References
- Abdullah, et al., 2017. Hepatoprotective effect of the solvent extracts of Viola canescens Wall. ex. Roxb. against CCl4 induced toxicity through antioxidant and membrane stabilizing activity. BMC Complementary and Alternative Medicine, 17, 10.
- Abdullah, et al., 2020. Exploration of hepatoprotective potential and phytochemicals of Ziziphus oxyphylla Edgew. Pakistan Veterinary Journal, 40, 431–436.
- Anand, K., et al., 1992. Structure and hepatoprotective activity of a biflavonoid from Canarium manii. Planta Medica, 58 (6), 493–495.
- Banno, N., et al., 2004. Triterpene acids from the leaves of Perilla frutescens and their anti-inflammatory and antitumor-promoting effects. Bioscience, Biotechnology, and Biochemistry, 68 (1), 85–90.
- Barton, G.M., 2008. A calculated response: control of inflammation by the innate immune system. Journal of Clinical Investigation, 118 (2), 413–420.
- Beers, R.F., and Sizer, I.W., 1952. A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. Journal of Biological Chemistry, 195 (1), 133–140.
- Braca, A., et al., 2011. Triterpene derivatives as inhibitors of protein involved in the inflammatory process: molecules interfering with phospholipase A2, cycloxygenase, and lipoxygenase. Current Drug Targets, 12 (3), 302–321.
- Braca, A., et al., 2002. Antioxidant activity of flavonoids from Licania licaniaeflora. Journal of Ethnopharmacology, 79 (3), 379–381.
- Breinbauer, R., Vetter, I.R., and Waldmann, H., 2002. From protein domains to drug candidates—natural products as guiding principles in the design and synthesis of compound libraries. Angewandte Chemie International Edition, 41 (16), 2878–2890.
- Chandramu, C., et al., 2003. Isolation, characterization and biological activity of betulinic acid and ursolic acid from Vitex negundo L. Phytotherapy Research : Ptr, 17 (2), 129–134.
- de Dieu, T., et al., 2012. Antioxidant and antimicrobial activities of ethyl acetate extract, fractions and compounds from stem bark of Albizia adianthifolia (Mimosoideae). BMC Complementary and Alternative Medicine, 12, 99.
- Djordjević, V.B., 2004. Free radicals in cell biology. International Review of Cytology, 237, 57–89.
- Dong, Y., et al., 2014. Hepatoprotective effects of Yulangsan polysaccharide against isoniazid and rifampicin-induced liver injury in mice. Journal of Ethnopharmacology, 152 (1), 201–206.
- Enwerem, N., et al., 2001. Anthelmintic activity of the stem bark extracts of Berlina grandiflora and one of its active principles, betulinic acid. Phytomedicine : international Journal of Phytotherapy and Phytopharmacology, 8 (2), 112–114.
- Fulda, S., 2008. Betulinic acid for cancer treatment and prevention. International Journal of Molecular Sciences, 9 (6), 1096–1107.
- Galati, G., et al., 2002. Idiosyncratic NSAID drug induced oxidative stress. Chemico-Biological Interactions, 142 (1–2), 25–41.
- Gao, J., et al., 2004. Hepatoprotective activity of Terminalia catappa L. leaves and its two triterpenoids. The Journal of Pharmacy and Pharmacology, 56 (11), 1449–1455.
- Guo, S., et al., 2009. Two new terpenoids from fruits of Ziziphus jujuba. Chinese Chemical Letters, 20 (2), 197–200.
- Han, B., and Park, M., 1986. Folk medicine: The art and science. Washington, DC: American Chemical Society Publications, 205.
- Hosseinzadeh, H., Haddadkhodaparast, M.H., and Arash, A.R., 2003. Antinociceptive, antiinflammatory and acute toxicity effects of Salvia leriifolia Benth. seed extract in mice and rats. Phytotherapy Research, 17 (4), 422–425.
- Huang, Q., et al., 2012. Hepatoprotective effects of total saponins isolated from Taraphochlamys affinis against carbon tetrachloride induced liver injury in rats. Food and Chemical Toxicology, 50 (3–4), 713–718.
- Jagadeesh, S., Krupadanam, G., and Srimannarayana, G., 2000. A new triterpenoid from Zizyphus xylopyrus stem wood. Indian Journal of Chemistry Section B, Organic Including Medicinal, 39, 396–398.
- Jain, M., et al., 2012. Hepatoprotective potential of Tecomella undulata stem bark is partially due to the presence of betulinic acid. Journal of Ethnopharmacology, 143 (1), 194–200.
- Johnston, D.E., and Kroening, C., 1998. Mechanism of early carbon tetrachloride toxicity in cultured rat hepatocytes. Pharmacology & Toxicology, 83 (6), 231–239.
- Kaleem, W.A., et al., 2012. New 14-membered cyclopeptide alkaloids from Zizyphus oxyphylla Edgew. International Journal of Molecular Sciences, 13 (9), 11520–11529.
- Kaleem, W.A., et al., 2013. Urease inhibitory potential of Zizyphus oxyphylla Edgew. extracts and isolated compounds. Turkish Journal of Medical Sciences, 43, 497–500.
- Kandimalla, R., et al., 2016. Protective effect of bioactivity guided fractions of Ziziphus jujuba Mill. root bark against hepatic injury and chronic inflammation via inhibiting inflammatory markers and oxidative stress. Frontiers in Pharmacology, 7, 298.
- Kandimalla, R., et al., 2017. Bioactive fraction of Annona reticulata bark (or) Ziziphus jujuba root bark along with insulin attenuates painful diabetic neuropathy through inhibiting NF-κB inflammatory cascade. Frontiers in Cellular Neuroscience, 11, 73.
- Katewa, S., Chaudhary, B., and Jain, A., 2004. Folk herbal medicines from tribal area of Rajasthan, India. Journal of Ethnopharmacology, 92 (1), 41–46.
- Koster, R., Anderson, M., and De Beer, E., 1959. Acetic acid-induced analgesic screening. Federation Proceedings, 18, 412–417.
- Krogh, R., et al., 1999. Isolation and identification of compounds with antinociceptive action from Ipomoea pes-caprae (L.) R. Br. Die Pharmazie, 54 (6), 464–466.
- Labbe, G., Pessayre, D., and Fromenty, B., 2008. Drug-induced liver injury through mitochondrial dysfunction: mechanisms and detection during preclinical safety studies . Fundamental & Clinical Pharmacology, 22 (4), 335–353.
- Laszczyk, M.N., 2009. Pentacyclic triterpenes of the lupane, oleanane and ursane group as tools in cancer therapy. Planta Medica, 75 (15), 1549–1560.
- Leal, I.C.R., et al., 2010. Ceanothane and lupane type triterpenes from Zizyphus joazeiro - an anti-staphylococcal evaluation. Planta Medica, 76 (1), 47–52.
- Lee, S.-S., Lin, B.-F., and Liu, K.C., 1996. Three triterpene esters from Zizyphus jujuba. Phytochemistry, 43 (4), 847–851.
- Li, W.-H., et al., 2007. A new anti-HIV lupane acid from Gleditsia sinensis Lam. Journal of Asian Natural Products Research, 9 (6-8), 551–555.
- Liby, K.T., Yore, M.M., and Sporn, M.B., 2007. Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer. Nature Reviews Cancer, 7 (5), 357–369.
- Mantovani, A., and Pierotti, M.A., 2008. Cancer and inflammation: a complex relationship. Cancer Letters, 267 (2), 180–181.
- Michael, J., 2008. The toxicologist’s pocket handbook. New York, NY: Informa Healthcare USA. Inc.
- Muffler, K., et al., 2011. Biotransformation of triterpenes. Process Biochemistry, 46 (1), 1–15.
- Muhammad, N., Saeed, M., and Khan, H., 2012. Antipyretic, analgesic and anti-inflammatory activity of Viola betonicifolia whole plant. BMC Complementary and Alternative Medicine, 12 (1), 1.
- Mujwah, A.A., Mohammed, M.A., and Ahmed, M.H., 2010. First isolation of a flavonoid from Juniperus procera using ethyl acetate extract. Arabian Journal of Chemistry, 3 (2), 85–88.
- Nathan, C., 2002. Points of control in inflammation. Nature, 420 (6917), 846–852.
- Navarro, M., et al., 1993. Free radical scavenger and antihepatotoxic activity of Rosmarinus tomentosus. Planta Medica, 59 (04), 312–314.
- Newman, D.J., and Cragg, G.M., 2007. Natural products as sources of new drugs over the last 25 years. Journal of Natural Products, 70 (3), 461–477.
- Nisar, M., et al., 2010a. Biological screening of Zizyphus oxyphylla Edgew leaves. Pakistan Journal of Botany, 42, 4063–4069.
- Nisar, M., et al., 2010b. Stereochemistry and NMR data assignment of cyclopeptide alkaloids from Zizyphus oxyphylla. Natural Product Communications, 5 (8), 1205–1208.
- OECD 1994. OECD Guidelines for the Testing of Chemicals. Organization for Economic.
- Oyebanji, B.O., Saba, A.B., and Oridupa, O.A., 2014. Studies on the anti-inflammatory, analgesic and antipyrexic activities of betulinic acid derived from Tetracera potatoria. African Journal of Traditional, Complementary and Alternative Medicines, 11, 30–33.
- Rizwan, A., Niyaz, A., and Atta, A.N., 2017. Ziziphus oxyphylla”: Ethnobotanical, ethnopharmacological and phytochemical review. Biomedicine & Pharmacotherapy, 91, 970–998.
- Roitman, J.N., and Jurd, L., 1978. Triterpenoid and phenolic constituents of Colubrina granulosa. Phytochemistry, 17 (3), 491–494.
- Rosa, M., 1972. Biological properties of carrageenan. Journal of Pharmacy and Pharmacology, 24 (2), 89–102.
- Ruch, R.J., Cheng, Sj., and Klaunig, J.E., 1989. Prevention of cytotoxicity and inhibition of intercellular communication by antioxidant catechins isolated from Chinese green tea. Carcinogenesis, 10 (6), 1003–1008.
- Rufino-Palomares, E.E., et al., 2015. Anti-cancer and anti-angiogenic properties of various natural pentacyclic tri-terpenoids and some of their chemical derivatives. Current Organic Chemistry, 19 (10), 919–947.
- Sadique, J., et al., 1989. The bio-activity of certain medicinal plants on the stabilization of RBC membrane system. Fitoterapia, 60, 525–532.
- Saggu, H., et al., 1989. A selective increase in particulate superoxide dismutase activity in Parkinsonian substantia nigra. Journal of Neurochemistry, 53 (3), 692–697.
- Sánchez‐González, M., et al., 2013. Assessment of the safety of maslinic acid, a bioactive compound from Olea europaea L. Molecular Nutrition & Food Research, 57, 339–346.
- Sevanian, A., and Ursini, F., 2000. Lipid peroxidation in membranes and low-density lipoproteins: similarities and differences. Free Radical Biology & Medicine, 29 (3–4), 306–311.
- Shah, S., et al., 2006. Ethnobotanical studies of the flora of district Musakhel and Barkhan in Balochistan. Pakistan. Pakistan Journal of Weed Science Research, 12, 199–211.
- Shang, X., et al., 2011. Antinociceptive and anti-inflammatory activities of Phlomis umbrosa Turcz extract. Fitoterapia, 82 (4), 716–721.
- Sporn, M.B., et al., 2011. New synthetic triterpenoids: potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress. Journal of Natural Products, 74 (3), 537–545.
- Steele, J.C., et al., 1999. Evaluation of the anti-plasmodial activity of bisbenzylisoquinoline alkaloids from Abuta grandifolia. Planta Medica, 65 (5), 413–416.
- Suksamrarn, S., et al., 2006. Ceanothane- and lupane-type triterpenes with antiplasmodial and antimycobacterial activities from Ziziphus cambodiana . Chemical & Pharmaceutical Bulletin, 54 (4), 535–537.
- Sun, H., et al., 2006. Structure-activity relationships of oleanane-and ursane-type triterpenoids. Botanical Studies, 47, 339–368.
- Topcu, G., et al., 2007. Antioxidant activity tests on novel triterpenoids from Salvia macrochlamys. Arkivoc, 7, 195–208.
- Vidya, L., Malini, M., and Varalakshmi, P., 2000. Effect of pentacyclic triterpenes on oxalate-induced changes in rat erythrocytes. Pharmacological Research, 42 (4), 313–316.
- Wagner, H., and Wolff, P., 1977. Natural substances with effects on the liver. In: G. Vogel, ed. Proceedings in life sciences–New natural products and plant drugs with pharmacological, biological or therapeutical activity. New York: Springer-Verlag Berlin, Heidelberg, 249–265.
- Wang, J., et al., 2015. Antibacterial oleanane-type triterpenoids from pericarps of Akebia trifoliata. Food Chemistry, 168, 623–629.
- Yi, J., et al., 2014. Betulinic acid prevents alcohol-induced liver damage by improving the antioxidant system in mice. Journal of Veterinary Science, 15 (1), 141–148.
- Zheng, X., et al., 2015. Advances in research on hepatoprotective activity and synthesis of oleanolic acid derivatives. Journal of Applied Biopharmaceutics and Pharmacokinetics, 3 (1), 27–33.
- Zheng, Z.W., et al., 2011. Betulinic acid prevention of d-galactosamine/lipopolysaccharide liver toxicity is triggered by activation of Bcl-2 and antioxidant mechanisms. The Journal of Pharmacy and Pharmacology, 63 (4), 572–578.