. Oxidative Medicine and Cellular Longevity, 2017, 1.
   Web of Science ®Google Scholar
• Mattagajasingh, I., et al., 2007. SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase. Proceedings of the National Academy of Sciences, 104 (37), 14855–14860.
   PubMed Web of Science ®Google Scholar
• Medzhitov, R., 2008. Origin and physiological roles of inflammation. Nature, 454 (7203), 428.
   PubMed Web of Science ®Google Scholar
• Meneses, G., et al., 2019. Sepsis: developing new alternatives to reduce neuroinflammation and attenuate brain injury. Annals of the New York Academy of Sciences, 1437 (1), 43–56.
   PubMed Web of Science ®Google Scholar
• Molteni, R., et al., 2013. Modulation of the inflammatory response in rats chronically treated with the antidepressant agomelatine. European Neuropsychopharmacology, 23 (11), 1645–1655.
   PubMed Web of Science ®Google Scholar
• Nezic, L., et al., 2018. Simvastatin protects cardiomyocytes against endotoxin-induced apoptosis and up-regulates survivin/NF-κB/p65 expression. Scientific Reports, 8 (1), 14652.
   PubMed Web of Science ®Google Scholar
• Norouzi, F., et al., 2017. The effect of Nigella sativa on inflammation-induced myocardial fibrosis in male rats. Research in Pharmaceutical Sciences, 12 (1), 74–81.
   PubMed Web of Science ®Google Scholar
• Oki, M., et al., 2014. Dual blockade of endothelin action exacerbates up-regulated VEGF angiogenic signaling in the heart of lipopolysaccharide-induced endotoxemic rat model. Life Sciences, 118 (2), 364–369.
   PubMed Web of Science ®Google Scholar
• Ozolina, A., et al., 2016. Activation of coagulation and fibrinolysis in acute respiratory distress syndrome: a prospective pilot study. Frontiers in Medicine, 3, 64.
   PubMed Web of Science ®Google Scholar
• Pan, W., et al., 2016. Resveratrol protects against TNF-α-induced injury in human umbilical endothelial cells through promoting sirtuin-1-induced repression of NF-KB and p38 MAPK. PLoS One, 11 (1), e0147034.
   PubMed Web of Science ®Google Scholar
• Planavila, A., et al., 2011. Sirt1 acts in association with PPARα to protect the heart from hypertrophy, metabolic dysregulation, and inflammation. Cardiovascular Research, 90 (2), 276–284.
   PubMed Web of Science ®Google Scholar
• Prauchner, C.A., 2017. Oxidative stress in sepsis: pathophysiological implications justifying antioxidant co-therapy. Burns, 43 (3), 471–485.
   PubMed Web of Science ®Google Scholar
• Rabelo, T.K., et al., 2016. Shikimic acid inhibits LPS-induced cellular pro-inflammatory cytokines and attenuates mechanical hyperalgesia in mice. International Immunopharmacology, 39, 97–105.
   PubMed Web of Science ®Google Scholar
• Rehman, S.U., et al., 2018. Ferulic acid rescues LPS-induced neurotoxicity via modulation of the TLR4 receptor in the mouse hippocampus. Molecular Neurobiology, 56, 2774–2790.
   PubMed Web of Science ®Google Scholar
• Rippe, C., et al., 2010. Short‐term calorie restriction reverses vascular endothelial dysfunction in old mice by increasing nitric oxide and reducing oxidative stress. Aging Cell, 9 (3), 304–312.
   PubMed Web of Science ®Google Scholar
• Sato, Y., et al., 1999. Serial circulating concentrations of C‐reactive protein, interleukin (IL)‐4, and IL‐6 in patients with acute left heart decompensation. Clinical Cardiology, 22 (12), 811–813.
   PubMed Web of Science ®Google Scholar
• Savas, H.B., et al., 2013. Effects of Food Based Yeast on Oxidant-Antioxidant Systems in Rats fed by High Cholesterol Diet. Cell Membranes and Free Radical Research, 5 (3), 252–255.
   Google Scholar
• Shen, X.F., et al., 2017. Neutrophil dysregulation during sepsis: an overview and update. Journal of Cellular and Molecular Medicine, 21 (9), 1687–1697.
   PubMed Web of Science ®Google Scholar
• Singh, A.K., and Jiang, Y., 2003. Lipopolysaccharide (LPS) induced activation of the immune system in control rats and rats chronically exposed to a low level of the organothiophosphate insecticide, acephate. Toxicology and Industrial Health, 19 (2-6), 93–108.
   PubMed Web of Science ®Google Scholar
• Strieter, R.M., et al., 1989. Endothelial cell gene expression of a neutrophil chemotactic factor by TNF-alpha, LPS, and IL-1 beta. Science, 243 (4897), 1467–1469.
   PubMed Web of Science ®Google Scholar
• Su, H., et al., 2005. Requirement for caspase-8 in NF-kappaB activation by antigen receptor . Science (New York, N.Y.), 307 (5714), 1465–1468.
   PubMed Web of Science ®Google Scholar
• Taylor, D.E., Ghio, A.J., and Piantadosi, C.A., 1995. Reactive oxygen species produced by liver mitochondria of rats in sepsis. Archives of Biochemistry and Biophysics, 316 (1), 70–76.
   PubMed Web of Science ®Google Scholar
• Trumbeckaite, S., et al., 2001. Different sensitivity of rabbit heart and skeletal muscle to endotoxin-induced impairment of mitochondrial function . European Journal of Biochemistry, 268 (5), 1422–1429.
   PubMedGoogle Scholar
• Turkkan, A., et al., 2016. The prophylactic effect of Viscum album in streptozotocin-induced diabetic rats. Northern Clinics of Istanbul, 3 (2), 83.
   PubMed Web of Science ®Google Scholar
• Wang, Q.L., et al., 2019. Ginsenoside Rg1 Regulates SIRT1 to Ameliorate Sepsis-Induced Lung Inflammation and Injury via Inhibiting Endoplasmic Reticulum Stress and Inflammation. Mediators of Inflammation, 2019, 1.
   Web of Science ®Google Scholar
• Werdan, K., et al., 1991. Mechanisms in acute septic cardiomyopathy: evidence from isolated myocytes. Basic Research in Cardiology, 86 (5), 411–421.
   PubMed Web of Science ®Google Scholar
• Xie, C., et al., 2011. Blueberries reduce pro‐inflammatory cytokine TNF‐α and IL‐6 production in mouse macrophages by inhibiting NF‐κB activation and the MAPK pathway. Molecular Nutrition & Food Research, 55 (10), 1587–1591.
   PubMed Web of Science ®Google Scholar
• Xu, J., et al., 2018. Ergosterol attenuates lps-induced myocardial injury by modulating oxidative stress and apoptosis in rats. Cellular Physiology and Biochemistry, 48 (2), 583–592.
   PubMedGoogle Scholar
• Yeh, C.H., et al., 2015. Protective effect of wogonin on proinflammatory cytokine generation via Jak1/3-STAT1/3 pathway in lipopolysaccharide stimulated BV2 microglial cells. Toxicology and Industrial Health, 31 (10), 960–966.
   PubMed Web of Science ®Google Scholar
• Yigitturk, G., et al., 2017. The antioxidant role of agomelatine and gallic acid on oxidative stress in STZ induced type I diabetic rat testes. Biomedicine & Pharmacotherapy, 87, 240–246.
   PubMed Web of Science ®Google Scholar
• Zhang, Q.J., et al., 2008. Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice. Cardiovascular Research, 80 (2), 191–199.
   PubMed Web of Science ®Google Scholar
• Zhang, W., et al., 2017. Sirt1 protects endothelial cells against LPS-induced barrier dysfunction. Oxidative Medicine and Cellular Longevity, 2017, 1.
   Web of Science ®Google Scholar
• Zhang, Q., Lenardo, M.J., and Baltimore, D., 2017. 30 years of NF-κB: A blossoming of relevance to human pathobiology. Cell, 168 (1–2), 37–57.
   PubMed Web of Science ®Google Scholar
• Zhao, J., et al., 2019. Neuroinflammation induced by lipopolysaccharide causes cognitive impairment in mice. Scientific Reports, 9 (1), 5790.
   PubMed Web of Science ®Google Scholar
• Zhao, X., et al., 2018. Protective effects of dioscin against systemic inflammatory response syndromevia adjusting TLR2/MyD88/NF-κb signal pathway. International Immunopharmacology, 65, 458–469.
   PubMed Web of Science ®Google Scholar
• Zhou, J., et al., 2018. Brusatol ameliorates 2, 4, 6-trinitrobenzenesulfonic acid-induced experimental colitis in rats: Involvement of NF-κB pathway and NLRP3 inflammasome. International Immunopharmacology, 64, 264–274.
   PubMed Web of Science ®Google Scholar
• Zhou, M.Q., et al., 2017. Dihydromyricetin protects against lipopolysaccharide-induced cardiomyocyte injury through the toll-like receptor-4/nuclear factor-κB pathway. Molecular Medicine Reports, 16 (6), 8983–8988.
   PubMed Web of Science ®Google Scholar
• Zhu, J., et al., 2006. TNF-α-induced impairment of mitochondrial integrity and apoptosis mediated by caspase-8 in adult ventricular myocytes. Cytokine, 34 (1–2), 96–105.
   PubMed Web of Science ®Google Scholar