References
- Al Kury, L.T., et al., 2020. Ginkgo biloba extract protects against methotrexate-induced hepatotoxicity: a computational and pharmacological approach. Molecules, 25 (11), 2540.
- Al-Motabagani, M.A., 2006. Histological and histochemical studies on the effects of methotrexate on the liver of adult male albino rat. International Journal of Morphology, 24 (3), 417–422.
- Calo, N., et al., 2016. Stress-activated miR-21/miR-21* in hepatocytes promotes lipid and glucose metabolic disorders associated with high-fat diet consumption. Gut, 65 (11), 1871–1881.
- Cao, Y., et al., 2019. Protective effects of magnesium glycyrrhizinate on methotrexate-induced hepatotoxicity and intestinal toxicity may be by reducing COX-2. Frontiers in Pharmacology, 10, 1871.
- Chen, L.Y., et al., 2019. Activation of the STAT3/microRNA‐21 pathway participates in angiotensin II‐induced angiogenesis. Journal of Cellular Physiology, 234 (11), 19640–19654.
- Chen, M., et al., 2015. Drug-induced liver injury: Interactions between drug properties and host factors. Journal of Hepatology, 63 (2), 503–514.
- De, S., Sen, T., and Chatterjee, M., 2015. Reduction of oxidative stress by an ethanolic extract of leaves of Piper betle (Paan) Linn. decreased methotrexate-induced toxicity. Molecular and Cellular Biochemistry, 409 (1-2), 191–197.
- Dippold, R.P., et al., 2012. Chronic ethanol feeding enhances miR-21 induction during liver regeneration while inhibiting proliferation in rats. American Journal of Physiology. Gastrointestinal and Liver Physiology, 303 (6), G733–G743.
- Ebrahimi, R., et al., 2019. Ellagic acid reduces methotrexate-induced apoptosis and mitochondrial dysfunction via up-regulating Nrf2 expression and inhibiting the IĸBα/NFĸB in rats. Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 27 (2), 721–733.
- El‐Shitany, N.A., and Eid, B., 2017. Proanthocyanidin protects against cisplatin‐induced oxidative liver damage through inhibition of inflammation and NF‐κβ/TLR‐4 pathway. Environmental Toxicology, 32 (7), 1952–1963.
- Erdogan, E., et al., 2015. Rutin ameliorates methotrexate induced hepatic injury in rats. Acta Cirurgica Brasileira, 30 (11), 778–784.
- Fouad, A., Hafez, H., and Hamouda, A., 2020. Hydrogen sulfide modulates IL-6/STAT3 pathway and inhibits oxidative stress, inflammation, and apoptosis in rat model of methotrexate hepatotoxicity. Human & Experimental Toxicology, 39 (1), 77–85.
- Galun, E., and Axelrod, J.H., 2002. The role of cytokines in liver failure and regeneration: potential new molecular therapies. Biochimica et Biophysica Acta, 1592 (3), 345–358.
- Günay, N.E., Muhtaroğlu, S., and Bedirli, A., 2018. Administration of Ginkgo biloba extract (EGb761) alone and in combination with FK506 promotes liver regeneration in a rat model of partial hepatectomy. Balkan Medical Journal, 35 (2), 174–180.
- Gutsaeva, D.R., et al., 2017. STAT3-mediated activation of miR-21 is involved in down-regulation of TIMP3 and neovascularization in the ischemic retina. Oncotarget, 8 (61), 103568–103580.
- Hafez, M.M., et al., 2015. Hepato-protective effect of rutin via IL-6/STAT3 pathway in CCl 4-induced hepatotoxicity in rats. Biological Research, 48 (1), 30.
- Hoshyar, R., et al., 2019. The impact of Crocus sativus stigma against methotrexate-induced liver toxicity in rats. Journal of Complementary and Integrative Medicine, 17 (2), 1–9.
- Huang, Z., et al., 2016. Signal transducer and activator of transcription 3/microRNA-21 feedback loop contributes to atrial fibrillation by promoting atrial fibrosis in a rat sterile pericarditis model. Circulation: Arrhythmia and Electrophysiology, 9 (7), e003396.
- Hui, C., et al., 2012. MicroRNA-34a and microRNA-21 play roles in the chemopreventive effects of 3,6-dihydroxyflavone on 1-methyl-1-nitrosourea-induced breast carcinogenesis. Breast Cancer Research : BCR, 14 (3), R80.
- Kalantar, M., et al., 2019. Crocin ameliorates methotrexate-induced liver injury via inhibition of oxidative stress and inflammation in rats. Pharmacol Rep, 71 (4), 746–752.
- Kalantari, H., et al., 2019. Protective effect of inulin on methotrexate- induced liver toxicity in mice. Biomedicine & Pharmacotherapy = Biomedecine & pharmacotherapie, 110, 943–950.
- Kelleni, M.T., Ibrahim, S.A., and Abdelrahman, A.M., 2016. Effect of captopril and telmisartan on methotrexate-induced hepatotoxicity in rats: impact of oxidative stress, inflammation and apoptosis. Toxicology Mechanisms and Methods, 26 (5), 371–377.
- Khafaga, A.F., and El-Sayed, Y.S., 2018. Spirulina ameliorates methotrexate hepatotoxicity via antioxidant, immune stimulation, and proinflammatory cytokines and apoptotic proteins modulation. Life Sciences, 196, 9–17.
- Khan, M.G.M., et al., 2019. Hepatocyte growth control by SOCS1 and SOCS3. Cytokine, 121, 154733.
- Kishimoto, T., 2005. Interleukin-6: from basic science to medicine-40 years in immunology. Annual Review of Immunology, 23, 1–21.
- Lalani, E.-N., et al., 2005. Expression of hepatocyte growth factor and its receptor c-met, correlates with severity of pathological injury in experimental alcoholic liver disease. International Journal of Molecular Medicine, 15 (5), 811–817.
- Liu, A., et al., 2014. Saikosaponin d protects against acetaminophen-induced hepatotoxicity by inhibiting NF-κB and STAT3 signaling. Chemico-Biological Interactions, 223, 80–86.
- Loyer, X., et al., 2016. Liver microRNA-21 is overexpressed in non-alcoholic steatohepatitis and contributes to the disease in experimental models by inhibiting PPARα expression. Gut, 65 (11), 1882–1894.
- Mehrzadi, S., et al., 2018. Hepatoprotective effect of berberine against methotrexate induced liver toxicity in rats. Biomedicine & Pharmacotherapy, 97, 233–239.
- Mühl, H., 2016. STAT3, a key parameter of cytokine-driven tissue protection during sterile inflammation – the case of experimental acetaminophen (paracetamol)-induced liver damage. Frontiers in Immunology, 7, 163.
- Okay, E., et al., 2015. Cross effects of resveratrol and mesenchymal stem cells on liver regeneration and homing in partially hepatectomized rats. Stem Cell Reviews and Reports, 11 (2), 322–331.
- Okayama, H., Schetter, A.J., and Harris, C.C., 2012. MicroRNAs and inflammation in the pathogenesis and progression of colon cancer. Digestive Diseases, 30 (s2), 9–15.
- Ou, Y., et al., 2010. Protective effect of C-phycocyanin against carbon tetrachloride-induced hepatocyte damage in vitro and in vivo. Chemico-Biological Interactions, 185 (2), 94–100.
- Ozen, B., and Uyanoglu, M., 2018. Effect of carvacrol on IL-6/STAT3 pathway after partial hepatectomy in rat liver. Bratislavske lekarske listy, 119 (9), 593–601.
- Pogribny, I.P., et al., 2009. The tumor-promoting activity of 2-acetylaminofluorene is associated with disruption of the p53 signaling pathway and the balance between apoptosis and cell proliferation. Toxicology and Applied Pharmacology, 235 (3), 305–311.
- Prystupa, A., et al., 2015. Proinflammatory cytokines (IL-1α, IL-6) and hepatocyte growth factor in patients with alcoholic liver cirrhosis. Gastroenterology Research and Practice, 2015, 532615.
- Radik, M., et al., 2019. Hepatocyte growth factor plays a particular role in progression of overall cardiac damage in experimental pulmonary hypertension. International Journal of Medical Sciences, 16 (6), 854–863.
- Schmidt-Arras, D., and Rose-John, S., 2016. IL-6 pathway in the liver: from physiopathology to therapy. Journal of Hepatology, 64 (6), 1403–1415.
- Shaker, M.E., Hazem, S.H., and Ashamallah, S.A., 2016. Inhibition of the JAK/STAT pathway by ruxolitinib ameliorates thioacetamide-induced hepatotoxicity. Food and Chemical Toxicology : An International Journal Published for the British Industrial Biological Research Association, 96, 290–301.
- Sharma, A.D., et al., 2011. MicroRNA-221 regulates FAS-induced fulminant liver failure. Hepatology (Baltimore, Md.), 53 (5), 1651–1661.
- Sherif, I.O., Al-Shaalan, N.H., and Sabry, D., 2019. Ginkgo biloba extract alleviates methotrexate-induced renal injury: new impact on PI3K/Akt/mTOR signaling and MALAT1 expression. Biomolecules, 9 (11), 691.
- Sun, Y., et al., 2015. Gingko biloba extract (Ginaton) ameliorates dextran sulfate sodium (DSS)-induced acute experimental colitis in mice via reducing IL-6/STAT3 and IL-23/IL-17. International Journal of Clinical and Experimental Medicine, 8 (10), 17235–17247.
- Suzuki, T., et al., 2015. Protective effect of aqueous extracts from R hizopus oryzae on liver injury induced by carbon tetrachloride in rats. Animal Science Journal, 86 (5), 532–540.
- Tag, H.M., 2015. Hepatoprotective effect of mulberry (Morus nigra) leaves extract against methotrexate induced hepatotoxicity in male albino rat. BMC Complementary and Alternative Medicine, 15 (1), 252.
- Tao, Y., et al., 2017. Liver regeneration: analysis of the main relevant signaling molecules. Mediators of Inflammation, 2017, 1–9.
- Taub, R., 2003. Hepatoprotection via the IL-6/Stat3 pathway. The Journal of Clinical Investigation, 112 (7), 978–980.
- Tousson, E., et al., 2014. Abrogation by Ginkgo byloba leaf extract on hepatic and renal toxicity induced by methotrexate in rats. Journal of Cancer Treatment and Research, 2 (3), 44–51.
- Trehanpati, N., et al., 2017. miRNA signatures can predict acute liver failure in hepatitis E infected pregnant females. Heliyon, 3 (4), e00287.
- Wang, F., et al., 2015a. Prenatal and neonatal exposure to perfluorooctane sulfonic acid results in aberrant changes in miRNA expression profile and levels in developing rat livers. Environmental Toxicology, 30 (6), 712–723.
- Wang, G., et al., 2015b. Resveratrol inhibits glioma cell growth via targeting oncogenic microRNAs and multiple signaling pathways. International Journal of Oncology, 46 (4), 1739–1747.
- Wang, J., et al., 2018. Enhanced efficacy of curcumin with phosphatidylserine-decorated nanoparticles in the treatment of hepatic fibrosis. Drug Delivery, 25 (1), 1–11.
- Wang, S.-W., and Sun, Y.-M., 2014. The IL-6/JAK/STAT3 pathway: potential therapeutic strategies in treating colorectal cancer (Review). International Journal of Oncology, 44 (4), 1032–1040.
- Wang, Y., et al., 2015c. Ginkgo biloba extract mitigates liver fibrosis and apoptosis by regulating p38 MAPK, NF-κB/IκBα, and Bcl-2/Bax signaling. Drug Design, Development and Therapy, 9, 6303–6317.
- Wu, J.-P., et al., 2015. Hepatoprotective effects of traditional chinese medicine on liver fibrosis from ethanol administration following partial hepatectomy. The Chinese Journal of Physiology, 58 (6), 393–403.
- Xian, C., et al., 2000. Increased expression of HGF and c-met in rat small intestine during recovery from methotrexate-induced mucositis. British Journal of Cancer, 82 (4), 945–952.
- Xu, Q., et al., 2012. Suppression of acute hepatic injury by a synthetic prostacyclin agonist through hepatocyte growth factor expression. American Journal of Physiology. Gastrointestinal and Liver Physiology, 302 (4), G420–G429.
- Yucel, Y., et al., 2017. The effects of lycopene on methotrexate-induced liver injury in rats. Bratislavske Lekarske Listy, 118 (4), 212–216.
- Zhang, Y., et al., 2018. Ginkgo biloba extract inhibits astrocytic lipocalin-2 expression and alleviates neuroinflammatory injury via the jak2/stat3 pathway after ischemic brain stroke. Frontiers in Pharmacology, 9, 518
- Zhao, J., et al., 2014. MiR-21 simultaneously regulates ERK1 signaling in HSC activation and hepatocyte EMT in hepatic fibrosis. PLoS One, 9 (10), e108005.
- Zhu, C., et al., 2018. Prognostic effect of IL-6/JAK2/STAT3 signal-induced microRNA-21-5p expression on short term recurrence of hepatocellular carcinoma after hepatectomy. International Journal of Clinical and Experimental Pathology, 11 (8), 4169–4178.
- Zou, X., et al., 2018. Magnesium isoglycyrrhizinate has hepatoprotective effects in an oxaliplatin-induced model of liver injury. International Journal of Molecular Medicine, 42 (4), 2020–2030.