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Research Articles

Protocatechuic acid protects against hepatorenal toxicities in rats exposed to Furan

ORCID Icon, , , ORCID Icon &
Pages 1840-1850 | Received 13 May 2020, Accepted 07 Feb 2021, Published online: 28 Feb 2021

References

  • Akele, E.S., and Tarekegn, M.M., 2017. Assessment of dioxin and furan emission levels and management practices in addis ababa. Journal of Health and Pollution, 7 (15), 85–94.
  • Alshabeeb, M.A., Aithal, G.P., and Daly, A.K., 2020. Investigation of oxidative stress-related candidate genes as risk factors for drug-induced liver injury due to co-amoxiclav. DNA and Cell Biology, 39 (3), 349–354.
  • Awad, A., et al., 2018. Differential susceptibility of kidneys and livers to proliferative processes and transcriptional level of the genes encoding desmin, vimentin, connexin 43, and nestin in rats exposed to furan. Ecotoxicology and Environmental Safety, 162, 235–244.
  • Bancroft, J. D., and Gamble, M., 2008. Theory and Practice of Histological Techniques. 6th ed. China: Churchill Livingston/Elsevier.
  • Becalski, A., and Seaman, S., 2005. Furan precursors in food: a model study and development of a simple headspace method for determination of furan. Journal of AOAC International, 88 (1), 102–106.
  • Ben Hsouna, A., et al., 2019. Potential anti-inflammatory and antioxidant effects of Citrus aurantium essential oil against carbon tetrachloride-mediated hepatotoxicity: a biochemical, molecular and histopathological changes in adult rats. Environmental Toxicology, 34 (4), 388–400.
  • Ben Hsouna, A., et al., 2020. Lobularia maritima leave extract, a nutraceutical agent with antioxidant activity, protects against CCl4-induced liver injury in mice. Drug and Chemical Toxicology, 31, 1–14.
  • Benford, D., et al., 2010. Application of the Margin of Exposure (MOE) approach to substances in food that are genotoxic and carcinogenic. Food and Chemical Toxicology, 48, S2–S24.
  • Bradford, M.M., 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry, 72 (1-2), 248–254.
  • Burka, L.T., Washburn, K.D., and Irwin, R.D., 1991. Disposition of [14C]furan in the male F344 rat. Journal of Toxicology and Environmental Health, 34 (2), 245–257.
  • Byrns, M.C., et al., 2006. Detection of DNA adducts derived from the reactive metabolite of furan, cis-2-butene-1,4-dial. Chemical Research in Toxicology, 19 (3), 414–420.
  • Cancer, I. A. f R. o., 1995. IARC Monographs on the Evaluation of Carcinogenic Risk to Humans. Dry Cleaning, Some Chlorinated Solvents and Other Industrial Chemicals, 63. Lyon, France: The International Agency for Research on Cancer.
  • Chen, L.J., Hecht, S.S., and Peterson, L.A., 1997. Characterization of amino acid and glutathione adducts of cis-2-butene-1,4-dial, a reactive metabolite of furan. Chemical Research in Toxicology, 10 (8), 866–874.
  • Churchwell, M.I., et al., 2015. Evaluation of serum and liver toxicokinetics for furan and liver DNA adduct formation in male Fischer 344 rats. Food and Chemical Toxicology, 86, 1–8.
  • Clairborne, A., 1995. Catalase activity. Boca Raton, FL: CRC Press.
  • Crews, C., and Castle, L., 2007. A review of the occurrence, formation and analysis of furan in heat-processed foods. Trends in Food Science and Technology, 18 (7), 365–372.
  • de Conti, A., Beland, F.A., and Pogribny, I.P., 2017. The role of epigenomic alterations in furan-induced hepatobiliary pathologies. Food and Chemical Toxicology, 109 (Pt), 677–682.
  • Ding, W., et al., 2012. In vivo genotoxicity of furan in F344 rats at cancer bioassay doses. Toxicology and Applied Pharmacology, 261 (2), 164–171.
  • Dong, H., et al., 2016. Toxicogenomic assessment of liver responses following subchronic exposure to furan in Fischer F344 rats. Archives of Toxicology, 90 (6), 1351–1367.
  • Egle, J.L., Jr., and Gochberg, B.J., 1979. Respiratory retention and acute toxicity of furan. American Industrial Hygiene Association Journal, 40 (4), 310–314.
  • Ellman, G.L., 1959. Tissue sulfhydryl groups. Archives of Biochemistry and Biophysics, 82 (1), 70–77.
  • Farombi, E.O., et al., 2000. Chemoprevention of 2-acetylaminofluorene-induced hepatotoxicity and lipid peroxidation in rats by kolaviron–a Garcinia kola seed extract. Food and Chemical Toxicology, 38 (6), 535–541.
  • Gibson-Corley, K.N., Olivier, A.K., and Meyerholz, D.K., 2013. Principles for valid histopathologic scoring in research. Veterinary Pathology, 50 (6), 1007–1015.
  • Gill, S., et al., 2010. Subchronic oral toxicity study of furan in Fischer-344 rats. Toxicologic Pathology, 38 (4), 619–630.
  • Granell, S., et al., 2003. Heparin mobilizes xanthine oxidase and induces lung inflammation in acute pancreatitis. Critical Care Medicine, 31 (2), 525–530.
  • Green, L.C., et al., 1982. Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Analytical Biochemistry, 126 (1), 131–138.
  • Grill, A.E., et al., 2015. Abundant rodent furan-derived urinary metabolites are associated with tobacco smoke exposure in humans. Chemical Research in Toxicology, 28 (7), 1508–1516.
  • Gruczynska, E., et al., 2018. Furan in roasted, ground and brewed coffee. Rocz Panstw Zakl Hig, 69 (2), 111–118.
  • Habig, W.H., Pabst, M.J., and Jakoby, W.B., 1974. Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. The Journal of Biological Chemistry, 249 (22), 7130–7139.
  • Hsouna, A.B., et al., 2019. Essential oil from halophyte Lobularia maritima: protective effects against CCl4-induced hepatic oxidative damage in rats and inhibition of the production of proinflammatory gene expression by lipopolysaccharide-stimulated RAW 264.7 macrophages. RSC Advances, 9 (63), 36758–36770.
  • JECFA, 2011. Acrylamide in safety evaluation of certain contaminants in food. In: Prepared by the 72nd Meeting of the Joint FAO/WHO Committee on Food Ad- ditives.
  • Kakkar, S., and Bais, S., 2014. A review on protocatechuic acid and its pharmacological potential. ISRN Pharmacology, 2014, 952943.
  • Kato, Y., 2016. Neutrophil myeloperoxidase and its substrates: formation of specific markers and reactive compounds during inflammation. J Clin Biochem Nutr, 58 (2), 99–104.
  • Kedderis, G.L., et al., 1993. Kinetic analysis of furan biotransformation by F-344 rats in vivo and in vitro. Toxicology and Applied Pharmacology, 123 (2), 274–282.
  • Kedderis, G.L.P. S.A., 1999. The biochemical toxicology of furan chemical industry institute of. Toxicology (CIIT) Activities, 19, 1–6.
  • Kellert, M., et al., 2008. Biomarkers of furan exposure by metabolic profiling of rat urine with liquid chromatography-tandem mass spectrometry and principal component analysis. Chemical Research in Toxicology, 21 (3), 761–768.
  • Kettlitz, B., et al., 2019. Furan and methylfurans in foods: an update on occurrence, mitigation, and risk assessment. Comprehensive Reviews in Food Science and Food Safety, 18 (3), 738–752.
  • Khan, A.K., et al., 2015. Pharmacological activities of protocatechuic acid. Acta Poloniae Pharmaceutica, 72 (4), 643–650.
  • Klopfleisch, R., 2013. Multiparametric and semiquantitative scoring systems for the evaluation of mouse model histopathology-a systematic review. BMC Veterinary Research, 9, 123.
  • Krzysztoforska, K., Mirowska-Guzel, D., and Widy-Tyszkiewicz, E., 2019. Pharmacological effects of protocatechuic acid and its therapeutic potential in neurodegenerative diseases: review on the basis of in vitro and in vivo studies in rodents and humans. Nutr Neurosci, 22 (2), 72–82.
  • Leopardi, P., et al., 2010. Assessment of in vivo genotoxicity of the rodent carcinogen furan: evaluation of DNA damage and induction of micronuclei in mouse splenocytes. Mutagenesis, 25 (1), 57–62.
  • Lin, H.H., et al., 2011. Protocatechuic acid inhibits cancer cell metastasis involving the down-regulation of Ras/Akt/NF-κB pathway and MMP-2 production by targeting RhoB activation. British Journal of Pharmacology, 162 (1), 237–254.
  • Lu, D., et al., 2009. Degraded protein adducts of cis-2-butene-1,4-dial are urinary and hepatocyte metabolites of furan. Chemical Research in Toxicology, 22 (6), 997–1007.
  • Masella, R., et al., 2012. Protocatechuic acid and human disease prevention: biological activities and molecular mechanisms. Current Medicinal Chemistry, 19 (18), 2901–2917.
  • McDaniel, L.P., et al., 2012. Genotoxicity of furan in Big Blue rats. Mutation Research, 742 (1-2), 72–78.
  • Milbrath, M.O.W., et al., 2009. Apparent half-lives of dioxins, furans, and polychlorinated biphenyls as a function of age, body fat, smoking status, and breast-feeding. Environmental Health Perspectives, 117 (3), 417–425.
  • Min, S.-W., Ryu, S.-N., and Kim, D.-H., 2010. Anti-inflammatory effects of black rice, cyanidin-3-O-beta-D-glycoside, and its metabolites, cyanidin and protocatechuic acid. International Immunopharmacology, 10 (8), 959–966.
  • Misra, H.P., and Fridovich, I., 1972. The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. Journal of Biological Chemistry, 247 (10), 3170–3175.
  • Moser, G.J., et al., 2009. Furan-induced dose-response relationships for liver cytotoxicity, cell proliferation, and tumorigenicity (furan-induced liver tumorigenicity). Experimental and Toxicologic Pathology, 61 (2), 101–111.
  • National Center for Biotechnology Information. 2020. PubChem Compound Summary for CID 72, 3,4-Dihydroxybenzoic acid [online]. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/3_4-Dihydroxybenzoic-acid. [Accessed 9 Nov 2020].
  • National Research Council (US) Committee on Acute Exposure Guideline Levels 2010. Furan acute exposure guideline levels [online]. Washington (DC): National Academies Press.
  • National Toxicology Program 1993a. Toxicology and Carcinogenesis Studies of Furan (CAS No.110-00-9) in F344/N Rats and B6C3F1 Mice (gavage studies). Research Triangle Park (NC): U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health.
  • National Toxicology Program 1993b. Toxicology and Carcinogenesis Studies of Furan (CAS No. 110-00-9) in F344 Rats and B6C3F1 Mice (Gavage Studies). Bethesda, MD: National Toxicology Program.
  • OECD 2008. Test No. 407: Repeated Dose 28-day Oral Toxicity Study in Rodents.
  • Owumi, S. E., et al., 2021a. Chlorogenic acid co-administration abates tamoxifen-mediated reproductive toxicities in male rats: an experimental approach. Journal of Food Biochemistry, 24, e13615.doi:https://doi.org/10.1111/jfbc.13615. Epub ahead of print.
  • Owumi, S. E., et al., 2021b. Chlorogenic acid abates oxido-inflammatory and apoptotic responses in the liver and kidney of Tamoxifen-treated rats. Toxicology Research, 1–14. doi:https://doi.org/10.1093/toxres/tfab002.
  • Owumi, S.E., et al., 2019c. Protocatechuic acid inhibits testicular and epididymal toxicity associated with methotrexate in rats. Andrologia, 51 (9), e13350.
  • Owumi, S.E., et al., 2020. Protocatechuic acid modulates reproductive dysfunction linked to furan exposure in rats. Toxicology, 442, 152556.
  • Owumi, S.E., Ajijola, I.J., and Agbeti, O.M., 2019a. Hepatorenal protective effects of protocatechuic acid in rats administered with anticancer drug methotrexate. Human & Experimental Toxicology, 38 (11), 1254–1265.
  • Owumi, S.E., Aliyu-Banjo, N.O., and Danso, O.F., 2019b. Fluoride and diethylnitrosamine coexposure enhances oxido-inflammatory responses and caspase-3 activation in liver and kidney of adult rats. J Biochem Mol Toxicol, 33 (7), e22327.
  • Owumi, S.E., and Dim, U.J., 2019. Manganese suppresses oxidative stress, inflammation and caspase-3 activation in rats exposed to chlorpyrifos. Toxicology Reports, 6, 202–209.
  • Owumi, S.E., and Najophe, E.S., 2019. Dichloromethane and ethanol co-exposure aggravates oxidative stress indices causing hepatic and renal dysfunction in pubertal rats. Toxicology Research and Application, 3, 239784731985528.
  • Pacher, P., Beckman, J.S., and Liaudet, L., 2007. Nitric oxide and peroxynitrite in health and disease. Physiol Rev, 87 (1), 315–424.
  • Parameswaran, N., and Patial, S., 2010. Tumor necrosis factor-α signaling in macrophages. Critical Reviews in Eukaryotic Gene Expression, 20 (2), 87–103.
  • Park, S.-H., et al., 2016. Protocatechuic acid attenuates osteoclastogenesis by downregulating JNK/c-Fos/NFATc1 signaling and prevents Inflammatory Bone Loss in Mice. Phytotherapy Research: PTR, 30 (4), 604–612.
  • Perez-Severiano, F., et al., 2004. Increased formation of reactive oxygen species, but no changes in glutathione peroxidase activity, in striata of mice transgenic for the Huntington's disease mutation. Neurochemical Research, 29 (4), 729–733.
  • Peterson, L.A., 2013. Reactive metabolites in the biotransformation of molecules containing a furan ring. Chemical Research in Toxicology, 26 (1), 6–25.
  • Rietjens, I., et al., 2018. Exposure assessment of process-related contaminants in food by biomarker monitoring. Archives of Toxicology, 92 (1), 15–40.
  • Rotruck, J.T., et al., 1973. Selenium: biochemical role as a component of glutathione peroxidase. Science (New York, N.Y.), 179 (4073), 588–590.
  • Savitskaya, M.A., and Onishchenko, G.E., 2015. Mechanisms of apoptosis. Biochemistry, 80 (11), 1393–1405.
  • SDS/MSDS and S.-A.S.D.S. 2020. Furan CAS No-110-00-9 [online]. United States: Sigma-Aldrich Inc. Available from: https://www.sigmaaldrich.com/MSDS/MSDS/DisplayMSDSPage.do?country=US&language=en&productNumber=185922&brand=ALDRICH&PageToGoToURL=https%3A%2F%2Fwww.sigmaaldrich.com%2Fcatalog%2Fproduct%2Faldrich%2F185922%3Flang%3Den. [accessed 11 Oct 2020].
  • Selmanoglu, G., et al., 2012. Toxicity of food contaminant furan on liver and kidney of growing male rats. Environmental Toxicology, 27 (10), 613–622.
  • Semaming, Y., et al., 2015. Pharmacological properties of protocatechuic acid and its potential roles as complementary medicine. Evidence-Based Complementary and Alternative Medicine, 2015, 593902.
  • Shirani, K., et al., 2020. Protective effects of naringin against drugs and chemical toxins induced hepatotoxicity: a review. Phytotherapy Research, 34 (8), 1734–1744.
  • Tabaran, A.F., et al., 2019. Inhaled furan selectively damages club cells in lungs of A/J mice. Toxicologic Pathology, 47 (7), 842–850.
  • Taysi, S., et al., 2019. Radicals, oxidative/nitrosative stress and preeclampsia. Mini-Reviews in Medicinal Chemistry, 19 (3), 178–193.
  • Terrell, A.N., et al., 2014. Mutagenicity of furan in female Big Blue B6C3F1 mice. Mutation Research Genetic Toxicology and Environmental Mutagenesis, 770, 46–54.
  • Thoolen, B., et al., 2010. Proliferative and nonproliferative lesions of the rat and mouse hepatobiliary system. Toxicologic Pathology, 38 (7 Suppl), 5S–81S.
  • Traesel, G.K., et al., 2014. Acute and subacute (28 days) oral toxicity assessment of the oil extracted from acrocomia aculeata pulp in rats. Food and Chemical Toxicology, 74, 320–325.
  • U.S. Food and Drug Administration 2007. An updated exposure assessment for furan from the consumption of adult and baby foods [online]. Available from: http://www.fda.gov/Food/FoodborneIllnessContaminants/ChemicalContaminants/ucm110770.htm.
  • Vari, R., et al., 2011. Protocatechuic acid induces antioxidant/detoxifying enzyme expression through JNK-mediated Nrf2 activation in murine macrophages. Journal of Nutritional Biochemistry, 22 (5), 409–417.
  • Vitaglione, P., et al., 2007. Protocatechuic acid is the major human metabolite of cyanidin-glucosides. The Journal of Nutrition, 137 (9), 2043–2048.
  • Xie, Z., et al., 2018. Protocatechuic acid inhibits the growth of ovarian cancer cells by inducing apoptosis and autophagy. Phytotherapy Research, 32 (11), 2256–2263.
  • Yaylayan, V.A., 2006. Precursors, formation and determination of furan in food. Journal Für Verbraucherschutz Und Lebensmittelsicherheit, 1 (1), 5–9.
  • Yin, M.C.L. C.C., and Wu, H.C., 2009. Apoptotic effects of protocatechuic acid in human breast, lung, liver, cer- vix, and prostate cancer cells: potential mechanisms of action. Journal of Agricultural and Food Chemistry, 57, 6468–6473.
  • Zhuang, S., Demirs, J.T., and Kochevar, I.E., 2000. p38 mitogen-activated protein kinase med- iates bid cleavage, mitochondrial dysfunction, and caspase-3 activation during apoptosis induced by singlet oxygen but not by hydrogen peroxide. Journal of Biological Chemistry, 275 (34), 25939–25948.

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