127
Views
12
CrossRef citations to date
0
Altmetric
Research Article

Modulatory effects of stonebreaker (Phyllanthus amarus) and bitter gourd (Momordica charantia) on enzymes linked with cardiac function in heart tissue of doxorubicin-stressed rats

, , &
Pages 331-339 | Received 21 Aug 2019, Accepted 24 Nov 2019, Published online: 11 Dec 2019

References

  • Abas, R., Othman, F., and Thent, Z.C., 2014. Protective effect of Momordica charantia fruit extract on hyperglycaemia-induced cardiac fibrosis. Oxidative Medicine and Cellular Longevity, 2014, 429060.
  • Adefegha, S.A., et al., 2015. Antioxidant and antidiabetic effects of gallic and protocatechuic acids: a structure–function perspective. Comparative Clinical Pathology, 24 (6), 1579–1585.
  • Adefegha, A.A., et al., 2018a. Quercetin, rutin, and their combinations modulate penile phosphodiesterase-5′, arginase, acetylcholinesterase, and angiotensin-I-converting enzyme activities: a comparative study. Comparative Clinical Pathology, 27 (3), 773–780.
  • Adefegha, S.A., et al., 2018. Modulatory effect of quercetin and its glycosylated form on key enzymes and antioxidant status in rats penile tissue of paroxetine-induced erectile dysfunction. Biomedicine and Pharmacotherapy, 107, 1473–1479.
  • Ademosun, A.O., Adebayo, A.A., and Oboh, G., 2019. Modulatory effect of some citrus (Citrus limon, Citrus reticulata, Citrus maxima) peels on monoamine oxidase, phosphodiesterase-5 and angiotensin-1 converting enzyme activities in rat heart homogenate. Journal of Complementary and Integrative Medicine, 16 (1). Available from: https://doi.org/https://doi.org/10.1515/jcim-2016-0155.
  • Adeneye, A.A., 2012. The leaf and seed aqueous extract of Phyllanthus amarus improves insulin resistance diabetes in experimental animal studies. Journal of Ethnopharmacology, 144 (3), 705–711.
  • Afsar, T., et al., 2017. Acacia hydaspica R. parker prevents doxorubicin-induced cardiac injury by attenuation of oxidative stress and structural cardiomyocyte alterations in rats. BMC Complementary and Alternative Medicine, 17 (1), 554.
  • Ahles, T.A., 2012. Brain vulnerability to chemotherapy toxicities. Psycho-Oncology, 21 (11), 1141–1148.
  • Akinyemi, A.J., et al., 2016. Dietary supplementation of ginger and turmeric rhizomes modulates platelets ectonucleotidase and adenosine deaminase activities in normotensive and hypertensive rats. Phytotherapy Research, 30 (7), 1156–1163.
  • Akinyemi, A.J., et al., 2017. Anti-amnestic effect of curcumin in combination with donepezil, an anticholinesterase drug: involvement of cholinergic system. Neurotoxicity Research, 31 (4), 560–569.
  • Akomolafe, S.A., et al., 2018. Phenolic characterization, antioxidant activities, and inhibitory effects of Physalis angulata and Newbouldia laevis on enzymes linked to erectile dysfunction. International Journal of Food Properties, 21 (1), 645–654.
  • Alam, S., et al., 2009. Antiulcer activity of methanolic extract of Momordica charantia L. in rats. Journal of Ethnopharmacology, 123 (3), 464–469.
  • Al-Harthi, S.E., et al., 2014. Amelioration of doxorubicin-induced cardiotoxicity by resveratrol. Molecular Medicine Reports, 10 (3), 1455–1460.
  • Amaechina, F.C., and Omogbai, E.K., 2007. Hypotensive effect of aqueous extract of the leaves of Phyllanthus amarus Schum and Thonn (Euphorbiaceae). Acta Pol Pharm, 64 (6), 547–552.
  • Badgujar, P.C., et al., 2015. Fipronil induced oxidative stress in kidney and brain of mice: protective effect of vitamin E and vitamin C. Pesticide Biochemistry and Physiology, 118, 10–18.
  • Balea, ŞS., et al., 2018. Polyphenolic compounds, antioxidant, and cardioprotective effects of pomace extracts from Fetească Neagră Cultivar. Oxidative Medicine and Cellular Longevity, 2018, 1–11.
  • Blaes, A., et al., 2015. Angiotensin Converting Enzyme Inhibitors (ACEI) and doxorubicin pharmacokinetics in women receiving adjuvant breast cancer treatment. SpringerPlus, 4 (1), 32.
  • Bradford, M. M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry, 72, 248–254.
  • Burnstock, G., 2017a. Purinergic signaling in the cardiovascular system. Circulation Research, 120 (1), 207–228.
  • Burnstock, G., 2017b. Purinergic signalling: therapeutic developments. Frontiers in Pharmacology, 8, 661.
  • Caldwell, R.B., et al., 2015. Arginase: an old enzyme with new tricks. Trends in Pharmacological Sciences, 36 (6), 395–405.
  • Chao, C. Y., Sung, P. J., Wang, W. H., and Kuo, Y. H. 2014. Anti-inflammatory effect of Momordica charantia in sepsis mice. Molecules, 19, 12777–12788.
  • Cheng, Y.C., et al., 2017. Polyphenols and oxidative stress in atherosclerosis-related ischemic heart disease and stroke. Oxidative Medicine and Cellular Longevity, 2017, 8526438.
  • Christy, A.O., et al., 2016. The antimalaria effect of Momordica charantia L. and Mirabilis jalapa leaf extracts using animal model. Journal of Medicinal Plants Research, 10 (24), 344–350.
  • Cushman, D.W., and Cheung, H. S. 1971. Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lung. Biochemical Pharmacology, 20, 1637–1648.
  • Deng Z., et al., 2019. Behavioral defects induced by chronic social defeat stress are protected by Momordica charantia polysaccharides via attenuation of JNK3/PI3K/AKT neuroinflammatory pathway. Annals of Translational Medicine, 7, 6.
  • Dikalov, S.I., and Nazarewicz, R.R., 2013. Angiotensin II-induced production of mitochondrial reactive oxygen species: potential mechanisms and relevance for cardiovascular disease. Antioxidants and Redox Signaling, 19 (10), 1085–1094.
  • Ellman, G.L., et al., 1961. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochemical Pharmacology, 7 (2), 88–95.
  • Ellman, G.L., 1959. Tissue sulfhydryl groups. Archives of Biochemistry and Biophysics, 82 (1), 70–77.
  • El-Moselhy, M.A., and El-Sheikh, A.A., 2014. Protective mechanisms of atorvastatin against doxorubicin-induced hepato-renal toxicity. Biomedicine and Pharmacotherapy, 68 (1), 101–110.
  • Eweka, A.O., and Enogieru, A., 2011. Effects of oral administration of Phyllanthus amarus leaf extract on the kidneys of adult wistar rats-a histological study. African Journal of Traditional, Complementary and Alternative Medicines, 8 (3), 307–311.
  • Faremi, T.Y., et al., 2008. Hepatoprotective potentials of Phyllanthus amarus against ethanol-induced oxidative stress in rats. Food and Chemical Toxicology, 46 (8), 2658–2664.
  • Förstermann, U., 2010. Nitric oxide and oxidative stress in vascular disease. Pflügers Archiv – European Journal of Physiology, 459 (6), 923–939.
  • Grassi, D., Desideri, G., and Ferri, C., 2010. Flavonoids: antioxidants against atherosclerosis. Nutrients, 2 (8), 889–902.
  • Greene, S.J., et al., 2016. Partial adenosine A1 receptor agonism: a potential new therapeutic strategy for heart failure. Heart Failure Reviews, 21 (1), 95–102.
  • Grigorian, A., and O’Brien, C.B., 2014. Hepatotoxicity secondary to chemotherapy. Journal of Clinical and Translational Hepatology, 2 (2), 95.
  • Guisti, G., and Galanti, B., 1984. Colorimetric method In: HU Bergmeyer, eds. Method of Enzymatic analysis. 3rd ed. Berlin, Germany: Verlag Chemie.
  • Gupta, M., and Vaghela, J.S., 2019. Recent advances in pharmacological and phytochemistry studies on Phyllanthus amarus. Pharmaceutical and Biosciences Journal, 7 (1), 01–08.
  • Harikrishnan, H., et al., 2018. Anti-inflammatory effects of Phyllanthus amarus Schum. & Thonn. through inhibition of NF-κB, MAPK, and PI3K-Akt signaling pathways in LPS-induced human macrophages. BMC Complementary and Alternative Medicine, 18 (1), 224.
  • Jaćević, V., et al., 2018. The efficacy of amifostine against multiple-dose doxorubicin-induced toxicity in rats. International Journal of Molecular Sciences, 19 (8), 2370.
  • Joseph, B., and Jini, D., 2013. Antidiabetic effects of Momordica charantia (bitter melon) and its medicinal potency. Asian Pacific Journal of Tropical Disease, 3 (2), 93–102.
  • Khafaga, A.F., and El-Sayed, Y.S., 2018. All-trans-retinoic acid ameliorates doxorubicin-induced cardiotoxicity: in vivo potential involvement of oxidative stress, inflammation, and apoptosis via caspase-3 and p53 down-expression. Naunyn-Schmiedeberg's Archives of Pharmacology, 391 (1), 59–70.
  • Koo, Y.E., Song, J., and Bae, S., 2018. Use of plant and herb derived medicine for therapeutic usage in cardiology. Medicines, 5 (2), 38.
  • Kowalczyk, E., et al., 2009. Effect of cardiovascular drugs on adenosine deaminase activity. Angiology, 59 (6), 740–744.
  • Li, G., et al., 2013. Estimated daily flavonoid and stilbene intake from fruits, vegetables, and nuts and associations with lipid profiles in Chinese adults. Journal of the Academy of Nutrition and Dietetics, 113 (6), 786–794.
  • Mathias, L.M., et al., 2019. Euterpe oleracea Mart.(Açai) supplementation attenuates acute doxorubicin-induced cardiotoxicity in rats. Cell Physiol Biochem, 53 (2), 388–399.
  • Minozzo, B.R., Fernandes, D., and Beltrame, F.L., 2018. Phenolic compounds as arginase inhibitors: new insights regarding endothelial dysfunction treatment. Planta Medica, 84 (05), 277–295.
  • Muñoz-Durango, N., et al., 2016. Role of the renin-angiotensin-aldosterone system beyond blood pressure regulation: molecular and cellular mechanisms involved in end-organ damage during arterial hypertension. International Journal of Molecular Sciences, 17 (7), 797.
  • Musuamba, C.T., et al., 2010. In vitro antiplasmodial and cytotoxic activities of ethanol extracts of apical stem of Phyllanthus amarus Schum. et Thonn.(Euphorbiaceae). Journal of Complementary and Integrative Medicine, 7 (1), 12–23.
  • Oboh, G., et al., 2013. Comparative study on the inhibitory effect of caffeic and chlorogenic acids on key enzymes linked to Alzheimer’s disease and some pro-oxidant induced oxidative stress in rats’ brain-in vitro. Neurochemical Research, 38 (2), 413–419.
  • Oboh, G., et al., 2015. Phenolic extract from Moringa oleifera leaves inhibits key enzymes linked to erectile dysfunction and oxidative stress in rats’ penile tissues. Biochemistry Research International, 2015, 1–8.
  • Oboh, G., et al., 2016. Polyphenolic compositions and in vitro angiotensin-I-converting enzyme inhibitory properties of common green leafy vegetables: a comparative study. Food Science and Biotechnology, 25 (5), 1243–1249.
  • Oboh, G., Oyeleye, S. I., Akintemi, O. A., and Olasehinde, T. A. 2018. Moringa oleifera supplemented diet modulates nootropic-related biomolecules in the brain of STZ-induced diabetic rats treated with acarbose. Metabolic brain disease, 33 (2), 457–466.
  • Octavia, Y., et al., 2012. Doxorubicin-induced cardiomyopathy: from molecular mechanisms to therapeutic strategies. Journal of molecular and cellular cardiology, 52 (6), 1213–1225.
  • Odubanjo, O.V., et al., 2018. Seed extracts from Myristica fragrans (Nutmeg) and Moringa oleifera (Drumstick tree) inhibits enzymes relevant to erectile dysfunction and metal‐ induced oxidative damage in rats’ penile tissues. Journal of Food Biochemistry, 42 (1), e12452.
  • Ohkawa, H., Ohishi, N., and Yagi, K., 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analytical Biochemistry, 95 (2), 351–358.
  • Oyeleye, S.I., et al., 2019a. Horseradish (Moringa oleifera) seed and leaf inclusive diets modulates activities of enzymes linked with hypertension, and lipid metabolites in high-fat fed rats. PharmaNutrition, 7, 100141.
  • Oyeleye, S.I., et al., 2019b. Effect of p‐coumaric acid on the erectogenic enzyme activities and non‐protein thiol level in the penile tissue of normal and doxorubicin‐induced oxidative stress male rat. Andrologia, 51 (6), e13281.
  • Parikh, M., et al., 2019. Ginseng berry extract rich in phenolic compounds attenuates oxidative stress but not cardiac remodeling post myocardial infarction. International Journal of Molecular Sciences, 20 (4), 983.
  • Patel, J.R., et al., 2011. Phyllanthus amarus: ethnomedicinal uses, phytochemistry and pharmacology: a review. Journal of Ethnopharmacology, 138 (2), 286–313.
  • Pernow, J., and Jung, C., 2013. Arginase as a potential target in the treatment of cardiovascular disease: reversal of arginine steal? Cardiovascular Research, 98 (3), 334–343.
  • Putakala, M., et al., 2017. Cardioprotective effect of Phyllanthus amarus against high fructose diet induced myocardial and aortic stress in rat model. Biomedicine & Pharmacotherapy, 95, 1359–1368.
  • Raish, M., 2017. Momordica charantia polysaccharides ameliorate oxidative stress, hyperlipidemia, inflammation, and apoptosis during myocardial infarction by inhibiting the NF-κB signaling pathway. International Journal of Biological Macromolecules, 97, 544–551.
  • Raman, A., and Lau, C., 1996. Anti-diabetic properties and phytochemistry of Momordica charantia L.(Cucurbitaceae). Phytomedicine, 2 (4), 349–362.
  • Razavi-Azarkhiavi, K., et al., 2016. The protective role of phenolic compounds against doxorubicin-induced cardiotoxicity: a comprehensive review. Nutrition and Cancer, 68 (6), 892–917.
  • Saibabu, V., et al., 2015. Therapeutic potential of dietary phenolic acids. Advances in Pharmacological Sciences, 2015, 823539.
  • Sani, F.A., Atiku, M.K., and Imam, A.A., 2016. Effect of oral administration of aqueous leaf extract of Momordica charantia (bitter melon) on serum glucose, and lipid profile in alloxan-induced diabetic rats. Bayero Journal of Pure and Applied Sciences, 8 (2), 170–174.
  • Shi, L., et al., 2010. Angiotensin-converting enzymes and drug discovery in cardiovascular diseases. Drug Discovery Today, 15 (9–10), 332–341.
  • Shodehinde, S.A., et al., 2017. Lasianthera Africana leaves inhibits α-amylase α-glucosidase, angiotensin-I converting enzyme activities and Fe2+-induced oxidative damage in pancreas and kidney homogenates. Oriental Pharmacy and Experimental Medicine, 17 (1), 41–49.
  • Shodehinde, S.A., et al., 2016. Phenolic composition and evaluation of methanol and aqueous extracts of bitter gourd (Momordica charantia L) leaves on Angiotensin-I-Converting enzyme and some pro-oxidant-induced lipid peroxidation in vitro. Journal of evidence-Based Complementary and Alternative Medicine, 21 (4), NP67–NP76.
  • Shokunbi, O.S., and Odetola, A.A., 2008. Gastroprotective and antioxidant activities of Phyllanthus amarus extracts on absolute ethanol-induced ulcer in albino rats. Journal of Medicinal Plants Research, 2 (10), 261–267.
  • Tronchini, E.A., de Miranda Neto, M.H., and Zanoni, J.N., 2010. Vitamin E (α‐tocopherol) supplementation enhances nitric oxide production in penile tissue of diabetic rats. BJU International, 106 (11), 1788–1793.
  • Tungmunnithum, D., et al., 2018. Flavonoids and other phenolic compounds from medicinal plants for pharmaceutical and medical aspects: an overview. Medicines, 5 (3), 93.
  • Waiskopf, N., Shenhar-Tsarfaty, S., and Soreq, H., 2015. Serum cholinesterase activities as biomarkers of cardiac malfunctioning. Biomarkers in Cardiovascular Disease, 16 (7–8), 1–22.
  • Wattanapitayakul, S.K., et al., 2005. Screening of antioxidants from medicinal plants for cardioprotective effect against doxorubicin toxicity. Basic Clinical Pharmacology Toxicology, 96 (1), 80–87.
  • Wu, C.H., et al., 2018. Renin-angiotensin system and cardiovascular functions. Arteriosclerosis, Thrombosis, and Vascular Biology, 38 (7), e108–e116.
  • Yang, Z., and Ming, X.F., 2013. Arginase: the emerging therapeutic target for vascular oxidative stress and inflammation. Frontiers in Immunology, 4, 149.
  • Zare, M.F.R., et al., 2019. Apigenin attenuates doxorubicin induced cardiotoxicity via reducing oxidative stress and apoptosis in male rats. Life Sciences, 232, 116623.
  • Zhang, Y.Y., Yi, M., and Huang, Y.P., 2017. Oxymatrine ameliorates doxorubicin-induced cardiotoxicity in rats. Cellular Physiology and Biochemistry, 43 (2), 626–635.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.