The PERK/ATF4/CHOP signaling branch of the unfolded protein response mediates cisplatin-induced ototoxicity in hair cells

References

• Ahmed-Ouameur, A., et al., 2006. The effects of drug complexation on the stability and conformation of human serum albumin: protein unfolding. Cell Biochemistry and Biophysics, 45 (2), 203–213.
   PubMed Web of Science ®Google Scholar
• Alhawiti, N.M., et al., 2017. TXNIP in metabolic regulation: physiological role and therapeutic outlook. Current Drug Targets, 18 (9), 1095–1103.
   PubMed Web of Science ®Google Scholar
• Breglio, A.M., et al., 2017. Cisplatin is retained in the cochlea indefinitely following chemotherapy. Nature Communications, 8 (1), 1654.
   PubMed Web of Science ®Google Scholar
• Chen, D., et al., 1994. Binding and aggregation of human gamma-globulin by cis-diamminedichloroplatinum (II) through disulfide bond. Biological and Pharmaceutical Bulletin, 17 (12), 1561–1566.
   PubMed Web of Science ®Google Scholar
• Chen, J., et al., 2018. Id1/NR2B receptor pathway regulates rat cochlear sensory epithelial cell survival after radiation. Audiology and Neurotology, 23 (3), 173–180.
   PubMed Web of Science ®Google Scholar
• Chen, Y., et al., 2013. Cotransfection of Pax2 and Math1 promote in situ cochlear hair cell regeneration after neomycin insult. Scientific Reports, 3, 2996.
   PubMed Web of Science ®Google Scholar
• Ding, Y., et al., 2020. The role of FoxG1 in the inner ear. Frontiers in Cell and Developmental Biology, 8, 614954.
   PubMed Web of Science ®Google Scholar
• Gardner, B.M., et al., 2013. Endoplasmic reticulum stress sensing in the unfolded protein response. Cold Spring Harbor Perspectives in Biology, 5 (3), a013169.
   PubMed Web of Science ®Google Scholar
• Gentilin, E., et al., 2019. Cisplatin-induced ototoxicity: updates on molecular targets. Trends in Molecular Medicine, 25 (12), 1123–1132.
   PubMed Web of Science ®Google Scholar
• Guo, F.J., et al., 2014. ATF6 upregulates XBP1S and inhibits ER stress-mediated apoptosis in osteoarthritis cartilage. Cellular Signalling, 26 (2), 332–342.
   PubMed Web of Science ®Google Scholar
• Haze, K., et al., 1999. Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress. Molecular Biology of the Cell, 10 (11), 3787–3799.
   PubMed Web of Science ®Google Scholar
• He, Z.H., et al., 2020. The nuclear transcription factor FoxG1 affects the sensitivity of mimetic aging hair cells to inflammation by regulating autophagy pathways. Redox Biology, 28, 101364.
   PubMed Web of Science ®Google Scholar
• He, Z.H., et al., 2021. FOXG1 promotes aging inner ear hair cell survival through activation of the autophagy pathway. Autophagy, 17 (12), 4341–4362.
   PubMed Web of Science ®Google Scholar
• He, Z., et al., 2017. Autophagy protects auditory hair cells against neomycin-induced damage. Autophagy, 13 (11), 1884–1904.
   PubMed Web of Science ®Google Scholar
• Hetz, C., 2012. The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Nature Reviews: Molecular Cell Biology, 13 (2), 89–102.
   PubMed Web of Science ®Google Scholar
• Hetz, C., and Papa, F.R., 2018. The unfolded protein response and cell fate control. Molecular Cell, 69 (2), 169–181.
   PubMed Web of Science ®Google Scholar
• Hetz, C., and Saxena, S., 2017. ER stress and the unfolded protein response in neurodegeneration. Nature Reviews: Neurology, 13 (8), 477–491.
   PubMed Web of Science ®Google Scholar
• Iurlaro, R., and Munoz-Pinedo, C., 2016. Cell death induced by endoplasmic reticulum stress. The FEBS Journal, 283 (14), 2640–2652.
   PubMed Web of Science ®Google Scholar
• Kanekura, K., et al., 2015. IRE1 prevents endoplasmic reticulum membrane permeabilization and cell death under pathological conditions. Science Signaling, 8 (382), ra62.
   PubMed Web of Science ®Google Scholar
• Kros, C.J., and Steyger, P.S., 2019. Aminoglycoside- and cisplatin-induced ototoxicity: mechanisms and otoprotective strategies. Cold Spring Harbor Perspectives in Medicine, 9 (11), a033548.
   PubMed Web of Science ®Google Scholar
• Li, A., et al., 2018a. Novel compounds protect auditory hair cells against gentamycin-induced apoptosis by maintaining the expression level of H3K4me2. Drug Delivery, 25 (1), 1033–1043.
   PubMed Web of Science ®Google Scholar
• Li, H., et al., 2018b. Meclofenamic acid reduces reactive oxygen species accumulation and apoptosis, inhibits excessive autophagy, and protects hair cell-like HEI-OC1 cells from cisplatin-induced damage. Frontiers in Cellular Neuroscience, 12, 139.
   PubMed Web of Science ®Google Scholar
• Liu, W., et al., 2019a. Wnt signaling activates TP53-induced glycolysis and apoptosis regulator and protects against cisplatin-induced spiral ganglion neuron damage in the mouse cochlea. Antioxidants and Redox Signaling, 30 (11), 1389–1410.
   PubMed Web of Science ®Google Scholar
• Liu, Y., et al., 2019b. Critical role of spectrin in hearing development and deafness. Science Advances, 5 (4), eaav7803.
   PubMed Web of Science ®Google Scholar
• Mollazadeh, H., et al., 2018. The effect of statin therapy on endoplasmic reticulum stress. Pharmacological Research, 137, 150–158.
   PubMed Web of Science ®Google Scholar
• Nakamura, M., et al., 2006. Activation of the endoplasmic reticulum stress pathway is associated with survival of myeloma cells. Leukemia and Lymphoma, 47 (3), 531–539.
   PubMed Web of Science ®Google Scholar
• Oakes, S.A., and Papa, F.R., 2015. The role of endoplasmic reticulum stress in human pathology. Annual Review of Pathology, 10, 173–194.
   PubMed Web of Science ®Google Scholar
• Ozeki, M., et al., 2003. Establishment and characterization of rat progenitor hair cell lines. Hearing Research, 179 (1-2), 43–52.
   PubMed Web of Science ®Google Scholar
• Ozeki, M., et al., 2007. Id1 induces the proliferation of cochlear sensory epithelial cells via the nuclear factor-kappaB/cyclin D1 pathway in vitro. Journal of Neuroscience Research, 85 (3), 515–524.
   PubMed Web of Science ®Google Scholar
• Palm, M.E., et al., 2011. Cisplatin binds human copper chaperone Atox1 and promotes unfolding in vitro. Proceedings of the National Academy of Sciences of the United States of America, 108 (17), 6951–6956.
   PubMed Web of Science ®Google Scholar
• Sado, M., et al., 2009. Protective effect against Parkinson's disease-related insults through the activation of XBP1. Brain Research, 1257, 16–24.
   PubMed Web of Science ®Google Scholar
• Sancho-Martinez, S.M., et al., 2012. Subcellular targets of cisplatin cytotoxicity: an integrated view. Pharmacology and Therapeutics., 136 (1), 35–55.
   PubMed Web of Science ®Google Scholar
• Shore, G.C., Papa, F.R., and Oakes, S.A., 2011. Signaling cell death from the endoplasmic reticulum stress response. Current Opinion in Cell Biology, 23 (2), 143–149.
   PubMed Web of Science ®Google Scholar
• Urra, H., et al., 2013. When ER stress reaches a dead end. Biochimica et Biophysica Acta, 1833 (12), 3507–3517.
   PubMed Web of Science ®Google Scholar
• van As, J.W., van den Berg, H., and van Dalen, E.C., 2018. Different infusion durations for preventing platinum-induced hearing loss in children with cancer. The Cochrane Database of Systematic Reviews, 7, CD010885.
   PubMed Web of Science ®Google Scholar
• Walter, F., et al., 2015. Imaging of single cell responses to ER stress indicates that the relative dynamics of IRE1/XBP1 and PERK/ATF4 signalling rather than a switch between signalling branches determine cell survival. Cell Death and Differentiation, 22 (9), 1502–1516.
   PubMed Web of Science ®Google Scholar
• Wang, M., and Kaufman, R.J., 2016. Protein misfolding in the endoplasmic reticulum as a conduit to human disease. Nature, 529 (7586), 326–335.
   PubMed Web of Science ®Google Scholar
• Wang, Y., et al., 2017. Loss of CIB2 causes profound hearing loss and abolishes mechanoelectrical transduction in mice. Frontiers in Molecular Neuroscience, 10, 401.
   PubMed Web of Science ®Google Scholar
• Wen, Y., et al., 2021. Tauroursodeoxycholic acid attenuates cisplatin-induced ototoxicity by inhibiting the accumulation and aggregation of unfolded or misfolded proteins in the endoplasmic reticulum. Toxicology, 453, 152736.
   PubMed Web of Science ®Google Scholar
• Xiong, S., Chng, W.J., and Zhou, J., 2021. Crosstalk between endoplasmic reticulum stress and oxidative stress: a dynamic duo in multiple myeloma. Cellular and Molecular Life Sciences, 78 (8), 3883–3906.
   PubMed Web of Science ®Google Scholar
• Zheng, Y., et al., 2008. EGF mediates survival of rat cochlear sensory cells via an NF-kappaB dependent mechanism in vitro. The Open Neuroscience Journal, 2, 9–15.
   PubMedGoogle Scholar
• Zong, S., et al., 2017. Endoplasmic reticulum stress is involved in cochlear cell apoptosis in a cisplatin-induced ototoxicity rat model. Audiology and Neurotology, 22 (3), 160–168.
   PubMed Web of Science ®Google Scholar