Salvianolic acid A suppresses CCl₄-induced liver fibrosis through regulating the Nrf2/HO-1, NF-κB/IκBα, p38 MAPK, and JAK1/STAT3 signaling pathways

References

• Bansal, R., Nagórniewicz, B., and Prakash, J., 2016. Clinical advancements in the targeted therapies against liver fibrosis. Mediators of Inflammation, 2016 (3), 1–16.
   Web of Science ®Google Scholar
• Bataller, R. and Brenner, D.A., 2005. Liver fibrosis. The Journal of Clinical Investigation, 115 (2), 209–218.
   PubMed Web of Science ®Google Scholar
• Cai, Z., et al., 2014. N-acetylcysteine protects against liver injure induced by carbon tetrachloride via activation of the Nrf2/HO-1 pathway. International Journal of Clinical and Experimental Pathology, 8 (7), 8655–8662.
   Web of Science ®Google Scholar
• Campo, J.A.D., Gallego, P., and Grande, L., 2018. Role of inflammatory response in liver diseases: therapeutic strategies. World Journal of Hepatology, 10 (1), 1–7.
   PubMed Web of Science ®Google Scholar
• Ji, J., et al., 2021. Apigenin alleviates liver fibrosis by inhibiting hepatic stellate cell activation and autophagy via TGF-β1/Smad3 and p38/PPARα pathways. PPAR Research, 2021 (4), 1–15.
   Web of Science ®Google Scholar
• Kyriakis, J.M. and Avruch, J., 2001. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiological Reviews, 81 (2), 807–869.
   PubMed Web of Science ®Google Scholar
• Li, S.T., et al., 2020. Activation of the AMPK-SIRT1 pathway contributes to protective effects of salvianolic acid A against lipotoxicity in hepatocytes and NAFLD in mice. Frontiers in Pharmacology, 11, 560905.
   PubMed Web of Science ®Google Scholar
• Li, W., et al., 2014. Anti-fibrosis effects of Huisheng oral solution in CCl4-induced hepatic fibrosis in rat. Indian Journal of Pharmacology, 46 (2), 216–221.
   PubMed Web of Science ®Google Scholar
• Li, Y.R., et al., 2017. Study of the inhibitory effects on TNF-α-induced NF-κB activation of IMD0354 analogs. Chemical Biology & Drug Design, 90 (6), 1307–1311.
   PubMed Web of Science ®Google Scholar
• Liu, M., et al., 2015. Dioscin alleviates alcoholic liver fibrosis by attenuating hepatic stellate cell activation via the TLR4/MyD88/NF-κB signaling pathway. Scientific Reports, 5, 18038.
   PubMed Web of Science ®Google Scholar
• Liu, Y., et al., 2018. Breviscapine ameliorates CCl4 induced liver injury in mice through inhibiting inflammatory apoptotic response and ROS generation. International Journal of Molecular Medicine, 42 (2), 755–768.
   PubMed Web of Science ®Google Scholar
• Markus, M., et al., 2011. JAK-STAT signaling in hepatic fibrosis. Frontiers in Bioscience (Landmark Edition), 16, 2794–2811.
   PubMed Web of Science ®Google Scholar
• Qian, W., et al., 2019. Anti-apoptotic effects and mechanisms of salvianolic acid A on cardiomyocytes in ischemia–reperfusion injury. Histology and Histopathology, 34 (3), 223–231.
   PubMed Web of Science ®Google Scholar
• Reza, H.M., et al., 2016. Angiotensin-converting enzyme inhibitor prevents oxidative stress, inflammation, and fibrosis in carbon tetrachloride-treated rat liver. Toxicology Mechanisms and Methods, 26 (1), 46–53.
   PubMed Web of Science ®Google Scholar
• Schuppan, D., 2015. Liver fibrosis: common mechanisms and antifibrotic therapies. Clinics and Research in Hepatology and Gastroenterology, 39, S51–S59.
   PubMed Web of Science ®Google Scholar
• Seki, E. and Brenner, D.A., 2015. Recent advancement of molecular mechanisms of liver fibrosis. Journal of Hepato-Biliary-Pancreatic Sciences, 22 (7), 512–518.
   PubMed Web of Science ®Google Scholar
• Sun, M.X. and Kisseleva, T., 2015. Reversibility of liver fibrosis. Clinics and Research in Hepatology and Gastroenterology, 39 (1), S60–S63.
   PubMed Web of Science ®Google Scholar
• Toosi, A.E., 2015. Liver fibrosis: causes and methods of assessment, a review. Romanian Journal of Internal Medicine, 53 (4), 304–314.
   PubMedGoogle Scholar
• Tsuchida, T. and Friedman, S.L., 2017. Mechanisms of hepatic stellate cell activation. Nature Reviews. Gastroenterology & Hepatology, 14 (7), 397–411.
   PubMed Web of Science ®Google Scholar
• Tsukada, S., et al., 2005. SMAD and p38 MAPK signaling pathways independently regulate alpha1(I) collagen gene expression in unstimulated and transforming growth factor-beta-stimulated hepatic stellate cells. The Journal of Biological Chemistry, 280 (11), 10055–10064.
   PubMed Web of Science ®Google Scholar
• Wang, D., et al., 2015. Thymoquinone inhibits IL-1β-induced inflammation in human osteoarthritis chondrocytes by suppressing NF-κB and MAPKs signaling pathway. Inflammation, 38 (6), 2235–2241.
   PubMed Web of Science ®Google Scholar
• Wang, R., et al., 2017. Inhibitory effects of quercetin on the progression of liver fibrosis through the regulation of NF-κB/IκBα, p38 MAPK, and Bcl-2/Bax signaling. International Immunopharmacology, 47, 126–133.
   PubMed Web of Science ®Google Scholar
• Wang, R., et al., 2018. Tanshinol ameliorates CCl4-induced liver fibrosis in rats through the regulation of Nrf2/HO-1 and NF-κB/IκBα signaling pathway. Drug Design, Development and Therapy, 12, 1281–1292.
   PubMed Web of Science ®Google Scholar
• Wang, R., et al., 2019. Salvianolic acid A attenuates CCl4-induced liver fibrosis by regulating the PI3K/AKT/mTOR, Bcl-2/Bax and caspase-3/cleaved caspase-3 signaling pathways. Drug Design, Development and Therapy, 13, 1889–1900.
   PubMed Web of Science ®Google Scholar
• Wang, X., et al., 2018. Emodin suppresses activation of hepatic stellate cells through p38 mitogen-activated protein kinase and Smad signaling pathways in vitro. Phytotherapy Research, 32 (12), 2436–2446.
   PubMed Web of Science ®Google Scholar
• Wang, Y.Y., et al., 2015. Ginkgo biloba extract mitigates liver fibrosis and apoptosis by regulating p38 MAPK, NF-κB/IκBα, and Bcl-2/Bax signaling. Drug Design, Development and Therapy, 9, 6303–6317.
   PubMed Web of Science ®Google Scholar
• Xu, H., et al., 2014. Metabolism of salvianolic acid A and antioxidant activities of its methylated metabolites. Drug Metabolism and Disposition, 42 (2), 274–281.
   PubMed Web of Science ®Google Scholar
• Xu, S.Z., et al., 2020. TGF-β/Smad and JAK/STAT pathways are involved in the anti-fibrotic effects of propylene glycol alginate sodium sulphate on hepatic fibrosis. Journal of Cellular and Molecular Medicine, 24 (9), 5224–5237.
   PubMed Web of Science ®Google Scholar
• Yang, C.H., et al., 2005. Interferon alpha activates NF-kappaB in JAK1-deficient cells through a TYK2-dependent pathway. The Journal of Biological Chemistry, 280 (27), 25849–25853.
   PubMed Web of Science ®Google Scholar
• Yang, N., et al., 2017. Caffeic acid phenethyl ester up-regulates antioxidant levels in hepatic stellate cell line T6 via an Nrf2-mediated mitogen activated protein kinases pathway. World Journal of Gastroenterology, 23 (7), 1203–1214.
   PubMed Web of Science ®Google Scholar
• Yin, C., et al., 2013. Hepatic stellate cells in liver development, regeneration, and cancer. The Journal of Clinical Investigation, 123 (5), 1902–1910.
   PubMed Web of Science ®Google Scholar
• Yu, Q., et al., 2021. PPARγ/NF-κB and TGF-β1/Smad pathway are involved in the anti-fibrotic effects of levo-tetrahydropalmatine on liver fibrosis. Journal of Cellular and Molecular Medicine, 25 (3), 1645–1660.
   PubMed Web of Science ®Google Scholar
• Zu, G., et al., 2018. Salvianolic acid A protects against oxidative stress and apoptosis induced by intestinal ischemia–reperfusion injury through activation of Nrf2/HO-1 pathways. Cellular Physiology and Biochemistry, 49 (6), 2320–2332.
   PubMedGoogle Scholar